Progesterone neuroprotection: The background of clinical trial failure

Journal of Steroid Biochemistry and Molecular Biology

Volumn 160, Issue , 2016, Pages 53-66

  Schumacher, Michael ^a   Denier, Christian ^a,b   Oudinet, Jean Paul ^a   Adams, David ^a,b   Guennoun, Rachida ^a  

^a Bicetre Hospital   (France)

^b BICÊTRE HOSPITAL   (France)

Author keywords

Animal models; Biomarkers; Clinical trials; Progesterone; Stroke; Translational research; Traumatic brain injury

Indexed keywords

GESTAGEN; PROGESTERONE; NEUROPROTECTIVE AGENT;

BLOOD BRAIN BARRIER; DRUG BRAIN LEVEL; DRUG SAFETY; EMERGENCY HEALTH SERVICE; EVIDENCE BASED PRACTICE; GLASGOW OUTCOME SCALE; HUMAN; MULTICENTER STUDY (TOPIC); NERVE REGENERATION; NEUROPROTECTION; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRECLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STROKE PATIENT; TRAUMATIC BRAIN INJURY; ANIMAL; ANIMAL MODEL; BRAIN; CLINICAL TRIAL (TOPIC); DRUG EFFECT; METABOLISM; PATHOLOGY;

ANIMALS; BRAIN; BRAIN INJURIES, TRAUMATIC; CLINICAL TRIALS AS TOPIC; DRUG EVALUATION, PRECLINICAL; HUMANS; MODELS, ANIMAL; NEUROPROTECTION; NEUROPROTECTIVE AGENTS; PROGESTERONE;

EID: 84948800221     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.11.010     Document Type: Review

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