Senescent cells in the intervertebral disc: numbers and mechanisms

Spine Journal

Volumn 9, Issue 8, 2009, Pages 677-678

  Kletsas, Dimitris ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL AGING; CELL DIVISION; CELL PROLIFERATION; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; LOW BACK PAIN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 67749114451     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2009.05.016     Document Type: Note

References (10)

1. Campisi J., and d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8 (2007) 729-740
2. Toussaint O., Medrano E.E., and von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35 (2000) 927-945
3. Price J.S., Waters J.G., Darrah C., et al. The role of chondrocyte senescence in osteoarthritis. Aging Cell 1 (2002) 57-65
4. Gorgoulis V.G., Pratsinis H., Zacharatos P., et al. p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions. Lab Invest 85 (2005) 502-511
5. Urban J.P., and Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther 5 (2003) 120-130
6. Roberts S., Evans E.H., Kletsas D., et al. Senescence in human intervertebral discs. Eur Spine J 15 Suppl 3 (2006) S312-S316
7. Gruber H.E., Ingram J.A., Norton H.J., and Hanley Jr. E.N. Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. Spine 32 (2007) 321-327
8. Kim K.W., Chung H.N., Ha K.Y., et al. Senescence mechanisms of nuclear pulposus chondrocytes in human intervertebral discs. Spine J 9 (2009) 658-666
9. Le Maitre C.L., Freemont A.J., and Hoyland J.A. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 9 (2007) R45
10. Severino J., Allen R.G., Balin S., and Cristofalo V.J. Is β-galactosidase staining a marker of senescence in vitro and in vivo?. Exp Cell Res 257 (2000) 162-171