메뉴 건너뛰기




Volumn 19, Issue 7, 2014, Pages 936-948

The role of molecular imaging in modern drug development

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ANTINEOPLASTIC AGENT; PROTEIN BINDING;

EID: 84903748665     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.01.003     Document Type: Review
Times cited : (46)

References (86)
  • 1
    • 78951480503 scopus 로고    scopus 로고
    • Pharmaceutical innovation in the 21st century: New drug approvals in the first decade, 2000-2009
    • K.I. Kaitin, and J.A. DiMasi Pharmaceutical innovation in the 21st century: new drug approvals in the first decade, 2000-2009 Clin. Pharmacol. Ther. 89 2011 183 188
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 183-188
    • Kaitin, K.I.1    Dimasi, J.A.2
  • 2
    • 34548324706 scopus 로고    scopus 로고
    • The cost of biopharmaceutical R&D: Is biotech different?
    • J.A. DiMasi, and H.G. Grabowski The cost of biopharmaceutical R&D: is biotech different? Manage. Decis. Econ. 28 2007 469 479
    • (2007) Manage. Decis. Econ. , vol.28 , pp. 469-479
    • Dimasi, J.A.1    Grabowski, H.G.2
  • 3
    • 3042643738 scopus 로고    scopus 로고
    • Science, pharmacoeconomics and ethics in drug R&D: A sustainable future scenario?
    • P. Preziosi Science, pharmacoeconomics and ethics in drug R&D: a sustainable future scenario? Nat. Rev. Drug Discov. 3 2004 521 526 (Pubitemid 38807534)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.6 , pp. 521-526
    • Preziosi, P.1
  • 5
    • 84885547301 scopus 로고    scopus 로고
    • Protein crystallography in structure-based drug design
    • A. Makriyannis, D. Biegel, Marcel Dekker
    • X. Qiu, and S.S. Abdel-Meguid Protein crystallography in structure-based drug design A. Makriyannis, D. Biegel, Drug Discovery Strategies and Methods 2004 Marcel Dekker 1 22
    • (2004) Drug Discovery Strategies and Methods , pp. 1-22
    • Qiu, X.1    Abdel-Meguid, S.S.2
  • 6
    • 85031271393 scopus 로고    scopus 로고
    • Integrated drug product development - From lead candidate selection to life-cycle management
    • C.G. Smith, J.T. O'Donnell, Informa Healthcare USA
    • M. Pudipeddi et al. Integrated drug product development - from lead candidate selection to life-cycle management C.G. Smith, J.T. O'Donnell, The Process of New Drug Discovery and Development 2006 Informa Healthcare USA 15 54
    • (2006) The Process of New Drug Discovery and Development , pp. 15-54
    • Pudipeddi, M.1
  • 8
    • 0037313516 scopus 로고    scopus 로고
    • Molecular imaging in drug discovery and development
    • DOI 10.1038/nrd1007
    • M. Rudin, and R. Weissleder Molecular imaging in drug discovery and development Nat. Rev. Drug Discov. 2 2003 123 131 (Pubitemid 37361644)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.2 , pp. 123-131
    • Rudin, M.1    Weissleder, R.2
  • 9
    • 46749140321 scopus 로고    scopus 로고
    • Molecular-genetic imaging based on reporter gene expression
    • J.H. Kang, and J.K. Chung Molecular-genetic imaging based on reporter gene expression J. Nucl. Med. 49 Suppl. 2 2008 164 179
    • (2008) J. Nucl. Med. , vol.49 , Issue.SUPPL. 2 , pp. 164-179
    • Kang, J.H.1    Chung, J.K.2
  • 10
    • 84986582585 scopus 로고    scopus 로고
    • Multimodality imaging: Overview of imaging techniques (CT, MRI, PET, optical imaging) and impact of multimodality imaging on drug development
    • P.H. Elsinga, World Scientific
    • Y. Waerzeggers et al. Multimodality imaging: overview of imaging techniques (CT, MRI, PET, optical imaging) and impact of multimodality imaging on drug development P.H. Elsinga, Trends on the Role of PET in Drug Development 2012 World Scientific 319 382
    • (2012) Trends on the Role of PET in Drug Development , pp. 319-382
    • Waerzeggers, Y.1
  • 13
    • 53749108252 scopus 로고    scopus 로고
    • Small-animal SPECT and SPECT/CT: Important tools for preclinical investigation
    • B.L. Franc et al. Small-animal SPECT and SPECT/CT: important tools for preclinical investigation J. Nucl. Med. 49 2008 1651 1663
    • (2008) J. Nucl. Med. , vol.49 , pp. 1651-1663
    • Franc, B.L.1
  • 14
    • 0036441844 scopus 로고    scopus 로고
    • The value of improving the productivity of the drug development process: Faster times and better decisions
    • J.A. DiMasi The value of improving the productivity of the drug development process: faster times and better decisions Pharmacoeconomics 20 Suppl. 3 2002 1 10
    • (2002) Pharmacoeconomics , vol.20 , Issue.SUPPL. 3 , pp. 1-10
    • Dimasi, J.A.1
  • 16
    • 84855516274 scopus 로고    scopus 로고
    • Positron emission tomography molecular imaging for drug development
    • P.M. Matthews et al. Positron emission tomography molecular imaging for drug development Br. J. Clin. Pharmacol. 73 2012 175 186
    • (2012) Br. J. Clin. Pharmacol. , vol.73 , pp. 175-186
    • Matthews, P.M.1
  • 17
    • 84903750751 scopus 로고    scopus 로고
    • Can medical image analysis change the economics of drug development?
