Plant protein and animal proteins: Do they differentially affect cardiovascular disease risk?

Advances in Nutrition

Volumn 6, Issue 6, 2015, Pages 712-728

  Richter, Chesney K ^a   Skulas Ray, Ann C ^a   Champagne, Catherine M ^b   Kris Etherton, Penny M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Amino acids; Cardiovascular diseases; DASH diet; Intestinal microbiota; OmniHeart

Indexed keywords

PLANT PROTEIN; PROTEIN INTAKE;

ADMINISTRATION AND DOSAGE; ADULT; AGED; ANIMAL; CARDIOVASCULAR DISEASES; DIET; FEMALE; FOOD; FRUIT; HUMAN; HYPERTENSION; INTESTINE FLORA; MALE; MIDDLE AGED; PROTEIN INTAKE; RISK FACTOR; VEGETABLE;

ADULT; AGED; ANIMALS; CARDIOVASCULAR DISEASES; DIET; DIETARY PROTEINS; FEMALE; FOOD; FRUIT; GASTROINTESTINAL MICROBIOME; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PLANT PROTEINS; RISK FACTORS; VEGETABLES;

EID: 84953213405     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.115.009654     Document Type: Review

References (111)

1. Hu FB. Protein, body weight, and cardiovascular health. Am J ClinNutr 2005;82(1 Suppl):242S-7S.
2. Leidy HJ, Clifton PM, Astrup A, Wycherley TP, Westerterp-PlantengaMS, Luscombe-Marsh ND, Woods SC, Mattes RD. The role of proteinin weight loss and maintenance. Am J Clin Nutr 2015;101:1320S-9S.
3. Vasdev S, Stuckless J. Antihypertensive effects of dietary protein andits mechanism. Int J Angiol 2010;19:e7-20.
4. Institute of Medicine, Food and Nutrition Board. Dietary reference intakesfor energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein,and amino acids. Washington (DC): Institute of Medicine; 2005.
5. Rodriguez NR, Miller SL. Effective translation of current dietary guidance:understanding and communicating the concepts of minimal andoptimal levels of dietary protein. Am J Clin Nutr 2015;101:1353S-8S.
6. US Department of Agriculture and US Department of Health and HumanServices. Report of the Dietary Guidelines Advisory Committeeon the Dietary Guidelines for Americans, 2010. Washington (DC):USDA and US Department of Health and Human Services; 2010.
7. Office of Disease Prevention and Health Promotion, 2015 DietaryGuidelines Advisory Committee. Scientific Report of the 2015 DietaryGuidelines Advisory Committee. Washington (DC): Office of DiseasePrevention and Health Promotion; 2015.
8. Sacks FM, Rosner B, Kass EH. Blood pressure in vegetarians. Am J Epidemiol1974;100:390-8.
9. Armstrong B, van Merwyk AJ, Coates H. Blood pressure in SeventhdayAdventist vegetarians. Am J Epidemiol 1977;105:444-9.
10. Sacks FM, Castelli WP, Donner A, Kass EH. Plasma lipids and lipoproteinsin vegetarians and controls. N Engl J Med 1975;292:1148-51.
11. Beilin LJ. Vegetarian and other complex diets, fats, fiber, and hypertension.Am J Clin Nutr 1994;59(5 Suppl):1130S-5S.
12. Wang YF, Yancy WS, Jr., Yu D, Champagne C, Appel LJ, Lin PH. Therelationship between dietary protein intake and blood pressure: resultsfrom the PREMIER study. J Hum Hypertens 2008;22:745-54.
13. Obarzanek E, Velletri PA, Cutler JA. Dietary protein and blood pressure.JAMA 1996;275:1598-603.
14. Teunissen-Beekman KF, van Baak MA. The role of dietary protein inblood pressure regulation. Curr Opin Lipidol 2013;24:65-70.
15. Appel LJ. The effects of protein intake on blood pressure and cardiovasculardisease. Curr Opin Lipidol 2003;14:55-9.
16. Stamler J, Liu K, Ruth KJ, Pryer J, Greenland P. Eight-year blood pressurechange in middle-aged men: relationship to multiple nutrients.Hypertension 2002;39:1000-6.
