MeCP2 Controls Excitatory Synaptic Strength by Regulating Glutamatergic Synapse Number

Neuron

Volumn 56, Issue 1, 2007, Pages 58-65

  Chao, Hsiao Tuan ^a   Zoghbi, Huda Y ^a   Rosenmund, Christian ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

DEVBIO; HUMDISEASE; MOLNEURO

Indexed keywords

GLUTAMATE RECEPTOR; METHYL CPG BINDING PROTEIN 2;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CORPUS STRIATUM; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTAMIC ACID; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PATCH-CLAMP TECHNIQUES; SYNAPSES; VESICULAR GLUTAMATE TRANSPORT PROTEINS;

EID: 34748831111     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2007.08.018     Document Type: Article

References (45)

1. Amir R.E., Van den Veyver I.B., Wan M., Tran C.Q., Francke U., and Zoghbi H.Y. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23 (1999) 185-188
2. Armstrong D., Dunn J.K., Antalffy B., and Trivedi R. Selective dendritic alterations in the cortex of Rett syndrome. J. Neuropathol. Exp. Neurol. 54 (1995) 195-201
3. Asaka Y., Jugloff D.G., Zhang L., Eubanks J.H., and Fitzsimonds R.M. Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiol. Dis. 21 (2006) 217-227
4. Bekkers J.M., and Stevens C.F. Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture. Proc. Natl. Acad. Sci. USA 88 (1991) 7834-7838
5. Belichenko P.V., Hagberg B., and Dahlstrom A. Morphological study of neocortical areas in Rett syndrome. Acta Neuropathol. (Berl.) 93 (1997) 50-61
6. Bellocchio E.E., Reimer R.J., Fremeau Jr. R.T., and Edwards R.H. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science 289 (2000) 957-960
7. Carney R.M., Wolpert C.M., Ravan S.A., Shahbazian M., Ashley-Koch A., Cuccaro M.L., Vance J.M., and Pericak-Vance M.A. Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr. Neurol. 28 (2003) 205-211
8. Chen R.Z., Akbarian S., Tudor M., and Jaenisch R. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat. Genet. 27 (2001) 327-331
9. Cho K.O., Hunt C.A., and Kennedy M.B. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9 (1992) 929-942
10. Collins A.L., Levenson J.M., Vilaythong A.P., Richman R., Armstrong D.L., Noebels J.L., David Sweatt J., and Zoghbi H.Y. Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum. Mol. Genet. 13 (2004) 2679-2689
11. Couvert P., Bienvenu T., Aquaviva C., Poirier K., Moraine C., Gendrot C., Verloes A., Andres C., Le Fevre A.C., Souville I., et al. MECP2 is highly mutated in X-linked mental retardation. Hum. Mol. Genet. 10 (2001) 941-946
12. Dani V.S., Chang Q., Maffei A., Turrigiano G.G., Jaenisch R., and Nelson S.B. Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. USA 102 (2005) 12560-12565
13. Davis G.W. Homeostatic control of neural activity: from phenomenology to molecular design. Annu. Rev. Neurosci. 29 (2006) 307-323
14. del Gaudio D., Fang P., Scaglia F., Ward P.A., Craigen W.J., Glaze D.G., Neul J.L., Patel A., Lee J.A., Irons M., et al. Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males. Genet. Med. 8 (2006) 784-792
15. Durand C.M., Betancur C., Boeckers T.M., Bockmann J., Chaste P., Fauchereau F., Nygren G., Rastam M., Gillberg I.C., Anckarsater H., et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat. Genet. 39 (2007) 25-27
16. Feng J., Schroer R., Yan J., Song W., Yang C., Bockholt A., Cook Jr. E.H., Skinner C., Schwartz C.E., and Sommer S.S. High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci. Lett. 409 (2006) 10-13
17. Friez M.J., Jones J.R., Clarkson K., Lubs H., Abuelo D., Bier J.A., Pai S., Simensen R., Williams C., Giampietro P.F., et al. Recurrent infections, hypotonia, and mental retardation caused by duplication of MECP2 and adjacent region in Xq28. Pediatrics 118 (2006) e1687-e1695
18. Giacometti E., Luikenhuis S., Beard C., and Jaenisch R. Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2. Proc. Natl. Acad. Sci. USA 104 (2007) 1931-1936
19. Groemer T.W., and Klingauf J. Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool. Nat. Neurosci. 10 (2007) 145-147
20. Guy J., Hendrich B., Holmes M., Martin J.E., and Bird A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27 (2001) 322-326