    • Available at
    • E. Ashton Can medical image analysis change the economics of drug development? Pharm. Discov. 2005 Available at: http://www.spectroscopyonline. com/spectroscopy/article/articleDetail.jsp?id=180274&sk=&date= &pageID=3
    • (2005) Pharm. Discov.
    • Ashton, E.1
  • 18
    • 0012164128 scopus 로고    scopus 로고
    • FDA (accessed January 2014)
    • FDA The Center for Drug Evaluation and Research Handbook 1998 Available at: http://www.fda.gov/downloads/AboutFDA/CentersOffices/CDER/UCM198415.pdf (accessed January 2014)
    • (1998) The Center for Drug Evaluation and Research Handbook
  • 19
    • 84880823219 scopus 로고    scopus 로고
    • Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity
    • X. Zhang et al. Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity J. Appl. Toxicol. 33 2013 861 868
    • (2013) J. Appl. Toxicol. , vol.33 , pp. 861-868
    • Zhang, X.1
  • 21
    • 34548324267 scopus 로고    scopus 로고
    • The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials
    • DOI 10.1038/sj.bjc.6603925, PII 6603925
    • S. Marchetti, and J.H. Schellens The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials Br. J. Cancer 97 2007 577 581 (Pubitemid 47339894)
    • (2007) British Journal of Cancer , vol.97 , Issue.5 , pp. 577-581
    • Marchetti, S.1    Schellens, J.H.M.2
  • 23
    • 63449108223 scopus 로고    scopus 로고
    • Effective incorporation of biomarkers into Phase II trials
    • L.M. McShane et al. Effective incorporation of biomarkers into Phase II trials Clin. Cancer Res. 15 2009 1898 1905
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1898-1905
    • McShane, L.M.1
  • 24
    • 0642286549 scopus 로고    scopus 로고
    • The contemporary drug development process: Advances and challenges in preclinical and clinical development
    • M.D. Garrett et al. The contemporary drug development process: advances and challenges in preclinical and clinical development Prog. Cell Cycle Res. 5 2003 145 158
    • (2003) Prog. Cell Cycle Res. , vol.5 , pp. 145-158
    • Garrett, M.D.1
  • 25
    • 84892374338 scopus 로고    scopus 로고
    • Biomarkers in pharmacology and drug discovery
    • 10.1016/j.bcp.2013.08.026
    • D.C. Anderson, and K. Kodukula Biomarkers in pharmacology and drug discovery Biochem. Pharmacol. 2013 10.1016/j.bcp.2013.08.026
    • (2013) Biochem. Pharmacol.
