Potential role of green tea catechins in various disease therapies: Progress and promise

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 3, 2012, Pages 265-273

  Mak, Judith C W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Anti oxidant; Cancer chemoprevention; Cardioprotection; Catechin; Green tea

Indexed keywords

CATECHIN; EPICATECHIN; EPICATECHIN 3 GALLATE; EPIGALLOCATECHIN GALLATE; EPIGALLOCATHECHIN; GREEN TEA EXTRACT; PHENOL; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHEMOPROPHYLAXIS; CHINA; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DIETARY INTAKE; DISEASE ASSOCIATION; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; HEART PROTECTION; HUMAN; IN VITRO STUDY; ISCHEMIC HEART DISEASE; LIPID METABOLISM; NEOPLASM; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PHYSIOLOGY; STROKE; TEA; WEIGHT REDUCTION;

ANIMALS; ANTIOXIDANTS; CARDIOVASCULAR DISEASES; CATECHIN; CLINICAL TRIALS AS TOPIC; HUMANS; NEOPLASMS; NEURODEGENERATIVE DISEASES; TEA;

EID: 84857376492     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2012.05673.x     Document Type: Article

References (84)

1. Graham HN. Green tea composition, consumption, and polyphenol chemistry. Prev. Med. 1992; 21: 334-50.
2. Zuo Y, Chen H, Deng Y. Simultaneous detection of the catechin, caffeine and gallic acid in green tea, oolong, black and pu-erh teas using HPLC with a photodiode array detector. Talanta 2002; 57: 307-16.
3. Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: A literature reiview. Chin. Med. 2010; 5: 13-21.
4. Hong J, Smith TJ, Ho CT, August DA, Yang CS. Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem. Pharmacol. 2001; 62: 1175-83.
5. Zheng J, Ramirez VD. Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals. Br. J. Pharmacol. 2000; 130: 1115-23.
6. Chen C, Yu R, Owuor ED, Kong AN. Activation of antioxidant response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch. Pharm. Res. 2000; 23: 605-12.
7. Du Y, Guo H, Lou H. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. J. Agric. Food. Chem. 2007; 55: 1695-701.
8. Steffen Y, Wiswedel I, Peter D, Schewe T, Sies H. Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7β-hydroxycholesterol to 7-ketocholesterol ratio. Free Radic. Biol. Med. 2006; 41: 1139-50.
9. Lo HM, Hung CF, Huang YY, Wu WB. Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell-ECM interaction. J. Biomed. Sci. 2007; 14: 637-45.
10. Choi YJ, Jeong YJ, Lee YJ, Kwon HM, Kang YH. (-)-Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis. J. Nutr. 2005; 135: 707-13.
11. Lorenz M, Wessler S, Follmann E, et al. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phophatidylinositol-3-OH-kinase, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J. Biol. Chem. 2004; 279: 6190-5.
12. Kim JA, Formoso G, Li Y, et al. Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J. Biol. Chem. 2007; 282: 13736-45.
13. Kim SJ, Jeong HJ, Lee KM, et al. Epigallocatechin-3-gallate suppresses NF-kappaB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells. J. Nutr. Biochem. 2007; 18: 587-96.
14. 2-induced apoptosis in rat PC12 cells. Life Sci. 2007; 80: 1355-63.
15. de Boer VC, de Goffau MC, Arts IC, Hollman PC, Keijer J. SIRT1 stimulation by polyphenols is affected by their stability and metabolism. Mech. Ageing Dev. 2006; 127: 618-27.
16. Levites Y, Amit T, Youdim MB, Mandel S. Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin-3-gallate neuron-protective action. J. Biol. Chem. 2002; 277: 30574-80.
17. Mercer LD, Kelly BL, Horne MK, Beart PM. Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: Investigations in primary rat mesencephalic cultures. Biochem. Pharmacol. 2005; 69: 339-45.
18. Kawai K, Tsuno NH, Kitayama J, et al. Epigallocatechin gallate induces apoptosis of monocytes. J. Allergy Clin. Immunol. 2005; 115: 186-91.
19. Kawai K, Tsuno NH, Kitayama J, et al. Epigallocatechin gallate attenuates adhesion and migration of CD8 + T cells by binding to CD11b. J. Allergy Clin. Immunol. 2004; 113: 1211-7.
20. Naasani I, Oh-Hashi F, Oh-Hara T, et al. Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res. 2003; 63: 824-30.
21. Nanjo F, Goto K, Seto R, Suzuki M, Sakai M, Hara Y. Scavenging effects of tea catechins and their derivatives on 1, 1-diphenyl-2-picrylhydrazyl radical. Free Radic. Biol. Med. 1996; 21: 895-902.
22. Valcic S, Muders A, Jacobsen NE, Liebler DC, Timmerrmann BN. Antioxidant chemistry of green tea catechins. Identification of products of the reaction of (-)-epigallocatechin gallate with proxyl radicals. Chem. Res. Toxicol. 1999; 12: 382-6.
