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Volumn 33, Issue , 2015, Pages 19-28

Immunopathogenesis of inflammatory bowel diseases: Functional role of T cells and T cell homing

Author keywords

Cytokines; Gut homing; Inflammatory bowel diseases; Regulatory T lymphocytes

Indexed keywords

CHEMOKINE RECEPTOR CCR9; ETROLIZUMAB; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; STAT3 PROTEIN; ANTIINFLAMMATORY AGENT; AUTACOID; GASTROINTESTINAL AGENT;

EID: 84953345096     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (40)

References (154)
  • 1
    • 80455140368 scopus 로고    scopus 로고
    • Ulcerative Colitis
    • DANESE S, FIOCCHI C: Ulcerative Colitis. N Engl J Med 2011; 365: 1713-25.
    • (2011) N Engl J Med , vol.365 , pp. 1713-1725
    • Danese, S.1    Fiocchi, C.2
  • 3
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • HUGOT JP, CHAMAILLARD M, ZOUALI H et al.: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 4
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • OGURA Y, BONEN DK, INOHARA N et al.: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-6.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 5
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • JOSTINS L, RIPKE S, WEERSMA RK et al.: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012; 491: 119-24.
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 7
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel diseases: current status and the future ahead
    • KOSTIC AD, XAVIER RJ, GEVERS D: The microbiome in inflammatory bowel diseases: current status and the future ahead. Gastroenterology 2014; 146: 1489-99.
    • (2014) Gastroenterology , vol.146 , pp. 1489-1499
    • Kostic, A.D.1    Xavier, R.J.2    Gevers, D.3
  • 8
    • 84888219662 scopus 로고    scopus 로고
    • Defective antibacterial barrier in inflammatory bowel disease
    • KLAG T, STANGE EF, WEHKAMP J: Defective antibacterial barrier in inflammatory bowel disease. Dig Dis Basel Switz 2013; 31: 310-6.
    • (2013) Dig Dis Basel Switz , vol.31 , pp. 310-316
    • Klag, T.1    Stange, E.F.2    Wehkamp, J.3
  • 9
    • 84899639879 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • NEURATH MF: Cytokines in inflammatory bowel disease. Nat Rev Immunol 2014; 14: 329-42.
    • (2014) Nat Rev Immunol , vol.14 , pp. 329-342
    • Neurath, M.F.1
  • 10
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • FUSS IJ, NEURATH M, BOIRIVANT M et al.: Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996; 157: 1261-70.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 11
    • 81855209849 scopus 로고    scopus 로고
    • Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14+ macrophages
    • ATREYA R, ZIMMER M, BARTSCH B et al.: Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14+ macrophages. Gastroenterology 2011; 141: 2026-38.
    • (2011) Gastroenterology , vol.141 , pp. 2026-2038
    • Atreya, R.1    Zimmer, M.2    Bartsch, B.3
  • 12
    • 45749107055 scopus 로고    scopus 로고
    • Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
    • KAMADA N, HISAMATSU T, OKAMOTO S et al.: Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest 2008; 118: 2269-80.
    • (2008) J Clin Invest , vol.118 , pp. 2269-2280
    • Kamada, N.1    Hisamatsu, T.2    Okamoto, S.3
  • 13
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • STROBER W, FUSS IJ, BLUMBERG RS: The immunology of mucosal models of inflammation. Annu Rev Immunol 2002; 20: 495-549.
    • (2002) Annu Rev Immunol , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3
  • 14
    • 65549098640 scopus 로고    scopus 로고
    • CD4 T-cell differentiation and inflammatory bowel disease
    • ZENEWICZ LA, ANTOV A, FLAVELL RA: CD4 T-cell differentiation and inflammatory bowel disease. Trends Mol Med 2009; 15: 199-207.
    • (2009) Trends Mol Med , vol.15 , pp. 199-207
    • Zenewicz, L.A.1    Antov, A.2    Flavell, R.A.3
  • 15
    • 56549104968 scopus 로고    scopus 로고
    • IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
    • KOBAYASHI T, OKAMOTO S, HISAMATSU T et al.: IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008; 57: 1682-9.
    • (2008) Gut , vol.57 , pp. 1682-1689
    • Kobayashi, T.1    Okamoto, S.2    Hisamatsu, T.3
  • 16
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    • NEURATH MF, WEIGMANN B, FINOTTO S et al.: The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med 2002; 195: 1129-43.
    • (2002) J Exp Med , vol.195 , pp. 1129-1143
    • Neurath, M.F.1    Weigmann, B.2    Finotto, S.3
  • 17
    • 72549107316 scopus 로고    scopus 로고
    • Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    • ROVEDATTI L, KUDO T, BIANCHERI P et al.: Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut 2009; 58: 1629-36.
    • (2009) Gut , vol.58 , pp. 1629-1636
    • Rovedatti, L.1    Kudo, T.2    Biancheri, P.3
  • 18
    • 0027441514 scopus 로고
    • Interleukin-2-and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
    • BREESE E, BRAEGGER CP, CORRIGAN CJ, WALKER-SMITH JA, MacDONALD TT: Interleukin-2-and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993; 78: 127-31.
    • (1993) Immunology , vol.78 , pp. 127-131
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3    Walker-Smith, J.A.4    Macdonald, T.T.5
  • 19
    • 0025804331 scopus 로고
    • Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers
    • FAIS S, CAPOBIANCHI MR, PALLONE F et al.: Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers. Gut 1991; 32: 403-7.
    • (1991) Gut , vol.32 , pp. 403-407
    • Fais, S.1    Capobianchi, M.R.2    Pallone, F.3
  • 20
    • 0034671633 scopus 로고    scopus 로고
    • Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease
    • PARRELLO T, MONTELEONE G, CUCCHIARA S et al.: Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease. J Immunol 2000; 165: 7234-9.
    • (2000) J Immunol , vol.165 , pp. 7234-7239
    • Parrello, T.1    Monteleone, G.2    Cucchiara, S.3
  • 21
    • 0033227692 scopus 로고    scopus 로고
    • Th1/Th2 Cells. [Review]
    • ROMAGNANI S: Th1/Th2 Cells. [Review]. Inflamm Bowel Dis 1999; 5: 285-94.
