Efficient gene delivery and multimodal imaging by lanthanide-based upconversion nanoparticles

Langmuir

Volumn 30, Issue 43, 2014, Pages 13042-13051

  Wang, Lin ^a,b   Liu, Jianhua ^c   Dai, Yunlu ^a,d   Yang, Qiang ^a   Zhang, Yuanxin ^a   Yang, Piaoping ^b   Cheng, Ziyong ^a   Lian, Hongzhou ^a   Li, Chunxia ^a   Hou, Zhiyao ^a   Ma, Pingan ^a   Lin, Jun ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b HARBIN ENGINEERING UNIVERSITY   (China)

^c THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; LANTHANIDE; NANOPARTICLE; POLYETHYLENEIMINE; PROTEIN BCL 2; SMALL INTERFERING RNA;

ANIMAL; CHEMISTRY; DEFICIENCY; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HELA CELL LINE; HUMAN; LUMINESCENCE; MOUSE; MULTIMODAL IMAGING; PLASMID; PROCEDURES;

ANIMALS; DRUG CARRIERS; GENE SILENCING; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LANTHANOID SERIES ELEMENTS; LUMINESCENCE; MICE; MULTIMODAL IMAGING; NANOPARTICLES; PLASMIDS; POLYETHYLENEIMINE; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84908671507     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/la503444g     Document Type: Article

References (61)

