메뉴 건너뛰기




Volumn 28, Issue 2, 2016, Pages 152-160

The biology behind interleukin-6 targeted interventions

Author keywords

biologics; cytokines; glycoprotein 130; interleukin 6; therapy

Indexed keywords

GLYCOPROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; TOCILIZUMAB; GLYCOPROTEIN GP 130; IL6 PROTEIN, HUMAN; IL6ST PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

EID: 84957440448     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000255     Document Type: Review
Times cited : (54)

References (100)
  • 1
    • 84922410788 scopus 로고    scopus 로고
    • Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis
    • Mease PJ. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. Curr Opin Rheumatol 2015; 27:127-133.
    • (2015) Curr Opin Rheumatol , vol.27 , pp. 127-133
    • Mease, P.J.1
  • 3
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W, Sands BE, Lewitzky S, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012; 61:1693-1700.
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 4
    • 51349134454 scopus 로고    scopus 로고
    • Actemra poised to launch IL-6 inhibitors
    • Melton L, Coombs A. Actemra poised to launch IL-6 inhibitors. Nat Biotechnol 2008; 26:957-959.
    • (2008) Nat Biotechnol , vol.26 , pp. 957-959
    • Melton, L.1    Coombs, A.2
  • 5
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol 2015; 16:448-457.
    • (2015) Nat Immunol , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 6
    • 0025190892 scopus 로고
    • Interleukin-6 and the acute phase response
    • Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990; 265:621-636.
    • (1990) Biochem J , vol.265 , pp. 621-636
    • Heinrich, P.C.1    Castell, J.V.2    Andus, T.3
  • 7
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf M, Baumann H, Freer G, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994; 368:339-342.
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3
  • 8
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 9
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano T, Yasukawa K, Harada H, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324:73-76.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3
  • 10
    • 0030794861 scopus 로고    scopus 로고
    • Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation
    • Liu F, Poursine-Laurent J, Wu HY, Link DC. Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 1997; 90:2583-2590.
    • (1997) Blood , vol.90 , pp. 2583-2590
    • Liu, F.1    Poursine-Laurent, J.2    Wu, H.Y.3    Link, D.C.4
  • 11
    • 0029846756 scopus 로고    scopus 로고
    • Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    • Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996; 274:1379-1383.
    • (1996) Science , vol.274 , pp. 1379-1383
    • Cressman, D.E.1    Greenbaum, L.E.2    DeAngelis, R.A.3
  • 12
    • 84942988008 scopus 로고    scopus 로고
    • Interdependent and independent roles of type i interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C
    • Murray C, Griffin EW, O'Loughlin E, et al. Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C. Brain Behav Immun 2015; 48:274-286.
    • (2015) Brain Behav Immun , vol.48 , pp. 274-286
    • Murray, C.1    Griffin, E.W.2    O'Loughlin, E.3
  • 13
    • 42949094793 scopus 로고    scopus 로고
    • IL-6-STAT-3-hepcidin: Linking inflammation to the iron metabolism
    • Stoian I, Manolescu B, Atanasiu V, et al. IL-6-STAT-3-hepcidin: linking inflammation to the iron metabolism. Rom J Intern Med 2007; 45:305-309.
    • (2007) Rom J Intern Med , vol.45 , pp. 305-309
    • Stoian, I.1    Manolescu, B.2    Atanasiu, V.3
  • 14
    • 84924415012 scopus 로고    scopus 로고
    • Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
    • Kraakman MJ, Kammoun HL, Allen TL, et al. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab 2015; 21:403-416.
    • (2015) Cell Metab , vol.21 , pp. 403-416
    • Kraakman, M.J.1    Kammoun, H.L.2    Allen, T.L.3
  • 15
    • 84924328294 scopus 로고    scopus 로고
    • A gp130-Src-YAP module links inflammation to epithelial regeneration
    • Taniguchi K, Wu LW, Grivennikov SI, et al. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature 2015; 519:57-62.
