Potent inhibition of angiogenesis by wortmannin, a fungal metabolite

European Journal of Pharmacology

Volumn 318, Issue 1, 1996, Pages 93-96

  Oikawa, Tsutomu ^a   Shimamura, Mariko ^a  

^a Tokyo Metropolitan Inst Technol   (Japan)

Author keywords

Angiogenesis, embryonic; Anti angiogenic activity; Chorioallantoic membrane; Phosphatidylinositol 3 kinase inhibitor; Wortmannin

Indexed keywords

ANGIOGENESIS INHIBITOR; WORTMANNIN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; BIOASSAY; CHICK EMBRYO; CHORIOALLANTOIS; CONTROLLED STUDY; EMBRYO; NONHUMAN; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALLANTOIS; ANDROSTADIENES; ANIMALS; CHICK EMBRYO; CHORION; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 0030604280     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00864-3     Document Type: Article

References (18)

1. Battegay, E.J., 1995, Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects, J. Mol. Med. 73, 333.
2. Bauer, J., M. Margolis, C. Schreiner, C.-J. Edgell, J. Azizkhan, E. Lazarowski and R.L. Juliano, 1992, In vitro model of angiogenesis using a human endothelium-derived permanent cell line: contributions of induced gene expression, G-proteins and integrins, J. Cell. Physiol. 153, 437.
3. Cantley, L.G., E.J.G. Barros, M. Gandhi, M. Rauchman and S.K. Nigam, 1994, Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells, Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36), F271.
4. Cantley, L.G., E.J.G. Barros, M. Gandhi, M. Rauchman and S.K. Nigam, 1994, Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells, Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36), F271.
5. 2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase, J. Biol. Chem. 270, 25352.
6. Derman, M.P., M.J. Cunha, E.J.G. Barros, S.K. Nigam and L.G. Cantley, 1995, HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase, Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37), F1211.
7. Derman, M.P., M.J. Cunha, E.J.G. Barros, S.K. Nigam and L.G. Cantley, 1995, HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase, Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37), F1211.
8. Folkman, J., 1995, Clinical applications of research on angiogenesis, New Engl. J. Med. 333, 175s7.
9. Hu, D.E. and T.P. Fan, 1995, Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A, Br. J. Pharmacol. 114, 262.
10. Oikawa, T., 1995, Strategies to find novel angiogenesis inhibitors as potential therapeutic agents for cancer, Curr. Med. Chem. 1, 406.
11. Oikawa, T., K. Hirotani, O. Nakamura, K. Shudo, A. Hiragun and T. Iwaguchi, 1989a, A highly potent antiangiogenic activity of retinoids, Cancer Lett. 48, 157.
12. Oikawa, T., K. Hirotani, M. Shimamura, H. Ashino-Fuse and T. Iwaguchi, 1989b, Powerful antiangiogenic activity of herbimycin A (named angiostatic antibiotic), J. Antibiot. 42, 1202.
13. Oikawa, T., H. Ashino, M. Shimamura, M. Hasegawa, I. Morita, S. Murota, M. Ishizuka and T. Takeuchi, 1993a, Inhibition of angiogenesis by erbstatin, an inhibitor of tyrosine kinase, J. Antibiot. 46, 785.
14. Oikawa, T., H. Ito, H. Ashino, M. Toi, T. Tominaga, I. Morita and S. Murota, 1993b, Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis, Eur. J. Pharmacol. 241, 221.
15. Rosen, E.M. and I.D. Goldberg, 1995, Scatter factor and angiogenesis, Adv. Cancer Res. 67, 257.
16. Shepherd, P.R., B.J. Reaves and H.W. Davidson, 1996, Phosphoinositide 3-kinases and membrane traffic, Trends Cell Biol. 6, 92.
17. Stephens, L.R., T.R. Jackson and P.T. Hawkins, 1993, Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-triphosphate: a new intracellular signalling system?, Biochim. Biophys. Acta 1179, 27.
18. Ui, M., T. Okada, K. Hazeki and O. Hazeki, 1995, Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase, Trends Biochem. Sci. 20, 303.