    • (1999) Inflamm Bowel Dis , vol.5 , pp. 285-294
    • Romagnani, S.1
  • 22
    • 70350093623 scopus 로고    scopus 로고
    • Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease
    • SAKURABA A, SATO T, KAMADA N et al.: Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease. Gastroenterology 2009; 137: 1736-45.
    • (2009) Gastroenterology , vol.137 , pp. 1736-1745
    • Sakuraba, A.1    Sato, T.2    Kamada, N.3
  • 23
    • 0033558364 scopus 로고    scopus 로고
    • Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF-plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens
    • WIRTZ S, FINOTTO S, KANZLER S et al.: Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF-plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens. J Immunol 1999; 162: 1884-8.
    • (1999) J Immunol , vol.162 , pp. 1884-1888
    • Wirtz, S.1    Finotto, S.2    Kanzler, S.3
  • 24
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells
    • SIMPSON SJ, SHAH S, COMISKEY M et al.: T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 1998; 187: 1225-34.
    • (1998) J Exp Med , vol.187 , pp. 1225-1234
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3
  • 25
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • NEURATH MF, FUSS I, KELSALL BL, STüBER E, STROBER W: Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182: 1281-90.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stüber, E.4    Strober, W.5
  • 26
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • POWRIE F, LEACH MW, MAUZE S et al.: Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994; 1: 553-62.
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3
  • 27
    • 33746132472 scopus 로고    scopus 로고
    • A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon γ antibody, in patients with moderate to severe Crohn's disease
    • REINISCH W, HOMMES DW, VAN ASSCHE G et al.: A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon γ antibody, in patients with moderate to severe Crohn's disease. Gut 2006; 55: 1138-44.
    • (2006) Gut , vol.55 , pp. 1138-1144
    • Reinisch, W.1    Hommes, D.W.2    Van Assche, G.3
  • 28
    • 79960035010 scopus 로고    scopus 로고
    • An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation
    • YAGI R, ZHU J, PAUL WE: An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. Int Immunol 2011; 23: 415-20.
    • (2011) Int Immunol , vol.23 , pp. 415-420
    • Yagi, R.1    Zhu, J.2    Paul, W.E.3
  • 29
    • 54349118972 scopus 로고    scopus 로고
    • The role of IL-13 and NK T cells in experimental and human ulcerative colitis
    • FUSS IJ, STROBER W: The role of IL-13 and NK T cells in experimental and human ulcerative colitis. Mucosal Immunol 2008; 1 (Suppl. 1): S31-33.
    • (2008) Mucosal Immunol , vol.1 , pp. S31-S33
    • Fuss, I.J.1    Strober, W.2
  • 30
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution
    • HELLER F, FLORIAN P, BOJARSKI C et al.: Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution. Gastroenterology 2005; 129: 550-64.
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1    Florian, P.2    Bojarski, C.3
  • 31
    • 79958244691 scopus 로고    scopus 로고
    • Is the Th1/Th2 paradigm of immune regulation applicable to IBD?
    • FUSS IJ: Is the Th1/Th2 paradigm of immune regulation applicable to IBD? Inflamm Bowel Dis 2008;.
    • (2008) Inflamm Bowel Dis
    • Fuss, I.J.1
  • 32
    • 84873537478 scopus 로고    scopus 로고
    • STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines
    • ROSEN MJ, CHATURVEDI R, WASHINGTON MK et al.: STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol 2013; 190: 1849-58.
    • (2013) J Immunol , vol.190 , pp. 1849-1858
    • Rosen, M.J.1    Chaturvedi, R.2    Washington, M.K.3
  • 33
    • 0036850908 scopus 로고    scopus 로고
    • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    • HELLER F, FUSS IJ, NIEUWENHUIS EE, BLUMBERG RS, STROBER W: Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 2002; 17: 629-38.
    • (2002) Immunity , vol.17 , pp. 629-638
    • Heller, F.1    Fuss, I.J.2    Nieuwenhuis, E.E.3    Blumberg, R.S.4    Strober, W.5
  • 34
    • 84872277296 scopus 로고    scopus 로고
    • Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13
    • CAMELO A, BARLOW JL, DRYNAN LF et al.: Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13. J Gastroenterol 2012; 47: 1198-211.
    • (2012) J Gastroenterol , vol.47 , pp. 1198-1211
    • Camelo, A.1    Barlow, J.L.2    Drynan, L.F.3
  • 35
    • 84893581723 scopus 로고    scopus 로고
    • Absence of a role for interleukin-13 in inflammatory bowel disease
    • BIANCHERI P, DI SABATINO A, AMMOSCATO F et al.: Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol 2014; 44: 370-85.
    • (2014) Eur J Immunol , vol.44 , pp. 370-385
    • Biancheri, P.1    Di Sabatino, A.2    Ammoscato, F.3
  • 36
    • 84920942417 scopus 로고    scopus 로고
    • Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study
    • DANESE S, RUDZINSKI J, BRANDT W et al.: Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study. Gut 2015; 64: 243-9.
    • (2015) Gut , vol.64 , pp. 243-249
    • Danese, S.1    Rudzinski, J.2    Brandt, W.3
  • 37
    • 84935030329 scopus 로고    scopus 로고
    • Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study
    • REINISCH W, PANéS J, KHURANA S et al.: Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study. Gut 2015; 64: 894-900.
    • (2015) Gut , vol.64 , pp. 894-900
    • Reinisch, W.1    Panés, J.2    Khurana, S.3
  • 38
    • 27744446058 scopus 로고    scopus 로고
    • IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    • SCHMITZ J, OWYANG A, OLDHAM E et al.: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005; 23: 479-90.
    • (2005) Immunity , vol.23 , pp. 479-490
    • Schmitz, J.1    Owyang, A.2    Oldham, E.3
  • 39
    • 84935926011 scopus 로고    scopus 로고
    • IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis
    • SEIDELIN JB, COSKUN M, KVIST PH et al.: IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis. J Gastroenterol 2015; 50: 180-90.
