5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

Nature Communications

Volumn 2, Issue 1, 2011, Pages

  Wossidlo, Mark ^a   Nakamura, Toshinobu ^b   Lepikhov, Konstantin ^a   Marques, C Joana ^c   Zakhartchenko, Valeri ^d   Boiani, Michele ^e   Arand, Julia ^a   Nakano, Toru ^b   Reik, Wolf ^c,f   Walter, Jörn ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b OSAKA UNIVERSITY   (Japan)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d UNIVERSITY OF MUNICH   (Germany)

^e MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; DIOXYGENASE; PGC7 PROTEIN; PROTEIN; TET1 PROTEIN; TET2 PROTEIN; TET3 PROTEIN; UNCLASSIFIED DRUG; 5-HYDROXYMETHYLCYTOSINE; CYTOSINE; DNA BINDING PROTEIN; DPPA3 PROTEIN, MOUSE; DRUG DERIVATIVE; ONCOPROTEIN; REPRESSOR PROTEIN; TET3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; COW; DEMETHYLATION; DNA METHYLATION; DNA REPLICATION; EMBRYO; EPIGENETICS; FEMALE; MOUSE; NONHUMAN; OXIDATION; PRONUCLEUS; RABBIT; ZYGOTE; ANIMAL; ANIMAL EMBRYO; CATTLE; CELL NUCLEUS; CELL NUCLEUS TRANSPLANTATION; CYTOLOGY; FERTILIZATION IN VITRO; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MAMMAL; METABOLISM; MOUSE MUTANT; OXIDATION REDUCTION REACTION; PRENATAL DEVELOPMENT; SEX DIFFERENCE;

BOVINAE; MAMMALIA; ORYCTOLAGUS CUNICULUS;

5-METHYLCYTOSINE; ANIMALS; CATTLE; CELL NUCLEUS; CYTOSINE; DNA METHYLATION; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; EPIGENOMICS; FEMALE; FERTILIZATION IN VITRO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; MAMMALS; MICE; MICE, KNOCKOUT; NUCLEAR TRANSFER TECHNIQUES; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS; RABBITS; REPRESSOR PROTEINS; SEX FACTORS; ZYGOTE;

EID: 79952713567     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1240     Document Type: Article

References (33)

1. Reik, W., Dean, W. & Walter, J. Epigenetic reprogramming in mammalian development. Science 293, 1089-1093 (2001). (Pubitemid 32758081)
2. Sasaki, H. & Matsui, Y. Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev. Genet 9, 129-140 (2008).
3. Surani, M. A., Hayashi, K. & Hajkova, P. Genetic and epigenetic regulators of pluripotency. Cell 128, 747-762 (2007). (Pubitemid 46273582)
4. Mayer, W., Niveleau, A., Walter, J., Fundele, R. & Haaf, T. Demethylation of the zygotic paternal genome. Nature 403, 501-502 (2000). (Pubitemid 30082186)
5. Dean, W. et al Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc. Natl Acad. Sci. USA 98, 13734-13738 (2001). (Pubitemid 33115967)
6. Santos, F., Hendrich, B., Reik, W. & Dean, W. Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev. Biol. 241, 172-182 (2002). (Pubitemid 34066770)
7. Wossidlo, M. et al Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes. Embo. J. 29, 1877-1888 (2010).
8. Gehring, M., Reik, W. & Henikof, S. DNA demethylation by DNA repair. Trends Genet 25, 82-90 (2009).
9. Wu, S. C & Zhang, Y. Active DNA demethylation: many roads lead to Rome. Nat Rev. Mol. Cell Biol. 11, 607-620 (2010).
10. Sanz, L. A., Kota, S. K. & Feil, R. Genome-wide DNA demethylation in mammals. Genome Biol. 11, 110 (2010).
11. Kriaucionis, S. & Heintz, N. Te nuclear DNA base 5- hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324, 929-930 (2009).
12. Tahiliani, M. et al Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).
13. Huang, Y. et al Te behaviour of 5-hydroxymethylcytosine in bisulfte sequencing. PLoS One 5, e8888 (2010).
14. Ito, S. et al. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specifcation. Nature 466, 1129-1133 (2010).
15. Sutherland, E., Coe, L. & Raleigh, E. A. McrBC: a multisubunit GTP-dependent restriction endonuclease. J. Mol. Biol. 225, 327-348 (1992).
16. Koji, T., Kondo, S., Hishikawa, Y, An, S. & Sato, Y In situ detection of methylated DNA by histo endonuclease-linked detection of methylated DNA sites: a new principle of analysis of DNA methylation. Histochem. Cell Biol. 130, 917-925 (2008).
17. Lepikhov, K. et al. Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes. Epigenetics Chromatin 1, 8 (2008).
18. Liutkeviciute, Z., Lukinavicius, G., Masevicius, V., Daujotyte, D. & Klimasauskas, S. Cytosine-5-methyltransferases add aldehydes to DNA. Nat Chem. Biol. 5, 400-402 (2009).
19. Okada, Y, Yamagata, K., Hong, K., Wakayama, T. & Zhang, Y A role for the elongator complex in zygotic paternal genome demethylation. Nature 463, 554-558 (2010).
20. Nakamura, T. et al. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat. Cell Biol. 9, 64-71 (2007). (Pubitemid 46024198)
21. Oswald, J. et al. Active demethylation of the paternal genome in the mouse zygote. Curr. Biol. 10, 475-478 (2000). (Pubitemid 30247337)
22. Lane, N. et al. Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis 35, 88-93 (2003). (Pubitemid 36330631)
23. Hajkova, P. et al. Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway Science 329, 78-82 (2010).
24. Valinluck, V. et al. Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic. Acids Res. 32, 4100-4108 (2004). (Pubitemid 39232282)
25. Walter, J. An Epigenetic Tet a Tet with Pluripotency Cell Stem Cell 8, 121-122 (2011).
26. Koh, K. P. et al. Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine production and cell lineage specifcation in mouse embryonic stem cells. Cell Stem Cell 8, 200-213 (2011).
27. Nagy, A. Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Laboratory Press, 2003).
28. Adenot, P. G., Mercier, Y, Renard, J. P. & Tompson, E. M. Diferential H4 acetylation of paternal and maternal chromatin precedes DNA replication and diferential transcriptional activity in pronuclei of 1-cell mouse embryos. Development 124, 4615-4625 (1997). (Pubitemid 27519256)
29. Hiendleder, S. et al. Tissue-specifc elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques. Biol. Reprod. 71, 217-223 (2004). (Pubitemid 38915328)
30. Shi, W., Dirim, F., Wolf, E., Zakhartchenko, V. & Haaf, T. Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos. Biol. Reprod. 71, 340-347 (2004). (Pubitemid 38915341)
31. Galat, V., Lagutina, I., Mezina, M., Prokofev, M. I. & Zakhartchenko, V Efect of donor cell age on the efciency of nuclear transfer in rabbits. Reprod. Biomed. Online 4, 32-37 (2002).
32. Boiani, M., Eckardt, S., Scholer, H. R. & McLaughlin, K. J. Oct4 distribution and level in mouse clones: consequences for pluripotency Genes Dev. 16, 1209-1219 (2002). (Pubitemid 34553102)
33. Hellemans, J., Mortier, G., De Paepe, A., Speleman, F. & Vandesompele, J. qBase relative quantifcation framework and sofware for management and automated analysis of real-time quantitative PCR data. Genome Biol. 8, R19 (2007).