Progesterone treatment for experimental stroke: An individual animal meta-analysis

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 9, 2013, Pages 1362-1372

  Wong, Raymond ^a   Renton, Cheryl ^a   Gibson, Claire L ^b   Murphy, Stephanie J ^c   Kendall, David A ^a   Bath, Philip M W ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

individual animal data; meta analysis; neuroprotection; progesterone; steroid hormones; systematic review

Indexed keywords

PROGESTERONE;

BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; DEATH; DRUG EFFECT; HORMONAL THERAPY; INCIDENCE; LOADING DRUG DOSE; META ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PUBLISHING; REVIEW; SYSTEMATIC REVIEW; VALIDITY;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; MALE; META-ANALYSIS AS TOPIC; NEUROPROTECTIVE AGENTS; PROGESTERONE; PROGESTINS; SEX FACTORS; STROKE;

EID: 84883742193     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.120     Document Type: Review

References (53)

1. Wolfe C. The burden of stroke. In: Wolfe C, Rudd T, Beech R (eds). Stroke services and research. London: The Stroke Association, 1996, pp 13-39.
2. Adamson JBA, Ebrahim S. Is stroke the most common cause of disability? J Stroke Cerebrovasc Dis 2004; 13: 171-177. (Pubitemid 39349462)
3. Feigin VL. Stroke epidemiology in the developing world. Lancet 2005; 365: 2160-2161. (Pubitemid 40853896)
4. Alkayed NJ, Murphy SJ, Traystman RJ, Hurn PD. Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke 2000; 31: 161-168. (Pubitemid 30035770)
5. Gibson CL, Murphy SP. Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 2004; 24: 805-813. (Pubitemid 38880226)
6. Jiang N, Chopp M, Stein D, Feit H. Progesterone ss neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res 1996; 735: 101-107. (Pubitemid 26336624)
7. Kumon Y, Kim SC, Tompkins P, Stevens A, Sakaki S, Loftus CM. Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral sschemia. J Neurosurg 2000; 92: 848-852. (Pubitemid 30243934)
8. Murphy SJ, Littleton-Kearney MM, Hurn PD. Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats. J Cereb Blood Flow Metab 2002; 22: 1181-1188.
9. Gibson CL, Constantin D, Prior MJW, Bath PMW, Murphy SP. Progesterone supresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol 2005; 193: 522-530. (Pubitemid 40616199)
10. Sayeed I, Wali B, Stein DG. Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor Neurol Neurosci 2007; 25: 151-159. (Pubitemid 47290443)
11. Sayeed I, Parvez S, Wali B, Siemen D, Stein DG. Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone. Brain Res 2009; 1263: 165-173.
12. Ishrat T, Sayeed I, Atif F, Stein DG. Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats. Brain Res 2009; 1257: 94-101.
13. Chen J, Chopp M. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J Neurol Sci 1999; 171: 24-30. (Pubitemid 29525574)
14. Gibson CL, Gray LJ, Bath PMW, Murphy S. Progesterone for the treatment of experimental brain injury; a systematic review. Brain 2007; 131: 318-328.
15. Goletiani NV, Keith DR, Gorsky SJ. Progesterone: review of safety for clinical studies. Exp Clin Psychopharm 2007; 15: 427-444. (Pubitemid 350102230)
16. Little BC, Matta RJ, Zahn TP. Physiological and psychological effects of progesterone in man. J Nerv Ment Dis 1974; 159: 256-262.
17. Gaver RC, Pittman KA, Reilly CM, Smyth RD, Goodson PJ, Fenzi E et al. Bioequivalence evaluation of new megestrol-acetate formulations in humans. Semin Oncol 1985; 12: 17-19. (Pubitemid 15149391)
18. Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC et al. Protect: a randomized clinical trial of progresterone for acute traumatic brain injury. Ann Emerg Med 2007; 49: 391-402.
19. Xiao GM, Wei J, Yan WQ, Wang WM, Lu ZH. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care 2008; 12: 10.
20. Roof RL, Duvdevani R, Heyburn JE, Stein DG. Progesterone rapidly decreases brain edema: treatment delayed up to 24 Hours is still effective. Exp Neurol 1996; 138: 246-251. (Pubitemid 26132712)
21. Murphy SJ, Traystman RJ, Hurn PD, Duckles SP. Progesterone exacerbates striatal stroke injury in progesterone deficient female animals. Stroke 2000; 31: 1173-1178. (Pubitemid 30253542)
22. He J, Evans CO, Hoffman SW, Oyesiku NM, Stein DG. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol 2004; 189: 404-412. (Pubitemid 39221832)
23. Bath PMW, Gray LJ, Bath AJG, Buchan A, Miyata T, Green AR. Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br J Pharmacol 2009; 157: 1157-1171.
24. Gibson CL, Gray LJ, Bath PMW, Murphy SP. Progesterone for the treatment of experimental brain injury; a systematic review. Brain 2008; 131: 318-328. (Pubitemid 351197603)
25. Roof RL, Hall ED. Gender differences in acute cns trauma and stroke: neuroprotective effects of estrogen and progesterone. J Neurotrauma 2000; 17: 367-388. (Pubitemid 30327300)