21. Guy J., Gan J., Selfridge J., Cobb S., and Bird A. Reversal of neurological defects in a mouse model of Rett syndrome. Science 315 (2007) 1143-1147
22. Hagberg B., Aicardi J., Dias K., and Ramos O. A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann. Neurol. 14 (1983) 471-479
23. Harris K.M., Jensen F.E., and Tsao B. Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation. J. Neurosci. 12 (1992) 2685-2705
24. Hessler N.A., Shirke A.M., and Malinow R. The probability of transmitter release at a mammalian central synapse. Nature 366 (1993) 569-572
25. Jamain S., Quach H., Betancur C., Rastam M., Colineaux C., Gillberg I.C., Soderstrom H., Giros B., Leboyer M., Gillberg C., and Bourgeron T. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat. Genet. 34 (2003) 27-29
26. Kistner U., Wenzel B.M., Veh R.W., Cases-Langhoff C., Garner A.M., Appeltauer U., Voss B., Gundelfinger E.D., and Garner C.C. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J. Biol. Chem. 268 (1993) 4580-4583
27. Kornau H.C., Schenker L.T., Kennedy M.B., and Seeburg P.H. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269 (1995) 1737-1740
28. Meloni I., Bruttini M., Longo I., Mari F., Rizzolio F., D'Adamo P., Denvriendt K., Fryns J.P., Toniolo D., and Renieri A. A mutation in the rett syndrome gene, MECP2, causes X-linked mental retardation and progressive spasticity in males. Am. J. Hum. Genet. 67 (2000) 982-985
29. Moretti P., Levenson J.M., Battaglia F., Atkinson R., Teague R., Antalffy B., Armstrong D., Arancio O., Sweatt J.D., and Zoghbi H.Y. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J. Neurosci. 26 (2006) 319-327
30. Nelson E.D., Kavalali E.T., and Monteggia L.M. MeCP2-dependent transcriptional repression regulates excitatory neurotransmission. Curr. Biol. 16 (2006) 710-716
31. Niethammer M., Kim E., and Sheng M. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J. Neurosci. 16 (1996) 2157-2163
32. Orrico A., Lam C., Galli L., Dotti M.T., Hayek G., Tong S.F., Poon P.M., Zappella M., Federico A., and Sorrentino V. MECP2 mutation in male patients with non-specific X-linked mental retardation. FEBS Lett. 481 (2000) 285-288
33. Pyott S.J., and Rosenmund C. The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons. J. Physiol. 539 (2002) 523-535
34. Rao A., Kim E., Sheng M., and Craig A.M. Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture. J. Neurosci. 18 (1998) 1217-1229
35. Rett A. On a unusual brain atrophy syndrome in hyperammonemia in childhood. [in German]. Wien. Med. Wochenschr. 116 (1966) 723-726
36. Rosenmund C., Clements J.D., and Westbrook G.L. Nonuniform probability of glutamate release at a hippocampal synapse. Science 262 (1993) 754-757
37. Schneggenburger R., Meyer A.C., and Neher E. Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapse. Neuron 23 (1999) 399-409
38. Shahbazian M., Young J., Yuva-Paylor L., Spencer C., Antalffy B., Noebels J., Armstrong D., Paylor R., and Zoghbi H. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 35 (2002) 243-254
39. Shi J., Shibayama A., Liu Q., Nguyen V.Q., Feng J., Santos M., Temudo T., Maciel P., and Sommer S.S. Detection of heterozygous deletions and duplications in the MECP2 gene in Rett syndrome by Robust Dosage PCR (RD-PCR). Hum. Mutat. 25 (2005) 505
40. Takamori S., Rhee J.S., Rosenmund C., and Jahn R. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Nature 407 (2000) 189-194
41. Turrigiano G.G., and Nelson S.B. Homeostatic plasticity in the developing nervous system. Nat. Rev. Neurosci. 5 (2004) 97-107
42. Van Esch H., Bauters M., Ignatius J., Jansen M., Raynaud M., Hollanders K., Lugtenberg D., Bienvenu T., Jensen L.R., Gecz J., et al. Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. Am. J. Hum. Genet. 77 (2005) 442-453
43. Zhou Z., Hong E.J., Cohen S., Zhao W.N., Ho H.Y., Schmidt L., Chen W.G., Lin Y., Savner E., Griffith E.C., et al. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52 (2006) 255-269
44. Zoghbi H.Y. Postnatal neurodevelopmental disorders: meeting at the synapse?. Science 302 (2003) 826-830
45. Zucker R.S., and Regehr W.G. Short-term synaptic plasticity. Annu. Rev. Physiol. 64 (2002) 355-405