17. Elliott P, Stamler J, Dyer AR, Appel L, Dennis B, Kesteloot H, UeshimaH, Okayama A, Chan Q, Garside DB, et al. Association between proteinintake and blood pressure: the INTERMAP Study. Arch InternMed 2006;166:79-87.
18. Kihara M, Fujikawa J, Ohtaka M, Mano M, Nara Y, Horie R, TsunematsuT, Note S, Fukase M, Yamori Y. Interrelationships betweenblood pressure, sodium, potassium, serum cholesterol, and protein intakein Japanese. Hypertension 1984;6:736-42.
19. Zhou B, Zhang X, Zhu A, Zhao L, Zhu S, Ruan L, Zhu L, Liang S. Therelationship of dietary animal protein and electrolytes to blood pressure: astudy on three Chinese populations. Int J Epidemiol 1994;23:716-22.
20. Zhou BF, Wu XG, Tao SQ, Yang J, Cao TX, Zheng RP, Tian XZ, Lu CQ,Miao HY, Ye FM, et al. Dietary patterns in 10 groups and the relationshipwith blood pressure. Collaborative Study Group for CardiovascularDiseases and Their Risk Factors. Chin Med J (Engl) 1989;102:257-61.
21. Altorf-van der Kuil W, Engberink MF, Brink EJ, van Baak MA, BakkerSJ, Navis G, van 't Veer P, Geleijnse JM. Dietary protein and bloodpressure: a systematic review. PLoS One 2010;5:e12102.
22. Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Speizer FE,Hennekens CH, Willett WC. Dietary protein and risk of ischemicheart disease in women. Am J Clin Nutr 1999;70:221-7.
23. Kelemen LE, Kushi LH, Jacobs DR, Jr., Cerhan JR. Associations of dietaryprotein with disease and mortality in a prospective study of postmenopausalwomen. Am J Epidemiol 2005;161:239-49.
24. Halton TL, Willett WC, Liu S, Manson JE, Albert CM, Rexrode K, HuFB. Low-carbohydrate-diet score and the risk of coronary heart diseasein women. N Engl J Med 2006;355:1991-2002.
25. Sinha R, Cross AJ, Graubard BI, Leitzmann MF, Schatzkin A. Meat intakeand mortality: a prospective study of over half a million people.Arch Intern Med 2009;169:562-71.
26. Bernstein AM, Sun Q, Hu FB, Stampfer MJ, Manson JE, Willett WC.Major dietary protein sources and risk of coronary heart disease inwomen. Circulation 2010;122:876-83.
27. Preis SR, Stampfer MJ, Spiegelman D, Willett WC, Rimm EB. Dietaryprotein and risk of ischemic heart disease in middle-aged men. Am JClin Nutr 2010;92:1265-72.
28. Preis SR, Stampfer MJ, Spiegelman D, Willett WC, Rimm EB. Lack ofassociation between dietary protein intake and risk of stroke amongmiddle-aged men. Am J Clin Nutr 2010;91:39-45.
29. Fung TT, van Dam RM, Hankinson SE, Stampfer M, Willett WC, HuFB. Low-carbohydrate diets and all-cause and cause-specific mortality:two cohort studies. Ann Intern Med 2010;153:289-98.
30. Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Stampfer MJ,Willett WC, Hu FB. Red meat consumption and mortality: resultsfrom 2 prospective cohort studies. Arch Intern Med 2012;172:555-63.
31. Rohrmann S, Overvad K, Bueno-de-Mesquita HB, Jakobsen MU,Egeberg R, Tjonneland A, Nailler L, Boutron-Ruault MC, Clavel-Chapelon F, Krogh V, et al. Meat consumption and mortality-results from the European Prospective Investigation into Cancerand Nutrition. BMC Med 2013;11:63.
32. Kaluza J, Akesson A, Wolk A. Processed and unprocessed red meatconsumption and risk of heart failure: prospective study of men.Circ Heart Fail 2014;7:552-7.
33. American Heart Association [Internet]. Dallas: The Association.What is a serving? [cited 2015 Jul 22]. Available from: http://www.heart.org/HEARTORG/Caregiver/Replenish/WhatisaServing/What-isa-Serving_UCM_301838_Article.jsp.