    • Anderson, D.C.1    Kodukula, K.2
  • 26
    • 33746559665 scopus 로고    scopus 로고
    • Imaging biomarkers as surrogate endpoints for drug development
    • W.S. Richter Imaging biomarkers as surrogate endpoints for drug development Eur. J. Nucl. Med. Mol. Imaging 33 Suppl. 1 2006 6 10
    • (2006) Eur. J. Nucl. Med. Mol. Imaging , vol.33 , Issue.SUPPL. 1 , pp. 6-10
    • Richter, W.S.1
  • 27
    • 39649084919 scopus 로고    scopus 로고
    • The FDA critical path initiative and its influence on new drug development
    • DOI 10.1146/annurev.med.59.090506.155819
    • J. Woodcock, and R. Woosley The FDA critical path initiative and its influence on new drug development Annu. Rev. Med. 59 2008 1 12 (Pubitemid 351287920)
    • (2008) Annual Review of Medicine , vol.59 , pp. 1-12
    • Woodcock, J.1    Woosley, R.2
  • 28
    • 0035037328 scopus 로고    scopus 로고
    • Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: Criteria, validation, strategies
    • DOI 10.1146/annurev.pharmtox.41.1.347
    • L.J. Lesko, and A.J. Atkinson Jr. Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies Annu. Rev. Pharmacol. Toxicol. 41 2001 347 366 (Pubitemid 32390116)
    • (2001) Annual Review of Pharmacology and Toxicology , vol.41 , pp. 347-366
    • Lesko, L.J.1    Atkinson Jr., A.J.2
  • 29
    • 36849020401 scopus 로고    scopus 로고
    • Principles of CT: Radiation dose and image quality
    • DOI 10.2967/jnmt.106.037846
    • L.W. Goldman Principles of CT: radiation dose and image quality J. Nucl. Med. Technol. 35 2007 213 225 (quiz 226-218) (Pubitemid 350232322)
    • (2007) Journal of Nuclear Medicine Technology , vol.35 , Issue.4 , pp. 213-225
    • Goldman, L.W.1
  • 30
    • 84878655753 scopus 로고    scopus 로고
    • PET imaging of proliferation with pyrimidines
    • O.S. Tehrani, and A.F. Shields PET imaging of proliferation with pyrimidines J. Nucl. Med. 54 2013 903 912
    • (2013) J. Nucl. Med. , vol.54 , pp. 903-912
    • Tehrani, O.S.1    Shields, A.F.2
  • 31
    • 84857059339 scopus 로고    scopus 로고
    • 18FFLT: An imaging biomarker of tumour proliferation for assessment of tumour response to treatment
    • 18FFLT: an imaging biomarker of tumour proliferation for assessment of tumour response to treatment Eur. J. Cancer 48 2012 416 424
    • (2012) Eur. J. Cancer , vol.48 , pp. 416-424
    • Soloviev, D.1
  • 32
    • 0034767013 scopus 로고    scopus 로고
    • In vivo imaging of gene and cell therapies
    • DOI 10.1016/S0301-472X(01)00739-1, PII S0301472X01007391
    • J.R. Allport, and R. Weissleder In vivo imaging of gene and cell therapies Exp. Hematol. 29 2001 1237 1246 (Pubitemid 33033300)
    • (2001) Experimental Hematology , vol.29 , Issue.11 , pp. 1237-1246
    • Allport, J.R.1    Weissleder, R.2
  • 33
    • 0042848538 scopus 로고    scopus 로고
    • Imaging studies of biodistribution and kinetics in drug development
    • DOI 10.1002/ddr.10220
    • M.S. Berridge et al. Imaging studies of biodistribution and kinetics in drug development Drug Dev. Res. 59 2003 208 226 (Pubitemid 36899890)
    • (2003) Drug Development Research , vol.59 , Issue.2 , pp. 208-226
    • Berridge, M.S.1    Heald, D.L.2    Lee, Z.3
  • 34
    • 78650150918 scopus 로고    scopus 로고
    • In vivo small animal imaging: Current status and future prospects
    • G.C. Kagadis et al. In vivo small animal imaging: current status and future prospects Med. Phys. 37 2010 6421 6442
    • (2010) Med. Phys. , vol.37 , pp. 6421-6442
    • Kagadis, G.C.1
  • 35
    • 84986570003 scopus 로고    scopus 로고
    • Molecular imaging biomarkers as a tool in development of novel medicines
    • P.H. Elsinga, World Scientific
    • R.P. Maguire Molecular imaging biomarkers as a tool in development of novel medicines P.H. Elsinga, Trends on the Role of PET in Drug Development 2012 World Scientific 33 48
    • (2012) Trends on the Role of PET in Drug Development , pp. 33-48