    • (2015) J Gastroenterol , vol.50 , pp. 180-190
    • Seidelin, J.B.1    Coskun, M.2    Kvist, P.H.3
  • 40
    • 74649085973 scopus 로고    scopus 로고
    • IL-33 is upregulated in colonocytes of ulcerative colitis
    • SEIDELIN JB, BJERRUM JT, COSKUN M et al.: IL-33 is upregulated in colonocytes of ulcerative colitis. Immunol Lett 2010; 128: 80-5.
    • (2010) Immunol Lett , vol.128 , pp. 80-85
    • Seidelin, J.B.1    Bjerrum, J.T.2    Coskun, M.3
  • 41
    • 78249249625 scopus 로고    scopus 로고
    • Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis
    • KOBORI A, YAGI Y, IMAEDA H et al.: Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis. J Gastroenterol 2010; 45: 999-1007.
    • (2010) J Gastroenterol , vol.45 , pp. 999-1007
    • Kobori, A.1    Yagi, Y.2    Imaeda, H.3
  • 42
    • 77953721901 scopus 로고    scopus 로고
    • Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease
    • BELTRAN CJ, NUNEZ LE, DIAZ-JIMENEZ D et al.: Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease. Inflamm Bowel Dis 2010; 16: 1097-107.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1097-1107
    • Beltran, C.J.1    Nunez, L.E.2    Diaz-Jimenez, D.3
  • 43
    • 77952324145 scopus 로고    scopus 로고
    • Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis
    • PASTORELLI L, GARG RR, HOANG SB et al.: Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. Proc Natl Acad Sci USA 2010; 107: 8017-22.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8017-8022
    • Pastorelli, L.1    Garg, R.R.2    Hoang, S.B.3
  • 44
    • 84887459057 scopus 로고    scopus 로고
    • Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
    • SEDHOM MAK, PICHERY M, MURDOCH JR et al.: Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut 2013; 62: 1714-23.
    • (2013) Gut , vol.62 , pp. 1714-1723
    • Sedhom, M.A.K.1    Pichery, M.2    Murdoch, J.R.3
  • 45
    • 84878642267 scopus 로고    scopus 로고
    • Interleukin-33 exacerbates acute colitis via interleukin-4 in mice
    • PUSHPARAJ PN, LI D, KOMAI-KOMA M et al.: Interleukin-33 exacerbates acute colitis via interleukin-4 in mice. Immunology 2013; 140: 70-7.
    • (2013) Immunology , vol.140 , pp. 70-77
    • Pushparaj, P.N.1    Li, D.2    Komai-Koma, M.3
  • 46
    • 84870527455 scopus 로고    scopus 로고
    • Interleukin-33 Ameliorates Experimental Colitis through Promoting Th2/Foxp3+ Regulatory T-Cell Responses in Mice
    • DUAN L, CHEN J, ZHANG H et al.: Interleukin-33 Ameliorates Experimental Colitis through Promoting Th2/Foxp3+ Regulatory T-Cell Responses in Mice. Mol Med 2012; 18: 753-61.
    • (2012) Mol Med , vol.18 , pp. 753-761
    • Duan, L.1    Chen, J.2    Zhang, H.3
  • 47
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12
    • OPPMANN B, LESLEY R, BLOM B et al.: Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12. Immunity 2000; 13: 715-25.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 48
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • CUA DJ, SHERLOCK J, CHEN Y et al.: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003; 421: 744-8.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3
  • 49
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • LANGRISH CL, CHEN Y, BLUMENSCHEIN WM et al.: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201: 233-40.
    • (2005) J Exp Med , vol.201 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3
  • 50
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • VOLPE E, SERVANT N, ZOLLINGER R et al.: A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 2008; 9: 650-7.
    • (2008) Nat Immunol , vol.9 , pp. 650-657
    • Volpe, E.1    Servant, N.2    Zollinger, R.3
  • 51
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • SUTTON C, BRERETON C, KEOGH B, MILLS KHG, LAVELLE EC: A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006; 203: 1685-91.
    • (2006) J Exp Med , vol.203 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.G.4    Lavelle, E.C.5
  • 52
    • 41349121555 scopus 로고    scopus 로고
    • Regulation of gut inflammation and th17 cell response by interleukin-21
    • FINA D, SARRA M, FANTINI MC et al.: Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 2008; 134: 103848.
    • (2008) Gastroenterology , vol.134
    • Fina, D.1    Sarra, M.2    Fantini, M.C.3
  • 53
    • 77949514515 scopus 로고    scopus 로고
    • TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease
    • KAMADA N, HISAMATSU T, HONDA H et al.: TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease. Inflamm Bowel Dis 2010; 16: 568-75.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 568-575
    • Kamada, N.1    Hisamatsu, T.2    Honda, H.3
  • 54
    • 78649689761 scopus 로고    scopus 로고
    • Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
    • HIRAHARA K, GHORESCHI K, LAURENCE A et al.: Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev 2010; 21: 425-34.
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 425-434
    • Hirahara, K.1    Ghoreschi, K.2    Laurence, A.3
  • 55
    • 81055150391 scopus 로고    scopus 로고
    • Th17-related cytokines: new players in the control of chronic intestinal inflammation
    • MONTELEONE I, PALLONE F, MONTELEONE G: Th17-related cytokines: new players in the control of chronic intestinal inflammation. BMC Med 2011; 9: 122.
    • (2011) BMC Med , vol.9 , pp. 122
    • Monteleone, I.1    Pallone, F.2    Monteleone, G.3
  • 56
    • 68849124464 scopus 로고    scopus 로고
    • The role of the novel Th17 cytokine IL-26 in intestinal inflammation
    • DAMBACHER J, BEIGEL F, ZITZMANN K et al.: The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut 2009; 58: 1207-17.
    • (2009) Gut , vol.58 , pp. 1207-1217
    • Dambacher, J.1    Beigel, F.2    Zitzmann, K.3
  • 57
    • 0141835046 scopus 로고    scopus 로고
    • Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    • BECKER C, WIRTZ S, BLESSING M et al.: Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 2003; 112: 693-706.
    • (2003) J Clin Invest , vol.112 , pp. 693-706
    • Becker, C.1    Wirtz, S.2    Blessing, M.3
  • 58
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • IVANOV II, ATARASHI K, MANEL N et al.: Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139: 485-98.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3
  • 59
    • 84920052435 scopus 로고    scopus 로고
    • Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease
    • JIANG W, SU J, ZHANG X et al.: Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease. Inflamm Res 2014; 63: 943-50.