34. Micha R, Wallace SK, Mozaffarian D. Red and processed meat consumptionand risk of incident coronary heart disease, stroke, and diabetesmellitus: a systematic review and meta-analysis. Circulation2010;121:2271-83.
35. National Cancer Institute Applied Research Program [Internet].Bethesda (MD): National Cancer Institute Applied Research Program[updated 2013 Oct 18; cited 2015 Jan 3]. Available from: http://appliedresearch.cancer.gov/diet/foodsources/sat_fat/sf.html.
36. Micha R, Michas G, Mozaffarian D. Unprocessed red and processedmeats and risk of coronary artery disease and type 2 diabetes-an updatedreview of the evidence. Curr Atheroscler Rep 2012;14:515-24.
37. Zhang Z, Xu G, Yang F, Zhu W, Liu X. Quantitative analysis of dietaryprotein intake and stroke risk. Neurology 2014;83:19-25.
38. Lagiou P, Sandin S, Weiderpass E, Lagiou A, Mucci L, Trichopoulos D,Adami HO. Low carbohydrate-high protein diet and mortality in a cohortof Swedish women. J Intern Med 2007;261:366-74.
39. Willett WC. Low-carbohydrate diets: a place in health promotion? JIntern Med 2007;261:363-5.
40. Gross LS, Li L, Ford ES, Liu S. Increased consumption of refined carbohydratesand the epidemic of type 2 diabetes in the United States:an ecologic assessment. Am J Clin Nutr 2004;79:774-9.
41. Liu S, Manson JE. Dietary carbohydrates, physical inactivity, obesity,and the 'metabolic syndrome' as predictors of coronary heart disease.Curr Opin Lipidol 2001;12:395-404.
42. Hu FB, van Dam RM, Liu S. Diet and risk of type II diabetes: the roleof types of fat and carbohydrate. Diabetologia 2001;44:805-17.
43. Reaven GM. Relationships among insulin resistance, type 2 diabetes,essential hypertension, and cardiovascular disease: similarities and differences.J Clin Hypertens (Greenwich) 2011;13:238-43.
44. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndromeresponsible for NIDDM, obesity, hypertension, dyslipidemia,and atherosclerotic cardiovascular disease. Diabetes Care 1991;14:173-94.
45. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic featureof primary hypertension independent of obesity. Metabolism1990;39:167-74.
46. Kopp W. Pathogenesis and etiology of essential hypertension: role ofdietary carbohydrate. Med Hypotheses 2005;64:782-7.
47. Anderson JW, Baird P, Davis RH, Jr., Ferreri S, Knudtson M, KoraymA, Waters V, Williams CL. Health benefits of dietary fiber. Nutr Rev2009;67:188-205.
48. Champagne CM. Magnesium in hypertension, cardiovascular disease,metabolic syndrome, and other conditions: a review. Nutr Clin Pract2008;23:142-51.
49. D'Elia L, Barba G, Cappuccio FP, Strazzullo P. Potassium intake,stroke, and cardiovascular disease a meta-analysis of prospective studies.J Am Coll Cardiol 2011;57:1210-9.
50. Obarzanek E, Sacks FM, Vollmer WM, Bray GA, Miller ER, 3rd, LinPH, Karanja NM, Most-Windhauser MM, Moore TJ, Swain JF, et al.Effects on blood lipids of a blood pressure-lowering diet: the DietaryApproaches to Stop Hypertension (DASH) Trial. Am J Clin Nutr2001;74:80-9.
51. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, SacksFM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, et al. A clinicaltrial of the effects of dietary patterns on blood pressure. DASH CollaborativeResearch Group. N Engl J Med 1997;336:1117-24.
52. Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller, 3rd ER,Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, et al. Effects of protein,monounsaturated fat, and carbohydrate intake on blood pressureand serum lipids: results of the OmniHeart randomized trial. JAMA2005;294:2455-64.
53. Roussell MA, Hill AM, Gaugler TL, West SG, Heuvel JP, Alaupovic P,Gillies PJ, Kris-Etherton PM. Beef in an Optimal Lean Diet study: effectson lipids, lipoproteins, and apolipoproteins. Am J Clin Nutr2012;95:9-16.
