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Volumn 12, Issue 2, 2016, Pages 111-122

Targeting of proangiogenic signalling pathways in chronic inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN RECEPTOR; CHEMOKINE; CYTOKINE; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR INHIBITOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SPHINGOSINE KINASE 1; STAT PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; CELL ADHESION MOLECULE; MATRIX METALLOPROTEINASE; SIGNAL PEPTIDE;

EID: 84956811659     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2015.164     Document Type: Review
Times cited : (88)

References (138)
  • 1
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 3
    • 35648933951 scopus 로고    scopus 로고
    • Mechanisms of disease: Angiogenesis in inflammatory diseases
    • Szekanecz, Z. & Koch, A. E. Mechanisms of disease: angiogenesis in inflammatory diseases. Nat. Clin. Pract. Rheumatol. 3, 635-643 (2007).
    • (2007) Nat. Clin. Pract. Rheumatol. , vol.3 , pp. 635-643
    • Szekanecz, Z.1    Koch, A.E.2
  • 4
    • 0020630407 scopus 로고
    • Capillary endothelial cell cultures: Phenotypic modulation by matrix components
    • Madri, J. A. & Williams, S. K. Capillary endothelial cell cultures: phenotypic modulation by matrix components. J. Cell. Biol. 97, 153-165 (1983).
    • (1983) J. Cell. Biol. , vol.97 , pp. 153-165
    • Madri, J.A.1    Williams, S.K.2
  • 5
    • 84943354831 scopus 로고    scopus 로고
    • The pathogenic role of angiogenesis in rheumatoid arthritis
    • Elshabrawy, H. A. et al. The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis http://dx.doi.org/10.1007/s10456-015-9477-2.
    • Angiogenesis
    • Elshabrawy, H.A.1
  • 6
    • 80051669017 scopus 로고    scopus 로고
    • Angiogenesis in rheumatoid arthritis: A disease specific process or a common response to chronic inflammation?
    • Marrelli, A. et al. Angiogenesis in rheumatoid arthritis: a disease specific process or a common response to chronic inflammation? Autoimmun. Rev. 10, 595-598 (2011).
    • (2011) Autoimmun. Rev. , vol.10 , pp. 595-598
    • Marrelli, A.1
  • 7
  • 8
    • 0025490094 scopus 로고
    • Cytokine-endothelial interactions in inflammation, immunity, and vascular injury
    • Cotran, R. S. & Pober, J. S. Cytokine-endothelial interactions in inflammation, immunity, and vascular injury. J. Am. Soc. Nephrol. 1, 225-235 (1990).
    • (1990) J. Am. Soc. Nephrol. , vol.1 , pp. 225-235
    • Cotran, R.S.1    Pober, J.S.2
  • 9
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971).
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 11
    • 77955003794 scopus 로고    scopus 로고
    • Synovial tissue hypoxia and inflammation in vivo
    • Ng, C. T. et al. Synovial tissue hypoxia and inflammation in vivo. Ann. Rheum. Dis. 69, 1389-1395 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1389-1395
    • Ng, C.T.1
  • 12
    • 18144391498 scopus 로고    scopus 로고
    • Hypoxia and angiogenesis in rheumatoid arthritis
    • Taylor, P. C. & Sivakumar, B. Hypoxia and angiogenesis in rheumatoid arthritis. Curr. Opin. Rheumatol. 17, 293-298 (2005).
    • (2005) Curr. Opin. Rheumatol. , vol.17 , pp. 293-298
    • Taylor, P.C.1    Sivakumar, B.2
  • 13
    • 33748499607 scopus 로고    scopus 로고
    • Inhibition of angiogenic pathways in rheumatoid arthritis: Potential for therapeutic targeting
    • Veale, D. J. & Fearon, U. Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting. Best Pract. Res. Clin. Rheumatol. 20, 941-947 (2006).
    • (2006) Best Pract. Res. Clin. Rheumatol. , vol.20 , pp. 941-947
    • Veale, D.J.1    Fearon, U.2
  • 14
    • 84927912748 scopus 로고    scopus 로고
    • Inhibitors of angiogenesis: Ready for prime time?
    • Maracle, C. X. & Tas, S. W. Inhibitors of angiogenesis: ready for prime time? Best Pract. Res. Clin. Rheumatol. 28, 637-649 (2014).
    • (2014) Best Pract. Res. Clin. Rheumatol. , vol.28 , pp. 637-649
    • Maracle, C.X.1    Tas, S.W.2
  • 15
    • 84866552180 scopus 로고    scopus 로고
    • Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis
    • Kanakaraj, P. et al. Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. MAbs 4, 600-613 (2012).
    • (2012) MAbs , vol.4 , pp. 600-613
    • Kanakaraj, P.1
  • 16
    • 0032504752 scopus 로고    scopus 로고
    • Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis
    • Asahara, T. et al. Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. Circ. Res. 83, 233-240 (1998).
    • (1998) Circ. Res. , vol.83 , pp. 233-240
    • Asahara, T.1
  • 17
    • 77953967440 scopus 로고    scopus 로고
    • Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy
    • Izquierdo, E. et al. Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy. PLoS ONE 4, e8131 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e8131
    • Izquierdo, E.1
  • 18
    • 77952924625 scopus 로고    scopus 로고
    • The axis of thrombospondin-1, transforming growth factor β and connective tissue growth factor: An emerging therapeutic target in rheumatoid arthritis
    • Rico, M. C., Rough, J. J., Del Carpio-Cano, F. E., Kunapuli, S. P. & DeLa Cadena, R. A. The axis of thrombospondin-1, transforming growth factor β and connective tissue growth factor: an emerging therapeutic target in rheumatoid arthritis. Curr. Vasc. Pharmacol. 8, 338-343 (2009).
