Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome

Journal of Immunology

Volumn 180, Issue 3, 2008, Pages 1921-1928

  Sekiguchi, Masahiro ^a   Iwasaki, Tsuyoshi ^a   Kitano, Masayasu ^a   Kuno, Hideki ^a   Hashimoto, Naoaki ^a   Kawahito, Yutaka ^b   Azuma, Masayuki ^c   Hla, Timothy ^d   Sano, Hajime ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 6; PERTUSSIS TOXIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; MESSENGER RNA; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1-PHOSPHATE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROL GROUP; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOPLASM; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MALE; MONONUCLEAR CELL; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVARY GLAND; SJOEGREN SYNDROME; VASCULAR ENDOTHELIUM; AUTOIMMUNE DISEASE; CHEMISTRY; DENDRITIC CELL; DRUG EFFECT; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; ANTIGENS, CD95; AUTOIMMUNE DISEASES; CASPASE 3; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; EPITHELIAL CELLS; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; LYSOPHOSPHOLIPIDS; MALE; MIDDLE AGED; RECEPTORS, LYSOSPHINGOLIPID; RNA, MESSENGER; SALIVARY GLANDS; SJOGREN'S SYNDROME; SPHINGOSINE;

EID: 40749142071     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.3.1921     Document Type: Article

References (42)

