메뉴 건너뛰기




Volumn , Issue , 2014, Pages 165-185

Chemopreventive Activities Of Hydroxytyrosol: The Major Phenol Alcohol Of Extra-Virgin Olive Oil

Author keywords

Chemoprevention; Hydroxytyrosol; Olive Oil

Indexed keywords


EID: 84953455699     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (2)

References (74)
  • 1
    • 33646848947 scopus 로고    scopus 로고
    • The Mediterranean-style diet for the prevention of cardiovascular diseases
    • de Lorgeril M., Salen P. (2006) The Mediterranean-style diet for the prevention of cardiovascular diseases. Public Health Nutr., 9(1A):118-23.
    • (2006) Public Health Nutr. , vol.9 , Issue.1 A , pp. 118-123
    • de Lorgeril, M.1    Salen, P.2
  • 2
    • 0036419541 scopus 로고    scopus 로고
    • Nutritional and health aspects of olive oil
    • Harwood J. L., Yaqoob P. (2002) Nutritional and health aspects of olive oil. Eur. J. Lipid Sci. Technol., 104:685-97.
    • (2002) Eur. J. Lipid Sci. Technol. , vol.104 , pp. 685-697
    • Harwood, J.L.1    Yaqoob, P.2
  • 3
    • 84872581773 scopus 로고    scopus 로고
    • Antiproliferative, antioxidant and anti-inflammatory effects of hydroxytyrosol on human hepatoma HepG2 and Hep3B cell lines
    • Tutino V., Caruso M. G., Messa C., Perri E., Notarnicola M. (2012) Antiproliferative, antioxidant and anti-inflammatory effects of hydroxytyrosol on human hepatoma HepG2 and Hep3B cell lines. Anticancer Res., 32(12):5371-77.
    • (2012) Anticancer Res. , vol.32 , Issue.12 , pp. 5371-5377
    • Tutino, V.1    Caruso, M.G.2    Messa, C.3    Perri, E.4    Notarnicola, M.5
  • 5
    • 79958214551 scopus 로고    scopus 로고
    • Extra virgin olive oil's polyphenols: biological activities
    • Review
    • Visioli F., Bernardini E. (2011). Extra virgin olive oil's polyphenols: biological activities. Curr. Pharm. Des., 17(8):786-804. Review.
    • (2011) Curr. Pharm. Des. , vol.17 , Issue.8 , pp. 786-804
    • Visioli, F.1    Bernardini, E.2
  • 6
    • 0034614637 scopus 로고    scopus 로고
    • The Hallmarks of cancer
    • Hanahan D., Weinberg R. A. (2000) The Hallmarks of cancer. Cell,100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Review
    • Hanahan D., Weinberg R. A. (2011) Hallmarks of cancer: the next generation. Cell, 144(5):646-74. Review.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 33745534542 scopus 로고    scopus 로고
    • The roles of polyphenols in cancer chemoprevention
    • Review
    • Lee K. W., Lee H. J. (2006) The roles of polyphenols in cancer chemoprevention. Biofactors, 26(2):105-121. Review.
    • (2006) Biofactors , vol.26 , Issue.2 , pp. 105-121
    • Lee, K.W.1    Lee, H.J.2
  • 9
    • 54349084374 scopus 로고    scopus 로고
    • Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinone adducts
    • Cornwell D. G., Ma J. (2008) Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinone adducts. J. Agric. Food Chem., 56(19): 8774-86.
    • (2008) J. Agric. Food Chem. , vol.56 , Issue.19 , pp. 8774-8776
    • Cornwell, D.G.1    Ma, J.2
  • 10
    • 84877979324 scopus 로고    scopus 로고
    • Naturally occurring hydroxytyrosol: synthesis and anticancer potential
    • Bernini R., Merendino N., Romani A., Velotti F. (2013) Naturally occurring hydroxytyrosol: synthesis and anticancer potential. Curr. Med. Chem., 20(5):655-70.