    • (2009) Curr. Vasc. Pharmacol. , vol.8 , pp. 338-343
    • Rico, M.C.1    Rough, J.J.2    Del Carpio-Cano, F.E.3    Kunapuli, S.P.4    DeLa Cadena, R.A.5
  • 19
    • 0028362876 scopus 로고
    • Requirement of vascular integrin αVβ3 for angiogenesis
    • Brooks, P. C., Clark, R. A. & Cheresh, D. A. Requirement of vascular integrin αVβ3 for angiogenesis. Science 264, 569-571 (1994).
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 20
    • 37349047162 scopus 로고    scopus 로고
    • Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues
    • Shahrara, S., Castro-Rueda, H. P., Haines, G. K. & Koch, A. E. Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues. Arthritis Res. Ther. 9, R112 (2007).
    • (2007) Arthritis Res. Ther. , vol.9 , pp. R112
    • Shahrara, S.1    Castro-Rueda, H.P.2    Haines, G.K.3    Koch, A.E.4
  • 21
    • 0036839554 scopus 로고    scopus 로고
    • Integrin αVβ3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases
    • Wilder, R. L. Integrin αVβ3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases. Ann. Rheum. Dis. 61 (Suppl. 2), ii96-ii99 (2002).
    • (2002) Ann. Rheum. Dis. , vol.61 , pp. ii96-ii99
    • Wilder, R.L.1
  • 22
  • 23
    • 77956419867 scopus 로고    scopus 로고
    • Junctional adhesion molecule-C is a soluble mediator of angiogenesis
    • Rabquer, B. J. et al. Junctional adhesion molecule-C is a soluble mediator of angiogenesis. J. Immunol. 185, 1777-1785 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1777-1785
    • Rabquer, B.J.1
  • 24
    • 0037903231 scopus 로고    scopus 로고
    • Roles of matrix metalloproteinases in tumor metastasis and angiogenesis
    • Yoon, S. O., Park, S. J., Yun, C. H. & Chung, A. S. Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J. Biochem. Mol. Biol. 36, 128-137 (2003).
    • (2003) J. Biochem. Mol. Biol. , vol.36 , pp. 128-137
    • Yoon, S.O.1    Park, S.J.2    Yun, C.H.3    Chung, A.S.4
  • 25
    • 33747152779 scopus 로고    scopus 로고
    • Cytokines and chemokines as regulators of angiogenesis in health and disease
    • Benelli, R., Lorusso, G., Albini, A. & Noonan, D. M. Cytokines and chemokines as regulators of angiogenesis in health and disease. Curr. Pharm. Des. 12, 3101-3115 (2006).
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 3101-3115
    • Benelli, R.1    Lorusso, G.2    Albini, A.3    Noonan, D.M.4
  • 26
    • 0031009807 scopus 로고    scopus 로고
    • Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor α-dependent angiogenesis
    • Yoshida, S. et al. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor α-dependent angiogenesis. Mol. Cell. Biol. 17, 4015-4023 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4015-4023
    • Yoshida, S.1
  • 27
    • 0023192006 scopus 로고
    • Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha
    • Leibovich, S. J. et al. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Nature 329, 630-632 (1987).
    • (1987) Nature , vol.329 , pp. 630-632
    • Leibovich, S.J.1
  • 28
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Li, Q. & Verma, I. M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 29
    • 29244486471 scopus 로고    scopus 로고
    • Sequential induction of angiogenic growth factors by TNF-α in choroidal endothelial cells
    • Hangai, M. et al. Sequential induction of angiogenic growth factors by TNF-α in choroidal endothelial cells. J. Neuroimmunol. 171, 45-56 (2006).
    • (2006) J. Neuroimmunol. , vol.171 , pp. 45-56
    • Hangai, M.1
  • 30
    • 20244390429 scopus 로고
    • The functional role of the ELR motif in CXC chemokine-mediated angiogenesis
    • Strieter, R. M. et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270, 27348-27357 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 27348-27357
    • Strieter, R.M.1
  • 31
    • 0032948123 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1α
    • Salcedo, R. et al. Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: in vivo neovascularization induced by stromal-derived factor-1α. Am. J. Pathol. 154, 1125-1135 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 1125-1135
    • Salcedo, R.1
  • 32
    • 34250724520 scopus 로고    scopus 로고
    • The SDF-1-CXCR4 signaling pathway: A molecular hub modulating neoangiogenesis
    • Petit, I., Jin, D. & Rafii, S. The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neoangiogenesis. Trends Immunol. 28, 299-307 (2007).
    • (2007) Trends Immunol. , vol.28 , pp. 299-307
    • Petit, I.1    Jin, D.2    Rafii, S.3
  • 33
    • 84879859034 scopus 로고    scopus 로고
    • Evidence that CXCL16 is a potent mediator of angiogenesis and is involved in endothelial progenitor cell chemotaxis: Studies in mice with K/B x N serum-induced arthritis
    • Isozaki, T. et al. Evidence that CXCL16 is a potent mediator of angiogenesis and is involved in endothelial progenitor cell chemotaxis: studies in mice with K/B x N serum-induced arthritis. Arthritis Rheum. 65, 1736-1746 (2013).
    • (2013) Arthritis Rheum. , vol.65 , pp. 1736-1746
    • Isozaki, T.1
  • 34
    • 84884563645 scopus 로고    scopus 로고
    • Macrophages and chemokines as mediators of angiogenesis
    • Owen, J. L. & Mohamadzadeh, M. Macrophages and chemokines as mediators of angiogenesis. Front. Physiol. 4, 159 (2013).