54. Sacks FM, Obarzanek E, Windhauser MM, Svetkey LP, Vollmer WM,McCullough M, Karanja N, Lin PH, Steele P, Proschan MA, et al. Rationaleand design of the Dietary Approaches to Stop Hypertensiontrial (DASH). A multicenter controlled-feeding study of dietary patternsto lower blood pressure. Ann Epidemiol 1995;5:108-18.
55. Roussell MA, Hill AM, Gaugler TL, West SG, Ulbrecht JS, VandenHeuvel JP, Gillies PJ, Kris-Etherton PM. Effects of a DASH-like dietcontaining lean beef on vascular health. J Hum Hypertens 2014;28:600-5.
56. Carroll KK. Dietary protein in relation to plasma cholesterol levelsand atherosclerosis. Nutr Rev 1978;36:1-5.
57. Carroll KK, Giovannetti PM, Huff MW, Moase O, Roberts DC, WolfeBM. Hypocholesterolemic effect of substituting soybean protein foranimal protein in the diet of healthy young women. Am J Clin Nutr1978;31:1312-21.
58. Sirtori CR, Agradi E, Conti F, Mantero O, Gatti E. Soybean-proteindiet in the treatment of type-II hyperlipoproteinaemia. Lancet 1977;1:275-7.
59. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of theeffects of soy protein intake on serum lipids. N Engl J Med 1995;333:276-82.
60. Weggemans RM, Trautwein EA. Relation between soy-associated isoflavonesand LDL and HDL cholesterol concentrations in humans: ameta-analysis. Eur J Clin Nutr 2003;57:940-6.
61. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containingisoflavones on the lipid profile. Am J Clin Nutr 2005;81:397-408.
62. Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P,Winston M. Soy protein, isoflavones, and cardiovascular health: anAmerican Heart Association Science Advisory for professionals fromthe Nutrition Committee. Circulation 2006;113:1034-44.
63. Jenkins DJ, Mirrahimi A, Srichaikul K, Berryman CE, Wang L,Carleton A, Abdulnour S, Sievenpiper JL, Kendall CW, Kris-EthertonPM. Soy protein reduces serum cholesterol by both intrinsic and fooddisplacement mechanisms. J Nutr 2010;140:2302S-11S.
64. Nagata C, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.Association of blood pressure with intake of soy products andother food groups in Japanese men and women. Prev Med 2003;36:692-7.
65. Liu XX, Li SH, Chen JZ, Sun K, Wang XJ, Wang XG, Hui RT. Effect ofsoy isoflavones on blood pressure: a meta-analysis of randomized controlledtrials. Nutr Metab Cardiovasc Dis 2012;22:463-70.
66. Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D,Obarzanek E, Conlin PR, Miller, 3rd ER, Simons-Morton DG, et al.Effects on blood pressure of reduced dietary sodium and the DietaryApproaches to Stop Hypertension (DASH) diet. DASH-Sodium CollaborativeResearch Group. N Engl J Med 2001;344:3-10.
67. Karanja NM, Obarzanek E, Lin PH, McCullough ML, Phillips KM,Swain JF, Champagne CM, Hoben KP. Descriptive characteristics ofthe dietary patterns used in the Dietary Approaches to Stop HypertensionTrial. DASH Collaborative Research Group. J Am Diet Assoc1999;99(8 Suppl):S19-27.
68. Swain JF, McCarron PB, Hamilton EF, Sacks FM, Appel LJ. Characteristicsof the diet patterns tested in the optimal macronutrient intaketrial to prevent heart disease (OmniHeart): options for a heart-healthydiet. J Am Diet Assoc 2008;108:257-65.
69. Patvardhan E, Heffernan KS, Ruan J, Hession M, Warner P, Karas RH,Kuvin JT. Augmentation index derived from peripheral arterial tonometrycorrelates with cardiovascular risk factors. Cardiol Res Pract2011;2011:253758.
70. Nürnberger J, Keflioglu-Scheiber A, Opazo Saez AM, Wenzel RR,Philipp T, Schäfers RF. Augmentation index is associated with cardiovascularrisk. J Hypertens 2002;20:2407-14.
