-
1
-
-
29144508843
-
Global prevalence of dementia: A Delphi consensus study
-
DOI 10.1016/S0140-6736(05)67889-0, PII S0140673605678890
-
Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, et al. (2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366:2112-2117. (Pubitemid 41797645)
-
(2005)
Lancet
, vol.366
, Issue.9503
, pp. 2112-2117
-
-
Ferri, C.P.1
Prince, M.2
Brayne, C.3
Brodaty, H.4
Fratiglioni, L.5
Ganguli, M.6
Hall, K.7
Hasegawa, K.8
Hendrie, H.9
Huang, Y.10
Jorm, A.11
Mathers, C.12
Menezes, P.R.13
Rimmer, E.14
Scazufca, M.15
-
2
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
DOI 10.1038/34910
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, et al. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391:387-390. (Pubitemid 28093512)
-
(1998)
Nature
, vol.391
, Issue.6665
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
3
-
-
15644363081
-
High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype
-
DOI 10.1001/archneur.55.7.937
-
Galasko D, Chang L, Motter R, Clark CM, Kaye J, et al. (1998) High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol 55:937-945. (Pubitemid 28335112)
-
(1998)
Archives of Neurology
, vol.55
, Issue.7
, pp. 937-945
-
-
Galasko, D.1
Chang, L.2
Motter, R.3
Clark, C.M.4
Kaye, J.5
Knopman, D.6
Thomas, R.7
Kholodenko, D.8
Schenk, D.9
Lieberburg, I.10
Miller, B.11
Green, R.12
Basherad, R.13
Kertiles, L.14
Boss, M.A.15
Seubert, P.16
-
4
-
-
0033061647
-
(1-42) in Alzheimer disease: Differences between early- and late-onset Alzheimer disease and stability during the course of disease
-
(1-42) in Alzheimer disease: Differences between early- and late-onset Alzheimer disease and stability during the course of disease. Arch Neurol 56:673-680.
-
(1999)
Arch Neurol
, vol.56
, pp. 673-680
-
-
Andreason, N.1
Hesse, C.2
Davidsson, P.3
Minthon, L.4
Wallin, A.5
-
7
-
-
33947507128
-
Fluctuations of CSF amyloid-beta levels: Implications for a diagnostic and therapeutic biomarker
-
DOI 10.1212/01.wnl.0000256043.50901.e3, PII 0000611420070227000011
-
Bateman RJ, Wen G, Morris JC, Holtzman DM (2007) Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker. Neurology 68:666-669. (Pubitemid 46667813)
-
(2007)
Neurology
, vol.68
, Issue.9
, pp. 666-669
-
-
Bateman, R.J.1
Wen, G.2
Morris, J.C.3
Holtzman, D.M.4
-
8
-
-
72449161215
-
Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle
-
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, et al. (2009) Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle. Science 326:1005-1007.
-
(2009)
Science
, vol.326
, pp. 1005-1007
-
-
Kang, J.E.1
Lim, M.M.2
Bateman, R.J.3
Lee, J.J.4
Smyth, L.P.5
-
9
-
-
84862908271
-
Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system
-
Huang Y, Potter R, Sigurdson W, Santacruz A, Shih S, et al. (2012) Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system. Arch Neurol 69:51-58.
-
(2012)
Arch Neurol
, vol.69
, pp. 51-58
-
-
Huang, Y.1
Potter, R.2
Sigurdson, W.3
Santacruz, A.4
Shih, S.5
-
10
-
-
84871235613
-
β-amyloid dynamics in human plasma
-
Huang Y, Potter R, Sigurdson W, Kasten T, Connors R, et al. (2012) β-amyloid dynamics in human plasma. Arch Neurol 69:1591-1597.
-
(2012)
Arch Neurol
, vol.69
, pp. 1591-1597
-
-
Huang, Y.1
Potter, R.2
Sigurdson, W.3
Kasten, T.4
Connors, R.5
-
11
-
-
79955128215
-
Biology and pathophysiology of the amyloid precursor protein
-
Zheng H, Koo EH (2011) Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener 6:27.
-
(2011)
Mol Neurodegener
, vol.6
, pp. 27
-
-
Zheng, H.1
Koo, E.H.2
-
12
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
-
13
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, et al. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402:533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
-
14
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta- amyloid precursor protein
-
DOI 10.1073/pnas.97.4.1456
-
Lin X, Koelsch G, Wu S, Downs D, Dashti A, et al. (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A 97:1456-1460. (Pubitemid 30118462)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
16
-
-
10744232413
-
Imaging Brain Amyloid in Alzheimer's Disease with Pittsburgh Compound-B
-
DOI 10.1002/ana.20009
-
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, et al. (2004) Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 55:306-319. (Pubitemid 38269583)
-
(2004)
Annals of Neurology
, vol.55
, Issue.3
, pp. 306-319
-
-
Klunk, W.E.1
Engler, H.2
Nordberg, A.3
Wang, Y.4
Blomqvist, G.5
Holt, D.P.6
Bergstrom, M.7
Savitcheva, I.8
Huang, G.-F.9
Estrada, S.10
Ausen, B.11
Debnath, M.L.12
Barletta, J.13
Price, J.C.14
Sandell, J.15
Lopresti, B.J.16
Wall, A.17
Koivisto, P.18
Antoni, G.19
Mathis, C.A.20
Langstrom, B.21
more..
