Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression

Journal of Orthopaedic Research

Volumn 22, Issue 6, 2004, Pages 1193-1200

  MacLean, Jeffery J ^a,b   Lee, Cynthia R ^a,b   Alini, Mauro ^b,c   Iatridis, James C ^a  

^a University of Vermont   (United States)

^b AO RESEARCH INSTITUTE   (Switzerland)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Animal model; Gene expression; Intervertebral disc; Mechanobiology; Real time RT PCR

Indexed keywords

AGGRECAN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGENASE 3; MESSENGER RNA; STROMELYSIN 3;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CATABOLISM; COMPRESSION; DISSECTION; DYNAMICS; GENE ACTIVATION; GENE EXPRESSION REGULATION; ILIZAROV TECHNIQUE; IN VIVO STUDY; INTERVERTEBRAL DISK; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WEIGHT BEARING;

ADAM PROTEINS; AGGRECANS; ANIMALS; COLLAGEN; COLLAGENASES; COMPRESSIVE STRENGTH; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; INTERVERTEBRAL DISK; LECTINS, C-TYPE; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; METALLOENDOPEPTIDASES; MODELS, ANIMAL; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEOGLYCANS; RATS; RATS, WISTAR; RNA, MESSENGER; RNA, RIBOSOMAL, 18S; WEIGHT-BEARING;

EID: 4844225379     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2004.04.004     Document Type: Article

References (47)