71. Weber T, Auer J, O'Rourke MF, Kvas E, Lassnig E, Berent R, Eber B.Arterial stiffness, wave reflections, and the risk of coronary artery disease.Circulation 2004;109:184-9.
72. Hayashi T, Nakayama Y, Tsumura K, Yoshimaru K, Ueda H. Reflectionin the arterial system and the risk of coronary heart disease. Am J Hypertens2002;15:405-9.
73. Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Wong JM, de SouzaR, Emam A, Parker TL, Vidgen E, Lapsley KG, et al. Effects of a dietaryportfolio of cholesterol-lowering foods vs lovastatin on serum lipidsand C-reactive protein. JAMA 2003;290:502-10.
74. Jenkins DJ, Kendall CW, Faulkner D, Vidgen E, Trautwein EA, ParkerTL, Marchie A, Koumbridis G, Lapsley KG, Josse RG, et al. A dietaryportfolio approach to cholesterol reduction: combined effects of plantsterols, vegetable proteins, and viscous fibers in hypercholesterolemia.Metabolism 2002;51:1596-604.
75. Jenkins DJ, Kendall CW, Marchie A, Faulkner D, Vidgen E, LapsleyKG, Trautwein EA, Parker TL, Josse RG, Leiter LA, et al. The effectof combining plant sterols, soy protein, viscous fibers, and almondsin treating hypercholesterolemia. Metabolism 2003;52:1478-83.
76. Jenkins DJ, Kendall CW, Faulkner DA, Nguyen T, Kemp T, Marchie A,Wong JM, de Souza R, Emam A, Vidgen E, et al. Assessment of thelonger-term effects of a dietary portfolio of cholesterol-lowering foodsin hypercholesterolemia. Am J Clin Nutr 2006;83:582-91.
77. Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Josse AR, WongJM, de Souza R, Emam A, Parker TL, Li TJ, et al. Direct comparisonof dietary portfolio vs statin on C-reactive protein. Eur J Clin Nutr2005;59:851-60.
78. Ornish D, Scherwitz LW, Doody RS, Kesten D, McLanahan SM,Brown SE, DePuey E, Sonnemaker R, Haynes C, Lester J, et al. Effectsof stress management training and dietary changes in treating ischemicheart disease. JAMA 1983;249:54-9.
79. Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, PortsTA, McLanahan SM, Kirkeeide RL, Brand RJ, Gould KL. Can lifestylechanges reverse coronary heart disease? The Lifestyle Heart Trial. Lancet1990;336:129-33.
80. Ornish D, Scherwitz LW, Billings JH, Brown SE, Gould KL, MerrittTA, Sparler S, Armstrong WT, Ports TA, Kirkeeide RL, et al. Intensivelifestyle changes for reversal of coronary heart disease. JAMA 1998;280:2001-7.
81. Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Wong JM, de SouzaR, Emam A, Parker TL, Vidgen E, Trautwein EA, et al. Direct comparisonof a dietary portfolio of cholesterol-lowering foods with a statinin hypercholesterolemic participants. Am J Clin Nutr 2005;81:380-7.
82. Rebello CJ, Greenway FL, Finley JW. A review of the nutritional valueof legumes and their effects on obesity and its related co-morbidities.Obes Rev 2014;15:392-407.
83. Bouchenak M, Lamri-Senhadji M. Nutritional quality of legumes, andtheir role in cardiometabolic risk prevention: a review. J Med Food2013;16:185-98.
84. Campos-Vega R, Loarca-Piña G, Oomah BD. Minor components ofpulses and their potential impact on human health. Food Res Int2010;43:461-82.
85. Fardet A. New hypotheses for the health-protective mechanisms ofwhole-grain cereals: what is beyond fibre? Nutr Res Rev 2010;23:65-134.
86. Alasalvar C, Shahidi F. Tree nuts: composition, phytochemicals, andhealth effects. Boca Raton: CRC Press, 2009.
87. Sabaté J, Wien M. Consumption of nuts in the prevention of cardiovasculardisease. Curr Nutr Rep 2013;2:258-66.
88. Young VR, Pellett PL. Plant proteins in relation to human protein andamino acid nutrition. Am J Clin Nutr 1994;59(5 Suppl):1203S-12S.