    • (2013) Curr. Med. Chem. , vol.20 , Issue.5 , pp. 655-670
    • Bernini, R.1    Merendino, N.2    Romani, A.3    Velotti, F.4
  • 13
    • 0000903754 scopus 로고
    • Antioxidant activity of tyrosol, hydroxytyrosol, caffeic acid, oleuropein and BHT in olive oil
    • Chimi H., Sadik A., Letutour B. (1988) Antioxidant activity of tyrosol, hydroxytyrosol, caffeic acid, oleuropein and BHT in olive oil. Revue Francaise Des Corps Gras,. 35 (8- 9): 339-344.
    • (1988) Revue Francaise Des Corps Gras , vol.35 , Issue.8-9 , pp. 339-344
    • Chimi, H.1    Sadik, A.2    Letutour, B.3
  • 15
    • 0031838116 scopus 로고    scopus 로고
    • The effect of minor constituents of olive oil on cardiovascular disease: new findings
    • (5 Pt 1), Review
    • Visioli F., Galli C. (1998) The effect of minor constituents of olive oil on cardiovascular disease: new findings. Nutr. Rev., 56(5 Pt 1):142-7. Review.
    • (1998) Nutr. Rev. , vol.56 , pp. 142-147
    • Visioli, F.1    Galli, C.2
  • 16
    • 0031055739 scopus 로고    scopus 로고
    • The protective effect of the olive oil polyphenol (3,4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2 cells
    • Manna C., Galletti P., Cucciolla V., Moltedo O., Leone A., Zappia V. (1997) The protective effect of the olive oil polyphenol (3,4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2 cells. J. Nutr., 127(2): 286-92.
    • (1997) J. Nutr. , vol.127 , Issue.2 , pp. 286-292
    • Manna, C.1    Galletti, P.2    Cucciolla, V.3    Moltedo, O.4    Leone, A.5    Zappia, V.6
  • 17
    • 0032995732 scopus 로고    scopus 로고
    • Olive oil hydroxytyrosol protects human erythrocytes against oxidative damages
    • Manna C., Galletti P., Cucciolla V., Montedoro G., Zappia V. (1999) Olive oil hydroxytyrosol protects human erythrocytes against oxidative damages. J. Nutr. Biochem., 10(3):159-65.
    • (1999) J. Nutr. Biochem. , vol.10 , Issue.3 , pp. 159-165
    • Manna, C.1    Galletti, P.2    Cucciolla, V.3    Montedoro, G.4    Zappia, V.5
  • 18
    • 5144235476 scopus 로고    scopus 로고
    • Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils
    • O'Dowd Y., Driss F., Dang P. M., Elbim C., Gougerot-Pocidalo M. A., Pasquier C., El-Benna J. (2004) Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Biochem. Pharmacol., 68(10):2003-8.
    • (2004) Biochem. Pharmacol. , vol.68 , Issue.10 , pp. 2003-2008
    • O'Dowd, Y.1    Driss, F.2    Dang, P.M.3    Elbim, C.4    Gougerot-Pocidalo, M.A.5    Pasquier, C.6    El-Benna, J.7
  • 19
  • 20
    • 77954001205 scopus 로고    scopus 로고
    • Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol
    • Incani A., Deiana M., Corona G., Vafeiadou K., Vauzour D., Dessì M. A., Spencer J. P. (2010) Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol. Mol. Nutr. Food Res., 54(6):788-96.
    • (2010) Mol. Nutr. Food Res. , vol.54 , Issue.6 , pp. 788-796
    • Incani, A.1    Deiana, M.2    Corona, G.3    Vafeiadou, K.4    Vauzour, D.5    Dessì, M.A.6    Spencer, J.P.7
  • 22
    • 0034096273 scopus 로고    scopus 로고
    • The antioxidant/anticancer potential of phenolic compounds isolated from olive oil
    • Owen R. W., Giacosa A., Hull W. E., Haubner R., Spiegelhalder B., Bartsch H. (2000) The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur. J. Cancer, 36(10):1235-47.