1. Adams M.A. Freeman B.J. Morrison H.P. Nelson I.W. Dolan P. Mechanical initiation of intervertebral disc degeneration Spine 25 2000 1625-1636
2. Anderson D.G. Izzo M.W. Hall D.J. Vaccaro A.R. Hilibrand A. Arnold W. et al. Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model Spine 27 2002 1291-1296
3. Antoniou J. Steffen T. Nelson F. Winterbottom N. Hollander A.P. Poole R.A. et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration J. Clin. Invest. 98 1996 996-1003
4. Baer A.E. Laursen T.A. Guilak F. Setton L.A. The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model J. Biomech. Eng. 125 2003 1-11
5. Buckwalter J. Martin J. Intervertebral disk degeneration and back pain In: Weinstein J.N. Rosemont I.L. (Eds.), Low Back Pain: A Scientific and Clinical Overview 1996 607-623 American Academy of Orthopaedic Surgeons
6. Chelberg M.K. Banks G.M. Geiger D.F. Oegema T.R. Jr. Identification of heterogeneous cell populations in normal human intervertebral disc J. Anat. 186 Pt 1 1995 43-53
7. Chen J. Baer A.E. Paik P.Y. Yan W. Setton L.A. Matrix protein gene expression in intervertebral disc cells subjected to altered osmolarity Biochem. Biophys. Res. Commun. 293 2002 932-938
8. Ching C.T. Chow D.H. Yao F.Y. Holmes A.D. The effect of cyclic compression on the mechanical properties of the inter-vertebral disc: an in vivo study in a rat tail model Clin. Biomech. (Bristol, Avon) 18 2003 182-189
9. Cole T.C. Ghosh P. Taylor T.K. Variations of the proteoglycans of the canine intervertebral disc with ageing Biochim. Biophys. Acta. 880 1986 209-219
10. Cs-Szabo G. Ragasa-San Juan D. Turumella V. Masuda K. Thonar E.J. An H.S. Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration Spine 27 2002 2212-2219
11. Flecknell P. Roughan J.V. Stewart R. Use of oral buprenorphine ('buprenorphine jello') for postoperative analgesia in rats - a clinical trial Lab Anim. 33 1999 169-174
12. Guilak F. Ting-Beall H.P. Baer A.E. Trickey W.R. Erickson G.R. Setton L.A. Viscoelastic properties of intervertebral disc cells. Identification of two biomechanically distinct cell populations Spine 24 1999 2475-2483
13. Handa T. Ishihara H. Ohshima H. Osada R. Tsuji H. Obata K. Effects of hydrostatic pressure on matrix synthesis and matrix metalloproteinase production in the human lumbar intervertebral disc Spine 22 1997 1085-1091
14. Heliovaara M. Risk factors for low back pain and sciatica Ann. Med. 21 1989 257-264
15. Horner H.A. Roberts S. Bielby R.C. Menage J. Evans H. Urban J.P. Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype Spine 27 2002 1018-1028
16. Horner H.A. Urban J.P. 2001 Volvo award winner in basic science studies: effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc Spine 26 2001 2543-2549
17. Hsieh A.H. Lotz J.C. Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs Spine 28 2003 1781-1788
18. Hutton W.C. Elmer W.A. Boden S.D. Hyon S. Toribatake Y. Tomita K. et al. The effect of hydrostatic pressure on intervertebral disc metabolism Spine 24 1999 1507-1515
19. Hutton W.C. Elmer W.A. Bryce L.M. Kozlowska E.E. Boden S.D. Kozlowski M. Do the intervertebral disc cells respond to different levels of hydrostatic pressure? Clin. Biomech. (Bristol, Avon) 16 2001 728-734
20. Hutton W.C. Ganey T.M. Elmer W.A. Kozlowska E. Ugbo J.L. Doh E.S. et al. Does long-term compressive loading on the intervertebral disc cause degeneration? Spine 25 2000 2993-3004
21. Hutton W.C. Toribatake Y. Elmer W.A. Ganey T.M. Tomita K. Whitesides T.E. The effect of compressive force applied to the intervertebral disc in vivo. A study of proteoglycans and collagen Spine 23 1998 2524-2537
22. Iatridis J.C. Mente P.L. Stokes I.A. Aronsson D.D. Alini M. Compression-induced changes in intervertebral disc properties in a rat tail model Spine 24 1999 996-1002
23. Iatridis JC, Risinger R, Monsey R, Goswanmi T, Alini M. Effects of Static Compression on Biochemical Composition of Caudal Discs In Vivo. Trans International Soc Lumbar Spine (ISSLS) Vancouver Canada:poster 101, 2003
24. Iatridis J.C. Setton L.A. Foster R.J. Rawlins B.A. Weidenbaum M. Mow V.C. Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression J. Biomech. 31 1998 535-544
25. Ishihara H. McNally D.S. Urban J.P. Hall A.C. Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk J. Appl. Physiol. 80 1996 839-846
26. Kasra M. Goel V. Martin J. Wang S.T. Choi W. Buckwalter J. Effect of dynamic hydrostatic pressure on rabbit intervertebral disc cells J. Orthop. Res. 21 2003 597-603
27. Kinkel M.D. Horton W.E. Jr. Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability J. Cell. Biochem. 88 2003 941-953
28. Lotz J.C. Chin J.R. Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading Spine 25 2000 1477-1483
29. Lotz J.C. Colliou O.K. Chin J.R. Duncan N.A. Liebenberg E. Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study Spine 23 1998 2493-2506
30. Luoma K. Riihimaki H. Luukkonen R. Raininko R. Viikari-Juntura E. Lamminen A. Low back pain in relation to lumbar disc degeneration in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability Spine 25 2000 487-492
31. Lyons G. Eisenstein S.M. Sweet M.B. Biochemical changes in intervertebral disc degeneration Biochim. Biophys. Acta 673 1981 443-453
32. MacLean J.J. Lee C.R. Grad S. Ito K. Alini M. Iatridis J.C. Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo Spine 28 2003 973-981
33. Matsumoto T. Kawakami M. Kuribayashi K. Takenaka T. Tamaki T. Cyclic mechanical stretch stress increases the growth rate and collagen synthesis of nucleus pulposus cells in vitro Spine 24 1999 315-319
34. Miller J.A. Schmatz C. Schultz A.B. Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens Spine 13 1988 173-178
35. Ohshima H. Urban J.P. Bergel D.H. Effect of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique J. Orthop. Res. 13 1995 22-29
36. Oshima H. Ishihara H. Urban J.P. Tsuji H. The use of coccygeal discs to study intervertebral disc metabolism J. Orthop. Res. 11 1993 332-338
37. Paajanen H. Erkintalo M. Parkkola R. Salminen J. Kormano M. Age-dependent correlation of low-back pain and lumbar disc regeneration Arch. Orthop. Trauma Surg. 116 1997 106-107
38. Pearce R.H. Grimmer B.J. Adams M.E. Degeneration and the chemical composition of the human lumbar intervertebral disc J. Orthop. Res. 5 1987 198-205
39. Pope M.H. Magnusson M. Wilder D.G. Kappa delta award. Low back pain and whole body vibration Clin. Orthop. 1998 241-248
40. Ragan P.M. Badger A.M. Cook M. Chin V.I. Gowen M. Grodzinsky A.J. et al. Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration J. Orthop. Res. 17 1999 836-842
41. Saamanen A.M. Puustjarvi K. Ilves K. Lammi M. Kiviranta I. Jurvelin J. et al. Effect of running exercise on proteoglycans and collagen content in the intervertebral disc of young dogs Int. J. Sports Med. 14 1993 48-51
42. Salminen J.J. Erkintalo M.O. Pentti J. Oksanen A. Kormano M.J. Recurrent low back pain and early disc degeneration in the young Spine 24 1999 1316-1321
43. Sato K. Kikuchi S. Yonezawa T. In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems Spine 24 1999 2468-2474
44. Stokes I.A. Aronsson D.D. Spence H. Iatridis J.C. Mechanical modulation of intervertebral disc thickness in growing rat tails J. Spinal Disord 11 1998 261-265
45. Urban J.P. The effect of physical factors on disk cell metabolism Buckwalter J. Goldberg V. Woo SLY. (Eds.), Musculoskeletal Soft-Tissue Aging: Impact on Mobility 1993 391-412 American Academey of Orthopaedic Surgeons Rosemont, IL
46. Walsh A, Lotz J. In-vivo response of the intervertebral disc to dynamic loading. In: Trans Orthop Res Soc, Paper 210, 2002
47. Kim C.H. Chen F.H. Chan M.L. Ateshian G.A. Hung C.T. Guo X.E. Intervertebral disc response to in vivo dynamic loading in a rat-tail model Trans. Orth. Res. Soc. 28 2003