89. Slavin JL, Lloyd B. Health benefits of fruits and vegetables. Adv Nutr2012;3:506-16.
90. Liu RH. Health-promoting components of fruits and vegetables in thediet. Adv Nutr 2013;4:384S-92S.
91. McAfee AJ, McSorley EM, Cuskelly GJ, Moss BW, Wallace JM,Bonham MP, Fearon AM. Red meat consumption: an overviewof the risks and benefits. Meat Sci 2010;84:1-13.
92. Williams P. Nutritional composition of red meat. Nutr Diet 2007;64:S113-9.
93. Lund EK. Health benefits of seafood; is it just the fatty acids? FoodChem 2013;140:413-20.
94. Larsen R, Eilertsen KE, Elvevoll EO. Health benefits of marine foodsand ingredients. Biotechnol Adv 2011;29:508-18.
95. Layman DK, Rodriguez NR. Egg protein as a source of power,strength, and energy. Nutr Today 2009;44:43-8.
96. El Khoury D, Anderson GH. Recent advances in dietary proteins andlipid metabolism. Curr Opin Lipidol 2013;24:207-13.
97. Weaver CM. How sound is the science behind the dietary recommendationsfor dairy? Am J Clin Nutr 2014;99(5 Suppl):1217S-22S.
98. Tuttle KR, Milton JE, Packard DP, Shuler LA, Short RA. Dietaryamino acids and blood pressure: a cohort study of patients with cardiovasculardisease. Am J Kidney Dis 2012;59:803-9.
99. Feskens EJ, Sluik D, van Woudenbergh GJ. Meat consumption, diabetes,and its complications. Curr Diab Rep 2013;13:298-306.
100. Wittenbecher C, Muhlenbruch K, Kroger J, Jacobs S, Kuxhaus O,Floegel A, Fritsche A, Pischon T, Prehn C, Adamski J, et al. Amino acids,lipid metabolites, and ferritin as potential mediators linking red meatconsumption to type 2 diabetes. Am J Clin Nutr 2015;101:1241-50.
101. Krajcovicova-Kudlackova M, Babinska K, Valachovicova M. Healthbenefits and risks of plant proteins. Bratisl Lek Listy 2005;106:231-4.
102. Giroux I, Kurowska EM, Carroll KK. Role of dietary lysine, methionine,and arginine in the regulation of hypercholesterolemia in rabbits.J Nutr Biochem 1999;10:166-71.
103. Blomstrand E, Eliasson J, Karlsson HK, Kohnke R. Branched-chainamino acids activate key enzymes in protein synthesis after physicalexercise. J Nutr 2006;136(1 Suppl):269S-73S.
104. Negro M, Giardina S, Marzani B, Marzatico F. Branched-chain aminoacid supplementation does not enhance athletic performance but affectsmuscle recovery and the immune system. J Sports Med Phys Fitness2008;48:347-51.
105. Layman DK, Anthony TG, Rasmussen BB, Adams SH, Lynch CJ,Brinkworth GD, Davis TA. Defining meal requirements for proteinto optimize metabolic roles of amino acids. Am J Clin Nutr 2015;101:1330S-8S.
106. Platell C, Kong SE, McCauley R, Hall JC. Branched-chain amino acids.J Gastroenterol Hepatol 2000;15:706-17.
107. Tang WH, Hazen SL. The contributory role of gut microbiota in cardiovasculardisease. J Clin Invest 2014;124:4204-11.
108. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B,Feldstein AE, Britt EB, Fu X, Chung YM, et al. Gut flora metabolismof phosphatidylcholine promotes cardiovascular disease. Nature 2011;472:57-63.
109. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y,Hazen SL. Intestinal microbial metabolism of phosphatidylcholineand cardiovascular risk. N Engl J Med 2013;368:1575-84.
110. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB,Fu X, Wu Y, Li L, et al. Intestinal microbiota metabolism of L-carnitine,a nutrient in red meat, promotes atherosclerosis. Nat Med 2013;19:576-85.
111. Smit E, Nieto FJ, Crespo CJ, Mitchell P. Estimates of animal and plantprotein intake in US adults: results from the Third National Healthand Nutrition Examination Survey, 1988-1991. J Am Diet Assoc1999;99:813-20.