    • (2000) Eur. J. Cancer , vol.36 , Issue.10 , pp. 1235-1247
    • Owen, R.W.1    Giacosa, A.2    Hull, W.E.3    Haubner, R.4    Spiegelhalder, B.5    Bartsch, H.6
  • 23
    • 77954626997 scopus 로고    scopus 로고
    • Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3- kinase/protein kinase B pathways in HepG2 cells
    • Martín M. A., Ramos S., Granado-Serrano A. B., Rodríguez-Ramiro I., Trujillo M., Bravo L., Goya L. (2010) Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3- kinase/protein kinase B pathways in HepG2 cells. Mol. Nutr. Food Res., 54(7):956-66.
    • (2010) Mol. Nutr. Food Res. , vol.54 , Issue.7 , pp. 956-966
    • Martín, M.A.1    Ramos, S.2    Granado-Serrano, A.B.3    Rodríguez-Ramiro, I.4    Trujillo, M.5    Bravo, L.6    Goya, L.7
  • 24
    • 33847103107 scopus 로고    scopus 로고
    • Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection against oxidative stress induced by tertbutylhydroperoxide
    • Goya L., Mateos R., Bravo L. (2007) Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection against oxidative stress induced by tertbutylhydroperoxide. Eur. J. Nutr., 46(2):70-8.
    • (2007) Eur. J. Nutr. , vol.46 , Issue.2 , pp. 70-78
    • Goya, L.1    Mateos, R.2    Bravo, L.3
  • 25
    • 77958152750 scopus 로고    scopus 로고
    • Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells
    • Zhu L., Liu Z., Feng Z., Hao J., Shen W., Li X., Sun L., Sharman E., Wang Y., Wertz K., Weber P., Shi X., Liu J. (2010) Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells. J. Nutr. Biochem., 21(11):1089-98.
    • (2010) J. Nutr. Biochem. , vol.21 , Issue.11 , pp. 1089-1098
    • Zhu, L.1    Liu, Z.2    Feng, Z.3    Hao, J.4    Shen, W.5    Li, X.6    Sun, L.7    Sharman, E.8    Wang, Y.9    Wertz, K.10    Weber, P.11    Shi, X.12    Liu, J.13
  • 27
    • 77349122377 scopus 로고    scopus 로고
    • The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells
    • Guo W., An Y., Jiang L., Geng C., Zhong L. (2010) The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells. Phytother. Res., 24(3):352-9.
    • (2010) Phytother. Res. , vol.24 , Issue.3 , pp. 352-359
    • Guo, W.1    An, Y.2    Jiang, L.3    Geng, C.4    Zhong, L.5
  • 28
    • 21844470451 scopus 로고    scopus 로고
    • DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide
    • Nousis L., Doulias P. T., Aligiannis N., Bazios D., Agalias A., Galaris D., Mitakou S. (2005) DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide. Free Radic. Res., 39(7):787-95.
    • (2005) Free Radic. Res. , vol.39 , Issue.7 , pp. 787-795
    • Nousis, L.1    Doulias, P.T.2    Aligiannis, N.3    Bazios, D.4    Agalias, A.5    Galaris, D.6    Mitakou, S.7
  • 29
    • 0036731647 scopus 로고    scopus 로고
    • Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells
    • discussion 223-4
    • Quiles J. L., Farquharson A. J., Simpson D. K., Grant I., Wahle K. W. (2002) Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells. Br. J. Nutr., 88(3):225-34; discussion 223-4.
    • (2002) Br. J. Nutr. , vol.88 , Issue.3 , pp. 225-234
    • Quiles, J.L.1    Farquharson, A.J.2    Simpson, D.K.3    Grant, I.4    Wahle, K.W.5
  • 30
    • 84873725317 scopus 로고    scopus 로고
    • Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1a
    • Cárdeno A., Sánchez-Hidalgo M., Rosillo M. A., Alarcón de la Lastra C. (2013) Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1a. Nutr. Cancer, 65(1):147-56.