    • (2013) Front. Physiol. , vol.4 , pp. 159
    • Owen, J.L.1    Mohamadzadeh, M.2
  • 35
    • 84900816359 scopus 로고    scopus 로고
    • IFNγ-responsiveness of endothelial cells leads to efficient angiostasis in tumours involving down-regulation of Dll4
    • Deng, J. et al. IFNγ-responsiveness of endothelial cells leads to efficient angiostasis in tumours involving down-regulation of Dll4. J. Pathol. 233, 170-182 (2014).
    • (2014) J. Pathol. , vol.233 , pp. 170-182
    • Deng, J.1
  • 36
    • 0042173089 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Cancer Res. 63, 4095-5100 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 4095-5100
    • Qin, Z.1
  • 38
    • 34247127472 scopus 로고    scopus 로고
    • Macrophages and their products in rheumatoid arthritis
    • Szekanecz, Z. & Koch, A. E. Macrophages and their products in rheumatoid arthritis. Curr. Opin. Rheumatol. 19, 289-295 (2007).
    • (2007) Curr. Opin. Rheumatol. , vol.19 , pp. 289-295
    • Szekanecz, Z.1    Koch, A.E.2
  • 40
    • 84858720357 scopus 로고    scopus 로고
    • Celebrating 25 years of NF-κB research
    • Ghosh, S. & Hayden, M. S. Celebrating 25 years of NF-κB research. Immunol. Rev. 246, 5-13 (2012).
    • (2012) Immunol. Rev. , vol.246 , pp. 5-13
    • Ghosh, S.1    Hayden, M.S.2
  • 41
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway
    • Senftleben, U. et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293, 1495-1499 (2001).
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1
  • 42
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin, M. Nuclear factor-κB in cancer development and progression. Nature 441, 431-436 (2006).
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 43
    • 85027944808 scopus 로고    scopus 로고
    • NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis
    • Noort, A. R. et al. NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis. J. Pathol. 234, 375-385 (2014).
    • (2014) J. Pathol. , vol.234 , pp. 375-385
    • Noort, A.R.1
  • 45
    • 34248575149 scopus 로고    scopus 로고
    • Integrating signals from RTKs to ERK/MAPK
    • McKay, M. M. & Morrison, D. K. Integrating signals from RTKs to ERK/MAPK. Oncogene 26, 3113-3121 (2007).
    • (2007) Oncogene , vol.26 , pp. 3113-3121
    • McKay, M.M.1    Morrison, D.K.2
  • 46
    • 0030905825 scopus 로고    scopus 로고
    • Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium
    • Asahara, H. et al. Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium. Arthritis Rheum. 40, 912-918 (1997).
    • (1997) Arthritis Rheum. , vol.40 , pp. 912-918
    • Asahara, H.1
  • 47
    • 34447532208 scopus 로고    scopus 로고
    • Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways
    • Amin, M. A. et al. Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways. Arthritis Rheum. 56, 1787-1797 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 1787-1797
    • Amin, M.A.1
  • 48
    • 0032832808 scopus 로고    scopus 로고
    • Activation of Jun N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor α leads to intercellular adhesion molecule-1 expression
    • De Cesaris, P. et al. Activation of Jun N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor α leads to intercellular adhesion molecule-1 expression. J. Biol. Chem. 274, 28978-28982 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 28978-28982
    • De Cesaris, P.1
  • 49
    • 60549114409 scopus 로고    scopus 로고
    • The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease
    • Scaldaferri, F. et al. The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease. Eur. J. Immunol. 39, 290-300 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 290-300
    • Scaldaferri, F.1
  • 50
    • 84874105225 scopus 로고    scopus 로고
    • Pro-angiogenic activity of TLRs and NLRs: A novel link between gut microbiota and intestinal angiogenesis
    • Schirbel, A. et al. Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis. Gastroenterology 144, 613-623 e9 (2013).
    • (2013) Gastroenterology , vol.144
    • Schirbel, A.1
  • 51
    • 0036240498 scopus 로고    scopus 로고
    • The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis
    • Wernert, N. et al. The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis. J. Mol. Med. 80, 258-266 (2002).
    • (2002) J. Mol. Med. , vol.80 , pp. 258-266
    • Wernert, N.1
  • 52
    • 33746696033 scopus 로고    scopus 로고
    • Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: Role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway
    • Forough, R. et al. Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway. J. Vasc. Res. 43, 327-337 (2006).
    • (2006) J. Vasc. Res. , vol.43 , pp. 327-337
    • Forough, R.1
  • 53
    • 77955279257 scopus 로고    scopus 로고
    • Transcription factor Ets-1 in cytokine and chemokine gene regulation
    • Russell, L. & Garrett-Sinha, L. A. Transcription factor Ets-1 in cytokine and chemokine gene regulation. Cytokine 51, 217-226 (2010).
    • (2010) Cytokine , vol.51 , pp. 217-226
    • Russell, L.1    Garrett-Sinha, L.A.2
  • 54
  • 55
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning, B. D. & Cantley, L. C. AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 (2007).
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 56
    • 84870405287 scopus 로고    scopus 로고
    • PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis
    • Li, G. Q. et al. PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis. Mol. Cell. Biochem. 372, 221-231 (2012).
    • (2012) Mol. Cell. Biochem. , vol.372 , pp. 221-231
    • Li, G.Q.1
  • 57
    • 0037589020 scopus 로고    scopus 로고
    • Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis
    • Kumar, P., Amin, M. A., Harlow, L. A., Polverini, P. J. & Koch, A. E. Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis. Blood 101, 3960-3968 (2003).