    • (2014) Inflamm Res , vol.63 , pp. 943-950
    • Jiang, W.1    Su, J.2    Zhang, X.3
  • 60
    • 80655122800 scopus 로고    scopus 로고
    • TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation
    • OLSEN T, RISMO R, CUI G et al.: TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation. Cytokine 2011; 56: 633-40.
    • (2011) Cytokine , vol.56 , pp. 633-640
    • Olsen, T.1    Rismo, R.2    Cui, G.3
  • 61
    • 63449133361 scopus 로고    scopus 로고
    • Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
    • KLEINSCHEK MA, BONIFACE K, SADEKOVA S et al.: Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J Exp Med 2009; 206: 525-34.
    • (2009) J Exp Med , vol.206 , pp. 525-534
    • Kleinschek, M.A.1    Boniface, K.2    Sadekova, S.3
  • 62
    • 79955835559 scopus 로고    scopus 로고
    • IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo
    • MUDTER J, YU J, ZUFFEREY C et al.: IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo. Inflamm Bowel Dis 2011; 17: 1343-58.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1343-1358
    • Mudter, J.1    Yu, J.2    Zufferey, C.3
  • 63
    • 46749154270 scopus 로고    scopus 로고
    • The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    • MUDTER J, AMOUSSINA L, SCHENK M et al.: The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest 2008; 118: 2415-26.
    • (2008) J Clin Invest , vol.118 , pp. 2415-2426
    • Mudter, J.1    Amoussina, L.2    Schenk, M.3
  • 64
    • 59849114998 scopus 로고    scopus 로고
    • RORγ-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
    • LEPPKES M, BECKER C, IVANOV II et al.: RORγ-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 2009; 136: 257-67.
    • (2009) Gastroenterology , vol.136 , pp. 257-267
    • Leppkes, M.1    Becker, C.2    Ivanov, I.I.3
  • 65
    • 77955890952 scopus 로고    scopus 로고
    • Interleukin-23 drives intestinal inflammation through direct activity on t cells
    • AHERN PP, SCHIERING C, BUONOCORE S et al.: Interleukin-23 drives intestinal inflammation through direct activity on t cells. Immunity 2010; 33: 279-88.
    • (2010) Immunity , vol.33 , pp. 279-288
    • Ahern, P.P.1    Schiering, C.2    Buonocore, S.3
  • 66
    • 65749091607 scopus 로고    scopus 로고
    • A protective function for interleukin 17A in T cell-mediated intestinal inflammation
    • O'CONNOR W, KAMANAKA M, BOOTH CJ et al.: A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 2009; 10: 603-9.
    • (2009) Nat Immunol , vol.10 , pp. 603-609
    • O'connor, W.1    Kamanaka, M.2    Booth, C.J.3
  • 67
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    • OGAWA A, ANDOH A, ARAKI Y, BAMBA T, FUJIYAMA Y: Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol 2004; 110: 55-62.
    • (2004) Clin Immunol , vol.110 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3    Bamba, T.4    Fujiyama, Y.5
  • 68
    • 15844402155 scopus 로고    scopus 로고
    • T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    • FOSSIEZ F, DJOSSOU O, CHOMARAT P et al.: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 1996; 183: 2593-603.
    • (1996) J Exp Med , vol.183 , pp. 2593-2603
    • Fossiez, F.1    Djossou, O.2    Chomarat, P.3
  • 69
    • 0032055597 scopus 로고    scopus 로고
    • IL-17 Stimulates the production and expression of proinflammatory cytokines, IL-β and TNF-α, by human macrophages
    • JOVANOVIC DV, BATTISTA JAD, MARTEL-PELLETIER J et al.: IL-17 Stimulates the production and expression of proinflammatory cytokines, IL-β and TNF-α, by human macrophages. J Immunol 1998; 160: 3513-21.
    • (1998) J Immunol , vol.160 , pp. 3513-3521
    • Jovanovic, D.V.1    Battista, J.A.D.2    Martel-Pelletier, J.3
  • 70
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • PARK H, LI Z, YANG XO et al.: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6: 1133-41.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3
  • 71
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
    • HUEBER W, SANDS BE, LEWITZKY S et al.: Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012; 61: 1693-700.
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 72
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL-17-producing T cells in inflammatory responses
    • HIROTA K, DUARTE JH, VELDHOEN M et al.: Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 2011; 12: 255-63.
    • (2011) Nat Immunol , vol.12 , pp. 255-263
    • Hirota, K.1    Duarte, J.H.2    Veldhoen, M.3
  • 73
    • 58149251898 scopus 로고    scopus 로고
    • Late developmental plasticity in the T helper 17 lineage
    • LEE YK, TURNER H, MAYNARD CL et al.: Late developmental plasticity in the T helper 17 lineage. Immunity 2009; 30: 92-107.
    • (2009) Immunity , vol.30 , pp. 92-107
    • Lee, Y.K.1    Turner, H.2    Maynard, C.L.3
  • 74
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • ANNUNZIATO F, COSMI L, SANTARLASCI V et al.: Phenotypic and functional features of human Th17 cells. J Exp Med 2007; 204: 1849-61.
    • (2007) J Exp Med , vol.204 , pp. 1849-1861
    • Annunziato, F.1    Cosmi, L.2    Santarlasci, V.3
  • 75
    • 80052122798 scopus 로고    scopus 로고
    • Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells
    • SUJINO T, KANAI T, ONO Y et al.: Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells. Gastroenterology 2011; 141: 1014-23.
    • (2011) Gastroenterology , vol.141 , pp. 1014-1023
    • Sujino, T.1    Kanai, T.2    Ono, Y.3
  • 76
    • 84927036250 scopus 로고    scopus 로고
    • TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression
    • LIU H-P, CAO AT, FENG T et al.: TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression. Eur J Immunol 2015; 45: 1010-8.
    • (2015) Eur J Immunol , vol.45 , pp. 1010-1018
    • Liu, H.-P.1    Cao, A.T.2    Feng, T.3
  • 77
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • VELDHOEN M, UYTTENHOVE C, van SNICK J et al.: Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008; 9: 1341-6.