    • (2013) Nutr. Cancer , vol.65 , Issue.1 , pp. 147-156
    • Cárdeno, A.1    Sánchez-Hidalgo, M.2    Rosillo, M.A.3    Alarcón de la Lastra, C.4
  • 33
    • 68149181871 scopus 로고    scopus 로고
    • Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1
    • Corona G., Deiana M., Incani A., Vauzour D., Dessì M. A., Spencer J. P. (2009) Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. Mol. Nutr. Food Res., 53(7):897-903.
    • (2009) Mol. Nutr. Food Res. , vol.53 , Issue.7 , pp. 897-903
    • Corona, G.1    Deiana, M.2    Incani, A.3    Vauzour, D.4    Dessì, M.A.5    Spencer, J.P.6
  • 34
    • 84873717414 scopus 로고    scopus 로고
    • Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol
    • Pereira-Caro G., Mateos R., Traka M. H., Bacon J. R., Bongaerts R., Sarriá B., Bravo L., Kroon P. A. (2013) Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol. Food Chem., 138(2-3):1172-82.
    • (2013) Food Chem. , vol.138 , Issue.2-3 , pp. 1172-1182
    • Pereira-Caro, G.1    Mateos, R.2    Traka, M.H.3    Bacon, J.R.4    Bongaerts, R.5    Sarriá, B.6    Bravo, L.7    Kroon, P.A.8
  • 35
    • 0021681873 scopus 로고
    • Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth
    • Review
    • Siperstein M. D. (1984) Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth. J. Lipid Res., 25(13):1462-8. Review.
    • (1984) J. Lipid Res. , vol.25 , Issue.13 , pp. 1462-1468
    • Siperstein, M.D.1
  • 36
    • 0037137175 scopus 로고    scopus 로고
    • Isoprenoids influence expression of Ras and Ras-related proteins
    • Holstein S. A., Wohlford-Lenane C. L., Hohl R. J. (2002) Isoprenoids influence expression of Ras and Ras-related proteins. Biochemistry, 41(46):13698-704.
    • (2002) Biochemistry , vol.41 , Issue.46 , pp. 13698-13704
    • Holstein, S.A.1    Wohlford-Lenane, C.L.2    Hohl, R.J.3
  • 39
    • 78650292220 scopus 로고    scopus 로고
    • Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells
    • Bouallagui Z., Han J., Isoda H., Sayadi S. (2011) Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells. Food Chem. Toxicol., 49(1):179-84.
    • (2011) Food Chem. Toxicol. , vol.49 , Issue.1 , pp. 179-184
    • Bouallagui, Z.1    Han, J.2    Isoda, H.3    Sayadi, S.4
  • 40
    • 67349201394 scopus 로고    scopus 로고
    • Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells
    • Han J., Talorete T. P., Yamada P., Isoda H. (2009) Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology, 59(1):45-53.
    • (2009) Cytotechnology , vol.59 , Issue.1 , pp. 45-53
    • Han, J.1    Talorete, T.P.2    Yamada, P.3    Isoda, H.4
  • 41
    • 84888121068 scopus 로고    scopus 로고
    • Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells
    • Luo C., Li Y., Wang H., Cui Y., Feng Z., Li H., Li Y., Wang Y., Wurtz K., Weber P., Long J., Liu J. (2013) Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells. Curr. Cancer Drug Targets, 13(6):625-39.
    • (2013) Curr. Cancer Drug Targets , vol.13 , Issue.6 , pp. 625-639
    • Luo, C.1    Li, Y.2    Wang, H.3    Cui, Y.4    Feng, Z.5    Li, H.6    Li, Y.7    Wang, Y.8    Wurtz, K.9    Weber, P.10    Long, J.11    Liu, J.12
  • 43
    • 84867101055 scopus 로고    scopus 로고
    • Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer
    • Scoditti E., Calabriso N., Massaro M., Pellegrino M., Storelli C., Martines G., De Caterina R., Carluccio M. A. (2012) Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch. Biochem. Biophys., 527(2):81-9.