    • Maguire, R.P.1
  • 36
    • 84903728577 scopus 로고    scopus 로고
    • Principles of PET and PET/CT imaging
    • R.E. Henkin, Elsevier
    • R.D. Hichwa, and J.R. Halama Principles of PET and PET/CT imaging R.E. Henkin, Nuclear Medicine vol. 1 2006 Elsevier 257 270
    • (2006) Nuclear Medicine , vol.1 , pp. 257-270
    • Hichwa, R.D.1    Halama, J.R.2
  • 37
    • 41849104653 scopus 로고    scopus 로고
    • PET versus SPECT: Strengths, limitations and challenges
    • DOI 10.1097/MNM.0b013e3282f3a515, PII 0000623120080300000002
    • A. Rahmim, and H. Zaidi PET versus SPECT: strengths, limitations and challenges Nucl. Med. Commun. 29 2008 193 207 (Pubitemid 351499295)
    • (2008) Nuclear Medicine Communications , vol.29 , Issue.3 , pp. 193-207
    • Rahmim, A.1    Zaidi, H.2
  • 38
    • 0038408827 scopus 로고    scopus 로고
    • Positron emission tomographic analysis of dose-dependent NAD-299 binding to 5-hydroxytryptamine-1A receptors in the human brain
    • B. Andree et al. Positron emission tomographic analysis of dose-dependent NAD-299 binding to 5-hydroxytryptamine-1 A receptors in the human brain Psychopharmacology (Berl.) 167 2003 37 45 (Pubitemid 36535290)
    • (2003) Psychopharmacology , vol.167 , Issue.1 , pp. 37-45
    • Andree, B.1    Hedman, A.2    Thorberg, S.-O.3    Nilsson, D.4    Halldin, C.5    Farde, L.6
  • 41
    • 0034743495 scopus 로고    scopus 로고
    • Neuroimaging and drug development: An algorithm for decision making
    • S. Kapur Neuroimaging and drug development: an algorithm for decision making J. Clin. Pharmacol. Suppl. 2001 64 71
    • (2001) J. Clin. Pharmacol. Suppl. , pp. 64-71
    • Kapur, S.1
  • 42
    • 0026306051 scopus 로고
    • 11C-clozapine to frontal cortex and striatum in drug-free schizophrenics and healthy controls studied by positron emission tomography
    • 11C-clozapine to frontal cortex and striatum in drug-free schizophrenics and healthy controls studied by positron emission tomography Acta Radiol. Suppl. 376 1991 153 154
    • (1991) Acta Radiol. Suppl. , vol.376 , pp. 153-154
    • Lundberg, T.1
  • 43
    • 0028991822 scopus 로고
    • D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: A PET study of schizophrenic patients
    • A.L. Nordstrom et al. D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients Am. J. Psychiatry 152 1995 1444 1449
    • (1995) Am. J. Psychiatry , vol.152 , pp. 1444-1449
    • Nordstrom, A.L.1
  • 45
    • 33746472882 scopus 로고    scopus 로고
    • PET tracers for imaging of the dopaminergic system
    • DOI 10.2174/092986706777935258
    • P.H. Elsinga et al. PET tracers for imaging of the dopaminergic system Curr. Med. Chem. 13 2006 2139 2153 (Pubitemid 44132606)
    • (2006) Current Medicinal Chemistry , vol.13 , Issue.18 , pp. 2139-2153
    • Elsinga, P.H.1    Hatano, K.2    Ishiwata, K.3
  • 46
    • 0026718710 scopus 로고
    • Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects
    • L. Farde et al. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects Arch. Gen. Psychiatry 49 1992 538 544
    • (1992) Arch. Gen. Psychiatry , vol.49 , pp. 538-544
    • Farde, L.1
  • 47
    • 27644531019 scopus 로고    scopus 로고
    • Small animal SPECT and its place in the matrix of molecular imaging technologies
    • S.R. Meikle et al. Small animal SPECT and its place in the matrix of molecular imaging technologies Phys. Med. Biol. 50 2005 45 61
    • (2005) Phys. Med. Biol. , vol.50 , pp. 45-61
    • Meikle, S.R.1
  • 48
    • 84872047523 scopus 로고    scopus 로고
    • An evidence-based review of quantitative SPECT imaging and potential clinical applications
    • D.L. Bailey, and K.P. Willowson An evidence-based review of quantitative SPECT imaging and potential clinical applications J. Nucl. Med. 54 2013 83 89
    • (2013) J. Nucl. Med. , vol.54 , pp. 83-89
    • Bailey, D.L.1    Willowson, K.P.2