    • (2003) Blood , vol.101 , pp. 3960-3968
    • Kumar, P.1    Amin, M.A.2    Harlow, L.A.3    Polverini, P.J.4    Koch, A.E.5
  • 58
    • 78649742262 scopus 로고    scopus 로고
    • Interleukin 18 induces angiogenesis in vitro and in vivo via Src and JNK kinases
    • Amin, M. A. et al. Interleukin 18 induces angiogenesis in vitro and in vivo via Src and JNK kinases. Ann. Rheum. Dis. 69, 2204-2212 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 2204-2212
    • Amin, M.A.1
  • 59
    • 0034944752 scopus 로고    scopus 로고
    • Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt
    • Zhang, H. G. et al. Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Arthritis Rheum. 44, 1555-1567 (2001).
    • (2001) Arthritis Rheum. , vol.44 , pp. 1555-1567
    • Zhang, H.G.1
  • 60
    • 79957541726 scopus 로고    scopus 로고
    • NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells
    • Yu, W. et al. NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. PLoS ONE 6, e20454 (2011).
    • (2011) PLoS ONE , vol.6
    • Yu, W.1
  • 61
    • 77955475970 scopus 로고    scopus 로고
    • Mechanical signals activate vascular endothelial growth factor receptor-2 to upregulate endothelial cell proliferation during inflammation
    • Liu, J. & Agarwal, S. Mechanical signals activate vascular endothelial growth factor receptor-2 to upregulate endothelial cell proliferation during inflammation. J. Immunol. 185, 1215-1221 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1215-1221
    • Liu, J.1    Agarwal, S.2
  • 62
    • 41549107522 scopus 로고    scopus 로고
    • Cytokine signaling modules in inflammatory responses
    • O'Shea, J. J. & Murray, P. J. Cytokine signaling modules in inflammatory responses. Immunity 28, 477-487 (2008).
    • (2008) Immunity , vol.28 , pp. 477-487
    • O'Shea, J.J.1    Murray, P.J.2
  • 63
    • 33751300575 scopus 로고    scopus 로고
    • Changes in synovial tissue JAK-STAT expression in rheumatoid arthritis in response to successful DMARD treatment
    • Walker, J. G. et al. Changes in synovial tissue JAK-STAT expression in rheumatoid arthritis in response to successful DMARD treatment. Ann. Rheum. Dis. 65, 1558-1564 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 1558-1564
    • Walker, J.G.1
  • 64
    • 31144460322 scopus 로고    scopus 로고
    • Expression of JAK3, STAT1, STAT4, and STAT6 in inflammatory arthritis: Unique JAK3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis
    • Walker, J. G. et al. Expression of JAK3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique JAK3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann. Rheum. Dis. 65, 149-156 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 149-156
    • Walker, J.G.1
  • 65
    • 0042655250 scopus 로고    scopus 로고
    • Rheumatoid arthritis is a heterogeneous disease: Evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues
    • van der Pouw Kraan, T. C. et al. Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum. 48, 2132-2145 (2003).
    • (2003) Arthritis Rheum. , vol.48 , pp. 2132-2145
    • Van Der Pouw Kraan, T.C.1
  • 66
    • 0028925533 scopus 로고
    • Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon γ
    • Sengupta, T. K., Chen, A., Zhong, Z., Darnell, J. E. Jr & Ivashkiv, L. B. Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon γ. J. Exp. Med. 181, 1015-1025 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 1015-1025
    • Sengupta, T.K.1    Chen, A.2    Zhong, Z.3    Darnell, J.E.4    Ivashkiv, L.B.5
  • 67
    • 0034867446 scopus 로고    scopus 로고
    • Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells
    • Yokota, A. et al. Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells. J. Rheumatol. 28, 1952-1959 (2001).
    • (2001) J. Rheumatol. , vol.28 , pp. 1952-1959
    • Yokota, A.1
  • 68
    • 84863987301 scopus 로고    scopus 로고
    • Temporal genome expression profile analysis during T-cell-mediated colitis: Identification of novel targets and pathways
    • Fang, K., Zhang, S., Glawe, J., Grisham, M. B. & Kevil, C. G. Temporal genome expression profile analysis during T-cell-mediated colitis: identification of novel targets and pathways. Inflamm. Bowel. Dis. 18, 1411-1423 (2012).
    • (2012) Inflamm. Bowel. Dis. , vol.18 , pp. 1411-1423
    • Fang, K.1    Zhang, S.2    Glawe, J.3    Grisham, M.B.4    Kevil, C.G.5
  • 69
    • 0036484836 scopus 로고    scopus 로고
    • In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF
    • Valdembri, D., Serini, G., Vacca, A., Ribatti, D. & Bussolino, F. In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF. FASEB J. 16, 225-227 (2002).
    • (2002) FASEB J. , vol.16 , pp. 225-227
    • Valdembri, D.1    Serini, G.2    Vacca, A.3    Ribatti, D.4    Bussolino, F.5
  • 70
    • 82955248114 scopus 로고    scopus 로고
    • Endothelial FAK as a therapeutic target in disease
    • Infusino, G. A. & Jacobson, J. R. Endothelial FAK as a therapeutic target in disease. Microvasc. Res. 83, 89-96 (2012).
    • (2012) Microvasc. Res. , vol.83 , pp. 89-96
    • Infusino, G.A.1    Jacobson, J.R.2
  • 71
    • 84906935511 scopus 로고    scopus 로고
    • FAK in cancer: Mechanistic findings and clinical applications
    • Sulzmaier, F. J., Jean, C. & Schlaepfer, D. D. FAK in cancer: mechanistic findings and clinical applications. Nat. Rev. Cancer 14, 598-610 (2014).