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    Van Snick, J.3
  • 78
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells
    • STAUDT V, BOTHUR E, KLEIN M et al.: Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells. Immunity 2010; 33: 192-202.
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1    Bothur, E.2    Klein, M.3
  • 79
    • 77952584843 scopus 로고    scopus 로고
    • The transcription factor PU.1 is required for the development of interleukin 9-producing T cells and allergic inflammation
    • CHANG H-C, SEHRA S, GOSWAMI R et al.: The transcription factor PU.1 is required for the development of interleukin 9-producing T cells and allergic inflammation. Nat Immunol 2010; 11: 527-34.
    • (2010) Nat Immunol , vol.11 , pp. 527-534
    • Chang, H.-C.1    Sehra, S.2    Goswami, R.3
  • 80
    • 84860342052 scopus 로고    scopus 로고
    • The Unique Features of Th9 Cells and their Products
    • TAN C, GERY I: The Unique Features of Th9 Cells and their Products. Crit Rev Immunol 2012; 32: 1-10.
    • (2012) Crit Rev Immunol , vol.32 , pp. 1-10
    • Tan, C.1    Gery, I.2
  • 81
    • 84884730124 scopus 로고    scopus 로고
    • IL-9 and Th9 cells: progress and challenges
    • ZHAO P, XIAO X, GHOBRIAL RM, LI XC: IL-9 and Th9 cells: progress and challenges. Int Immunol 2013; 25: 547-51.
    • (2013) Int Immunol , vol.25 , pp. 547-551
    • Zhao, P.1    Xiao, X.2    Ghobrial, R.M.3    Li, X.C.4
  • 82
    • 77952583601 scopus 로고    scopus 로고
    • PU.1 regulates TCR expression by modulating GATA-3 activity
    • CHANG H-C, HAN L, JABEEN R et al.: PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol 2009; 183: 4887-94.
    • (2009) J Immunol , vol.183 , pp. 4887-4894
    • Chang, H.-C.1    Han, L.2    Jabeen, R.3
  • 83
    • 56349093347 scopus 로고    scopus 로고
    • Interleukin 4 inhibits TGF-β-induced-Foxp3+T cells and generates, in combination with TGF-β, Foxp3-effector T cells that produce interleukins 9 and 10
    • DARDALHON V, AWASTHI A, KWON H et al.: Interleukin 4 inhibits TGF-β-induced-Foxp3+T cells and generates, in combination with TGF-β, Foxp3-effector T cells that produce interleukins 9 and 10. Nat Immunol 2008; 9: 1347-55.
    • (2008) Nat Immunol , vol.9 , pp. 1347-1355
    • Dardalhon, V.1    Awasthi, A.2    Kwon, H.3
  • 84
    • 84866552162 scopus 로고    scopus 로고
    • OX40 signaling favors the induction of T(H)9 cells and airway inflammation
    • XIAO X, BALASUBRAMANIAN S, LIU W et al.: OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol 2012; 13: 981-90.
    • (2012) Nat Immunol , vol.13 , pp. 981-990
    • Xiao, X.1    Balasubramanian, S.2    Liu, W.3
  • 85
    • 84868611628 scopus 로고    scopus 로고
    • Th9 cells promote antitumor immune responses in vivo
    • LU Y, HONG S, LI H et al.: Th9 cells promote antitumor immune responses in vivo. J Clin Invest 2012; 122: 4160-71.
    • (2012) J Clin Invest , vol.122 , pp. 4160-4171
    • Lu, Y.1    Hong, S.2    Li, H.3
  • 86
    • 84864648969 scopus 로고    scopus 로고
    • Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
    • PURWAR R, SCHLAPBACH C, XIAO S et al.: Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med 2012; 18: 1248-53.
    • (2012) Nat Med , vol.18 , pp. 1248-1253
    • Purwar, R.1    Schlapbach, C.2    Xiao, S.3
  • 87
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • JäGER A, DARDALHON V, SOBEL RA, BETTELLI E, KUCHROO VK: Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol 2009; 183: 7169-77.
    • (2009) J Immunol , vol.183 , pp. 7169-7177
    • Jäger, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 88
    • 84902653958 scopus 로고    scopus 로고
    • TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    • GERLACH K, HWANG Y, NIKOLAEV A et al.: TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol 2014; 15: 676-86.
    • (2014) Nat Immunol , vol.15 , pp. 676-686
    • Gerlach, K.1    Hwang, Y.2    Nikolaev, A.3
  • 89
    • 84928584525 scopus 로고    scopus 로고
    • IL-9 and its receptor are predominantly involved in the pathogenesis of UC
    • NALLEWEG N, CHIRIAC MT, PODSTAWA E et al.: IL-9 and its receptor are predominantly involved in the pathogenesis of UC. Gut 2015; 64: 743-55.
    • (2015) Gut , vol.64 , pp. 743-755
    • Nalleweg, N.1    Chiriac, M.T.2    Podstawa, E.3
  • 90
    • 84949572543 scopus 로고    scopus 로고
    • IL-9 regulates intestinal barrier function in experimental T cell-mediated colitis
    • GERLACH K, McKENZIE AN, NEURATH MF, WEIGMANN B: IL-9 regulates intestinal barrier function in experimental T cell-mediated colitis. Tissue Barriers 2015; 3: e983777.
    • (2015) Tissue Barriers , vol.3
    • Gerlach, K.1    Mckenzie, A.N.2    Neurath, M.F.3    Weigmann, B.4
  • 91
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    • TRIFARI S, KAPLAN CD, TRAN EH, CRELLIN NK, SPITS H: Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol 2009; 10: 864-71.
    • (2009) Nat Immunol , vol.10 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 92
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    • DUHEN T, GEIGER R, JARROSSAY D, LANZAVECCHIA A, SALLUSTO F: Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 2009; 10: 857-63.
    • (2009) Nat Immunol , vol.10 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 93
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • ZENEWICZ LA, YANCOPOULOS GD, VALENZUELA DM et al.: Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008; 29: 947-57.
    • (2008) Immunity , vol.29 , pp. 947-957
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3
  • 94
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • SUGIMOTO K, OGAWA A, MIZOGUCHI E et al.: IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008; 118: 534-44.