    • (2015) Nature , vol.519 , pp. 57-62
    • Taniguchi, K.1    Wu, L.W.2    Grivennikov, S.I.3
  • 16
    • 84874660169 scopus 로고    scopus 로고
    • The problem of choice: Current biologic agents and future prospects in RA
    • Choy EH, Kavanaugh AF, Jones SA. The problem of choice: current biologic agents and future prospects in RA. Nat Rev Rheumatol 2013; 9:154-163.
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 154-163
    • Choy, E.H.1    Kavanaugh, A.F.2    Jones, S.A.3
  • 17
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones SA, Scheller J, Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest 2011; 121:3375-3383.
    • (2011) J Clin Invest , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 18
    • 31044449633 scopus 로고    scopus 로고
    • Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis
    • Wong PK, Quinn JM, Sims NA, et al. Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum 2006; 54:158-168.
    • (2006) Arthritis Rheum , vol.54 , pp. 158-168
    • Wong, P.K.1    Quinn, J.M.2    Sims, N.A.3
  • 19
    • 13144259627 scopus 로고    scopus 로고
    • Interleukin 6 plays a key role in the development of antigen-induced arthritis
    • Ohshima S, Saeki Y, Mima T, et al. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc Natl Acad Sci U S A 1998; 95:8222-8226.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8222-8226
    • Ohshima, S.1    Saeki, Y.2    Mima, T.3
  • 20
    • 0042834261 scopus 로고    scopus 로고
    • Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: Blockade of arthritis severity by soluble glycoprotein 130
    • Nowell MA, Richards PJ, Horiuchi S, et al. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J Immunol 2003; 171:3202-3209.
    • (2003) J Immunol , vol.171 , pp. 3202-3209
    • Nowell, M.A.1    Richards, P.J.2    Horiuchi, S.3
  • 21
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi T, Fattori E, Lazzaro D, et al. Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 1998; 187:461-468.
    • (1998) J Exp Med , vol.187 , pp. 461-468
    • Alonzi, T.1    Fattori, E.2    Lazzaro, D.3
  • 22
    • 0031852288 scopus 로고    scopus 로고
    • IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Eugster HP, Frei K, Kopf M, et al. IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur J Immunol 1998; 28:2178-2187.
    • (1998) Eur J Immunol , vol.28 , pp. 2178-2187
    • Eugster, H.P.1    Frei, K.2    Kopf, M.3
  • 23
    • 79961008060 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis
    • Haruta H, Ohguro N, Fujimoto M, et al. Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 2011; 52:3264-3271.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 3264-3271
    • Haruta, H.1    Ohguro, N.2    Fujimoto, M.3
  • 24
    • 10244246599 scopus 로고    scopus 로고
    • Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice
    • Screpanti I, Musiani P, Bellavia D, et al. Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice. J Exp Med 1996; 184:1561-1566.
    • (1996) J Exp Med , vol.184 , pp. 1561-1566
    • Screpanti, I.1    Musiani, P.2    Bellavia, D.3
  • 25
    • 0030929261 scopus 로고    scopus 로고
    • Defective development of pristane-oilinduced plasmacytomas in interleukin-6-deficient BALB/c mice
    • Lattanzio G, Libert C, Aquilina M, et al. Defective development of pristane-oilinduced plasmacytomas in interleukin-6-deficient BALB/c mice. Am J Pathol 1997; 151:689-696.
    • (1997) Am J Pathol , vol.151 , pp. 689-696
    • Lattanzio, G.1    Libert, C.2    Aquilina, M.3
  • 26
    • 85047689521 scopus 로고    scopus 로고
    • Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
    • McLoughlin RM, Witowski J, Robson RL, et al. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 2003; 112:598-607.
