Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the notch signaling

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Dong, Yanmin ^a   Zhang, Tao ^a   Li, Jingjie ^a   Deng, Huayun ^a   Song, Yajuan ^a   Zhai, Dong ^a   Peng, Yi ^c   Lu, Xiaoling ^c   Liu, Mingyao ^a,b   Zhao, Yongxiang ^c   Yi, Zhengfang ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; JAGGED2 PROTEIN; MEMBRANE PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; ORIDONIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CALCIUM BINDING PROTEIN; KAURANE DERIVATIVE; SERRATE PROTEINS; SIGNAL PEPTIDE; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL CONTACT; CELL JUNCTION; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; DOWN REGULATION; DRUG MECHANISM; EX VIVO STUDY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; CELL COMMUNICATION; CELL MOTION; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; METABOLISM; METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; TUMOR CELL LINE; TUMOR VOLUME;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM-BINDING PROTEINS; CELL COMMUNICATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DITERPENES, KAURANE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MICE; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RATS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84915750896     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113830     Document Type: Article

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