23. Crespy V, Williamson G. A review of the health effects of green tea catechins in in vivo animal models. J. Nutr. 2004; 134(Suppl.): S3431-40.
24. Chung SY, Wang H. Mechanistic issues concerning cancer prevention by tea catechins. Mol. Nutr. Food Res. 2011; 55: 819-31.
25. Chung SY, Wang H, Li GX, Yang Z, Guan F, Jin H. Cancer prevention by tea: Evidence from laboratory studies. Pharmacol. Res. 2011; 64: 113-22.
26. Hou Z, Lambert JD, Chin KV, Yang CS. Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. Mutat. Res. 2004; 555: 3-19.
27. Hou Z, Sang S, You H, et al. Mechanism of action of (-)-epigallocatechin-3-gallate: Auto-oxidation-dependent inactivation of epidermal growth factor and direct effects on growth inhibition in human esophageal cancer kyse 150 cells. Cancer Res. 2005; 65: 8049-56.
28. Yang GY, Liao J, Kim K, Yurkow EJ, Yang CS. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 1998; 19: 611-6.
29. Li GX, Chen YK, Hou Z, et al. Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: A comparative study in vivo and in vitro. Carcinogenesis 2010; 31: 902-10.
30. Na HK, Surh YJ. Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem. Toxicol. 2008; 46: 1271-8.
31. Chen PC, Wheeler DS, Malhotra V, Odoms K, Denenberg AG, Wong HR. A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium. Inflammation 2002; 26: 233-41.
32. Jung YD, Kim MS, Shin BA, et al. EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. Br. J. Cancer 2001; 84: 844-50.
33. Ahmad N, Cheng P, Mukhtar H. Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate. Biochem. Biophys. Res. Commun. 2000; 275: 328-34.
34. Weber AA, Neuhaus T, Skach RA, et al. Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis. FASEB J. 2004; 18: 128-30.
35. Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, Varilek GW. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol. Pharmacol. 2001; 60: 528-33.
36. Nomura M, Kaji A, He Z, et al. Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 2001; 276: 46624-31.
37. Yuan J-M, Sun C, Butler LM. Tea and cancer prevention: Epidemiological studies. Pharmacol. Res. 2011; 64: 123-35.
38. Deka A, Vita JA. Tea and cardiovascular disease. Pharmacol. Res. 2011; 64: 136-45.
39. Dhalla NS, Temsah RM, Netticadan T. Role of oxidative stress in cardiovascular diseases. J. Hypertens. 2000; 18: 655-73.
40. Jain KS, Kathiravan MK, Somani RS, Shishoo CJ. The biology and chemistry of hyperlipidemia. Bioorg. Med. Chem. 2007; 15: 4674-99.
41. Ruggeri ZM. Platelets in atherothrombosis. Nat. Med. 2002; 8: 1227-34.
42. Rudijanto A. The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis. Acta Med. Indones. 2007; 39: 86-93.
43. Shenouda SM, Vita JA. Effects of flavonoid-containing beverages and EGCG on endothelial function. J. Am. Coll. Nutr. 2007; 26: S366-72.
44. Stangl V, Derger H, Stangl K, Lorenz M. Molecular targets of tea polyphenols in the cardiovascular system. Cardiovasc. Res. 2007; 73: 348-58.
45. Nakagawa T, Yokozawa T. Direct scavenging of nitric oxide and superoxide by green tea. Food Chem. Toxicol. 2002; 40: 1745-50.
46. Osada K, Takahashi M, Hoshina S, Nakamura M, Nakamura S, Sugano M. Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2001; 128: 153-64.
47. Yang TT, Koo MW. Inhibiting effect of Chinese green tea on endothelial cell-induced LDL oxidation. Atherosclerosis 2000; 148: 67-73.
48. Yoshida H, Ishikawa T, Hosoai H, et al. Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein. Biochem. Pharmacol. 1999; 58: 1695-703.
49. Hofbauer R, Frass M, Gmeiner B, Handler S, Speiser W, Kapiotis S. The green tea extract epigallocatechin gallate is able to reduce neutrophil transmigration through monolayers of endothelial cells. Wien. Klin. Wochenschr. 1999; 111: 278-82.
50. Sartor L, Pezzato E, Garbisa S. (-)-Epigallocatechin-3-gallate inhibits leukocyte elastase. Potential of the phyto-factor in hindering inflammation, emphysema, and invasion. J. Leukoc. Biol. 2002; 71: 73-9.
51. Dona M, Dell'Aica I, Calabrese F, et al. Neutrophil restraint by green tea: Inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis. J. Immunol. 2003; 170: 4335-41.
52. Takano K, Nakaima K, Nitta M, Shibata F, Nakagawa H. Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. J. Agric. Food. Chem. 2004; 52: 4571-6.
53. Ludwig A, Lorenz M, Grimbo N, et al. The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. Biochem. Biophys. Res. Commun. 2004; 316: 659-65.