    • (2012) Arch. Biochem. Biophys. , vol.527 , Issue.2 , pp. 81-89
    • Scoditti, E.1    Calabriso, N.2    Massaro, M.3    Pellegrino, M.4    Storelli, C.5    Martines, G.6    De Caterina, R.7    Carluccio, M.A.8
  • 45
    • 82155197149 scopus 로고    scopus 로고
    • Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages
    • Richard N., Arnold S., Hoeller U., Kilpert C., Wertz K., Schwager J. Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages. Planta Med., 77(17):1890-7.
    • Planta Med. , vol.77 , Issue.17 , pp. 1890-1897
    • Richard, N.1    Arnold, S.2    Hoeller, U.3    Kilpert, C.4    Wertz, K.5    Schwager, J.6
  • 47
    • 64749111428 scopus 로고    scopus 로고
    • Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells
    • Zhang X., Cao J., Zhong L. (2009) Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. Naunyn Schmiedebergs Arch. Pharmacol., 379(6):581-6.
    • (2009) Naunyn Schmiedebergs Arch. Pharmacol. , vol.379 , Issue.6 , pp. 581-586
    • Zhang, X.1    Cao, J.2    Zhong, L.3
  • 48
    • 65249177776 scopus 로고    scopus 로고
    • Suppressive effects of hydroxytyrosol on oxidative stress and nuclear Factor-kappaB activation in THP-1 cells
    • Zhang X., Cao J., Jiang L., Zhong L. (2009) Suppressive effects of hydroxytyrosol on oxidative stress and nuclear Factor-kappaB activation in THP-1 cells. Biol. Pharm. Bull., 32(4):578-82.
    • (2009) Biol. Pharm. Bull. , vol.32 , Issue.4 , pp. 578-582
    • Zhang, X.1    Cao, J.2    Jiang, L.3    Zhong, L.4
  • 49
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Review
    • Karin M. (2006) Nuclear factor-kappaB in cancer development and progression. Nature, 441(7092):431-6. Review.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 431-436
    • Karin, M.1
  • 52
    • 20444418737 scopus 로고    scopus 로고
    • Hydrolyzed olive vegetation water in mice has anti-inflammatory activity
    • Bitler C. M., Viale T. M., Damaj B., Crea R. (2005) Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. J. Nutr., 135(6):1475-9.
    • (2005) J. Nutr. , vol.135 , Issue.6 , pp. 1475-1479
    • Bitler, C.M.1    Viale, T.M.2    Damaj, B.3    Crea, R.4
  • 53
    • 65649099031 scopus 로고    scopus 로고
    • Effects of hydroxytyrosol-20 on carrageenan-induced acute inflammation and hyperalgesia in rats
    • Gong D., Geng C., Jiang L., Cao J., Yoshimura H., Zhong L. Effects of hydroxytyrosol-20 on carrageenan-induced acute inflammation and hyperalgesia in rats. Phytother. Res., 23(5):646-50.
    • Phytother. Res. , vol.23 , Issue.5 , pp. 646-650
    • Gong, D.1    Geng, C.2    Jiang, L.3    Cao, J.4    Yoshimura, H.5    Zhong, L.6
  • 54
  • 55
    • 0035057969 scopus 로고    scopus 로고
    • Hydroxytyrosol, as a component of olive mill waste water, is dosedependently absorbed and increases the antioxidant capacity of rat plasma
    • Visioli F., Caruso D., Plasmati E., Patelli R., Mulinacci N., Romani A., Galli G., Galli C. (2001) Hydroxytyrosol, as a component of olive mill waste water, is dosedependently absorbed and increases the antioxidant capacity of rat plasma. Free Radic. Res., 34(3):301-5.
