Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography

Bioconjugate Chemistry

Volumn 21, Issue 4, 2010, Pages 756-763

  Hatanaka, Kentaro ^a   Asai, Tomohiro ^a   Koide, Hiroyuki ^a   Kenjo, Eriya ^a   Tsuzuku, Takuma ^a   Harada, Norihiro ^b   Tsukada, Hideo ^b   Oku, Naoto ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b CENTRAL RESEARCH LABORATORY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRONS; IMAGING SYSTEMS; INFRARED DEVICES; POSITRON EMISSION TOMOGRAPHY; POSITRONS; RNA;

AMINO GROUP; BIODISTRIBUTIONS; CATIONIC LIPOSOMES; FLUORINE-18; IN-VIVO; LABELING METHODS; PHARMACOKINETIC STUDIES; POSITRON EMITTERS; REAL TIME ANALYSIS; SMALL INTERFERING RNA;

FLUORESCENCE IMAGING;

BENZOIC ACID DERIVATIVE; DOUBLE STRANDED RNA; FLUORINE 18; LIPOSOME; N SUCCINIMIDYL 4 FLUOROBENZOATE F 18; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG STABILITY; DRUG TRANSPORT; FLUORESCENCE IMAGING; IMAGE ANALYSIS; IMAGING SYSTEM; MALE; MOUSE; NONHUMAN; PLANAR POSITRON IMAGING SYSTEM; POSITRON; POSITRON EMISSION TOMOGRAPHY;

MUS;

EID: 77951260189     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc9005267     Document Type: Article

References (30)

1. Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., and Mello, C. C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391, 806-811 (Pubitemid 28099681)
2. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411, 494-498
3. Pai, S. I., Lin, Y. Y., Macaes, B., Meneshian, A., Hung, C. F., and Wu, T. C. (2006) Prospects of RNA interference therapy for cancer Gene Ther. 13, 464-477
4. Jeong, J. H., Mok, H., Oh, Y. K., and Park, T. G. (2009) siRNA conjugate delivery systems Bioconjugate Chem. 20, 5-14
5. Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., Judge, A. D., Lam, K., McClintock, K., Nechev, L. V., Palmer, L. R., Racie, T., Rohl, I., Seiffert, S., Shanmugam, S., Sood, V., Soutschek, J., Toudjarska, I., Wheat, A. J., Yaworski, E., Zedalis, W., Koteliansky, V., Manoharan, M., Vornlocher, H. P., and MacLachlan, I. (2006) RNAi-mediated gene silencing in non-human primates Nature 441, 111-114
6. Kim, S. H., Jeong, J. H., Lee, S. H., Kim, S. W., and Park, T. G. (2008) LHRH receptor-mediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI Bioconjugate Chem. 19, 2156-2162
7. Medarova, Z., Pham, W., Farrar, C., Petkova, V., and Moore, A. (2007) In vivo imaging of siRNA delivery and silencing in tumors Nat. Med. 13, 372-377
8. 18F]-radiolabeling preformed liposomes and determination of liposomal trafficking by positron emission tomography J. Med. Chem. 50, 6454-6457
9. Bartlett, D. W., Su, H., Hildebrandt, I. J., Weber, W. A., and Davis, M. E. (2007) Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc. Natl. Acad. Sci. U.S.A. 104, 15549-15554
10. Viel, T., Kuhnast, B., Hinnen, F., Boisgard, R., Tavitian, B., and Dolle, F. (2007) Fluorine-18 labelling of small interfering RNAs (siRNAs) for PET imaging J. Labelled Compd. Radiopharm. 50, 1159-1168
11. Viel, T., Boisgard, R., Kuhnast, B., Jego, B., Siquier-Pernet, K., Hinnen, F., Dolle, F., and Tavitian, B. (2008) Molecular imaging study on in vivo distribution and pharmacokinetics of modified small interfering RNAs (siRNAs) Oligonucleotides 18, 201-212
12. Chen, X., Park, R., Shahinian, A. H., Tohme, M., Khankaldyyan, V., Bozorgzadeh, M. H., Bading, J. R., Moats, R., Laug, W. E., and Conti, P. S. (2004) 18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis Nucl. Med. Biol. 31, 179-189 (Pubitemid 38315112)
13. 18F]fluorobenzoate and its application to the labeling of a monoclonal-antibody fragment Bioconjugate Chem. 5, 352-356
14. 18F]fluorobenzoate (S18FB) J. Labelled Compd. Radiopharm. 49, 1213-1221
15. 18F] GBR-13119 J. Labelled Compd. Radiopharm. 27, 823-833
16. 18F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the conscious monkey brain Synapse 54, 37-45
17. 18F]SFB) for protein labeling J. Labelled Compd. Radiopharm. 51, 68-71
18. Takamatsu, H., Kakiuchi, T., Noda, A., Uchida, H., Nishiyama, S., Ichise, R., Iwashita, A., Mihara, K., Yamazaki, S., Matsuoka, N., Tsukada, H., and Nishimura, S. (2004) An application of a new planar positron imaging system (PPIS) in a small animal: MPTP-induced parkinsonism in mouse Ann. Nucl. Med. 18, 427-431
19. Uchida, H., Okamoto, T., Ohmura, T., Shimizu, K., Satoh, N., Koike, T., and Yamashita, T. (2004) A compact planar positron imaging system Nucl. Instrum. Methods Phys. Res., Sect. A 516, 564-574
20. Uchida, H., Sato, K., Kakiuchi, T., Fukumoto, D., and Tsukada, H. (2008) Feasibility study of quantitative radioactivity monitoring of tumor tissues inoculated into mice with a planar positron imaging system (PPIS) Ann. Nucl. Med. 22, 57-63
21. de Fougerolles, A. R. (2008) Delivery vehicles for small interfering RNA in vivo Hum. Gene Ther. 19, 125-32
22. Bauer, M., Wagner, C. C., and Langer, O. (2008) Microdosing studies in humans: the role of positron emission tomography Drugs in R&D 9, 73-81
23. Wagner, C. C., Muller, M., Lappin, G., and Langer, O. (2008) Positron emission tomography for use in microdosing studies Curr. Opin. Drug Discovery Dev. 11, 104-110
24. Litzinger, D. C., Brown, J. M., Wala, I., Kaufman, S. A., Van, G. Y., Farrell, C. L., and Collins, D. (1996) Fate of cationic liposomes and their complex with oligonucleotide in vivo Biochim. Biophys. Acta, Biomembr. 1281, 139-149
25. Li, S., Tseng, W. C., Stolz, D. B., Wu, S. P., Watkins, S. C., and Huang, L. (1999) Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection Gene Ther. 6, 585-594
26. McLean, J. W., Fox, E. A., Baluk, P., Bolton, P. B., Haskell, A., Pearlman, R., Thurston, G., Umemoto, E. Y., and McDonald, D. M. (1997) Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice Am. J. Physiol. 273, H387-404
27. van de Water, F. M., Boerman, O. C., Wouterse, A. C., Peters, J. G., Russel, F. G., and Masereeuw, R. (2006) Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules Drug Metab. Dispos. 34, 1393-1397
28. Lendvai, G., Velikyan, I., Bergstrom, M., Estrada, S., Laryea, D., Valila, M., Salomaki, S., Langstrom, B., and Roivainen, A. (2005) Biodistribution of 68Ga-labelled phosphodiester, phosphorothioate, and 2-O-methyl phosphodiester oligonucleotides in normal rats Eur. J. Pharm. Sci. 26, 26-38
29. Braasch, D. A., Paroo, Z., Constantinescu, A., Ren, G., Oz, O. K., Mason, R. P., and Corey, D. R. (2004) Biodistribution of phosphodiester and phosphorothioate siRNA Bioorg. Med. Chem. Lett. 14, 1139-1143
30. Liu, N., Ding, H., Vanderheyden, J. L., Zhu, Z., and Zhang, Y. (2007) Radiolabeling small RNA with technetium-99m for visualizing cellular delivery and mouse biodistribution Nucl. Med. Biol. 34, 399-404