    • (2003) J Clin Invest , vol.112 , pp. 598-607
    • McLoughlin, R.M.1    Witowski, J.2    Robson, R.L.3
  • 27
    • 11144357767 scopus 로고    scopus 로고
    • Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms
    • McLoughlin RM, Hurst SM, Nowell MA, et al. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. J Immunol 2004; 172:5676-5683.
    • (2004) J Immunol , vol.172 , pp. 5676-5683
    • McLoughlin, R.M.1    Hurst, S.M.2    Nowell, M.A.3
  • 28
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer, gp130
    • Hibi M, Murakami M, Saito M, et al. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990; 63:1149-1157.
    • (1990) Cell , vol.63 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3
  • 29
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    • Taga T, Hibi M, Hirata Y, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989; 58:573-581.
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3
  • 30
    • 0023685762 scopus 로고
    • Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
    • Yamasaki K, Taga T, Hirata Y, et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science 1988; 241:825-828.
    • (1988) Science , vol.241 , pp. 825-828
    • Yamasaki, K.1    Taga, T.2    Hirata, Y.3
  • 31
    • 9044222888 scopus 로고    scopus 로고
    • Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
    • Yoshida K, Taga T, Saito M, et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A 1996; 93:407-411.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 407-411
    • Yoshida, K.1    Taga, T.2    Saito, M.3
  • 32
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • Heinrich PC, Behrmann I, Haan S, et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003; 374:1-20.
    • (2003) Biochem J , vol.374 , pp. 1-20
    • Heinrich, P.C.1    Behrmann, I.2    Haan, S.3
  • 33
    • 0346157324 scopus 로고    scopus 로고
    • Acquiring signalling specificity from the cytokine receptor gp130
    • Ernst M, Jenkins BJ. Acquiring signalling specificity from the cytokine receptor gp130. Trends Genet 2004; 20:23-32.
    • (2004) Trends Genet , vol.20 , pp. 23-32
    • Ernst, M.1    Jenkins, B.J.2
  • 34
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007; 7:41-51.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 35
    • 84874658901 scopus 로고    scopus 로고
    • Back to the future: Oral targeted therapy for RA and other autoimmune diseases
    • O'Shea JJ, Laurence A, McInnes IB. Back to the future: Oral targeted therapy for RA and other autoimmune diseases. Nat Rev Rheumatol 2013; 9:173-182.
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 173-182
    • O'Shea, J.J.1    Laurence, A.2    McInnes, I.B.3
  • 36
    • 77953980528 scopus 로고    scopus 로고
    • IL-6: From its discovery to clinical applications
    • Kishimoto T. IL-6: from its discovery to clinical applications. Int Immunol 2010; 22:347-352.
    • (2010) Int Immunol , vol.22 , pp. 347-352
    • Kishimoto, T.1
  • 37
    • 14144251446 scopus 로고    scopus 로고
    • Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane
    • Schroers A, Hecht O, Kallen KJ, et al. Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane. Protein Sci 2005; 14:783-790.
    • (2005) Protein Sci , vol.14 , pp. 783-790
    • Schroers, A.1    Hecht, O.2    Kallen, K.J.3
  • 38
    • 0026554229 scopus 로고
    • Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection
    • Honda M, Yamamoto S, Cheng M, et al. Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J Immunol 1992; 148:2175-2180.
    • (1992) J Immunol , vol.148 , pp. 2175-2180
    • Honda, M.1    Yamamoto, S.2    Cheng, M.3
  • 39
    • 0024458160 scopus 로고
    • Soluble cytokine receptors are present in normal human urine
    • Novick D, Engelmann H, Wallach D, Rubinstein M. Soluble cytokine receptors are present in normal human urine. J Exp Med 1989; 170:1409-1414.
    • (1989) J Exp Med , vol.170 , pp. 1409-1414
    • Novick, D.1    Engelmann, H.2    Wallach, D.3    Rubinstein, M.4
  • 40
    • 84878247187 scopus 로고    scopus 로고
    • Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling
    • Baran P, Nitz R, Grotzinger J, et al. Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling. J Biol Chem 2013; 288:14756-14768.
