FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 374, Issue 4, 2007, Pages 311-316

  Ohori, Makoto ^a   Takeuchi, Mikio ^a   Maruki, Riyo ^a   Nakajima, Hidenori ^a   Miyake, Hiroshi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Collagen induced arthritis; ERK inhibitor; Extracellular signal regulated kinase; FR180204; Mitogen activated protein kinase

Indexed keywords

5 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 1H PYRAZOLO[3,4 C]PYRIDAZIN 3 AMINE; ANTIBODY; COLLAGEN TYPE 2; FR 180204; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; BLOOD LEVEL; CELL PROLIFERATION; CELLULAR IMMUNITY; DBA 1 MOUSE; DELAYED HYPERSENSITIVITY; DOSE RESPONSE; DRUG EFFECT; HUMORAL IMMUNITY; IMMUNIZATION; IN VITRO STUDY; INFLAMMATION; LYMPH NODE CELL; MALE; NONHUMAN; RAT; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; WEIGHT REDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; COLLAGEN TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOCORTICOIDS; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN ISOTYPES; INJECTIONS, INTRAPERITONEAL; LYMPHOCYTE ACTIVATION; MALE; METHYLPREDNISOLONE; MICE; MICE, INBRED DBA; PYRAZOLES; PYRIDAZINES; T-LYMPHOCYTES; THYMIDINE; WEIGHT LOSS;

EID: 33846175113     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-006-0117-7     Document Type: Article

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