The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease

European Journal of Immunology

Volumn 39, Issue 1, 2009, Pages 290-300

  Scaldaferri, Franco ^a,b   Sans, Miquel ^c   Vetrano, Stefania ^a   Correale, Carmen ^a   Arena, Vincenzo ^b   Pagano, Nico ^a   Rando, Giacomo ^a   Romeo, Fabio ^a   Potenza, Angelo E ^a,d   Repici, Alessandro ^a   Malesci, Alberto ^a   Danese, Silvio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

Endothelium; Inflammation; Inflammatory bowel disease; Protein kinases

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; CCL2 PROTEIN, HUMAN; FRACTALKINE; IL8 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4;

ARTICLE; CELL ADHESION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENTERITIS; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE; LYMPHOCYTE MIGRATION; MICROVASCULATURE; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; UPREGULATION; BIOSYNTHESIS; CELL MOTION; DRUG EFFECT; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; T LYMPHOCYTE;

CELL ADHESION; CELL MOVEMENT; CHEMOKINE CCL2; CHEMOKINE CX3CL1; FIBROBLASTS; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-8; MAP KINASE KINASE 4; MICROVESSELS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 60549114409     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838316     Document Type: Article

References (36)

1. Danese, S. and Fiocchi, C., Etiopathogenesis of inflammatory bowel diseases. World J. Gastroenterol. 2006. 12: 4807-4812.
2. Fiocchi, C., Intestinal inflammation: A complex interplay of immune and nonimmune cell interactions. Am. J. Physiol. 1997. 273: G769-G775.
3. Papadakis, K. A. and Targan, S. R., The role of chemokines and chemokine receptors in mucosal inflammation. Inflamm. Bowel Dis. 2000. 6: 303-313.
4. Butcher, E. C. and Picker, L. J., Lymphocyte homing and homeostasis. Science 1996. 272: 60-66.
5. Campbell, J. J., Hedrick, J., Zlotnik, A., Siani, M. A., Thompson, D. A. and Butcher, E. C., Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 1998. 279: 381-384.
6. Lee, S. C., Brummet, M. E., Shahabuddin, S., Woodworth, T. G., Georas, S. N., Leiferman, K. M., Gilman, S. C. et al., Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes. J. Immunol. 2000. 164: 3392-3401.
7. Danese, S., Inflammation and the mucosal microcirculation in inflammatory bowel disease: The ebb and flow. Curr. Opin. Gastroenterol. 2007. 23: 384-389.
8. Danese, S., Dejana, E. and Fiocchi, C., Immune regulation by microvascular endothelial cells: Directing innate and adaptive immunity, coagulation, and inflammation. J. Immunol. 2007. 178: 6017-6022.
9. Binion, D. G., West, G. A., Ina, K., Ziats, N. P., Emancipator, S. N. and Fiocchi, C., Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 1997. 112: 1895-1907.
10. Sans, M., Danese, S., de la Motte, C., de Souza, H. S., Rivera-Reyes, B. M., West, G. A., Phillips, M. et al., Enhanced recruitment of CX3CR11T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology 2007. 132: 139-153.
11. Chang, L. and Karin, M., Mammalian MAP kinase signalling cascades. Nature 2001. 410: 37-40.
12. Dong, C., Davis, R. J. and Flavell, R. A., MAP kinases in the immune response. Annu. Rev. Immunol. 2002. 20: 55-72.
13. Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H. D. and Gaestel, M., MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat. Cell Biol. 1999. 1: 94-97.
14. Kontoyiannis, D., Pasparakis, M., Pizarro, T. T., Cominelli, F. and Kollias, G., Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies. Immunity 1999. 10: 387-398.
15. Dumitru, C. D., Ceci, J. D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J. H., Patriotis, C. et al., TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ ERK-dependent pathway. Cell 2000. 103: 1071-1083.