    • (2013) J Biol Chem , vol.288 , pp. 14756-14768
    • Baran, P.1    Nitz, R.2    Grotzinger, J.3
  • 41
    • 24744435772 scopus 로고    scopus 로고
    • Directing transition from innate to acquired immunity: Defining a role for IL-6
    • Jones SA. Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol 2005; 175:3463-3468.
    • (2005) J Immunol , vol.175 , pp. 3463-3468
    • Jones, S.A.1
  • 42
    • 0035164602 scopus 로고    scopus 로고
    • The soluble interleukin 6 receptor: Mechanisms of production and implications in disease
    • Jones SA, Horiuchi S, Topley N, et al. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 2001; 15:43-58.
    • (2001) FASEB J , vol.15 , pp. 43-58
    • Jones, S.A.1    Horiuchi, S.2    Topley, N.3
  • 43
    • 0029863504 scopus 로고    scopus 로고
    • The function of the soluble interleukin 6 (IL-6) receptor in vivo: Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
    • Peters M, Jacobs S, Ehlers M, et al. The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med 1996; 183:1399-1406.
    • (1996) J Exp Med , vol.183 , pp. 1399-1406
    • Peters, M.1    Jacobs, S.2    Ehlers, M.3
  • 44
    • 0025783528 scopus 로고
    • Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor
    • Gearing DP, Cosman D. Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 1991; 66:9-10.
    • (1991) Cell , vol.66 , pp. 9-10
    • Gearing, D.P.1    Cosman, D.2
  • 45
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the pro-inflammatory activities of IL-6
    • Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci 2012; 8:1237-1247.
    • (2012) Int J Biol Sci , vol.8 , pp. 1237-1247
    • Rose-John, S.1
  • 46
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock T, Mullberg J, Ozbek S, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 2001; 268:160-167.
    • (2001) Eur J Biochem , vol.268 , pp. 160-167
    • Jostock, T.1    Mullberg, J.2    Ozbek, S.3
  • 47
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • Narazaki M, Yasukawa K, Saito T, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 1993; 82:1120-1126.
    • (1993) Blood , vol.82 , pp. 1120-1126
    • Narazaki, M.1    Yasukawa, K.2    Saito, T.3
  • 48
    • 59849091830 scopus 로고    scopus 로고
    • Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis
    • Nowell MA, Williams AS, Carty SA, et al. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J Immunol 2009; 182:613-622.
    • (2009) J Immunol , vol.182 , pp. 613-622
    • Nowell, M.A.1    Williams, A.S.2    Carty, S.A.3
  • 49
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 2000; 6:583-588.
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3
  • 50
    • 84946605400 scopus 로고    scopus 로고
    • Novel Insights into Interleukin 6 (IL-6) Cis-and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex
    • Lacroix M, Rousseau F, Guilhot F, et al. Novel Insights into Interleukin 6 (IL-6) Cis-and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex. J Biol Chem 2015; 290:26943-26953.
    • (2015) J Biol Chem , vol.290 , pp. 26943-26953
    • Lacroix, M.1    Rousseau, F.2    Guilhot, F.3
  • 51
    • 78149474747 scopus 로고    scopus 로고
    • Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity
    • Lissilaa R, Buatois V, Magistrelli G, et al. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. J Immunol 2010; 185:5512-5521.
    • (2010) J Immunol , vol.185 , pp. 5512-5521
    • Lissilaa, R.1    Buatois, V.2    Magistrelli, G.3
  • 52
    • 0001288334 scopus 로고
    • Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro
    • Ishibashi T, Kimura H, Uchida T, et al. Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci U S A 1989; 86:5953-5957.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 5953-5957
    • Ishibashi, T.1    Kimura, H.2    Uchida, T.3
  • 53
    • 84896490641 scopus 로고    scopus 로고
    • Clinical experience of IL-6 blockade in rheumatic diseases: Implications on IL-6 biology and disease pathogenesis
    • Davies R, Choy E. Clinical experience of IL-6 blockade in rheumatic diseases: implications on IL-6 biology and disease pathogenesis. Semin Immunol 2014; 26:97-104.