26. Stroke Therapy Academic Industry Roundtable (Stair). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1999; 30: 2752-2758.
27. Toung TJ, Chen T-Y, Littleton-Kearney MT, Hurn PD, Murphy SJ. Effects of combined estrogen and progresterone on brain infarction in reproductively senescent female rats. J Cereb Blood Flow Metab 2004; 24: 1160-1166. (Pubitemid 39332155)
28. Choi YC Lee JH Hong KW Lee KS. Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and creb in association with reduced pten phosphorylation in rats. Fundam Clin Pharm 2004; 18: 547-557. (Pubitemid 39468963)
29. Liu AL, Margaill I, Zhang SD, Labombarda F, Coqueran B, Delespierre B et al. Progesterone receptors: a key for neuroprotection in experimental stroke. Endocrinology 2012; 153: 3747-3757.
30. Parker SM, Hurn PD, Murphy SJ. Progesterone and allopregnanolone as neuroprotectants in ischemic ovariectomized mouse brain. J Cereb Blood Flow Metab 2005; 25: S21-S21.
31. Wong R, Ray D, Kendall DA. Progesterone pharmacokinetics in the mouse: implications for potential stroke therapy. J Pharm Pharmacol 2012; 64: 1614-1620.
32. Stewart LA, Parmar MK. Meta-analysis of the literature or of individual patient data: is there a difference? Lancet 1993; 341: 418-422. (Pubitemid 23048157)
33. Coomber B, Gibson CL. Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice. Brain Res 2010; 1361: 124-132.
34. Gibson CL, Coomber B, Murphy SP. Progesterone Is neuroprotective following cerebral ischaemia in reproductively ageing female mice. Brain 2011; 134: 2125-2133.
35. Saxena R, Wijnhoud AD, Carton H, Hacke W, Kaste M, Przybelski et al. Controlled safety study of a hemoglobin-based oxygen carrier, dclhb, in acute ischemic stroke. Stroke 1999; 30: 993-996. (Pubitemid 29211616)
36. Furuya K, Takeda H, Azhar S, McCarron RM, Chen Y, Ruetzler et al. Examination of several Potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside to bench Study. Stroke 2001; 32: 2665-2674. (Pubitemid 33055322)
37. Tirilazad Int Steering Comm. Tirilazad mesylate in acute ischemic stroke: a systematic review. Stroke 2000; 31: 2257-2265.
38. Davis SM, Lees KR, Albers GW, Diener HC, Markabi S, Karisson G et al. Selfotel in acute ischemic stroke-possible neurotoxic effects of an NMDA antagonist. Stroke 2000; 31: 347-354. (Pubitemid 30078164)
39. Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM et al. NXY-059 for the treatment of acute ischemic stroke. N Eng J Med 2007; 357: 562-571. (Pubitemid 47236281)
40. Diener HC, Lees KR, Lyden P, Grotta J, Davalos A, Davis S et al. NXY-059 for the treatment of acute stroke: pooled analysis of the Saint I and II trials. Stroke 2008; 39: 1751-1758.
41. Egger M, Smith GD. Bias in location and selection of studies. Br Med J 1998; 316: 61-66.
42. Mehra M, Henninger N, Hirsch JA, Chueh J, Wakhloo AK, Gounis MJ. Preclinical acute ischemic stroke modeling. J Neurointerv Surg 2012; 4: 307-313.
43. Ankolekar S, Rewell S, Howells DW, Bath PMW. The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals. Int J Stroke 2012; 7: 386-397.
44. Bailey EL, Mcculloch J, Sudlow C, Wardlaw M. Potential animal models of lacunar stroke a systematic review. Stroke 2009; 40: E451-E458.
45. Pineiro R, Pendlebury ST, Smith S, Flitney D, Blamire AM, Styles P et al. Relating MRI changes to motor deficit after ischemic stroke by segmentation of functional motor pathways. Stroke 2000; 31: 672-679. (Pubitemid 30131654)
46. Aronowski J, Samways E, Strong R, Rhoades HM, Grotta JC. An alternative method for the quantitation of neuronal damage after experimental middle cerebral artery occlusion in rats: analysis of behavioral deficit. J Cereb Blood Flow Metab 1996; 16: 705-713. (Pubitemid 26227081)
47. Lees KR, Bath PM, Schellinger PD, Kerr DM, Fulton R, Hacke W et al. Contemporary outcome measures in acute stroke research: choice of primary outcome measure. Stroke 2012; 43: 1163-1170.
48. Durukan A, Talisumak T. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral sschemia. Pharmacol Biochem Behav 2007; 87: 179-197. (Pubitemid 46860315)
49. Sanders RD, Ma D, Maze M. Anaesthesia induced neuroprotection. Best Pract Res Clin Anaesthesiol 2005; 19: 461-474. (Pubitemid 40753812)
50. Kitano H, Kirsch JR, Hurn PD, Murphy SJ. Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain. J Cereb Blood Flow Metab 2007; 27: 1108-1128. (Pubitemid 46808701)
51. Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PM et al. Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 2008; 39: 929-934. (Pubitemid 351619572)
52. Sayeed I, Guo QM, Hoffman SW, Stein DG. Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. Ann Emerg Med 2006; 47: 381-389.
53. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634. (Pubitemid 27387172)