16. Wysk, M., Yang, D. D., Lu, H. T., Flavell, R. A. and Davis, R. J., Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc. Natl. Acad. Sci. USA 1999. 96: 3763-3768.
17. Chu, W. M., Ostertag, D., Li, Z. W., Chang, L., Chen, Y., Hu, Y., Williams, B. et al., JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity 1999. 11: 721-731.
18. Panes, J. and Granger, D. N., Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease. Gastroenterology 1998. 114: 1066-1090.
19. Otte, J. M., Rosenberg, I. M. and Podolsky, D. K., Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 2003. 124: 1866-1878.
20. Vogel, J. D., West, G. A., Danese, S., De La Motte, C., Phillips, M. H., Strong, S. A., Willis, J. and Fiocchi, C., CD40-mediated immunenonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration. Gastroenterology 2004. 126: 63-80.
21. Alon, R. and Feigelson, S., From rolling to arrest on blood vessels: Leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts. Semin. Immunol. 2002. 14: 93-104.
22. Waetzig, G. H., Seegert, D., Rosenstiel, P., Nikolaus, S. and Schreiber, S., p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease. J. Immunol. 2002. 168: 5342-5351.
23. Mitsuyama, K., Suzuki, A., Tomiyasu, N., Tsuruta, O., Kitazaki, S., Takeda, T., Satoh, Y. et al., Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease. Int. J. Mol. Med. 2006. 17: 449-455.
24. Malamut, G., Cabane, C., Dubuquoy, L., Malapel, M., Derijard, B., Gay, J., Tamboli, C. et al., No evidence for an involvement of the p38 and JNK mitogen-activated protein in inflammatory bowel diseases. Dig. Dis. Sci. 2006. 51: 1443-1453.
25. Salh, B., Assi, K., Templeman, V., Parhar, K., Owen, D., Gomez-Munoz, A. and Jacobson, K., Curcumin attenuates DNB-induced murine colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2003. 285: G235-G243.
26. Hollenbach, E., Vieth, M., Roessner, A., Neumann, M., Malfertheiner, P. and Naumann, M., Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease. J. Biol. Chem. 2005. 280: 14981-14988.
27. Hollenbach, E., Neumann, M., Vieth, M., Roessner, A., Malfertheiner, P. and Naumann, M., Inhibition of p38 MAP kinase- and RICK/ NF-kappaB-signaling suppresses inflammatory bowel disease. FASEB J. 2004. 18: 1550-1552.
28. Kim, J. M., Jung, H. Y., Lee, J. Y., Youn, J., Lee, C. H. and Kim, K. H., Mitogen-activated protein kinase and activator protein-1 dependent signals are essential for Bacteroides fragilis enterotoxin-induced enteritis. Eur. J. Immunol. 2005. 35: 2648-2657.
29. Assi, K., Pillai, R., Gomez-Munoz, A., Owen, D. and Salh, B., The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology 2006. 118: 112-121.
30. Hommes, D., van den Blink, B., Plasse, T., Bartelsman, J., Xu, C., Macpherson, B., Tytgat, G. et al., Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 2002. 122: 7-14.
31. Harvey, R. F. and Bradshaw, J. M., A simple index of Crohn's-disease activity. Lancet 1980. 1: 514.
32. Sutherland, L. R., Martin, F., Greer, S., Robinson, M., Greenberger, N., Saibil, F., Martin, T. et al., 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology 1987. 92: 1894-1898.
33. Danese, S., Sans, M., de la Motte, C., Graziani, C., West, G., Phillips, M. H., Pola, R. et al., Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 2006. 130: 2060-2073.
34. Danese, S., de la Motte, C., Sturm, A., Vogel, J. D., West, G. A., Strong, S. A., Katz, J. A. and Fiocchi, C., Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 2003. 124: 1249-1264.
35. Sturm, A., Itoh, J., Jacobberger, J. W. and Fiocchi, C., p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling. J. Clin. Invest. 2002. 109: 1481-1492.
36. Scaldaferri, F., Sans, M., Vetrano, S., Graziani, C., De Cristofaro, R., Gerlitz, B., Repici, A. et al., Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J. Clin. Invest. 2007. 117: 1951-1960.