    • (2014) Semin Immunol , vol.26 , pp. 97-104
    • Davies, R.1    Choy, E.2
  • 54
    • 84920285641 scopus 로고    scopus 로고
    • IL-6 biology: Implications for clinical targeting in rheumatic disease
    • Calabrese LH, Rose-John S. IL-6 biology: implications for clinical targeting in rheumatic disease. Nat Rev Rheumatol 2014; 10:720-727.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 720-727
    • Calabrese, L.H.1    Rose-John, S.2
  • 55
    • 0032518415 scopus 로고    scopus 로고
    • IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
    • Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998; 101:311-320.
    • (1998) J Clin Invest , vol.101 , pp. 311-320
    • Xing, Z.1    Gauldie, J.2    Cox, G.3
  • 56
    • 0034960582 scopus 로고    scopus 로고
    • Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
    • Hurst SM, Wilkinson TS, McLoughlin RM, et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 2001; 14:705-714.
    • (2001) Immunity , vol.14 , pp. 705-714
    • Hurst, S.M.1    Wilkinson, T.S.2    McLoughlin, R.M.3
  • 57
    • 49649104776 scopus 로고    scopus 로고
    • IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
    • Fielding CA, McLoughlin RM, McLeod L, et al. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. J Immunol 2008; 181:2189-2195.
    • (2008) J Immunol , vol.181 , pp. 2189-2195
    • Fielding, C.A.1    McLoughlin, R.M.2    McLeod, L.3
  • 58
    • 38949164424 scopus 로고    scopus 로고
    • Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
    • Rabe B, Chalaris A, May U, et al. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 2008; 111:1021-1028.
    • (2008) Blood , vol.111 , pp. 1021-1028
    • Rabe, B.1    Chalaris, A.2    May, U.3
  • 59
    • 34548856204 scopus 로고    scopus 로고
    • Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
    • Chalaris A, Rabe B, Paliga K, et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 2007; 110:1748-1755.
    • (2007) Blood , vol.110 , pp. 1748-1755
    • Chalaris, A.1    Rabe, B.2    Paliga, K.3
  • 60
    • 22144492213 scopus 로고    scopus 로고
    • IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
    • McLoughlin RM, Jenkins BJ, Grail D, et al. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc Natl Acad Sci U S A 2005; 102:9589-9594.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9589-9594
    • McLoughlin, R.M.1    Jenkins, B.J.2    Grail, D.3
  • 61
    • 9144220760 scopus 로고    scopus 로고
    • Central role of IL-6 receptor signaltransducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress
    • Chen Q, Wang WC, Bruce R, et al. Central role of IL-6 receptor signaltransducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress. Immunity 2004; 20:59-70.
    • (2004) Immunity , vol.20 , pp. 59-70
    • Chen, Q.1    Wang, W.C.2    Bruce, R.3
  • 63
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of Treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 2010; 40:1830-1835.
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 64
    • 84864481289 scopus 로고    scopus 로고
    • Brief report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis
    • Samson M, Audia S, Janikashvili N, et al. Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. Arthritis Rheum 2012; 64:2499-2503.
    • (2012) Arthritis Rheum , vol.64 , pp. 2499-2503
    • Samson, M.1    Audia, S.2    Janikashvili, N.3
  • 65
    • 77957661299 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
    • Matthews VB, Allen TL, Risis S, et al. Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia 2010; 53:2431-2441.
