Mechanics and biology in intervertebral disc degeneration: A vicious circle

Osteoarthritis and Cartilage

Volumn 23, Issue 7, 2015, Pages 1057-1070

  Vergroesen, P P A ^a,b   Kingma, I ^b   Emanuel, K S ^a   Hoogendoorn, R J W ^a   Welting, T J ^c   van Royen, B J ^a,b   van Dieen J H ^b   Smit, T H ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Intervertebral disc; Intervertebral disc degeneration; Mechanobiology; Pathology; Physiology

Indexed keywords

AGGRECAN; COLLAGEN TYPE 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 2; NERVE GROWTH FACTOR; PROTEOGLYCAN;

ANATOMIC LANDMARK; ANNULUS FIBROSUS; BIOMECHANICS; CYTOKINE PRODUCTION; DEGENERATION; DIABETES MELLITUS; DISEASE COURSE; DNA DAMAGE; EXTRACELLULAR MATRIX; GENE; HUMAN; IL1RA GENE; INTERVERTEBRAL DISK DEGENERATION; KNOCKOUT GENE; MOLECULAR BIOLOGY; NONHUMAN; NUCLEUS PULPOSUS; PATHOLOGICAL ANATOMY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; RISK FACTOR; SHEAR STRESS; SMOKING; UPREGULATION; ANATOMY AND HISTOLOGY; ANIMAL; DISEASE MODEL; INTERVERTEBRAL DISK; MECHANICAL STRESS; MECHANOTRANSDUCTION; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BIOMECHANICAL PHENOMENA; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; HUMANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MECHANOTRANSDUCTION, CELLULAR; STRESS, MECHANICAL;

EID: 84930822168     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.03.028     Document Type: Review

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