    • (2008) J Clin Invest , vol.118 , pp. 534-544
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3
  • 95
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • PICKERT G, NEUFERT C, LEPPKES M et al.: STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 2009; 206: 1465-72.
    • (2009) J Exp Med , vol.206 , pp. 1465-1472
    • Pickert, G.1    Neufert, C.2    Leppkes, M.3
  • 96
    • 84907211086 scopus 로고    scopus 로고
    • STAT3 Activation in Th17 and Th22 Cells Controls IL-22-Mediated Epithelial Host Defense during Infectious Colitis
    • BACKERT I, KORALOV SB, WIRTZ S et al.: STAT3 Activation in Th17 and Th22 Cells Controls IL-22-Mediated Epithelial Host Defense during Infectious Colitis. J Immunol 2014; 193: 3779-91.
    • (2014) J Immunol , vol.193 , pp. 3779-3791
    • Backert, I.1    Koralov, S.B.2    Wirtz, S.3
  • 97
    • 84864966419 scopus 로고    scopus 로고
    • Healing of intestinal inflammation by IL-22
    • MIZOGUCHI A: Healing of intestinal inflammation by IL-22. Inflamm Bowel Dis 2012; 18: 1777-84.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1777-1784
    • Mizoguchi, A.1
  • 98
    • 79959918506 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract
    • 248.e1
    • MONTELEONE I, RIZZO A, SARRA M et al.: Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology 2011; 141: 237-48, 248.e1.
    • (2011) Gastroenterology , vol.141 , pp. 237-248
    • Monteleone, I.1    Rizzo, A.2    Sarra, M.3
  • 99
    • 79954608756 scopus 로고    scopus 로고
    • Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
    • KAMANAKA M, HUBER S, ZENEWICZ LA et al.: Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J Exp Med 2011; 208: 1027-40.
    • (2011) J Exp Med , vol.208 , pp. 1027-1040
    • Kamanaka, M.1    Huber, S.2    Zenewicz, L.A.3
  • 100
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • HORI S, NOMURA T, SAKAGUCHI S: Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 101
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • FONTENOT JD, GAVIN MA, RUDENSKY AY: Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-6.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 102
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • ZHENG Y, JOSEFOWICZ S, CHAUDHRY A et al.: Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010; 463: 808-12.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3
  • 103
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • ALMEIDA ARM, LEGRAND N, PAPIERNIK M, FREITAS AA: Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 2002; 169: 4850-60.
    • (2002) J Immunol , vol.169 , pp. 4850-4860
    • Almeida, A.R.M.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 104
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • CHEN W, JIN W, HARDEGEN N et al.: Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-86.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 105
    • 0034894059 scopus 로고    scopus 로고
    • Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
    • MONTELEONE G, KUMBEROVA A, CROFT NM et al.: Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest 2001; 108: 601-9.
    • (2001) J Clin Invest , vol.108 , pp. 601-609
    • Monteleone, G.1    Kumberova, A.2    Croft, N.M.3
  • 106
    • 0035876913 scopus 로고    scopus 로고
    • A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood
    • YAMAGIWA S, GRAY JD, HASHIMOTO S, HORWITZ DA: A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 2001; 166: 7282-9.
    • (2001) J Immunol , vol.166 , pp. 7282-7289
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 107
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • MUCIDA D, PARK Y, KIM G et al.: Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007; 317: 256-60.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3
  • 108
    • 70349635629 scopus 로고    scopus 로고
    • All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis
    • BAI A, LU N, GUO Y et al.: All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. J Leukoc Biol 2009; 86: 959-69.
    • (2009) J Leukoc Biol , vol.86 , pp. 959-969
    • Bai, A.1    Lu, N.2    Guo, Y.3
  • 109
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • SMITH PM, HOWITT MR, PANIKOV N et al.: The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569-73.
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3
  • 110
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • FURUSAWA Y, OBATA Y, FUKUDA S et al.: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013; 504: 446-50.
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3
  • 111
    • 0034960320 scopus 로고    scopus 로고
    • TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
    • CHEN W, FRANK ME, JIN W, WAHL SM: TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001; 14: 715-25.
    • (2001) Immunity , vol.14 , pp. 715-725
    • Chen, W.1    Frank, M.E.2    Jin, W.3    Wahl, S.M.4
  • 112
    • 62949223226 scopus 로고    scopus 로고
    • Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
    • e1-3
    • FANTINI MC, RIZZO A, FINA D et al.: Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 2009; 136: 1308-16, e1-3.
    • (2009) Gastroenterology , vol.136 , pp. 1308-1316
    • Fantini, M.C.1    Rizzo, A.2    Fina, D.3
  • 113
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • RUBTSOV YP, RASMUSSEN JP, CHI EY et al.: Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008; 28: 546-58.
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3
  • 114
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • COLLISON LW, WORKMAN CJ, KUO TT et al.: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007; 450: 566-9.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 115
    • 33749132564 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
    • READ S, GREENWALD R, IZCUE A et al.: Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 2006; 177: 4376-83.
    • (2006) J Immunol , vol.177 , pp. 4376-4383
    • Read, S.1    Greenwald, R.2    Izcue, A.3
  • 116
    • 33846011898 scopus 로고    scopus 로고
    • GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice
    • SANTUCCI L, AGOSTINI M, BRUSCOLI S et al.: GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice. Gut 2007; 56: 52-60.
    • (2007) Gut , vol.56 , pp. 52-60
    • Santucci, L.1    Agostini, M.2    Bruscoli, S.3
  • 117
    • 33847376532 scopus 로고    scopus 로고
    • Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells
    • GARíN MI, CHU C-C, GOLSHAYAN D et al.: Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 2007; 109: 2058-65.
    • (2007) Blood , vol.109 , pp. 2058-2065
    • Garín, M.I.1    Chu, C.-C.2    Golshayan, D.3
  • 118
    • 0030018186 scopus 로고    scopus 로고
    • T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    • DAVIDSON NJ, LEACH MW, FORT MM et al.: T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 1996; 184: 241-51.
    • (1996) J Exp Med , vol.184 , pp. 241-251
    • Davidson, N.J.1    Leach, M.W.2    Fort, M.M.3
  • 119
    • 0034924028 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
    • HAHM KB, IM YH, PARKS TW et al.: Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001; 49: 190-8.