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 598-610
    • Sulzmaier, F.J.1    Jean, C.2    Schlaepfer, D.D.3
  • 72
    • 78650266014 scopus 로고    scopus 로고
    • Endothelial FAK is required for tumour angiogenesis
    • Tavora, B. et al. Endothelial FAK is required for tumour angiogenesis. EMBO Mol. Med. 2, 516-528 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , pp. 516-528
    • Tavora, B.1
  • 73
    • 0034603197 scopus 로고    scopus 로고
    • New roles for Src kinases in control of cell survival and angiogenesis
    • Schlessinger, J. New roles for Src kinases in control of cell survival and angiogenesis. Cell 100, 293-296 (2000).
    • (2000) Cell , vol.100 , pp. 293-296
    • Schlessinger, J.1
  • 74
    • 80052436766 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: A potential therapeutic target for rheumatoid arthritis
    • Hu, P. F., Chen, Y., Cai, P. F., Jiang, L. F. & Wu, L. D. Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis. Mol. Biol. Rep. 38, 4225-4230 (2011).
    • (2011) Mol. Biol. Rep. , vol.38 , pp. 4225-4230
    • Hu, P.F.1    Chen, Y.2    Cai, P.F.3    Jiang, L.F.4    Wu, L.D.5
  • 75
    • 71849087397 scopus 로고    scopus 로고
    • Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis
    • Lai, W. Q. et al. Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. J. Immunol. 181, 8010-8017 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8010-8017
    • Lai, W.Q.1
  • 76
    • 70349573285 scopus 로고    scopus 로고
    • Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, proangiogenic phenotype in endothelial cells
    • Limaye, V. et al. Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, proangiogenic phenotype in endothelial cells. Cell Mol. Biol. Lett. 14, 424-441 (2009).
    • (2009) Cell Mol. Biol. Lett. , vol.14 , pp. 424-441
    • Limaye, V.1
  • 77
    • 33644880217 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: Regulation of synovial proliferation and inflammatory gene expression
    • Kitano, M. et al. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 54, 742-753 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 742-753
    • Kitano, M.1
  • 78
    • 40749142071 scopus 로고    scopus 로고
    • Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome
    • Sekiguchi, M. et al. Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. J. Immunol. 180, 1921-1928 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 1921-1928
    • Sekiguchi, M.1
  • 79
    • 84926365657 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
    • Nussbaum, C. et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat. Commun. 6, 6416 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6416
    • Nussbaum, C.1
  • 80
    • 84865297437 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: A possible new role in arthritis
    • Masuko, K. et al. Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis. Int. J. Rheum. Dis. 15, 366-373 (2012).
    • (2012) Int. J. Rheum. Dis. , vol.15 , pp. 366-373
    • Masuko, K.1
  • 81
    • 84877625111 scopus 로고    scopus 로고
    • Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2
    • Gao, W. et al. Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2. Ann. Rheum. Dis. 72, 1080-1088 (2012).
    • (2012) Ann. Rheum. Dis. , vol.72 , pp. 1080-1088
    • Gao, W.1
  • 82
    • 84863195085 scopus 로고    scopus 로고
    • Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis
    • Gao, W. et al. Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. 64, 2104-2113 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. 2104-2113
    • Gao, W.1
  • 83
    • 84915750896 scopus 로고    scopus 로고
    • Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling
    • Dong, Y. et al. Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling. PLoS ONE 9, e113830 (2014).
    • (2014) PLoS ONE , vol.9
    • Dong, Y.1
  • 85
    • 84895071848 scopus 로고    scopus 로고
    • Possible involvement of Notch signaling in the pathogenesis of Buerger's disease
    • Tamai, H. et al. Possible involvement of Notch signaling in the pathogenesis of Buerger's disease. Surg. Today 44, 307-313 (2013).
    • (2013) Surg. Today , vol.44 , pp. 307-313
    • Tamai, H.1
  • 86
    • 84900400345 scopus 로고    scopus 로고
    • Therapeutic effects of sunitinib, one of the anti-angiogenetic drugs, in a murine arthritis
    • Furuya, K., Kaku, Y., Yoshida, K., Joh, K. & Kurosaka, D. Therapeutic effects of sunitinib, one of the anti-angiogenetic drugs, in a murine arthritis. Mod. Rheumatol. 24, 487-491 (2014).
    • (2014) Mod. Rheumatol. , vol.24 , pp. 487-491
    • Furuya, K.1    Kaku, Y.2    Yoshida, K.3    Joh, K.4    Kurosaka, D.5
  • 87
    • 84915822267 scopus 로고    scopus 로고
    • Pazopanib, a receptor tyrosine kinase inhibitor, suppresses tumor growth through angiogenesis in dedifferentiated liposarcoma xenograft models
    • Li, H. et al. Pazopanib, a receptor tyrosine kinase inhibitor, suppresses tumor growth through angiogenesis in dedifferentiated liposarcoma xenograft models. Transl. Oncol. 7, 665-671 (2014).
    • (2014) Transl. Oncol. , vol.7 , pp. 665-671
    • Li, H.1
  • 88
    • 84924425529 scopus 로고    scopus 로고
    • Phase II study of pazopanib as second-line treatment after sunitinib in patients with metastatic renal cell carcinoma: A Southern China Urology Cancer Consortium Trial
    • Xie, M., He, C. S., Huang, J. K. & Lin, Q. Z. Phase II study of pazopanib as second-line treatment after sunitinib in patients with metastatic renal cell carcinoma: a Southern China Urology Cancer Consortium Trial. Eur. J. Cancer 51, 595-603 (2015).