  • 49
    • 84903723814 scopus 로고    scopus 로고
    • Radiopharmaceuticals for positron emission tomography
    • R.J. Kowalsky, S.W. Falen, American Pharmacists Association
    • S.M. Moerlein Radiopharmaceuticals for positron emission tomography R.J. Kowalsky, S.W. Falen, Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine 2004 American Pharmacists Association 337 339
    • (2004) Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine , pp. 337-339
    • Moerlein, S.M.1
  • 50
    • 46849085176 scopus 로고    scopus 로고
    • Imaging and cancer: A review
    • L. Fass Imaging and cancer: a review Mol. Oncol. 2 2008 115 152
    • (2008) Mol. Oncol. , vol.2 , pp. 115-152
    • Fass, L.1
  • 51
    • 84870265819 scopus 로고    scopus 로고
    • X-ray and X-ray CT
    • F. Kiessling, B.J. Pichler, Springer-Verlag
    • W.A. Kalender et al. X-ray and X-ray CT F. Kiessling, B.J. Pichler, Small Animal Imaging 2011 Springer-Verlag 125 139
    • (2011) Small Animal Imaging , pp. 125-139
    • Kalender, W.A.1
  • 52
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • P. Therasse et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J. Natl. Cancer Inst 92 2000 205 216
    • (2000) J. Natl. Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1
  • 53
    • 84875210245 scopus 로고    scopus 로고
    • Advances in multimodal neuroimaging: Hybrid MR-PET and MR-PET-EEG at 3T and 9.4T
    • N.J. Shah et al. Advances in multimodal neuroimaging: hybrid MR-PET and MR-PET-EEG at 3T and 9.4T J. Magn. Reson. 229 2013 101 115
    • (2013) J. Magn. Reson. , vol.229 , pp. 101-115
    • Shah, N.J.1
  • 54
    • 79953190432 scopus 로고    scopus 로고
    • Imaging devices for use in small animals
    • W. Koba et al. Imaging devices for use in small animals Sem. Nucl. Med. 41 2011 151 165
    • (2011) Sem. Nucl. Med. , vol.41 , pp. 151-165
    • Koba, W.1
  • 56
    • 33846478656 scopus 로고    scopus 로고
    • DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
    • DOI 10.1038/sj.bjc.6603515, PII 6603515
    • J.P. O'Connor et al. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents Br. J. Cancer 96 2007 189 195 (Pubitemid 46160619)
    • (2007) British Journal of Cancer , vol.96 , Issue.2 , pp. 189-195
    • O'Connor, J.P.B.1    Jackson, A.2    Parker, G.J.M.3    Jayson, G.C.4
  • 57
    • 84903699315 scopus 로고    scopus 로고
    • The use of positron emission tomography in drug discovery and development
    • D.L. Bailey, Springer
    • W.C. Eckelman The use of positron emission tomography in drug discovery and development D.L. Bailey, Positron Emission Tomography: Basic Sciences 2005 Springer 327 341
    • (2005) Positron Emission Tomography: Basic Sciences , pp. 327-341
    • Eckelman, W.C.1
  • 58
    • 0038756512 scopus 로고    scopus 로고
    • Optical-based molecular imaging: Contrast agents and potential medical applications
    • C. Bremer et al. Optical-based molecular imaging: contrast agents and potential medical applications Eur. Radiol. 13 2003 231 243 (Pubitemid 36798598)
    • (2003) European Radiology , vol.13 , Issue.2 , pp. 231-243
    • Bremer, C.1    Ntziachristos, V.2    Weissleder, R.3
  • 59
    • 33646160434 scopus 로고    scopus 로고
    • Emerging imaging techniques
    • E.R. McVeigh Emerging imaging techniques Circ. Res. 98 2006 879 886
    • (2006) Circ. Res. , vol.98 , pp. 879-886
    • McVeigh, E.R.1
  • 60
    • 0037338436 scopus 로고    scopus 로고
    • Molecular imaging in living subjects: Seeing fundamental biological processes in a new light
    • DOI 10.1101/gad.1047403
    • T.F. Massoud, and S.S. Gambhir Molecular imaging in living subjects: seeing fundamental biological processes in a new light Genes Dev. 17 2003 545 580 (Pubitemid 36307540)
    • (2003) Genes and Development , vol.17 , Issue.5 , pp. 545-580
    • Massoud, T.F.1    Gambhir, S.S.2
  • 62
    • 79960982093 scopus 로고    scopus 로고