    • (2010) Diabetologia , vol.53 , pp. 2431-2441
    • Matthews, V.B.1    Allen, T.L.2    Risis, S.3
  • 66
    • 55949119252 scopus 로고    scopus 로고
    • Muscle as an endocrine organ: Focus on musclederived interleukin-6
    • Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on musclederived interleukin-6. Physiol Rev 2008; 88:1379-1406.
    • (2008) Physiol Rev , vol.88 , pp. 1379-1406
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 67
    • 77956335194 scopus 로고    scopus 로고
    • Interleukin-6 signaling in liverparenchymal cells suppresses hepatic inflammation and improves systemic insulin action
    • Wunderlich FT, Strohle P, Konner AC, et al. Interleukin-6 signaling in liverparenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab 2010; 12:237-249.
    • (2010) Cell Metab , vol.12 , pp. 237-249
    • Wunderlich, F.T.1    Strohle, P.2    Konner, A.C.3
  • 68
    • 18244419398 scopus 로고    scopus 로고
    • Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice
    • Peters M, Schirmacher P, Goldschmitt J, et al. Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice. J Exp Med 1997; 185:755-766.
    • (1997) J Exp Med , vol.185 , pp. 755-766
    • Peters, M.1    Schirmacher, P.2    Goldschmitt, J.3
  • 70
    • 0141570562 scopus 로고    scopus 로고
    • Interleukin-6 production by contracting human skeletal muscle: Autocrine regulation by IL-6
    • Keller P, Keller C, Carey AL, et al. Interleukin-6 production by contracting human skeletal muscle: Autocrine regulation by IL-6. Biochem Biophys Res Commun 2003; 310:550-554.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 550-554
    • Keller, P.1    Keller, C.2    Carey, A.L.3
  • 71
    • 0642364997 scopus 로고    scopus 로고
    • Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise
    • Penkowa M, Keller C, Keller P, et al. Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise. FASEB J 2003; 17:2166-2168.
    • (2003) FASEB J , vol.17 , pp. 2166-2168
    • Penkowa, M.1    Keller, C.2    Keller, P.3
  • 72
    • 0038372035 scopus 로고    scopus 로고
    • Interleukin-6 stimulates lipolysis and fat oxidation in humans
    • van Hall G, Steensberg A, Sacchetti M, et al. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab 2003; 88:3005-3010.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3005-3010
    • Van Hall, G.1    Steensberg, A.2    Sacchetti, M.3
  • 73
    • 33750859187 scopus 로고    scopus 로고
    • Interleukin-6 increases insulinstimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    • Carey AL, Steinberg GR, Macaulay SL, et al. Interleukin-6 increases insulinstimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 2006; 55:2688-2697.
    • (2006) Diabetes , vol.55 , pp. 2688-2697
    • Carey, A.L.1    Steinberg, G.R.2    Macaulay, S.L.3
  • 74
    • 0028266906 scopus 로고
    • Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion
    • Poli V, Balena R, Fattori E, et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 1994; 13:1189-1196.
    • (1994) EMBO J , vol.13 , pp. 1189-1196
    • Poli, V.1    Balena, R.2    Fattori, E.3
  • 75
    • 0027136189 scopus 로고
    • Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
    • Tamura T, Udagawa N, Takahashi N, et al. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A 1993; 90:11924-11928.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11924-11928
    • Tamura, T.1    Udagawa, N.2    Takahashi, N.3
  • 76
    • 73149112786 scopus 로고    scopus 로고
    • A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma
    • Fulciniti M, Hideshima T, Vermot-Desroches C, et al. A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin Cancer Res 2009; 15:7144-7152.
    • (2009) Clin Cancer Res , vol.15 , pp. 7144-7152
    • Fulciniti, M.1    Hideshima, T.2    Vermot-Desroches, C.3
  • 77
    • 42549168550 scopus 로고    scopus 로고
    • Gut, inflammation and osteoporosis: Basic and clinical concepts
    • Tilg H, Moschen AR, Kaser A, et al. Gut, inflammation and osteoporosis: basic and clinical concepts. Gut 2008; 57:684-694.