    • (2015) Eur. J. Cancer , vol.51 , pp. 595-603
    • Xie, M.1    He, C.S.2    Huang, J.K.3    Lin, Q.Z.4
  • 89
    • 84923373652 scopus 로고    scopus 로고
    • A multicenter phase I study of pazopanib in combination with paclitaxel in first-line treatment of patients with advanced solid tumors
    • Kendra, K. L. et al. A multicenter phase I study of pazopanib in combination with paclitaxel in first-line treatment of patients with advanced solid tumors. Mol. Cancer Ther. 14, 461-469 (2014).
    • (2014) Mol. Cancer Ther. , vol.14 , pp. 461-469
    • Kendra, K.L.1
  • 91
    • 0031821631 scopus 로고    scopus 로고
    • In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase
    • Panek, R. L. et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J. Pharmacol. Exp. Ther. 286, 569-577 (1998).
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 569-577
    • Panek, R.L.1
  • 92
    • 81855199748 scopus 로고    scopus 로고
    • Nuclear factor-κB inhibitors; a patent review (2006-2010)
    • Kwak, J. H., Jung, J. K. & Lee, H. Nuclear factor-κB inhibitors; a patent review (2006-2010). Expert Opin. Ther. Pat. 21, 1897-1910 (2011).
    • (2011) Expert Opin. Ther. Pat. , vol.21 , pp. 1897-1910
    • Kwak, J.H.1    Jung, J.K.2    Lee, H.3
  • 93
    • 70350545937 scopus 로고    scopus 로고
    • Local treatment with the selective IκB kinase β inhibitor NEMO-binding domain peptide ameliorates synovial inflammation
    • Tas, S. W. et al. Local treatment with the selective IκB kinase β inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res. Ther. 8, R86 (2006).
    • (2006) Arthritis Res. Ther. , vol.8 , pp. R86
    • Tas, S.W.1
  • 94
    • 33750577799 scopus 로고    scopus 로고
    • Amelioration of arthritis by intraarticular dominant negative IKK β gene therapy using adeno-associated virus type 5
    • Tas, S. W. et al. Amelioration of arthritis by intraarticular dominant negative IKK β gene therapy using adeno-associated virus type 5. Hum. Gene Ther. 17, 821-832 (2006).
    • (2006) Hum. Gene Ther. , vol.17 , pp. 821-832
    • Tas, S.W.1
  • 95
    • 84885338213 scopus 로고    scopus 로고
    • NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases
    • Sehnert, B. et al. NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases. Proc. Natl Acad. Sci. USA 110, 16556-16561 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 16556-16561
    • Sehnert, B.1
  • 96
    • 84857798435 scopus 로고    scopus 로고
    • Tacrolimus (FK506) inhibits interleukin-1β-induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
    • Choe, J. Y., Lee, S. J., Park, S. H. & Kim, S. K. Tacrolimus (FK506) inhibits interleukin-1β-induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes. Joint Bone Spine 79, 137-143 (2011).
    • (2011) Joint Bone Spine , vol.79 , pp. 137-143
    • Choe, J.Y.1    Lee, S.J.2    Park, S.H.3    Kim, S.K.4
  • 97
    • 33846175113 scopus 로고    scopus 로고
    • FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice
    • Ohori, M., Takeuchi, M., Maruki, R., Nakajima, H. & Miyake, H. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch, Pharmacol, 374, 311-316 (2007).
    • (2007) Naunyn Schmiedebergs Arch, Pharmacol , vol.374 , pp. 311-316
    • Ohori, M.1    Takeuchi, M.2    Maruki, R.3    Nakajima, H.4    Miyake, H.5
  • 98
    • 15744374561 scopus 로고    scopus 로고
    • Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase
    • Ennis, B. W. et al. Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase. J. Pharmacol. Exp. Ther. 313, 325-332 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 325-332
    • Ennis, B.W.1
  • 99
    • 0034931503 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    • Han, Z. et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108, 73-81 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 73-81
    • Han, Z.1
  • 100
    • 84874773881 scopus 로고    scopus 로고
    • LY2228820 dimesylate, a selective inhibitor of p38 mitogen-activated protein kinase, reduces angiogenic endothelial cord formation in vitro and in vivo
    • Tate, C. M. et al. LY2228820 dimesylate, a selective inhibitor of p38 mitogen-activated protein kinase, reduces angiogenic endothelial cord formation in vitro and in vivo. J. Biol. Chem. 288, 6743-6753 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 6743-6753
    • Tate, C.M.1
  • 101
    • 0036142395 scopus 로고    scopus 로고
    • Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease
    • Hommes, D. et al. Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 122, 7-14 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 7-14
    • Hommes, D.1
  • 102
    • 75749092187 scopus 로고    scopus 로고
    • "Go upstream, young man": Lessons learned from the p38 saga
    • Hammaker, D. & Firestein, G. S. "Go upstream, young man": lessons learned from the p38 saga. Ann. Rheum. Dis. 69 (Suppl. 1), i77-i82 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. i77-i82
    • Hammaker, D.1    Firestein, G.S.2
  • 103
    • 59649114148 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis
    • Cohen, S. B. et al. Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis Rheum. 60, 335-344 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 335-344
    • Cohen, S.B.1
  • 104
    • 77953703822 scopus 로고    scopus 로고
    • A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease
    • Dotan, I. et al. A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease. Gut 59, 760-766 (2010).
    • (2010) Gut , vol.59 , pp. 760-766
    • Dotan, I.1
  • 105
    • 0242468891 scopus 로고    scopus 로고
    • CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
    • Allen, L. F., Sebolt-Leopold, J. & Meyer, M. B. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin. Oncol. 30, 105-116 (2003).
