Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis

Journal of Immunology

Volumn 181, Issue 11, 2009, Pages 8010-8017

  Lai, Wen Qi ^a   Irwan, Anastasia Windy ^a   Goh, Hong Heng ^a   Howe, Hwee Siew ^b   Yu, David T ^c   Valle Oñate, Rafael ^d   McInnes, Iain B ^e   Melendez, Alirio J ^a   Leung, Bernard P ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b TAN TOCK SENG HOSPITAL   (Singapore)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSIDAD DE LA SABANA   (Colombia)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN ANTIBODY; COLLAGEN TYPE 2; GAMMA INTERFERON; GELATINASE B; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOENZYME; MONOCYTE CHEMOTACTIC PROTEIN 1; N,N DIMETHYLSPHINGOSINE; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; SPHINGOSINE KINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ASSAY; CELL CONTACT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE SEVERITY; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCIDENCE; JOINT DESTRUCTION; KNOCKOUT GENE; MALE; MODULATION; MOUSE; NONHUMAN; OSTEOARTHRITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

EID: 71849087397     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.11.8010     Document Type: Article

References (49)

1. Spiegel, S., and S. Milstien. 2003. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 4: 397-407.
2. Melendez, A. J. 2008. Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets. Biochim. Biophys. Acta 1784: 66-75.
3. Sanchez, T., and T. Hla. 2004. Structural and functional characteristics of S1P receptors. J. Cell. Biochem. 92: 913-922. (Pubitemid 44264241)
4. Pyne, S., and N. J. Pyne. 2000. Sphingosine 1-phosphate signalling in mammalian cells. Biochem. J. 349: 385-402. (Pubitemid 30465772)
5. Kohama, T., A. Olivera, L. Edsall, M. M. Nagiec, R. Dickson, and S. Spiegel. 1998. Molecular cloning and functional characterization of murine sphingosine kinase. J. Biol. Chem. 273: 23722-23728. (Pubitemid 28435703)
6. Melendez, A. J., E. Carlos-Dias, M. Gosink, J. M. Allen, and L. Takacs. 2000. Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. Gene 251: 19-26. (Pubitemid 30339413)
7. Liu, H., M. Sugiura, V. E. Nava, L. C. Edsall, K. Kono, S. Poulton, S. Milstien, T. Kohama, and S. Spiegel. 2000. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem. 275: 19513-19520. (Pubitemid 30441543)
8. 2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem. 277: 17255-17262.
9. Choi, O. H., J. H. Kim, and J. P. Kinet. 1996. Calcium mobilization via sphingosine kinase in signalling by the FcεRI antigen receptor. Nature 380: 634-636.
10. Van Brocklyn, J. R., M. J. Lee, R. Menzeleev, A. Olivera, L. Edsall, O. Cuvillier, D. M. Thomas, P. J. Coopman, S. Thangada, C. H. Liu, et al. 1998. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J. Cell Biol. 142: 229-240. (Pubitemid 28341153)
11. Alemany, R., D. Meyer zu Heringdorf, C. J. van Koppen, and K. H. Jakobs. 1999. Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. J. Biol. Chem. 274: 3994-3999.
12. 2+ signals, enzyme release, cytokine production, and chemotaxis. J. Immunol. 173: 1596-1603.
13. Ibrahim, F. B., S. J. Pang, and A. J. Melendez. 2004. Anaphylatoxin signaling in human neutrophils: a key role for sphingosine kinase. J. Biol. Chem. 279: 44802-44811.
14. Zhi, L., B. P. Leung, and A. J. Melendez. 2006. Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFα in primary human monocytes. J. Cell. Physiol. 208: 109-115. (Pubitemid 43848994)
15. Vlasenko, L. P., and A. J. Melendez. 2005. A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo. J. Immunol. 174: 6456-6461.
16. Feldmann, M., F. M. Brennan, and R. N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14: 397-440.
17. McInnes, I. B., and G. Schett. 2007. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7: 429-442.
18. Smolen, J. S., and G. Steiner. 2003. Therapeutic strategies for rheumatoid arthritis. Nat. Rev. Drug Discov. 2: 473-488.
19. McInnes, I. B., and F. Y. Liew. 2005. Cytokine networks: towards new therapies for rheumatoid arthritis. Nat. Clin. Pract. Rheumatol. 1: 31-39.
20. Koenders, M. I., L. A. Joosten, and W. B. van den Berg. 2006. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann. Rheum. Dis. 65 (Suppl. 3): iii29-iii33.
21. Katz, Y., O. Nadiv, and Y. Beer. 2001. Interleukin-17 enhances tumor necrosis factor α-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts: a possible role as a "fine-tuning cytokine" in inflammation processes. Arthritis Rheum. 44: 2176-2184.
22. McInnes, I. B., B. P. Leung, R. D. Sturrock, M. Field, and F. Y. Liew. 1997. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis. Nat. Med. 3: 189-195.
23. Vey, E., J. H. Zhang, and J. M. Dayer. 1992. IFN-gamm] and 1,25(OH)2D3 induce on THP-1 cells distinct patterns of cell surface antigen expression, cytokine production, and responsiveness to contact with activated T cells. J. Immunol. 149: 2040-2046.