    • (2008) Gut , vol.57 , pp. 684-694
    • Tilg, H.1    Moschen, A.R.2    Kaser, A.3
  • 78
    • 0032968705 scopus 로고    scopus 로고
    • Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice
    • Murphy PG, Ramer MS, Borthwick L, et al. Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice. Eur J Neurosci 1999; 11:2243-2253.
    • (1999) Eur J Neurosci , vol.11 , pp. 2243-2253
    • Murphy, P.G.1    Ramer, M.S.2    Borthwick, L.3
  • 79
    • 84877860166 scopus 로고    scopus 로고
    • Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice
    • Braun O, Dewitz C, Moller-Hackbarth K, et al. Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice. J Interferon Cytokine Res 2013; 33:254-260.
    • (2013) J Interferon Cytokine Res , vol.33 , pp. 254-260
    • Braun, O.1    Dewitz, C.2    Moller-Hackbarth, K.3
  • 80
    • 0025990893 scopus 로고
    • Murine antiinterleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia
    • Klein B, Wijdenes J, Zhang XG, et al. Murine antiinterleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 1991; 78:1198-1204.
    • (1991) Blood , vol.78 , pp. 1198-1204
    • Klein, B.1    Wijdenes, J.2    Zhang, X.G.3
  • 82
    • 0026475047 scopus 로고
    • High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy: Towards a new methodology for measuring overall cytokine production in human in vivo
    • Lu ZY, Brochier J, Wijdenes J, et al. High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy: towards a new methodology for measuring overall cytokine production in human in vivo. Eur J Immunol 1992; 22:2819-2824.
    • (1992) Eur J Immunol , vol.22 , pp. 2819-2824
    • Lu, Z.Y.1    Brochier, J.2    Wijdenes, J.3
  • 83
    • 58149154996 scopus 로고    scopus 로고
    • Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
    • Nishimoto N, Terao K, Mima T, et al. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood 2008; 112:3959-3964.
    • (2008) Blood , vol.112 , pp. 3959-3964
    • Nishimoto, N.1    Terao, K.2    Mima, T.3
  • 84
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the longterm efficacy of infliximab in Crohn's disease
    • Baert F, Noman M, Vermeire S, et al. Influence of immunogenicity on the longterm efficacy of infliximab in Crohn's disease. N Engl J Med 2003; 348:601-608.
    • (2003) N Engl J Med , vol.348 , pp. 601-608
    • Baert, F.1    Noman, M.2    Vermeire, S.3
  • 85
    • 0842304936 scopus 로고    scopus 로고
    • Minimizing the immunogenicity of protein therapeutics
    • Chirino AJ, Ary ML, Marshall SA. Minimizing the immunogenicity of protein therapeutics. Drug Discov Today 2004; 9:82-90.
    • (2004) Drug Discov Today , vol.9 , pp. 82-90
    • Chirino, A.J.1    Ary, M.L.2    Marshall, S.A.3
  • 86
    • 0021713342 scopus 로고
    • Production of functional chimaeric mouse/human antibody
    • Boulianne GL, Hozumi N, Shulman MJ. Production of functional chimaeric mouse/human antibody. Nature 1984; 312:643-646.
    • (1984) Nature , vol.312 , pp. 643-646
    • Boulianne, G.L.1    Hozumi, N.2    Shulman, M.J.3
  • 87
    • 0021716682 scopus 로고
    • Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
    • Morrison SL, Johnson MJ, Herzenberg LA, Oi VT. Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci U S A 1984; 81:6851-6855.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 6851-6855
    • Morrison, S.L.1    Johnson, M.J.2    Herzenberg, L.A.3    Oi, V.T.4
  • 88
    • 84934444785 scopus 로고    scopus 로고
    • Introduction to heavy chain antibodies and derived Nanobodies
    • Vincke C, Muyldermans S. Introduction to heavy chain antibodies and derived Nanobodies. Methods Mol Biol 2012; 911:15-26.
