Vertebral endplate architecture and vascularization: Application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat

Spine

Volumn 30, Issue 23, 2005, Pages 2593-2600

  Gruber, Helen E ^a   Ashraf, Nomaan ^a   Kilburn, Jeremy ^a   Williams, Cliff ^a   Norton, H James ^a   Gordon, Brian E ^b   Hanley Jr , Edward N ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Aging; Anti factor VIII immunocytochemistry; Disc degeneration; Micro computerized tomography; Psammomys obesus; Sand rat; Vascular tracer; Vertebral endplate

Indexed keywords

TRACER;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BONE BLOOD FLOW; BONE DENSITY; CALCIFICATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HISTOLOGY; IMMUNOCYTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; LUMBAR VERTEBRA; MALE; NERVE ENDING; NONHUMAN; NUTRIENT AVAILABILITY; OSTEOSCLEROSIS; POROSITY; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; VASCULARIZATION;

AGING; ANIMALS; FLUORESCEIN; GERBILLINAE; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; LUMBAR VERTEBRAE; MALE; MICRORADIOGRAPHY; NEOVASCULARIZATION, PATHOLOGIC; SPINAL DISEASES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 28844502298     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000187877.30149.83     Document Type: Article

References (27)

1. Crock HV, Goldwasser M, Yoshizawa H. Vascular anatomy related to the intervertebral disc. In: Ghosh P, ed. The Biology of the Intervertebral Disc. Vol 1. Boca Raton, FL: CRC Press; 1988:109-33.
2. Modic MT, Steinberg PM, Ross JS, et al. Degenerative disk disease: Assessment of changes in vertebral body marrow with MR imaging. Radiology 1988;166:193-9.
3. Gruber HE, Johnson T, Norton HJ, et al. The sand rat model for disc degeneration: Radiologic characterization of age-related changes. Cross-sectional and prospective analyses. Spine 2002;27:230-4.
4. Gruber HE, Gordon B, Williams C, et al. Bone mineral density of lumbar vertebral end plates in the aging male sand rat spine. Spine 2003;28:1766-72.
5. Brown MD, Tsaltas TT. Studies on the permeability of the intervertebral disc during skeletal maturation. Spine 1976;1:240-4.
6. Gruber HE. Adaptations of Goldner's Masson trichrome stain for the study of undecalcified plastic embedded bone. Biotechnic Histochem 1992;67:30-4.
7. Kellgren JH, Lawrence JS. Osteo-arthrosis and disk degeneration in an urban population. Ann Rheum Dis 1958;17:388-97.
8. Fraser RD, Bleasel JF, Moskowitz RW. Spinal degeneration: Pathogenesis and Medical Management. In: Ducker TB, Hadler NM, Kostuik JP, et al, eds. The Adult Spine. Principles and Practices. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1997:735-59.
9. Bernick S, Caillet R. Vertebral end-plate changes with aging of human vertebrae. Spine 1982;7:97-102.
10. Horner HA, Urban JPG. 2001 Volvo Award winner in basic science studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine 2002;26:2543-9.
11. Holm SH. Nutrition of the intervertebral disc. In: Weinstein JN, Wiesel SW, eds. The Lumbar Spine. Philadelphia, PA: WB Saunders Co; 1994:244-60.
12. Urban JPG, Holm S, Maroudas A, et al. Nutrition of the intervertebral disk. An in vivo study of solute transport. Clin Orthop Relat Res 1997;129:101-14.
13. Ogata K, Whiteside LA. Nutritional pathways of the intervertebral disc. An experimental study using hydrogen washout technique. Spine 1981;6:211-6.
14. Maroudas A. Nutrition and metabolism of the intervertebral disc. In: Ghosh P, ed. The Biology of the Intervertebral Disc. Vol 2. Boca Raton, FL: CRC Press; 1988:1-37.
15. Grignon B, Grignon Y, Mainard D, et al. The structure of the cartilaginous end-plates in elder people. Surg Radiol Anat 2000;22:13-9.
16. Turgut M, Uysal A, Uslu S, et al. The effects of calcium channel antagonist nimodipine on end-plate vascularity of the degenerated intervertebral disc in rats. J Clin Neurosci 2003;10:219-33.
17. Turgut M, Sargin H, Oenol B, et al. Changes in end-plate vascularity after Nd: YAG laser application to the guinea pig intervertebral disc. Acta Neurochir (Wien) 1998;140:819-25.
18. Turgut M, Uslu S, Uysal A, et al. Changes in vascularity of cartilage endplate of degenerated intervertebral discs in response to melatonin administration in rats. Neurosurg Rev 2003;26:133-8.
19. Holm S, Holm AK, Ekstrõm L, et al. Experimental disc degeneration due to endplate injury. J Spinal Disord Tech 2004;17:64-71.
20. Bishop PB, Pearce RH. The proteoglycans of the cartilaginous end-plate of the human intervertebral disc change after maturity. J Orthop Res 1993;11:324-31.
21. Brodin H. Paths of nutrition in articular cartilage and intervertebral discs. Acta Orthop Scand 1955;24:177-83.
22. Bibby SRS, Urban JPG. Effect of nutrient deprivation on the viability of intervertebral disc cells. Eur Spine J 2004;13:695-701.
23. Moore RJ. The vertebral end-plate: What do we know? Eur Spine J 2000;9:92-6.
24. Hukins DWL. Disc structure and function. In: Ghosh P, ed. The Biology of the Intervertebral Disc. Vol 1. Boca Raton, FL: CRC Press; 1988:1-37.
25. Cooper DML, Turinsky AL, Sensen CW, et al. Quantitative 3D analysis of the canal network in cortical bone by micro-computed tomography. Anat Rec B New Anat 2003;274:169-79.
26. Hutton WC, Murakami H, Li J, et al. The effect of blocking a nutritional pathway to the intervertebral disc in the dog model. J Spinal Disord Tech 2004;17:53-63.
27. Rajasekaran S, Babu JN, Arun R, et al. ISSLS Prize Winner: A study of diffusion in human lumbar discs: A serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine 2004;23:2654-67.