LY2228820 dimesylate, a selective inhibitor of p38 mitogen-activated protein kinase, reduces angiogenic endothelial cord formation in vitro and in vivo

Journal of Biological Chemistry

Volumn 288, Issue 9, 2013, Pages 6743-6753

  Tate, Courtney M ^a   Blosser, Wayne ^a   Wyss, Lisa ^b   Evans, Glenn ^a   Xue, Qi ^a   Pan, Yong ^a   Stancato, Louis ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Advanced Testing Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; BIOLOGICAL PROCESS; CANCER THERAPY; CLINICAL INVESTIGATION; COCULTURE; CYTOKINE SECRETIONS; CYTOKINE SIGNALING; GENE KNOCK DOWN; GROWTH FACTOR; HUMAN MALIGNANCIES; IN-VITRO; IN-VIVO; MICROENVIRONMENTS; MITOGEN ACTIVATED PROTEIN KINASE; NEOANGIOGENESIS; P38 MAPK; P38 MITOGEN-ACTIVATED PROTEIN KINASE; SELECTIVE INHIBITORS; SMALL MOLECULE INHIBITOR; TUMOR ANGIOGENESIS; TUMOR CELLS; TUMOR GROWTH; TUMOR VASCULATURE; TUMORIGENESIS; VASCULARIZATION;

CELL SIGNALING; ENDOTHELIAL CELLS; ENZYME ACTIVITY; IMMUNOLOGY; PHYSIOLOGY;

TUMORS;

EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; HEAT SHOCK PROTEIN 27; HEMOGLOBIN; INTERLEUKIN 6; LY 2228820 DIMESYLATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; SHORT HAIRPIN RNA; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EAR; ENDOTHELIAL CORD FORMATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; IMMUNOASSAY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STROMA CELL; TUMOR CELL; VASCULARIZATION; WESTERN BLOTTING;

ANIMALS; CYTOKINES; ENDOTHELIUM, VASCULAR; HSP27 HEAT-SHOCK PROTEINS; HUMANS; IMIDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE 14; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; TUMOR MICROENVIRONMENT;

EID: 84874773881     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.425553     Document Type: Article

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