-
17
-
-
33644832047
-
42 in humans
-
DOI 10.1002/ana.20730
-
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, et al. (2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans. Ann Neurol 59:512-519. (Pubitemid 43358072)
-
(2006)
Annals of Neurology
, vol.59
, Issue.3
, pp. 512-519
-
-
Fagan, A.M.1
Mintun, M.A.2
Mach, R.H.3
Lee, S.-Y.4
Dence, C.S.5
Shah, A.R.6
LaRossa, G.N.7
Spinner, M.L.8
Klunk, W.E.9
Mathis, C.A.10
DeKosky, S.T.11
Morris, J.C.12
Holtzman, D.M.13
-
18
-
-
33947507128
-
Fluctuations of CSF amyloid-beta levels: Implications for a diagnostic and therapeutic biomarker
-
DOI 10.1212/01.wnl.0000256043.50901.e3, PII 0000611420070227000011
-
Bateman RJ, Wen G, Morris JC, Holtzman DM (2007) Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker. Neurology 68:666-669. (Pubitemid 46667813)
-
(2007)
Neurology
, vol.68
, Issue.9
, pp. 666-669
-
-
Bateman, R.J.1
Wen, G.2
Morris, J.C.3
Holtzman, D.M.4
-
19
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, et al (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373:523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
-
20
-
-
0023916455
-
Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide
-
Kim KS, Miller DL, Sapienza VJ, Chen C-MJ, Bai C, et al. (1988) Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Commun 2:121-130.
-
(1988)
Neurosci Res Commun
, vol.2
, pp. 121-130
-
-
Kim, K.S.1
Miller, D.L.2
Sapienza, V.J.3
Chen, C.-M.J.4
Bai, C.5
-
21
-
-
84865955498
-
Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology
-
Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, et al. (2012) Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology. Sci Transl Med 4:150ra122.
-
(2012)
Sci Transl Med
, vol.4
-
-
Roh, J.H.1
Huang, Y.2
Bero, A.W.3
Kasten, T.4
Stewart, F.R.5
-
22
-
-
80051571901
-
Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
-
Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, et al. (2011) Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 306:613-619.
-
(2011)
JAMA
, vol.306
, pp. 613-619
-
-
Yaffe, K.1
Laffan, A.M.2
Harrison, S.L.3
Redline, S.4
Spira, A.P.5
-
23
-
-
83255175636
-
Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women
-
Tranah GJ, Blackwell T, Stone KL, Ancoli-Israel S, Paudel ML, et al. (2011) Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann Neurol 70:722-732.
-
(2011)
Ann Neurol
, vol.70
, pp. 722-732
-
-
Tranah, G.J.1
Blackwell, T.2
Stone, K.L.3
Ancoli-Israel, S.4
Paudel, M.L.5
-
24
-
-
84885775321
-
Sleep drives metabolite clearance from the adult brain
-
doi: 10.1126/science.1241224
-
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, et al. (2013) Sleep drives metabolite clearance from the adult brain. Science 342:373-377. doi: 10.1126/science.1241224.
-
(2013)
Science
, vol.342
, pp. 373-377
-
-
Xie, L.1
Kang, H.2
Xu, Q.3
Chen, M.J.4
Liao, Y.5
-
25
-
-
0030999597
-
Circadian characteristics of sleep propensity function in healthy elderly: A comparison with young adults
-
Haimov I, Lavie P (1997) Circadian characteristics of sleep propensity function in healthy elderly: a comparison with young adults. Sleep 20:294-300. (Pubitemid 27276645)
-
(1997)
Sleep
, vol.20
, Issue.4
, pp. 294-300
-
-
Haimov, I.1
Lavie, P.2
-
26
-
-
75549090428
-
Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: A multicenter study
-
Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, et al. (2010) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry 15:138-145.
-
(2010)
Mol Psychiatry
, vol.15
, pp. 138-145
-
-
Lewczuk, P.1
Kamrowski-Kruck, H.2
Peters, O.3
Heuser, I.4
Jessen, F.5
-
27
-
-
77957267776
-
Correlations between soluble α/β forms of amyloid precursor protein and Aβ38, 40, and 42 in human cerebrospinal fluid
-
Gabelle A, Roche S, Gény C, Bennys K, Labauge P, et al. (2010) Correlations between soluble α/β forms of amyloid precursor protein and Aβ38, 40, and 42 in human cerebrospinal fluid. Brain Res 1357:175-183.
-
(2010)
Brain Res
, vol.1357
, pp. 175-183
-
-
Gabelle, A.1
Roche, S.2
Gény, C.3
Bennys, K.4
Labauge, P.5
-
28
-
-
84863207476
-
Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid
-
Alexopoulos P, Tsolakidou A, Roselli F, Arnold A, Grimmer T, et al. (2012) Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid. Alzheimers Dement 8:304-311.