    • (2003) Semin. Oncol. , vol.30 , pp. 105-116
    • Allen, L.F.1    Sebolt-Leopold, J.2    Meyer, M.B.3
  • 106
    • 77954599025 scopus 로고    scopus 로고
    • MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo
    • Henderson, Y. C., Chen, Y., Frederick, M. J., Lai, S. Y. & Clayman, G. L. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. Mol. Cancer Ther. 9, 1968-1976 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1968-1976
    • Henderson, Y.C.1    Chen, Y.2    Frederick, M.J.3    Lai, S.Y.4    Clayman, G.L.5
  • 107
    • 84923108243 scopus 로고    scopus 로고
    • Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinoma
    • Matulonis, U. et al. Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinoma. Gynecol. Oncol. 136, 246-253 (2014).
    • (2014) Gynecol. Oncol. , vol.136 , pp. 246-253
    • Matulonis, U.1
  • 108
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu, P., Cheng, H., Roberts, T. M. & Zhao, J. J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 8, 627-644 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 109
    • 0030604280 scopus 로고    scopus 로고
    • Potent inhibition of angiogenesis by wortmannin, a fungal metabolite
    • Oikawa, T. & Shimamura, M. Potent inhibition of angiogenesis by wortmannin, a fungal metabolite. Eur. J. Pharmacol. 318, 93-96 (1996).
    • (1996) Eur. J. Pharmacol. , vol.318 , pp. 93-96
    • Oikawa, T.1    Shimamura, M.2
  • 110
    • 84865562515 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors
    • Markman, B. et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors. Ann. Oncol. 23, 2399-2408 (2012).
    • (2012) Ann. Oncol. , vol.23 , pp. 2399-2408
    • Markman, B.1
  • 111
    • 84932147143 scopus 로고    scopus 로고
    • Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor: A phase 1 expansion cohort in patients with relapsed or refractory lymphoma
    • Papadopoulos, K. P. et al. Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor: a phase 1 expansion cohort in patients with relapsed or refractory lymphoma. Leuk. Lymphoma 56, 1763-1770 (2015).
    • (2015) Leuk. Lymphoma , vol.56 , pp. 1763-1770
    • Papadopoulos, K.P.1
  • 112
    • 84921789603 scopus 로고    scopus 로고
    • PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway
    • Xing, X. et al. PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. Anticancer Drugs 25, 1129-1140 (2014).
    • (2014) Anticancer Drugs , vol.25 , pp. 1129-1140
    • Xing, X.1
  • 113
    • 84875910671 scopus 로고    scopus 로고
    • Small molecular compounds in development for rheumatoid arthritis
    • van Vollenhoven, R. F. Small molecular compounds in development for rheumatoid arthritis. Curr. Opin. Rheumatol. 25, 391-397 (2013).
    • (2013) Curr. Opin. Rheumatol. , vol.25 , pp. 391-397
    • Van Vollenhoven, R.F.1
  • 114
    • 84864703156 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
    • van Vollenhoven, R. F. et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N. Engl. J. Med. 367, 508-519 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 508-519
    • Van Vollenhoven, R.F.1
  • 115
    • 84864716411 scopus 로고    scopus 로고
    • Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
    • Fleischmann, R. et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N. Engl. J. Med. 367, 495-507 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 495-507
    • Fleischmann, R.1
  • 116
    • 84873707288 scopus 로고    scopus 로고
    • Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
    • Burmester, G. R. et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 381, 451-460 (2013).
    • (2013) Lancet , vol.381 , pp. 451-460
    • Burmester, G.R.1
  • 117
    • 84874402383 scopus 로고    scopus 로고
    • Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study
    • van der Heijde, D. et al. Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum. 65, 559-570 (2013).
    • (2013) Arthritis Rheum. , vol.65 , pp. 559-570
    • Van Der Heijde, D.1
  • 118
    • 84921475867 scopus 로고    scopus 로고
    • Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate
    • Keystone, E. C. et al. Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate. Ann. Rheum. Dis. 74, 333-340 (2015).
    • (2015) Ann. Rheum. Dis. , vol.74 , pp. 333-340
    • Keystone, E.C.1
  • 119
    • 80155171655 scopus 로고    scopus 로고
    • Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480
    • Xin, H. et al. Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71, 6601-6610 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 6601-6610
    • Xin, H.1
  • 120
    • 81855207292 scopus 로고    scopus 로고
    • Focal adhesion kinase inhibitors are potent anti-angiogenic agents
    • Cabrita, M. A. et al. Focal adhesion kinase inhibitors are potent anti-angiogenic agents. Mol. Oncol. 5, 517-526 (2011).
    • (2011) Mol. Oncol. , vol.5 , pp. 517-526
    • Cabrita, M.A.1
  • 121
    • 84907554049 scopus 로고    scopus 로고
    • A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells
    • Kurenova, E. et al. A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells. Cell Cycle 13, 2542-2553 (2014).
    • (2014) Cell Cycle , vol.13 , pp. 2542-2553
    • Kurenova, E.1
  • 122
    • 84897437048 scopus 로고    scopus 로고
    • Targeting FAK in human cancer: From finding to first clinical trials
    • Golubovskaya, V. M. Targeting FAK in human cancer: from finding to first clinical trials. Front. Biosci. (Landmark Ed.) 19, 687-706 (2014).
    • (2014) Front. Biosci. (Landmark Ed.) , vol.19 , pp. 687-706
    • Golubovskaya, V.M.1
  • 123
    • 84920577517 scopus 로고    scopus 로고
    • The clinically approved drugs dasatinib and bosutinib induce antiinflammatory macrophages by inhibiting the salt-inducible kinases
    • Ozanne, J., Prescott, A. R. & Clark, K. The clinically approved drugs dasatinib and bosutinib induce antiinflammatory macrophages by inhibiting the salt-inducible kinases. Biochem. J. 465, 271-279 (2014).