    • In vivo preclinical imaging: An essential tool in translational research
    • J. Comley In vivo preclinical imaging: an essential tool in translational research Drug Discov. World Summer 11 2011 58 71
    • (2011) Drug Discov. World Summer , vol.11 , pp. 58-71
    • Comley, J.1
  • 63
    • 68249135385 scopus 로고    scopus 로고
    • A review of imaging agent development
    • E.D. Agdeppa, and M.E. Spilker A review of imaging agent development AAPS J. 11 2009 286 299
    • (2009) AAPS J. , vol.11 , pp. 286-299
    • Agdeppa, E.D.1    Spilker, M.E.2
  • 64
    • 84903710909 scopus 로고    scopus 로고
    • State-of-the-art Nuclear Medicine: SPECT and SPECT/CT imaging - An introduction to mainstay diagnostic testing in non-invasive medicine
    • AIPES (accessed January 2014)
    • AIPES State-of-the-art Nuclear Medicine: SPECT and SPECT/CT imaging - an introduction to mainstay diagnostic testing in non-invasive medicine White Paper 2012 Available at: http://www.aipes-eeig.org/white-paper-spect-spect-ct.html (accessed January 2014)
    • (2012) White Paper
  • 65
    • 84986626909 scopus 로고    scopus 로고
    • Small animal imaging for accelerating drug development, and comparison to other techniques
    • P.H. Elsinga, World Scientific
    • A. Kristian, and O. Alstrup Small animal imaging for accelerating drug development, and comparison to other techniques P.H. Elsinga, Trends on the Role of PET in Drug Development 2012 World Scientific 219 239
    • (2012) Trends on the Role of PET in Drug Development , pp. 219-239
    • Kristian, A.1    Alstrup, O.2
  • 66
    • 25144441873 scopus 로고    scopus 로고
    • Molecular imaging in drug discovery and development: Potential and limitations of nonnuclear methods
    • DOI 10.1007/s11307-004-0954-z
    • M. Rudin et al. Molecular imaging in drug discovery and development: potential and limitations of nonnuclear methods Mol. Imaging Biol. 7 2005 5 13 (Pubitemid 41348870)
    • (2005) Molecular Imaging and Biology , vol.7 , Issue.1 , pp. 5-13
    • Rudin, M.1    Rausch, M.2    Stoeckli, M.3
  • 67
    • 51549083693 scopus 로고    scopus 로고
    • Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo
    • J.K. Willmann et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo Radiology 248 2008 936 944
    • (2008) Radiology , vol.248 , pp. 936-944
    • Willmann, J.K.1
  • 69
    • 0031963279 scopus 로고    scopus 로고
    • 2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel®) in patients with schizophrenia
    • DOI 10.1007/s002130050492
    • O. Gefvert et al. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia Psychopharmacology (Berl.) 135 1998 119 126 (Pubitemid 28055494)
    • (1998) Psychopharmacology , vol.135 , Issue.2 , pp. 119-126
    • Gefvert, O.1    Bergstrom, M.2    Langstrom, B.3    Lundberg, T.4    Lindstrom, L.5    Yates, R.6
  • 70
    • 84884281105 scopus 로고    scopus 로고
    • 5-HTT and 5-HT1 A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects
    • P. Stenkrona et al. 5-HTT and 5-HT1 A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects Eur. Neuropsychopharmacol. 23 2013 1190 1198
    • (2013) Eur. Neuropsychopharmacol. , vol.23 , pp. 1190-1198
    • Stenkrona, P.1
  • 71
    • 47749134584 scopus 로고    scopus 로고
    • The lessons of GIST - PET and PET/CT: A new paradigm for imaging
    • A.D. Van den Abbeele The lessons of GIST - PET and PET/CT: a new paradigm for imaging Oncologist 13 Suppl. 2 2008 8 13
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 2 , pp. 8-13
    • Van Den Abbeele, A.D.1
  • 72
    • 84889828501 scopus 로고    scopus 로고
    • In vivo radiotracer imaging
    • V. Ntziachristos, John Wiley & Sons
    • B. Tavitian et al. In vivo radiotracer imaging V. Ntziachristos, Textbook of In Vivo Imaging in Vertebrates 2007 John Wiley & Sons 103 147
    • (2007) Textbook of in Vivo Imaging in Vertebrates , pp. 103-147