    • (2001) Free Radic. Res. , vol.34 , Issue.3 , pp. 301-305
    • Visioli, F.1    Caruso, D.2    Plasmati, E.3    Patelli, R.4    Mulinacci, N.5    Romani, A.6    Galli, G.7    Galli, C.8
  • 58
    • 84861426015 scopus 로고    scopus 로고
    • The anticancer effects of resveratrol: modulation of transcription factors
    • Review
    • Whitlock N. C., Baek S. J. (2012) The anticancer effects of resveratrol: modulation of transcription factors. Nutr. Cancer, 64(4):493-502. Review.
    • (2012) Nutr. Cancer , vol.64 , Issue.4 , pp. 493-502
    • Whitlock, N.C.1    Baek, S.J.2
  • 59
    • 84857376492 scopus 로고    scopus 로고
    • Potential role of green tea catechins in various disease therapies: progress and promise
    • Review
    • Mak J. C. (2012) Potential role of green tea catechins in various disease therapies: progress and promise. Clin. Exp. Pharmacol. Physiol., 39(3):265-73. Review.
    • (2012) Clin. Exp. Pharmacol. Physiol. , vol.39 , Issue.3 , pp. 265-273
    • Mak, J.C.1
  • 60
    • 0036684228 scopus 로고    scopus 로고
    • Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis
    • Fabiani R., De Bartolomeo A., Rosignoli P., Servili M., Montedoro G. F., Morozzi G. (2002) Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis. Eur. J. Cancer Prev., 11(4):351-8.
    • (2002) Eur. J. Cancer Prev. , vol.11 , Issue.4 , pp. 351-358
    • Fabiani, R.1    De Bartolomeo, A.2    Rosignoli, P.3    Servili, M.4    Montedoro, G.F.5    Morozzi, G.6
  • 61
    • 33644847101 scopus 로고    scopus 로고
    • Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation
    • Fabiani R., De Bartolomeo A., Rosignoli P., Servili M., Selvaggini R., Montedoro G. F., Di Saverio C., Morozzi G. (2006) Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation. J. Nutr., 136(3):614-9.
    • (2006) J. Nutr. , vol.136 , Issue.3 , pp. 614-619
    • Fabiani, R.1    De Bartolomeo, A.2    Rosignoli, P.3    Servili, M.4    Selvaggini, R.5    Montedoro, G.F.6    Di Saverio, C.7    Morozzi, G.8
  • 62
    • 84864682185 scopus 로고    scopus 로고
    • Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide
    • Fabiani R., Sepporta M. V., Rosignoli P., De Bartolomeo A., Crescimanno M., Morozzi G. (2012) Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide. Eur. J. Nutr., 51(4):455-64.
    • (2012) Eur. J. Nutr. , vol.51 , Issue.4 , pp. 455-464
    • Fabiani, R.1    Sepporta, M.V.2    Rosignoli, P.3    De Bartolomeo, A.4    Crescimanno, M.5    Morozzi, G.6
  • 63
    • 38149050388 scopus 로고    scopus 로고
    • Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclindependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells
    • Fabiani R., Rosignoli P., De Bartolomeo A., Fuccelli R., Morozzi G. (2008) Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclindependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells. J. Nutr., 138(1):42-8.
    • (2008) J. Nutr. , vol.138 , Issue.1 , pp. 42-48
    • Fabiani, R.1    Rosignoli, P.2    De Bartolomeo, A.3    Fuccelli, R.4    Morozzi, G.5
  • 64
    • 3242752786 scopus 로고    scopus 로고
    • Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells
    • Boonstra, J., Post, J. A. (2004) Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene, 337, 1-13.
    • (2004) Gene , vol.337 , pp. 1-13
    • Boonstra, J.1    Post, J.A.2
  • 65
    • 0035341998 scopus 로고    scopus 로고
    • carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells
    • Palozza, P., Calviello, G., Serini, S., Maggiano, N., (2001) carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells. Free Radic. Biol. Med., 30, 1000-100.
