Focal adhesion kinase inhibitors are potent anti-angiogenic agents

Molecular Oncology

Volumn 5, Issue 6, 2011, Pages 517-526

  Cabrita, Miguel A ^a   Jones, Laura M ^a   Quizi, Jennifer L ^a,b   Sabourin, Luc A ^a,b   McKay, Bruce C ^a,b   Addison, Christina L ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Anti angiogenic; Endothelial cell; FAK; Focal adhesion kinase; Tyrosine kinase inhibitor

Indexed keywords

ACTIN; FOCAL ADHESION KINASE INHIBITOR; FOCAL ADHESION KINASE INHIBITOR 14; PAXILLIN; PF 573228; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CYTOSKELETON; DRUG EFFICACY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRESS FIBER;

EID: 81855207292     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2011.10.004     Document Type: Article

References (35)

1. Abedi H., Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. The Journal of Biological Chemistry 1997, 272:15442-15451.
2. Abu-Ghazaleh R., Kabir J., Jia H., Lobo M., Zachary I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. The Biochemical Journal 2001, 360:255-264.
3. Addison C.L., Nor J.E., Zhao H., Linn S.A., Polverini P.J., Delaney C.E. The response of VEGF-stimulated endothelial cells to angiostatic molecules is substrate-dependent. BMC Cell Biology 2005, 6:38.
4. Bagi C.M., Christensen J., Cohen D.P., Roberts W.G., Wilkie D., Swanson T., Tuthill T., Andresen C.J. Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model. Cancer Biology & Therapy 2009, 8:856-865.
5. Bagi C.M., Roberts G.W., Andresen C.J. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. Cancer 2008, 112:2313-2321.
6. Beierle E.A., Trujillo A., Nagaram A., Golubovskaya V.M., Cance W.G., Kurenova E.V. TAE226 inhibits human neuroblastoma cell survival. Cancer Investigation 2008, 26:145-151.
7. Bellis S.L., Miller J.T., Turner C.E. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. Journal of Biological Chemistry 1995, 270:17437-17441.
8. Bergers G., Hanahan D. Modes of resistance to anti-angiogenic therapy. Nature Reviews 2008, 8:592-603.
9. Braren R., Hu H., Kim Y.H., Beggs H.E., Reichardt L.F., Wang R. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. The Journal of Cell Biology 2006, 172:151-162.
10. Delaney C.E., Weagant B.T., Addison C.L. The inhibitory effects of endostatin on endothelial cells are modulated by extracellular matrix. Experimental Cell Research 2006, 312:2476-2489.
11. Ebos J.M., Kerbel R.S. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nature Reviews Clinical Oncology 2011, 8:210-221.
12. Ellis L.M., Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nature Reviews 2008, 8:579-591.
13. Gimbrone M.A., Leapman S.B., Cotran R.S., Folkman J. Tumor dormancy in vivo by prevention of neovascularization. The Journal of Experimental Medicine 1972, 136:261-276.
14. Golubovskaya V.M., Nyberg C., Zheng M., Kweh F., Magis A., Ostrov D., Cance W.G. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. Journal of Medicinal Chemistry 2008, 51:7405-7416.
15. Golubovskaya V.M., Zheng M., Zhang L., Li J.-L., Cance W.G. The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. BMC Cancer 2009, 9:280.
16. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
17. Hochwald S.N., Nyberg C., Zheng M., Zheng D., Wood C., Massoll N.A., Magis A., Ostrov D., Cance W.G., Golubovskaya V.M. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 2009, 8:2435-2443.
18. Ilic D., Furuta Y., Kanazawa S., Takeda N., Sobue K., Nakatsuji N., Nomura S., Fujimoto J., Okada M., Yamamoto T. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 1995, 377:539-544.
19. Ilic D., Kovacic B., McDonagh S., Jin F., Baumbusch C., Gardner D.G., Damsky C.H. Focal adhesion kinase is required for blood vessel morphogenesis. Circulation Research 2003, 92:300-307.
20. McLean G.W., Carragher N.O., Avizienyte E., Evans J., Brunton V.G., Frame M.C. The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nature Reviews Cancer 2005, 5:505-515.
21. Meredith J.E., Fazeli B., Schwartz M.A. The extracellular matrix as a cell survival factor. Molecular Biology of the Cell 1993, 4:953-961.
22. Mitra S.K., Schlaepfer D.D. Integrin-regulated FAK-Src signaling in normal and cancer cells. Current Opinion in Cell Biology 2006, 18:516-523.
23. Nakao-Hayashi J., Ito H., Kanayasu T., Morita I., Murota S. Stimulatory effects of insulin and insulin-like growth factor I on migration and tube formation by vascular endothelial cells. Atherosclerosis 1992, 92:141-149.
24. Nitert M.D., Chisalita S.I., Olsson K., Bornfeldt K.E., Arnqvist H.J. IGF-I/insulin hybrid receptors in human endothelial cells. Molecular and Cellular Endocrinology 2005, 229:31-37.
25. Roberts W.G., Ung E., Whalen P., Cooper B., Hulford C., Autry C., Richter D., Emerson E., Lin J., Kath J., Coleman K., Yao L., Martinez-Alsina L., Lorenzen M., Berliner M., Luzzio M., Patel N., Schmitt E., LaGreca S., Jani J., Wessel M., Marr E., Griffor M., Vajdos F. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Research 2008, 68:1935-1944.
26. Sabourin L.A., Rudnicki M.A. Induction of apoptosis by SLK, a Ste20-related kinase. Oncogene 1999, 18:7566-7575.
27. Schultze A., Decker S., Otten J., Horst A.K., Vohwinkel G., Schuch G., Bokemeyer C., Loges S., Fiedler W. TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis. Investigational New Drugs 2010, 28:825-833.
28. Schultze A., Fiedler W. Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer. Expert Opinion on Investigational Drugs 2010, 19:777-788.
29. Schwock J., Dhani N., Hedley D.W. Targeting focal adhesion kinase signaling in tumor growth and metastasis. Expert Opinion on Therapeutic Targets 2010, 14:77-94.
30. Shen T.-L., Park A.Y.J., Alcaraz A., Peng X., Jang I., Koni P., Flavell R.A., Gu H., Guan J.-L. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. The Journal of Cell Biology 2005, 169:941-952.
31. Slack-Davis J.K., Martin K.H., Tilghman R.W., Iwanicki M., Ung E.J., Autry C., Luzzio M.J., Cooper B., Kath J.C., Roberts W.G., Parsons J.T. Cellular characterization of a novel focal adhesion kinase inhibitor. The Journal of Biological Chemistry 2007, 282:14845-14852.
32. Smith N.R., Baker D., James N.H., Ratcliffe K., Jenkins M., Ashton S.E., Sproat G., Swann R., Gray N., Ryan A., Jurgensmeier J.M., Womack C. Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Clinical Cancer Research 2010, 16:3548-3561.
33. Tavora B., Batista S., Reynolds L.E., Jadeja S., Robinson S., Kostourou V., Hart I., Fruttiger M., Parsons M., Hodivala-Dilke K.M. Endothelial FAK is required for tumour angiogenesis. EMBO Molecular Medicine 2010, 2:516-528.
34. Veikkola T., Karkkainen M., Claesson-Welsh L., Alitalo K. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Research 2000, 60:203-212.
35. Zhao J., Guan J.-L. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Reviews 2009, 28:35-49.