Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

Nature Medicine

Volumn 10, Issue 7, 2004, Pages 704-711

  Griffin, Lisa D ^a   Gong, Wenhui ^b   Verot, Lucie ^c   Mellon, Synthia H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 5ALPHA PREGNANE 3,20 DIONE; BETA CYCLODEXTRIN; GANGLIOSIDE GM2; GANGLIOSIDE GM3; NEUROSTEROID; PREGNENOLONE; STEROID 5ALPHA REDUCTASE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BRAIN REGION; CELL DEATH; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; DEGENERATIVE DISEASE; GRANULE CELL; IMMUNOHISTOCHEMISTRY; LIFESPAN; LOCOMOTION; MOTOR COORDINATION; MOUSE; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; NIEMANN PICK DISEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; STEROIDOGENESIS;

20-ALPHA-HYDROXYSTEROID DEHYDROGENASE; 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); ANIMALS; BRAIN; MICE; NIEMANN-PICK DISEASES; PREGNANOLONE; PREGNENOLONE; RATS;

ANIMALIA;

EID: 3142774112     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1073     Document Type: Article

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