24. Ribbens, C., J. M. Dayer, and C. Chizzolini. 2000. CD40-CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin-2- or interleukin-15-driven, contact-dependent, interleukin-1β production by monocytes. Immunology 99: 279-286. (Pubitemid 30093675)
25. Kitano, M., T. Hla, M. Sekiguchi, Y. Kawahito, R. Yoshimura, K. Miyazawa, T. Iwasaki, H. Sano, J. D. Saba, and Y. Y. Tam. 2006. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 54: 742-753.
26. Pi, X., S. Y. Tan, M. Hayes, L. Xiao, J. A. Shayman, S. Ling, and J. Holoshitz. 2006. Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells. Arthritis Rheum. 54: 754-764.
27. Arnett, F. C., S. M. Edworthy, D. A. Bloch, D. J. McShane, J. F. Fries, N. S. Cooper, L. A. Healey, S. R. Kaplan, M. H. Liang, H. S. Luthra, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31: 315-324.
28. Lai, W. Q., H. H. Goh, Z. Bao, W. S. Wong, A. J. Melendez, and B. P. Leung. 2008. The role of sphingosine kinase in a murine model of allergic asthma. J. Immunol. 180: 4323-4329.
29. McInnes, I. B., B. P. Leung, and F. Y. Liew. 2000. Cell-cell interactions in synovitis: interactions between T lymphocytes and synovial cells. Arthritis Res. 2: 374-378. (Pubitemid 32223767)
30. Burger, D., and J. M. Dayer. 2002. The role of human T-lymphocyte- monocyte contact in inflammation and tissue destruction. Arthritis Res. 4 (Suppl. 3): S169-S176.
31. Jovanovic, D. V., J. Martel-Pelletier, J. A. Di Battista, F. Mineau, F. C. Jolicoeur, M. Benderdour, and J. P. Pelletier. 2000. Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. Arthritis Rheum. 43: 1134-1144.
32. Edsall, L. C., J. R. Van Brocklyn, O. Cuvillier, B. Kleuser, and S. Spiegel. 1998. N,N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37: 12892-12898.
33. Sekiguchi, M., T. Iwasaki, M. Kitano, H. Kuno, N. Hashimoto, Y. Kawahito, M. Azuma, T. Hla, and H. Sano. 2008. Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. J. Immunol. 180: 1921-1928.
34. Kappos, L., J. Antel, G. Comi, X. Montalban, P. O'Connor, C. H. Polman, T. Haas, A. A. Korn, G. Karlsson, and E. W. Radue. 2006. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N. Engl. J. Med. 355: 1124-1140. (Pubitemid 44394919)
35. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360. (Pubitemid 38133663)
36. Pappu, R., S. R. Schwab, I. Cornelissen, J. P. Pereira, J. B. Regard, Y. Xu, E. Camerer, Y. W. Zheng, Y. Huang, J. G. Cyster, and S. R. Coughlin. 2007. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316: 295-298. (Pubitemid 46633109)
37. Melendez, A., R. A. Floto, D. J. Gillooly, M. M. Harnett, and J. M. Allen. 1998. FcγRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. J. Biol. Chem. 273: 9393-9402. (Pubitemid 28183019)
38. Niwa, M., O. Kozawa, H. Matsuno, Y. Kanamori, A. Hara, and T. Uematsu. 2000. Tumor necrosis factor-α-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-α on the fMLP-stimulated superoxide production. Life Sci. 66: 245-256. (Pubitemid 30025476)
39. Lacraz, S., P. Isler, E. Vey, H. G. Welgus, and J. M. Dayer. 1994. Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression. J. Biol. Chem. 269: 22027-22033. (Pubitemid 24282123)
40. 2 production by human synovial cells and dermal fibroblasts. J. Exp. Med. 162: 2163-2168.
41. Melendez, A., R. A. Floto, A. J. Cameron, D. J. Gillooly, M. M. Harnett, and J. M. Allen. 1998. A molecular switch changes the signalling pathway used by the Fc gamma RI antibody receptor to mobilise calcium. Curr. Biol. 8: 210-221. (Pubitemid 28126611)
42. Stam, J. C., F. Michiels, R. A. van der Kammen, W. H. Moolenaar, and J. G. Collard. 1998. Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. EMBO J. 17: 4066-4074.
43. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360. (Pubitemid 38133663)
44. Kurashima, Y., J. Kunisawa, M. Higuchi, M. Gohda, I. Ishikawa, N. Takayama, M. Shimizu, and H. Kiyono. 2007. Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. J. Immunol. 179: 1577-1585.
45. Xia, P., J. R. Gamble, K. A. Rye, L. Wang, C. S. Hii, P. Cockerill, Y. Khew-Goodall, A. G. Bert, P. J. Barter, and M. A. Vadas. 1998. Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway. Proc. Natl. Acad. Sci. USA 95: 14196-14201. (Pubitemid 28549344)
46. Kunisawa, J., Y. Kurashima, M. Gohda, M. Higuchi, I. Ishikawa, F. Miura, I. Ogahara, and H. Kiyono. 2007. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood 109: 3749-3756. (Pubitemid 46641725)
47. Michaud, J., M. Kohno, R. L. Proia, and T. Hla. 2006. Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett. 580: 4607-4612. (Pubitemid 44189376)
48. Cheng, A. M., I. Negishi, S. J. Anderson, A. C. Chan, J. Bolen, D. Y. Loh, and T. Pawson. 1997. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl. Acad. Sci. USA 94: 9797-9801.
49. Pushparaj, P. N., S. C. H'Ng, and A. J. Melendez. 2008. Refining siRNA in vivo transfection: silencing SphK1 reveals its key role in C5a-induced inflammation in vivo. Int. J. Biochem. Cell Biol. 40: 1817-1825.