1. Whitehead, K. A.; Langer, R.; Anderson, D. G. Knocking Down Barriers: Advances in siRNA Delivery Nat. Rev. Drug Discovery 2009, 8, 129-138
2. Castanotto, D.; Rossi, J. J. The Promises and Pitfalls of RNA Interference-Based Therapeutics Nature 2009, 457, 426-433
3. Morgan, J.; Kerschensteiner, D. Shooting DNA, Dyes, or Indicators into Tissue Slices Using the Gene Gun Cold Spring Harb. Protoc. 2011, 12, 1512-1514
4. Rols, M.; Delteil, C.; Golzio, M.; Dumond, P.; Cros, S.; Teissie, J. In Vivo Electrically Mediated Protein and Gene Transfer in Murine Melanoma Nat. Biotechnol. 1998, 16, 168-171
5. Thomas, C. E.; Ehrhardt, A.; Kay, M. A. Progress and Problems with the Use of Viral Vectors for Gene Therapy Nat. Rev. Genet. 2003, 4, 346-358
6. Koirala, A.; Conley, S. M.; Naash, M. I. A Review of Therapeutic Prospects of Non-Viral Gene Therapy in the Retinal Pigment Epithelium Biomaterials 2013, 34, 7158-7167
7. Niidome, T.; Huang, L. Gene Therapy Progress and Prospects: Nonviral Vectors Gene Ther. 2002, 9, 1647-1652
8. Sokolova, V.; Epple, M. Inorganic Nanoparticles as Carriers of Nucleic Acids into Cells Angew. Chem., Int. Ed. 2008, 47, 1382-1395
9. Lv, H.; Zhang, S.; Wang, B.; Cui, S.; Yan, J. Toxicity of Cationic Lipids and Cationic Polymers in Gene Delivery J. Controlled Release 2006, 114, 100-109
10. Moghimi, S.; Symonds, P.; Murray, J.; Hunter, A.; Debska, G.; Szewczyk, A. A Two-Stage Poly(Ethylenimine)-Mediated Cytotoxicity: Implications for Gene Transfer/Therapy Mol. Ther. 2005, 11, 990-995
11. Tao, Y.; Li, Z.; Ju, E.; Ren, J.; Qu, X. Polycations-Functionalized Water-Soluble Gold Nanoclusters: a Potential Platform for Simultaneous Enhanced Gene Delivery and Cell Imaging Nanoscale 2013, 5, 6154-6160
12. Ghosh, P. S.; Kim, C. K.; Han, G.; Forbes, N. S.; Rotello, V. M. Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles ACS Nano 2008, 2, 2213-2218
13. Kim, M. H.; Na, H. K.; Kim, Y. K.; Ryoo, S. R.; Cho, H. S.; Lee, K. E.; Jeon, H.; Ryoo, R.; Min, D. H. Facile Synthesis of Monodispersed Mesoporous Silica Nanoparticles with Ultralarge Pores and Their Application in Gene Delivery ACS Nano 2011, 5, 3568-3576
14. Ren, Y.; Cheung, H. W.; Maltzhan, G. v.; Agrawal, A.; Cowley, G. S.; Weir, B. A.; Boehm, J. S.; Tamayo, P.; Karst, A. M.; Liu, J. F. Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4 Sci. Transl. Med. 2012, 4, 147ra112
15. Sokolova, V.; Kovtun, A.; Prymak, O.; Meyer Zaika, W.; Kubareva, E. A.; Romanova, E. A.; Oretskaya, T. S.; Heumann, R.; Epple, M. Functionalisation of Calcium Phosphate Nanoparticles by Oligonucleotides and Their Application for Gene Silencing J. Mater. Chem. 2007, 17, 721-727
16. Mostaghaci, B.; Loretz, B.; Haberkorn, R.; Kickelbick, G.; Lehr, C. M. One-Step Synthesis of Nano-Sized and Stable Amino-Functionalized Calcium Phosphate Particles for DNA Transfection Chem. Mater. 2013, 25, 3667-3674
17. Feng, L.; Zhang, S.; Liu, Z. Graphene Based Gene Transfection Nanoscale 2011, 3, 1252-1257
18. Kim, H.; Namgung, R.; Sinha, K.; Oh, I.-K.; Kim, W. J. Graphene Oxide-Polyethylenimine Nanoconstruct as a Gene Delivery Vector and Bioimaging Tool Bioconjugate Chem. 2011, 22, 2558-2567
19. Shi, J.; Votruba, A. R.; Farokhzad, O. C.; Langer, R. Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications Nano Lett. 2010, 10, 3223-3230
20. Debbage, P.; Jaschke, W. Molecular Imaging with Nanoparticles: Giant Roles for Dwarf Actors Histochem. Cell Biol. 2008, 130, 845-875
21. Jokerst, J. V.; Gambhir, S. S. Molecular Imaging with Theranostic Nanoparticles Acc. Chem. Res. 2011, 44, 1050-1060