    • (2001) Gut , vol.49 , pp. 190-198
    • Hahm, K.B.1    Im, Y.H.2    Parks, T.W.3
  • 120
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • POWRIE F, LEACH MW, MAUZE S, CADDLE LB, COFFMAN RL: Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 1993; 5: 1461-71.
    • (1993) Int Immunol , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 121
    • 33646251141 scopus 로고    scopus 로고
    • Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
    • FANTINI MC, BECKER C, TUBBE I et al.: Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 2006; 55: 671-80.
    • (2006) Gut , vol.55 , pp. 671-680
    • Fantini, M.C.1    Becker, C.2    Tubbe, I.3
  • 122
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • ASSEMAN C, MAUZE S, LEACH MW, COFFMAN RL, POWRIE F: An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190: 995-1004.
    • (1999) J Exp Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 123
    • 1642577126 scopus 로고    scopus 로고
    • TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    • NAKAMURA K, KITANI A, FUSS I et al.: TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 2004; 172: 834-42.
    • (2004) J Immunol , vol.172 , pp. 834-842
    • Nakamura, K.1    Kitani, A.2    Fuss, I.3
  • 124
    • 20444434616 scopus 로고    scopus 로고
    • Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease
    • MAUL J, LODDENKEMPER C, MUNDT P et al.: Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 2005; 128: 1868-78.
    • (2005) Gastroenterology , vol.128 , pp. 1868-1878
    • Maul, J.1    Loddenkemper, C.2    Mundt, P.3
  • 125
    • 34249309861 scopus 로고    scopus 로고
    • Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis
    • YU QT, SARUTA M, AVANESYAN A et al.: Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis 2007; 13: 191-9.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 191-199
    • Yu, Q.T.1    Saruta, M.2    Avanesyan, A.3
  • 126
    • 84868109200 scopus 로고    scopus 로고
    • Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease
    • 1207-17.e1-2
    • DESREUMAUX P, FOUSSAT A, ALLEZ M et al.: Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology 2012; 143: 1207-17.e1-2.
    • (2012) Gastroenterology , vol.143
    • Desreumaux, P.1    Foussat, A.2    Allez, M.3
  • 127
    • 84925064199 scopus 로고    scopus 로고
    • Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease
    • MONTELEONE G, NEURATH MF, ARDIZZONE S et al.: Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med 2015; 372: 1104-13.
    • (2015) N Engl J Med , vol.372 , pp. 1104-1113
    • Monteleone, G.1    Neurath, M.F.2    Ardizzone, S.3
  • 128
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: the leukocyte adhesion cascade updated
    • LEY K, LAUDANNA C, CYBULSKY MI, NOURSHARGH S: Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 2007; 7: 678-89.
    • (2007) Nat Rev Immunol , vol.7 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 129
    • 77951597881 scopus 로고    scopus 로고
    • Breaching multiple barriers: leukocyte motility through venular walls and the interstitium
    • NOURSHARGH S, HORDIJK PL, SIXT M: Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol 2010; 11: 366-78.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 366-378
    • Nourshargh, S.1    Hordijk, P.L.2    Sixt, M.3
  • 130
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • GHOSH S, GOLDIN E, GORDON FH et al.: Natalizumab for active Crohn's disease. N Engl J Med 2003; 348: 24-32.
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1    Goldin, E.2    Gordon, F.H.3
  • 131
    • 22844445587 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
    • VAN ASSCHE G, VAN RANST M, SCIOT R et al.: Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 2005; 353: 362-8.
    • (2005) N Engl J Med , vol.353 , pp. 362-368
    • Van Assche, G.1    Van Ranst, M.2    Sciot, R.3
  • 132
    • 84882769357 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for ulcerative colitis
    • FEAGAN BG, RUTGEERTS P, SANDS BE et al.: Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med 2013; 369: 699-710.
    • (2013) N Engl J Med , vol.369 , pp. 699-710
    • Feagan, B.G.1    Rutgeerts, P.2    Sands, B.E.3
  • 133
    • 84882749768 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for Crohn's disease
    • SANDBORN WJ, FEAGAN BG, RUTGEERTS P et al.: Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med 2013; 369: 711-21.
    • (2013) N Engl J Med , vol.369 , pp. 711-721
    • Sandborn, W.J.1    Feagan, B.G.2    Rutgeerts, P.3
  • 134
    • 0032797272 scopus 로고    scopus 로고
    • Chemokines and Cell Migration in Secondary Lymphoid Organs
    • CYSTER JG: Chemokines and Cell Migration in Secondary Lymphoid Organs. Science 1999; 286: 2098-102.
    • (1999) Science , vol.286 , pp. 2098-2102
    • Cyster, J.G.1
  • 136
    • 26844538936 scopus 로고    scopus 로고
    • Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
    • JOHANSSON-LINDBOM B, SVENSSON M, PABST O et al.: Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 2005; 202: 1063-73.
    • (2005) J Exp Med , vol.202 , pp. 1063-1073
    • Johansson-Lindbom, B.1    Svensson, M.2    Pabst, O.3
  • 137
    • 5644300399 scopus 로고    scopus 로고
    • Retinoic acid imprints gut-homing specificity on T cells
    • IWATA M, HIRAKIYAMA A, ESHIMA Y et al.: Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004; 21: 527-38.
    • (2004) Immunity , vol.21 , pp. 527-538
    • Iwata, M.1    Hirakiyama, A.2    Eshima, Y.3
  • 138
    • 0030802049 scopus 로고    scopus 로고
    • Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue
    • BRISKIN M, WINSOR-HINES D, SHYJAN A et al.: Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol 1997; 151: 97-110.
    • (1997) Am J Pathol , vol.151 , pp. 97-110
    • Briskin, M.1    Winsor-Hines, D.2    Shyjan, A.3
  • 139
    • 53849098346 scopus 로고    scopus 로고
    • T-cell recruitment to the intestinal mucosa
    • AGACE WW: T-cell recruitment to the intestinal mucosa. Trends Immunol 2008; 29: 514.22.