-
(2012)
Alzheimers Dement
, vol.8
, pp. 304-311
-
-
Alexopoulos, P.1
Tsolakidou, A.2
Roselli, F.3
Arnold, A.4
Grimmer, T.5
-
29
-
-
84877579899
-
Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease
-
Brinkmalm G, Brinkmalm A, Bourgeois P, Persson R, Hansson O, et al. (2013) Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease. Brain Res 1513:117-126.
-
(2013)
Brain Res
, vol.1513
, pp. 117-126
-
-
Brinkmalm, G.1
Brinkmalm, A.2
Bourgeois, P.3
Persson, R.4
Hansson, O.5
-
30
-
-
0026739083
-
The nature and metabolism of potentially amyloidogenic carboxylterminal fragments of the Alzheimer beta/A4-amyloid precursor protein: Some technical notes
-
Gandy SE, Buxbaum JD, Suzuki T, Ramabhadran TV, Caporaso GL, et al. (1992) The nature and metabolism of potentially amyloidogenic carboxylterminal fragments of the Alzheimer beta/A4-amyloid precursor protein: some technical notes. Neurobiol Aging 13:601-603.
-
(1992)
Neurobiol Aging
, vol.13
, pp. 601-603
-
-
Gandy, S.E.1
Buxbaum, J.D.2
Suzuki, T.3
Ramabhadran, T.V.4
Caporaso, G.L.5
-
32
-
-
0032032493
-
Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester
-
Savage MJ, Trusko SP, Howland DS, Pinsker LR, Mistretta S, et al. (1998) Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J Neurosci 18:1743-1752. (Pubitemid 28103082)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.5
, pp. 1743-1752
-
-
Savage, M.J.1
Trusko, S.P.2
Howland, D.S.3
Pinsker, L.R.4
Mistretta, S.5
Reaume, A.G.6
Greenberg, B.D.7
Siman, R.8
Scott, R.W.9
-
33
-
-
0034723418
-
Protein kinase C-dependent α-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the trans-Golgi network
-
DOI 10.1074/jbc.275.4.2568
-
Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM-Y (2000) Protein Kinase C-dependent α-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the Trans-Golgi Network. J Biol Chem 275:2568-2575. (Pubitemid 30082022)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.4
, pp. 2568-2575
-
-
Skovronsky, D.M.1
Moore, D.B.2
Milla, M.E.3
Doms, R.W.4
Lee, V.M.-Y.5
-
34
-
-
70349569016
-
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity
-
Kim M, Suh J, Romano D, Truong MH, Mullin K, et al. (2009) Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity. Hum Mol Genet 18:3987-3996.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3987-3996
-
-
Kim, M.1
Suh, J.2
Romano, D.3
Truong, M.H.4
Mullin, K.5
-
35
-
-
81255143061
-
Robust central reduction of Amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor
-
May PC, Dean RA, Lowe SL, Martenyi F, Sheehan SM, et al. (2011) Robust central reduction of Amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. J Neurosci 31:16507-16516.
-
(2011)
J Neurosci
, vol.31
, pp. 16507-16516
-
-
May, P.C.1
Dean, R.A.2
Lowe, S.L.3
Martenyi, F.4
Sheehan, S.M.5
-
36
-
-
40849083795
-
In vivo β-secretase 1 inhibition leads to brain aβ lowering and increased α-secretase processing of amyloid precursor protein without effect on neuregulin-1
-
DOI 10.1124/jpet.107.130039
-
Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, et al. (2008) In vivo β-secretase 1 inhibition leads to brain Aβ lowering and increased α-secretase processing of amyloid precursor protein without effect on neuregulin-1. J Pharmacol Exp Ther 324:957-969. (Pubitemid 351397853)
-
(2008)
Journal of Pharmacology and Experimental Therapeutics
, vol.324
, Issue.3
, pp. 957-969
-
-
Sankaranarayanan, S.1
Price, E.A.2
Wu, G.3
Crouthamel, M.-C.4
Shi, X.-P.5
Tugusheva, K.6
Tyler, K.X.7
Kahana, J.8
Ellis, J.9
Jin, L.10
Steele, T.11
Stachel, S.12
Coburn, C.13
Simon, A.J.14
-
37
-
-
0041886881
-
Measurement of α- and β-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
-
DOI 10.1016/S0014-4886(03)00027-X
-
Olsson A, Höglund K, Sjögren M, Andreasen N, Minthon L, et al. (2003) Measurement of α- and β-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients. Exp Neurol 183:74-80. (Pubitemid 37075858)
-
(2003)
Experimental Neurology
, vol.183
, Issue.1
, pp. 74-80
-
-
Olsson, A.1
Hoglund, K.2
Sjogren, M.3
Andreasen, N.4
Minthon, L.5
Lannfelt, L.6
Buerger, K.7
Moller, H.-J.8
Hampel, H.9
Davidsson, P.10
Blennow, K.11
|