1. Adamson, T. C., III, R. I. Fox, D. M. Frisman, and F. V. Howell. 1998. Immunohistologic analysis of lymphoid infiltrates in primary Sjögren's syndrome using monoclonal antibodies. J. Immunol. 16: 137-161.
2. Stott, D. A., F. Hiepe, M. Hummel, G. Steinhauser, and C. Berek. 1998. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome. J. Clin. Invest. 102: 938-946.
3. Hansen, A., M. Odendahl, K. Reiter, A. M. Jacobi, E. Feist, J. Scholze, G. R. Burmester, P. E. Lipsky, and T. Dorner. 2002. Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome. Arthritis. Rheum. 46: 2160-2171.
4. Bohnhorst, J., M. B. Bjorgan, J. E. Thoen, J. B. Natvig, and K. M. Thompson. 2001. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in health individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome. J. Immunol. 167: 3610-3618.
5. Oxholm, P., T. E. Daniels, and K. Bendtzen. 1992. Cytokine expression in labial salivary glands from patients with primary Sjögren's syndrome. Autoimmun. 12: 185-191.
6. Fox, R. I., H. I. Kang, D. Ando, J. Abrams, and E. Pisa. 1994. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J. Immunol. 152: 5532-5539.
7. Ohyama, Y., S. Nakamura, G. Matsuzaki, M. Shinohara, A. Hiroki, T. Fujimura, A. Yamada, K. Itoh, and K. Nomoto. 1996. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 39: 1376-1384.
8. Hjelmervik, T. O., K. Peterson, I. Jonassen, R. Jonsson, and A. I. Bolstad. 2005. Gene expression profiling of minor salivary glands clearly distinguish primary Sjögren's syndrome patients from healthy control subjects. Arthritis Rheum. 52: 1534-1544.
9. Bolstad, A. I., H. G. Eiken, B. Rosenlund, M. E. Alarcón-Requelme, and R. Josson. 2003. Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sjögren's syndrome. Arthritis Rheum. 48: 174-185.
10. Pérez, P., E. Goicovich, C. Alliende, S. Aguilera, C. Leyton, C. Molina, R. Pinto, B. Martinez, and M. J. González. 2000. Differential expression of matrix metalloproteinases in labial salivary glands of patients with primary Sjögren's syndrome: mechanisms of exocrine parenchyma destruction. Arthritis. Rheum. 43: 2807-2817.
11. Hla, T. 2004. Physiological and pathological actions of sphingosine 1-phosphste. Semin. Cell. Dev. Biol. 15: 513-520.
12. Pyne, S., and N. J. Pyne. 2000. Sphingosine 1-phosphate signaling in mammalian cells. Biochem. J. 349: 385-402.
13. Liu, Y., R. Wada, T. Yamashita, Y. Mi, C. X. Deng, J. P. Hobson, H. M. Rosenfeldt, V. E. Nava, S. S. Chae, M. J. Lee, et al. 2000. Edg-1, the G protein-coupled receptor for sphingosine 1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106: 951-961.
14. Goetzl, E. J., and H. Rosen. 2004. Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J. Clin. Invest. 114: 1531-1537.
15. Rosen, H., and E. J. Goetzl. 2005. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. 5: 560-570.
16. Vitali, C., S. Bombardieri, R. Jonsson, H. M. Moutsopoulos, E. L. Alexander, S. E. Carsons, T. E. Daniels, P. C. Fox, R. I. Fox, S. S. Kassan, et al. 2002. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann. Rheum. Dis. 61: 554-558.
17. Greenspan, J. S., T. E. Daniels, N. Talal, and R. A. Sylvester. 1974. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral. Surg. 37: 217-229.
18. Sano, H., T. Hla, J. A. Maier, L. J. Crofford, J. P. Case, T. Maciag, and R. L. Wilder. 1992. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J. Clin. Invest. 89: 97-108.
19. Lee, M. J., S. Thangada, J. H. Paik, G. P. Sapkota, N. Ancellin, S. S. Chae, M. Wu, M. Morales-Ruiz, W. C. Sessa, D. R. Alessi, and T. Hla. 2001. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol. Cell. 8: 693-704.
20. Kohno, M., M. Momoi, M. L. Oo, J. H. Paik, Y. M. Lee, K. Venkataraman, Y. Ai, A. P. Ristimaki, H. Fyrst, H. Sano, D. Rosenberg, et al. 2006. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol. Cell Biol. 26: 7211-7223.
21. Willemse, B. W., N. H. ten Hacken, B. Rutgers, D. S. Postma, and W. Timens. 2005. Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers. Respir. Res. 6: 38.
22. Fenhalls, G., L. Stevens, J. Bezuidenhout, G. E. Amphlett, K. Duncan, P. Bardin, and P. T. Lukey. Distribution of IFN-γ, IL-4 and TNF-α protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas. Immunology 105: 325-335.
23. Garcia-Tunóñ, I., M. Ricota, A. Ruiz, B. Fraile, R. Paniagua, and M. Royuela. 2005. IL-6, its receptors and its relationship with bcl-2 and bax proteins in infiltrating and in situ human breast carcinoma. Histopathology 47: 82-89.
24. Motegi, K., M. Azuma, T. Tamatani, Y. Ashida, and M. Sato. 2005. Expression of aquaporin-5 in and fluid secretion from immortalized human salivary gland ductal cells by treatment with 5-aza-2′-deoxycytidine: a possibility for improvement of xerostomia in patients with Sjögren's syndrome. Lab. Invest. 85: 342-353.
25. Kitano, M., T. Hla, M. Sekiguchi, Y. Kawahito, R. Yoshimura, K. Miyazawa, T. Iwasaki, H. Sano, J. D. Saba, and Y. Y. Tam. 2006. sphingosine 1-phosphate/ sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 54: 742-753.
26. Pitson, S. M., R. J. D'Andrea, L. Vandeleur, P. A. Moretti, P. Xia, J. R. Gamble, M. A. Vadas, and B. W. Wattenberg. 2000. Human sphingosine kinase: purification, molecular cloning and characterization of native and recombinant enzymes. Biochem. J. 350: 429-441.
27. Kohama, T., A. Olivera, L. Edsall, M. M. Nagiec, R. Dickson, and S. Spiegel. 1998. Molecular cloning and functional characterization of murine sphingosine kinase. J. Biol. Chem. 273: 23722-23728.
28. Liu, H., M. Sugiura, V. E. Nava, L. C. Edsall, K. Kono, S. Poulton, S. Milstien, T. Kohama, and S. Spiegel. 2000. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem. 275: 19513-19520.
29. Matsumura, R., K. Umemiya, T. Goto, T. Nakazawa, K. Ochiai, M. Kagami, H. Tomioka, E. Tanabe, T. Sugiyama, and M. Sueishi. 2000. Interferon γ and tumor necrosis factor α induce Fas expression and anti-Fas mediated apoptosis in salivary ductal cell line. Clin. Exp. Rheumatol. 18: 311-318.
30. Ashkenazi, A., and V. M. Dixit. 1999. Apoptosis control by death and decoy receptors. Curr. Opin. Cell. Biol. 11: 255-260.
31. Kishimoto, T. 1992. Interleukin-6 and its receptor in autoimmunity. J. Autoimmun. 5(Suppl. A): 123-132.
32. Tishler, M., I. Yaron, O. Geyer, I. Shirazi, E. Naftaliev, and M. Yaron. 1998. Elevated tear interleukin-6 levels in patients with Sjögren syndrome. Ophthalmology 105: 2327-2329.
33. Tishler, M., I. Yaron, I. Shirazi, Y. Yossipov, and M. Yaron. 1999. Increased salivary interleukin-6 levels in patients with primary Sjögren's syndrome. Rheumatol. Int. 18: 125-127.
34. Hulkkonen, J., M. Pertovaara, J. Antonen, A. Pasternack, and M. Hurme. 2001. Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren's syndrome and correlate with the clinical manifestations of the disease. Rheumatology 40: 656-661.
35. Pettus, B. J., C. E. Chalfant, and Y. A. Hannun. 2002. Ceramide in apoptosis: an overview and current perspectives. Biochem. Biophys. Acta 1585: 114-125.
36. Cuvillier, O. 2002. Sphingosine in apoptosis signaling. Biochem. Biophys. Acta. 1585: 153-162.
37. Kluk, M. J., and T. Hla. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. 2002. Biochem. Biophys. Acta 1582: 72-80.
38. Kawamori, T., W. Osta, K. R. Johnson, B. J. Pettus, J. Bielawski, T. Tanaka, M. J. Wargovich, B. S. Reddy, Y. A. Hannun, L. M. Obeid, and D. Zhou. 2006. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 20: 386-388.
39. Pi, X., S. Y. Tan, M. Hayes, L. Xiao, J. A. Shayman, S. Ling, and J. Holoshitz. 2006. Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells. Arthritis Rheum. 54: 754-764.
40. 1 G protein-coupled receptor. J. Immunol. 171: 3500-3507.
41. Jin, Y., E. Knudsen, L. Wang, Y. Bryceson, B. Damaj, S. Gessani, and A. A. Maghazachi. 2003. Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. Blood 101: 4909-4915.
42. Manganelli, P., and P. Fietta. 2003. Apoptosis and Sjögren syndrome. Semin. Arthritis Rheum. 33: 49-65.