Structure guided design of a series of sphingosine kinase (SphK) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4608-4616

  Gustin, Darin J ^a   Li, Yihong ^a   Brown, Matthew L ^a   Min, Xiaoshan ^a   Schmitt, Mike J ^a   Wanska, Malgorzata ^a   Wang, Xiaodong ^a   Connors, Richard ^a   Johnstone, Sheere ^a   Cardozo, Mario ^a   Cheng, Alan C ^a   Jeffries, Shawn ^a   Franks, Brendon ^a   Li, Shyun ^a   Shen, Shanling ^a   Wong, Mariwil ^a   Wesche, Holger ^a   Xu, Guifen ^a   Carlson, Timothy J ^a   Plant, Matthew ^a   Morgenstern, Kurt ^a   Rex, Karen ^b   Schmitt, Joanna ^b   Coxon, Angela ^b   Walker, Nigel ^a   Kayser, Frank ^a   Wang, Zhulun ^a   more..

^a AMGEN INC   (United States)

^b Department of Oncology Research ^*  (United States)

Author keywords

Drug design; Murine SphK; Sphingosine kinase 1 inhibitor; Sphingosine kinase 2 inhibitor; Structure based

Indexed keywords

ENZYME INHIBITOR; HYDROXYL GROUP; SPHINGOMYELIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; SPHINGOSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BINDING SITE; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVITY; ENZYME INHIBITION; GENOTYPE; HYDROGEN BOND; IC 50; MELANOMA CELL; MOUSE; NONHUMAN; PHENOTYPE; PHOSPHOLIPID METABOLISM; PHYSICAL CHEMISTRY; X RAY;

DRUG DESIGN; MURINE SPHK; SPHINGOSINE KINASE 1 INHIBITOR; SPHINGOSINE KINASE 2 INHIBITOR; STRUCTURE BASED;

ANIMALS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MICE; MOLECULAR STRUCTURE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN ISOFORMS; RATS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE; MUS; RODENTIA;

EID: 84880625796     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.030     Document Type: Article

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