54. Lorenz M, Wessler S, Follmann E, et al. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J. Biol. Chem. 2004; 279: 6190-5.
55. Li Y, Ying C, Zuo X, et al. Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38 MAPK in endothelial cells. J. Nutr. Biochem. 2009; 20: 1021-7.
56. Kang WS, Chung KH, Chung JH, et al. Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmic calcium increase. J. Cardiovasc. Pharmacol. 2001; 38: 875-84.
57. Jin YR, Im JH, Park ES, et al. Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. J. Cardiovasc. Pharmacol. 2008; 51: 45-54.
58. Ahn HY, Hadizadeh KR, Seul C, Yun YP, Vetter H, Sachinidis A. Epigallocatechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172). Mol. Biol. Cell 1999; 10: 1093-104.
59. Maeda K, Kuzuya M, Cheng XW, et al. Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. Atherosclerosis 2003; 166: 23-30.
60. Westerterp-Plantenga MS. Green tea catechins, caffeine and body-weight regulation. Physiol. Behav. 2010; 100: 42-6.
61. Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes. Res. 2005; 13: 1195-204.
62. Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y. Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. J. Med. Food 2006; 9: 451-8.
63. Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007; 292: R77-85.
64. Klaus S, Pultz S, Thone-Reineke C, Wolfram S. Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. Int. J. Obes. 2005; 29: 615-23.
65. Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I. Beneficial effects of tea catechins on diet-induced obesity: Stimulation of lipid catabolism in the liver. Int. J. Obes. Relat. Metab. Disord. 2002; 26: 1459-64.
66. Halliwell B. Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment. Drugs Aging 2001; 18: 685-716.
67. Mandel SA, Amit T, Weinreb O, Youdim MB. Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases. J. Alzheimers Dis. 2011; 25: 187-208.
68. Perron NR, Wang HC, Deguire SN, Jenkins M, Lawson M, Brumaghim JL. Kinetics of iron oxidation upon polyphenol binding. Dalton Trans. 2010; 39: 9982-7.
69. Assuncao M, Santos-Marques MJ, Carvalho F, Andrade JP. Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival. Free Radic. Biol. Med. 2010; 48: 831-8.
70. Ehrnhoefer DE, Bieschke J, Boeddrich A, et al. EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat. Struct. Mol. Biol. 2008; 15: 558-66.
71. Bieschke J, Russ J, Friedrich RP, et al. EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proc. Natl Acad. Sci. USA 2010; 107: 7710-5.
72. Weinreb O, Amit T, Youdim MB. A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate. Free Radic. Biol. Med. 2007; 43: 546-56.
73. Reznichenko L, Amit T, Zheng H, et al. Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth. J. Neurochem. 2005; 93: 1157-67.
74. Weinreb O, Amit T, Youdim MB. The application of proteomics for studying the neurorescue activity of the polyphenol (-)-epigallocatechin-3-gallate. Arch. Biochem. Biophys. 2008; 476: 152-60.
75. Koh SH, Kim SH, Kwon H, et al. Eepigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. Brain Res. Mol. Brain Res. 2003; 118: 72-81.
76. Tachibana H, Koga K, Fujimura Y, Yamada K. A receptor for green tea polyphenol EGCG. Nat. Struct. Mol. Biol. 2004; 11: 380-1.
77. Chan KH, Ho SP, Yeung SC, et al. Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats. Respir. Med. 2009; 103: 1746-54.
78. Barras A, Mezzetti A, Richard A, et al. Formulation and characterization of polyphenol-loaded lipid nanocapsules. Int. J. Pharm. 2009; 379: 270-7.
79. Siddiqui IA, Adhami VM, Bharali DJ, et al. Introducing nanochemoprevention as a novel approach for cancer control: Proof of principle with green tea polyphenol epigallocatechin-3-gallate. Cancer Res. 2009; 69: 1712-6.
80. Smith A, Giunta B, Bickford PC, Fountain M, Tan J, Shytle RD. Nanolipidic particles improve the bioavailability and alpha-secretase including ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. Int. J. Pharm. 2010; 389: 207-12.
81. Navarro-Peran E, Cabezas-Herrera J, Garcia-Canovas F, Durrant MC, Thorneley RN, Rodriguez-Lopez JN. The antifolate activity of tea catechins. Cancer Res. 2005; 65: 2059-64.
82. Gloro R, Hourmand-Ollivier I, Mosquet B, et al. Fulminant hepatitis during self-medication with hydroalcoholic extract of green tea. Eur. J. Gastroenterol. Hepatol. 2005; 17: 1135-7.
83. Schonthal AH. Adverse effects of concentrated green tea extracts. Mol. Nutr. Food Res. 2011; 55: 874-85.
84. Hara Y. Tea catechins and their applications as supplements and pharmaceutics. Pharmacol. Res. 2011; 64: 100-4.