22. Nasongkla, N.; Bey, E.; Ren, J.; Ai, H.; Khemtong, C.; Guthi, J. S.; Chin, S. F.; Sherry, A. D.; Boothman, D. A.; Gao, J. Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems Nano Lett. 2006, 6, 2427-2430
23. 2 Dual-Modal MRI-Visible Vectors for Safe and Efficient siRNA Delivery Nanoscale 2013, 5, 8098-8104
24. Liu, S.; Jia, B.; Qiao, R.; Yang, Z.; Yu, Z.; Liu, Z.; Liu, K.; Shi, J.; Ouyang, H.; Wang, F.; Gao, M. A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application Mol. Pharmaceutics 2009, 6, 1074-1082
25. Park, J. H.; von Maltzahn, G.; Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J. Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery Angew. Chem., Int. Ed. 2008, 47, 7284-7288
26. Bagalkot, V.; Zhang, L.; Levy-Nissenbaum, E.; Jon, S.; Kantoff, P.; Langer, R.; Farokhzad, O. Quantum Dot-Aptamer Conjugates for Synchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy Transfer Nano Lett. 2007, 7, 3065-3070
27. Liu, Y.; Tu, D.; Zhu, H.; Ma, E.; Chen, X. Lanthanide-Doped Luminescent Nano-Bioprobes: from Fundamentals to Biodetection Nanoscale 2013, 5, 1369-1384
28. Wang, G.; Peng, Q.; Li, Y. Lanthanide-Doped Nanocrystals: Synthesis, Optical-Magnetic Properties, and Applications Acc. Chem. Res. 2011, 44, 322-332
29. Zhou, J.; Liu, Z.; Li, F. Upconversion Nanophosphors for Small-Animal Imaging Chem. Soc. Rev. 2012, 41, 1323-1349
30. Haase, M.; Schafer, H. Upconverting Nanoparticles Angew. Chem., Int. Ed. 2011, 50, 5808-5829
31. Wang, F.; Liu, X. Recent Advances in the Chemistry of Lanthanide-Doped Upconversion Nanocrystals Chem. Soc. Rev. 2009, 38, 976-989
32. Wang, J.; Deng, R.; MacDonald, M. A.; Chen, B.; Yuan, J.; Wang, F.; Chi, D.; Hor, T. S. A.; Zhang, P.; Liu, G.; Han, Y.; Liu, X. Enhancing Multiphoton Upconversion through Energy Clustering at Sublattice Level Nat. Mater. 2014, 13, 157-162
33. Wang, L.; Dong, H.; Li, Y.; Xue, C.; Sun, L.-D.; Yan, C. H.; Li, Q. Reversible Near-Infrared Light Directed Reflection in a Self-Organized Helical Superstructure Loaded with Upconversion Nanoparticles J. Am. Chem. Soc. 2014, 136, 4480-4483
34. Zhang, F.; Che, R.; Li, X.; Yao, C.; Yang, J.; Shen, D.; Hu, P.; Li, W.; Zhao, D. Direct Imaging the Upconversion Nanocrystal Core/Shell Structure at the Subnanometer Level: Shell Thickness Dependence in Upconverting Optical Properties Nano Lett. 2012, 12, 2852-2858
35. Li, L. L.; Wu, P.; Hwang, K.; Lu, Y. An Exceptionally Simple Strategy for DNA-Functionalized Up-Conversion Nanoparticles as Biocompatible Agents for Nanoassembly, DNA Delivery, and Imaging J. Am. Chem. Soc. 2013, 135, 2411-2414
36. Xiong, L.; Chen, Z.; Tian, Q.; Cao, T.; Xu, C.; Li, F. High Contrast Upconversion Luminescence Targeted Imaging in Vivo Using Peptide-Labeled Nanophosphors Anal. Chem. 2009, 81, 8687-8694
37. Fan, W.; Shen, B.; Bu, W.; Chen, F.; Zhao, K.; Zhang, S.; Zhou, L.; Peng, W.; Xiao, Q.; Xing, H.; Liu, J.; Ni, D.; He, Q.; Shi, J. Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging J. Am. Chem. Soc. 2013, 135, 6494-6503
38. 3 Nanoparticles and Their Applications for Optical and Magnetic Resonance Imaging J. Mater. Chem. 2012, 22, 966-974
39. 1 MRI Contrast Enhancement Chem. Mater. 2011, 23, 3714-3722
40. 4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo ACS Nano 2013, 7, 7227-7240
41. Liu, Y.; Ai, K.; Liu, J.; Yuan, Q.; He, Y.; Lu, L. A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging Angew. Chem., Int. Ed. 2012, 51, 1437-1442
42. 4 Upconversion Nanocrystals Via an OA/Ionic Liquid Two-Phase System for In Vivo Dual-Modality Imaging Adv. Funct. Mater. 2011, 21, 4470-4477