    • (2012) Methods Mol Biol , vol.911 , pp. 15-26
    • Vincke, C.1    Muyldermans, S.2
  • 89
    • 28644436100 scopus 로고    scopus 로고
    • Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains
    • Silverman J, Liu Q, Bakker A, et al. Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains. Nat Biotechnol 2005; 23:1556-1561.
    • (2005) Nat Biotechnol , vol.23 , pp. 1556-1561
    • Silverman, J.1    Liu, Q.2    Bakker, A.3
  • 90
    • 84880269392 scopus 로고    scopus 로고
    • How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy
    • Schett G, Elewaut D, McInnes IB, et al. How cytokine networks fuel inflammation: toward a cytokine-based disease taxonomy. Nat Med 2013; 19:822-824.
    • (2013) Nat Med , vol.19 , pp. 822-824
    • Schett, G.1    Elewaut, D.2    McInnes, I.B.3
  • 91
    • 84905169508 scopus 로고    scopus 로고
    • IL-6 targeting compared to TNF targeting in rheumatoid arthritis: Studies of olokizumab, sarilumab and sirukumab
    • Tanaka Y, Martin Mola E. IL-6 targeting compared to TNF targeting in rheumatoid arthritis: studies of olokizumab, sarilumab and sirukumab. Ann Rheum Dis 2014; 73:1595-1597.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1595-1597
    • Tanaka, Y.1    Martin Mola, E.2
  • 93
    • 0032731374 scopus 로고    scopus 로고
    • CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis
    • Padberg F, Feneberg W, Schmidt S, et al. CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis. J Neuroimmunol 1999; 99:218-223.
    • (1999) J Neuroimmunol , vol.99 , pp. 218-223
    • Padberg, F.1    Feneberg, W.2    Schmidt, S.3
  • 94
    • 84856221966 scopus 로고    scopus 로고
    • Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
    • Schuett H, Oestreich R, Waetzig GH, et al. Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb Vasc Biol 2012; 32:281-290.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 281-290
    • Schuett, H.1    Oestreich, R.2    Waetzig, G.H.3
  • 95
    • 84885126530 scopus 로고    scopus 로고
    • Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice
    • Tsantikos E, Maxwell MJ, Putoczki T, et al. Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis Rheum 2013; 65:2691-2702.
    • (2013) Arthritis Rheum , vol.65 , pp. 2691-2702
    • Tsantikos, E.1    Maxwell, M.J.2    Putoczki, T.3
  • 96
    • 33646469222 scopus 로고    scopus 로고
    • Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
    • Richards PJ, Nowell MA, Horiuchi S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum 2006; 54:1662-1672.
    • (2006) Arthritis Rheum , vol.54 , pp. 1662-1672
    • Richards, P.J.1    Nowell, M.A.2    Horiuchi, S.3
  • 97
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C, Fantini MC, Schramm C, et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004; 21:491-501.
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3
  • 99
    • 77949326158 scopus 로고    scopus 로고
    • Essential roles of IL-6 transsignaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitisassociated premalignant cancer in a murine model
    • Matsumoto S, Hara T, Mitsuyama K, et al. Essential roles of IL-6 transsignaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitisassociated premalignant cancer in a murine model. J Immunol 2010; 184:1543-1551
    • (2010) J Immunol , vol.184 , pp. 1543-1551
    • Matsumoto, S.1    Hara, T.2    Mitsuyama, K.3
  • 100
    • 84865377662 scopus 로고    scopus 로고
    • Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis
    • Sodenkamp J, Waetzig GH, Scheller J, et al. Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. Immunobiology 2012; 217:996-1004.
    • (2012) Immunobiology , vol.217 , pp. 996-1004
    • Sodenkamp, J.1    Waetzig, G.H.2    Scheller, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.