    • (2014) Biochem. J. , vol.465 , pp. 271-279
    • Ozanne, J.1    Prescott, A.R.2    Clark, K.3
  • 124
    • 84855274887 scopus 로고    scopus 로고
    • Soluble VE-cadherin in rheumatoid arthritis patients correlates with disease activity: Evidence for tumor necrosis factor α-induced VE-cadherin cleavage
    • Sidibe, A. et al. Soluble VE-cadherin in rheumatoid arthritis patients correlates with disease activity: evidence for tumor necrosis factor α-induced VE-cadherin cleavage. Arthritis Rheum. 64, 77-87 (2011).
    • (2011) Arthritis Rheum. , vol.64 , pp. 77-87
    • Sidibe, A.1
  • 125
    • 77954317110 scopus 로고    scopus 로고
    • ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling
    • Sun, C. et al. ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling. Cardiovasc. Res. 87, 348-355 (2010).
    • (2010) Cardiovasc. Res. , vol.87 , pp. 348-355
    • Sun, C.1
  • 126
    • 84906936242 scopus 로고    scopus 로고
    • Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells
    • Shin, K. O. et al. Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. Arch. Pharm. Res. 37, 1183-1192 (2014).
    • (2014) Arch. Pharm. Res. , vol.37 , pp. 1183-1192
    • Shin, K.O.1
  • 127
    • 84880625796 scopus 로고    scopus 로고
    • Structure guided design of a series of sphingosine kinase (SphK) inhibitors
    • Gustin, D. J. et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg. Med. Chem. Lett. 23, 4608-4616 (2013).
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 4608-4616
    • Gustin, D.J.1
  • 128
    • 80053040376 scopus 로고    scopus 로고
    • Phase I trial of MK-0752 in children with refractory CNS malignancies: A Pediatric Brain Tumor Consortium study
    • Fouladi, M. et al. Phase I trial of MK-0752 in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study. J. Clin. Oncol. 29, 3529-3534 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3529-3534
    • Fouladi, M.1
  • 129
    • 84933279009 scopus 로고    scopus 로고
    • A phase II study of single-agent RO4929097, a γ-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia
    • Diaz-Padilla, I. et al. A phase II study of single-agent RO4929097, a γ-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: a study of the Princess Margaret, Chicago and California phase II consortia. Gynecol. Oncol. 137, 216-222 (2015).
    • (2015) Gynecol. Oncol. , vol.137 , pp. 216-222
    • Diaz-Padilla, I.1
  • 130
    • 84884818377 scopus 로고    scopus 로고
    • A phase Ib combination study of RO4929097, a γ-secretase inhibitor, and temsirolimus in patients with advanced solid tumors
    • Diaz-Padilla, I. et al. A phase Ib combination study of RO4929097, a γ-secretase inhibitor, and temsirolimus in patients with advanced solid tumors. Invest. New Drugs 31, 1182-1191 (2013).
    • (2013) Invest. New Drugs , vol.31 , pp. 1182-1191
    • Diaz-Padilla, I.1
  • 131
    • 84879422834 scopus 로고    scopus 로고
    • Notch inhibitors for cancer treatment
    • Espinoza, I. & Miele, L. Notch inhibitors for cancer treatment. Pharmacol.Ther. 139, 95-110 (2013).
    • (2013) Pharmacol.Ther. , vol.139 , pp. 95-110
    • Espinoza, I.1    Miele, L.2
  • 132
    • 84904550068 scopus 로고    scopus 로고
    • A phase II study of the γ secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma
    • De Jesus-Acosta, A. et al. A phase II study of the γ secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma. Invest. New Drugs 32, 739-745 (2014).
    • (2014) Invest. New Drugs , vol.32 , pp. 739-745
    • De Jesus-Acosta, A.1
  • 133
    • 84896391556 scopus 로고    scopus 로고
    • A phase I study of the oral γ secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
    • Richter, S. et al. A phase I study of the oral γ secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575). Invest. New Drugs 32, 243-249 (2013).
    • (2013) Invest. New Drugs , vol.32 , pp. 243-249
    • Richter, S.1
  • 134
    • 84856966635 scopus 로고    scopus 로고
    • Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin
    • Hayashi, I. et al. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene 31, 787-798 (2011).
    • (2011) Oncogene , vol.31 , pp. 787-798
    • Hayashi, I.1
  • 135
    • 84924285520 scopus 로고    scopus 로고
    • Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?
    • Noort, A. R., Tak, P. P. & Tas, S. W. Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? Arthritis Res. Ther. 17, 15 (2015).
    • (2015) Arthritis Res. Ther. , vol.17 , pp. 15
    • Noort, A.R.1    Tak, P.P.2    Tas, S.W.3
  • 136
    • 33749365296 scopus 로고    scopus 로고
    • Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study
    • Weinblatt, M. et al. Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: a one-year randomized, placebo-controlled study. Arthritis Rheum. 54, 2807-2816 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 2807-2816
    • Weinblatt, M.1
  • 137
    • 84899830608 scopus 로고    scopus 로고
    • 68Ga-PRGD2 PET/CT: A prospective proof-of-concept cohort study
    • 68Ga-PRGD2 PET/CT: a prospective proof-of-concept cohort study. Ann. Rheum. Dis. 73, 1269-1272 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1269-1272
    • Zhu, Z.1
  • 138
    • 84956742562 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/(2015).
    • (2015)
    • US National Library of Medicine1


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