43. 5:Yb/Er Nanoprobes for Multi-Modal Upconversion Fluorescent, In Vivo X-Ray Computed Tomography and Biomagnetic Imaging Biomaterials 2012, 33, 9232-9238
44. Jayakumara, M. K. G.; Idrisa, N. M.; Zhang, Y. Remote Activation of Biomolecules in Deep Tissues Using Near-Infrared-to-UV Upconversion Nanotransducers Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 8483-8488
45. Jiang, S.; Zhang, Y.; Lim, K. M.; Sim, E. K. W.; Ye, L. NIR-to-Visible Upconversion Nanoparticles for Fluorescent Labeling and Targeted Delivery of siRNA Nanotechnology 2009, 20, 155101
46. Yang, Y.; Liu, F.; Liu, X.; Xing, B. NIR Light Controlled Photorelease of siRNA and Its Targeted Intracellular Delivery Based on Upconversion Nanoparticles Nanoscale 2013, 5, 231-238
47. He, L.; Feng, L.; Cheng, L.; Liu, Y.; Li, Z.; Peng, R.; Li, Y.; Guo, L.; Liu, Z. Multilayer Dual-Polymer-Coated Upconversion Nanoparticles for Multimodal Imaging and Serum-Enhanced Gene Delivery ACS Appl. Mater. Interfaces 2013, 5, 10381-10388
48. Dai, Y.; Xiao, H.; Liu, J.; Yuan, Q.; Ma, P.; Yang, D.; Li, C.; Cheng, Z.; Hou, Z.; Yang, P.; Lin, J. In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered Trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles J. Am. Chem. Soc. 2013, 135, 18920-18929
49. Kang, X.; Cheng, Z.; Yang, D.; Ma, P.; Shang, M.; Peng, C.; Dai, Y.; Lin, J. Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch Adv. Funct. Mater. 2012, 22, 1470-1481
50. Ma, P.; Xiao, H.; Li, X.; Li, C.; Dai, Y.; Cheng, Z.; Jing, X.; Lin, J. Rational Design of Multifunctional Upconversion Nanocrystals/Polymer Nanocomposites for Cisplatin (IV) Delivery and Biomedical Imaging Adv. Mater. 2013, 25, 4898-4905
51. Park, J.; An, K.; Hwang, Y.; Park, J. G.; Noh, H. J.; Kim, J. Y.; Park, J. H.; Hwang, N. M.; Hyeon, T. Ultra-large-scale Syntheses of Monodisperse Nanocrystals Nat. Mater. 2004, 3, 891-895
52. 4:Yb,Er Nanoplates Chem. Mater. 2006, 18, 5733-5737
53. Akinc, A.; Thomas, M.; Klibanov, A. M.; Langer, R. Exploring Polyethylenimine-Mediated DNA Transfection and the Proton Sponge Hypothesis J. Gene Med. 2004, 7, 657-663
54. 4 Microcrystals: Hydrothermal Synthesis, Morphology Evolution, and Luminescence Properties Inorg. Chem. 2011, 50, 4116-4124
55. Oliveira, S.; Rooy, I.; Kranenburg, O.; Storm, G.; Schiffelers, R. Fusogenic Peptides Enhance Endosomal Escape Improving siRNA-Induced Silencing of Oncogenes Int. J. Pharm. 2007, 331, 211-214
56. Di Guglielmo, G. M.; Le Roy, C.; Goodfellow, A. F.; Wrana, J. L. Distinct Endocytic Pathways Regulate TGF-β Receptor Signalling and Turnover Nat. Cell Biol. 2003, 5, 410-421
57. Fischer, d.; Bieber, T.; Li, Y.; Elsasser, H.-P.; Kissel, T. A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity Pharm. Res. 1999, 16, 1273-1279
58. Fischera, D.; Lib, Y.; Ahlemeyerc, B.; Krieglsteinc, J.; Kissela, T. In Vitro Cytotoxicity Testing of Polycations: Influence of Polymer Structrue on Cell Viability and Hemolysis Biomaterials 2003, 24, 1121-1131
59. Hunter, A. C. Molecular Hurdles in Polyfectin Design and Mechanistic Background to Polycation Induced Cytotoxicity Adv. Drug Delivery Rev. 2006, 58, 1523-1531
60. Zhu, J.; Tang, A.; Law, L. P.; Feng, M.; Ho, K. M.; Lee, D. K. L.; Harris, F. W.; Li, P. Amphiphilic Core-Shell Nanoparticles with Poly(ethylenimine) Shells as Potential Gene Delivery Carriers Bioconjugate Chem. 2005, 16, 139-146
61. Putnam, D.; Gentry, C. A.; Pack, D. W.; Langer, R. Polymer-Based Gene Delivery with Low Cytotoxicity by a Unique Balance of Side-Chain Termini Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 1200-1205.