Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Science Translational Medicine

Volumn 6, Issue 250, 2014, Pages

  Thi, Emily P ^a   Mire, Chad E ^b,c   Ursic Bedoya, Raul ^a   Geisbert, Joan B ^b,c   Lee, Amy C H ^a   Agans, Krystle N ^b,c   Robbins, Marjorie ^a   Deer, Daniel J ^b,c   Fenton, Karla A ^b,c   MacLachlan, Ian ^a   Geisbert, Thomas W ^b,c  

^a Tekmira Pharmaceuticals Corporation   (Canada)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID NANOPARTICLE; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VIRUS RNA; LIPID; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ENCAPSULATION; FEMALE; MALE; MARBURG HEMORRHAGIC FEVER; NONHUMAN; RHESUS MONKEY; SURVIVAL; VIREMIA; VIRUS LOAD; ANIMAL; CHEMISTRY; HUMAN; IMMUNOLOGY; MARBURG VIRUS DISEASE; MARBURGVIRUS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VIROLOGY;

ANIMALS; ANTIGENS, VIRAL; HUMANS; LIPIDS; MACACA MULATTA; MARBURG VIRUS DISEASE; MARBURGVIRUS; NANOPARTICLES; RNA, SMALL INTERFERING; RNA, VIRAL; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VIREMIA;

EID: 84907409689     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3009706     Document Type: Article

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