    • Tavitian, B.1
  • 73
    • 69249216426 scopus 로고    scopus 로고
    • Standardized methods for the production of high specific-activity zirconium-89
    • J.P. Holland et al. Standardized methods for the production of high specific-activity zirconium-89 Nucl. Med. Biol. 36 2009 729 739
    • (2009) Nucl. Med. Biol. , vol.36 , pp. 729-739
    • Holland, J.P.1
  • 76
    • 84878468840 scopus 로고    scopus 로고
    • The effect of topiramate on cognitive fMRI
    • C.L. Yasuda et al. The effect of topiramate on cognitive fMRI Epilepsy Res. 105 2013 250 255
    • (2013) Epilepsy Res. , vol.105 , pp. 250-255
    • Yasuda, C.L.1
  • 77
    • 84880325199 scopus 로고    scopus 로고
    • Heat-stroke in an epileptic patient treated by topiramate: Follow-up by magnetic resonance imaging including diffusion-weighted imaging with apparent diffusion coefficient measure
    • C.F. Muccio et al. Heat-stroke in an epileptic patient treated by topiramate: follow-up by magnetic resonance imaging including diffusion-weighted imaging with apparent diffusion coefficient measure Clin. Neurol. Neurosurg. 115 2013 1558 1560
    • (2013) Clin. Neurol. Neurosurg. , vol.115 , pp. 1558-1560
    • Muccio, C.F.1
  • 78
    • 84860668935 scopus 로고    scopus 로고
    • Topiramate and its effect on fMRI of language in patients with right or left temporal lobe epilepsy
    • J.P. Szaflarski, and J.B. Allendorfer Topiramate and its effect on fMRI of language in patients with right or left temporal lobe epilepsy Epilepsy Behav. 24 2012 74 80
    • (2012) Epilepsy Behav. , vol.24 , pp. 74-80
    • Szaflarski, J.P.1    Allendorfer, J.B.2
  • 79
    • 84877764690 scopus 로고    scopus 로고
    • Modern treatment of gastric gastrointestinal stromal tumors
    • K.K. Roggin, and M.C. Posner Modern treatment of gastric gastrointestinal stromal tumors World J. Gastroenterol. 18 2012 6720 6728
    • (2012) World J. Gastroenterol. , vol.18 , pp. 6720-6728
    • Roggin, K.K.1    Posner, M.C.2
  • 80
    • 84871528258 scopus 로고    scopus 로고
    • FDG PET and FDG PET/CT in patients with gastrointestinal stromal tumours
    • P. Malle et al. FDG PET and FDG PET/CT in patients with gastrointestinal stromal tumours Wien Med. Wochenschr. 162 2012 423 429
    • (2012) Wien Med. Wochenschr. , vol.162 , pp. 423-429
    • Malle, P.1
  • 82
    • 84887241696 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: A children's oncology group Phase i consortium report
    • J.L. Glade Bender et al. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group Phase I consortium report J. Clin. Oncol. 31 2013 3034 3043
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3034-3043
    • Glade Bender, J.L.1
  • 83
    • 71549138874 scopus 로고    scopus 로고
    • Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib: A molecular imaging study
    • F.G. Blankenberg et al. Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib: a molecular imaging study Transl. Oncol. 3 2010 56 64
    • (2010) Transl. Oncol. , vol.3 , pp. 56-64
    • Blankenberg, F.G.1
  • 84
    • 84859813987 scopus 로고    scopus 로고
    • Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: Association with clinical endpoints in a Phase II clinical trial of pertuzumab and erlotinib
    • E.A. Punnoose et al. Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: association with clinical endpoints in a Phase II clinical trial of pertuzumab and erlotinib Clin. Cancer Res. 18 2012 2391 2401
    • (2012) Clin. Cancer Res. , vol.18 , pp. 2391-2401
    • Punnoose, E.A.1
  • 85
    • 79960188481 scopus 로고    scopus 로고
    • Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer
    • I. Vaneycken et al. Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer FASEB J. 25 2011 2433 2446
    • (2011) FASEB J. , vol.25 , pp. 2433-2446
    • Vaneycken, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.