Complex loading affects intervertebral disc mechanics and biology

Osteoarthritis and Cartilage

Volumn 19, Issue 8, 2011, Pages 1011-1018

  Walter, B A ^a,b   Korecki, C L ^a   Purmessur, D ^a,b   Roughley, P J ^c   Michalek, A J ^a   Iatridis, J C ^a,b  

^a University of Vermont   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c SHRINERS HOSPITAL FOR CHILDREN   (Canada)

Author keywords

Apoptosis; Catabolism; Intervertebral disc; Mechanical loading; Organ culture

Indexed keywords

AGGRECAN; AGGRECANASE 1; CASPASE 3; COLLAGEN TYPE 1; COLLAGEN TYPE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; MESSENGER RNA;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOMECHANICS; CATABOLISM; COMPRESSION; CONTROLLED STUDY; COW; EX VIVO STUDY; EXPLANT; HISTOLOGY; INFLAMMATION; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WEIGHT BEARING; WESTERN BLOTTING;

ADAM PROTEINS; AGGRECANS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CASPASE 3; CATTLE; CELL DEATH; DISEASE MODELS, ANIMAL; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERVERTEBRAL DISC; MATRIX METALLOPROTEINASE 1; PROCOLLAGEN N-ENDOPEPTIDASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL DISEASES; WEIGHT-BEARING;

EID: 79960340632     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.04.005     Document Type: Article

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