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 1000-1100
    • Palozza, P.1    Calviello, G.2    Serini, S.3    Maggiano, N.4
  • 66
    • 4143085009 scopus 로고    scopus 로고
    • L-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms
    • Park, S., Han, S. S., Park, C. H., Hahm, E. R., (2004) L-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms. Int. J. Biochem. Cell Biol., 36, 2180-2195
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 2180-2195
    • Park, S.1    Han, S.S.2    Park, C.H.3    Hahm, E.R.4
  • 67
    • 34447096276 scopus 로고    scopus 로고
    • Antioxidative and prooxidative effects of quercetin on A549 cells
    • Robaszkiewicz, A., Balcerczyk, A., Bartosz, G. (2007) Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biol. Int., 31, 1245-1250.
    • (2007) Cell Biol. Int. , vol.31 , pp. 1245-1250
    • Robaszkiewicz, A.1    Balcerczyk, A.2    Bartosz, G.3
  • 69
    • 68149181262 scopus 로고    scopus 로고
    • Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells
    • Fabiani R., Fuccelli R., Pieravanti F., De Bartolomeo A., Morozzi G. (2009) Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells. Mol. Nutr. Food Res., 53(7):887-96.
    • (2009) Mol. Nutr. Food Res. , vol.53 , Issue.7 , pp. 887-896
    • Fabiani, R.1    Fuccelli, R.2    Pieravanti, F.3    De Bartolomeo, A.4    Morozzi, G.5
  • 70
    • 0035237562 scopus 로고    scopus 로고
    • Antioxidants prevent the lymphocyte DNA damage induced by PMA-stimulated monocytes
    • Fabiani R., De Bartolomeo A., Rosignoli P., Morozzi G. (2001) Antioxidants prevent the lymphocyte DNA damage induced by PMA-stimulated monocytes. Nutr. Cancer, 39:284-91.
    • (2001) Nutr. Cancer , vol.39 , pp. 284-291
    • Fabiani, R.1    De Bartolomeo, A.2    Rosignoli, P.3    Morozzi, G.4
  • 71
    • 8544283254 scopus 로고    scopus 로고
    • The comet assay for DNA damage and repair
    • Collins A. R. (2004) The comet assay for DNA damage and repair. Mol. Biotechnol., 26:249-61.
    • (2004) Mol. Biotechnol. , vol.26 , pp. 249-261
    • Collins, A.R.1
  • 72
    • 49449106555 scopus 로고    scopus 로고
    • Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells
    • Fabiani R., Rosignoli P., De Bartolomeo A., Fuccelli R., Servili M., Montedoro G. F., Morozzi G. (2008) Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. J. Nutr., 138(8):1411-6.
    • (2008) J. Nutr. , vol.138 , Issue.8 , pp. 1411-1416
    • Fabiani, R.1    Rosignoli, P.2    De Bartolomeo, A.3    Fuccelli, R.4    Servili, M.5    Montedoro, G.F.6    Morozzi, G.7
  • 73
    • 84892444415 scopus 로고    scopus 로고
    • Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes
    • Rosignoli P., Fuccelli R., Fabiani R., Servili M., Morozzi G. (2013) Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes. J. Nutr. Biochem., 24(8):1513-9.
    • (2013) J. Nutr. Biochem. , vol.24 , Issue.8 , pp. 1513-1519
    • Rosignoli, P.1    Fuccelli, R.2    Fabiani, R.3    Servili, M.4    Morozzi, G.5
  • 74
    • 0037407899 scopus 로고    scopus 로고
    • In vitro cytotoxicity to human cells in culture of some phenolics from olive oil
    • Babich H., Visioli F. (2003) In vitro cytotoxicity to human cells in culture of some phenolics from olive oil. Farmaco., 58(5):403-7.
    • (2003) Farmaco. , vol.58 , Issue.5 , pp. 403-407
    • Babich, H.1    Visioli, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.