    • (2008) Trends Immunol , vol.29 , pp. 514-522
    • Agace, W.W.1
  • 140
    • 84927173528 scopus 로고    scopus 로고
    • Targeting Leukocyte Trafficking for the Treatment of Inflammatory Bowel Disease
    • ARSENEAU K, COMINELLI F: Targeting Leukocyte Trafficking for the Treatment of Inflammatory Bowel Disease. Clin Pharmacol Ther 2015; 97: 22-8.
    • (2015) Clin Pharmacol Ther , vol.97 , pp. 22-28
    • Arseneau, K.1    Cominelli, F.2
  • 141
    • 84944887463 scopus 로고    scopus 로고
    • OP021. TURANDOT: a randomized, multicenter double-blind, placebo-controlled study of the safety and efficacy of Anti-MAdCAM Antibody PF-00547659 (PF) in patients with moderate to severe Ulcerative Colitis (UC)
    • VERMEIRE S, SANDBORN W, DANESE S et al.: OP021. TURANDOT: a randomized, multicenter double-blind, placebo-controlled study of the safety and efficacy of Anti-MAdCAM Antibody PF-00547659 (PF) in patients with moderate to severe Ulcerative Colitis (UC). J Crohns Colitis 2015; 9: S13-S13.
    • (2015) J Crohns Colitis , vol.9 , pp. S13-S13
    • Vermeire, S.1    Sandborn, W.2    Danese, S.3
  • 142
    • 84904857048 scopus 로고    scopus 로고
    • Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial
    • VERMEIRE S, O'BYRNE S, KEIR M et al.: Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet 2014; 384: 309-18.
    • (2014) Lancet , vol.384 , pp. 309-318
    • Vermeire, S.1    O'byrne, S.2    Keir, M.3
  • 143
    • 7244248660 scopus 로고    scopus 로고
    • CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes
    • ERICSSON A, SVENSSON M, ARYA A, AGACE WW: CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes. Eur J Immunol 2004; 34: 2720-9.
    • (2004) Eur J Immunol , vol.34 , pp. 2720-2729
    • Ericsson, A.1    Svensson, M.2    Arya, A.3    Agace, W.W.4
  • 144
    • 0027324601 scopus 로고
    • Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells
    • CEPEK KL, PARKER CM, MADARA JL, BRENNER MB: Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol 1993; 150: 3459-70.
    • (1993) J Immunol , vol.150 , pp. 3459-3470
    • Cepek, K.L.1    Parker, C.M.2    Madara, J.L.3    Brenner, M.B.4
  • 145
    • 0033151953 scopus 로고    scopus 로고
    • Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice
    • SCHöN MP, ARYA A, MURPHY EA et al.: Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol 1999; 162: 6641-9.
    • (1999) J Immunol , vol.162 , pp. 6641-6649
    • Schön, M.P.1    Arya, A.2    Murphy, E.A.3
  • 146
    • 3242737793 scopus 로고    scopus 로고
    • Differential expression of homing receptor CD103 on lamina propria lymphocytes and association of CD103 with epithelial adhesion molecules in inflammatory bowel disease
    • OSHITANI N, WATANABE K, MAEDA K et al.: Differential expression of homing receptor CD103 on lamina propria lymphocytes and association of CD103 with epithelial adhesion molecules in inflammatory bowel disease. Int J Mol Med 2003; 12: 715-9.
    • (2003) Int J Mol Med , vol.12 , pp. 715-719
    • Oshitani, N.1    Watanabe, K.2    Maeda, K.3
  • 147
    • 0035284821 scopus 로고    scopus 로고
    • Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction
    • STRAUCH UG, MUELLER RC, LI XY et al.: Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction. J Immunol 2001; 166: 3506-14.
    • (2001) J Immunol , vol.166 , pp. 3506-3514
    • Strauch, U.G.1    Mueller, R.C.2    Li, X.Y.3
  • 148
    • 84879254845 scopus 로고    scopus 로고
    • GPR15-mediated homing controls immune homeostasis in the large intestine mucosa
    • KIM SV, XIANG WV, KWAK C et al.: GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science 2013; 340: 1456-9.
    • (2013) Science , vol.340 , pp. 1456-1459
    • Kim, S.V.1    Xiang, W.V.2    Kwak, C.3
  • 149
    • 84922979974 scopus 로고    scopus 로고
    • Role and species-specific expression of colon T cell homing receptor GPR15 in colitis
    • NGUYEN LP, PAN J, DINH TT et al.: Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol 2015; 16: 207-13.
    • (2015) Nat Immunol , vol.16 , pp. 207-213
    • Nguyen, L.P.1    Pan, J.2    Dinh, T.T.3
  • 150
    • 84990305440 scopus 로고    scopus 로고
    • Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo
    • Jul 24 [Epub ahead of print]
    • FISCHER A, ZUNDLER S, ATREYA R, et al: Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut 2015 Jul 24 [Epub ahead of print].
    • (2015) Gut
    • Fischer, A.1    Zundler, S.2    Atreya, R.3
  • 151
    • 84896117860 scopus 로고    scopus 로고
    • In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease
    • ATREYA R, NEUMANN H, NEUFERT C et al.: In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med 2014; 20: 313-8.
    • (2014) Nat Med , vol.20 , pp. 313-318
    • Atreya, R.1    Neumann, H.2    Neufert, C.3
  • 152
    • 35948936386 scopus 로고    scopus 로고
    • Two heads are better than one
    • MORRISON SL: Two heads are better than one. Nat Biotechnol 2007; 25: 1233-4.
    • (2007) Nat Biotechnol , vol.25 , pp. 1233-1234
    • Morrison, S.L.1
  • 153
    • 84890608517 scopus 로고    scopus 로고
    • Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice
    • 210-21.e13
    • HANSON ML, HIXON JA, LI W et al.: Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice. Gastroenterology 2014; 146: 210-21.e13.
    • (2014) Gastroenterology , vol.146
    • Hanson, M.L.1    Hixon, J.A.2    Li, W.3
  • 154
    • 77249133143 scopus 로고    scopus 로고
    • Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
    • VANDENBROUCKE K, de HAARD H, BEIRNAERT E et al.: Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis. Mucosal Immunol 2009; 3: 49-56.
    • (2009) Mucosal Immunol , vol.3 , pp. 49-56
    • Vandenbroucke, K.1    De Haard, H.2    Beirnaert, E.3


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