Paradigm shift in translational neuroimaging of CNS disorders

Biochemical Pharmacology

Volumn 81, Issue 12, 2011, Pages 1374-1387

  Sakoǧlu, Ünal ^a   Upadhyay, Jaymin ^a   Chin, Chih Liang ^a   Chandran, Prasant ^a   Baker, Scott J ^a   Cole, Todd B ^a   Fox, Gerard B ^a   Day, Mark ^a   Luo, Feng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Alzheimer's disease; Brain; Default mode network; Depression; Drug development; fMRI; Functional connectivity; Functional magnetic resonance imaging; Mood disorders; Neuroimaging; Pain; Psychiatric illnesses; Resting state networks; Schizophrenia

Indexed keywords

BIOLOGICAL MARKER;

ALZHEIMER DISEASE; ANXIETY DISORDER; BRAIN FUNCTION; BRAIN REGION; CENTRAL NERVOUS SYSTEM DISEASE; CHRONIC PAIN; DEPRESSION; EVOKED RESPONSE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MEDICAL RESEARCH; MOOD DISORDER; NEUROIMAGING; NONHUMAN; PAIN; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; MAGNETIC RESONANCE IMAGING; TRANSLATIONAL RESEARCH;

EID: 79956212314     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.12.029     Document Type: Review

References (146)

1. M.E. Raichle A paradigm shift in functional brain imaging J Neurosci 29 2009 12729 12734
2. M.E. Raichle Functional brain imaging and human brain function J Neurosci 23 2003 3959 3962 (Pubitemid 36958411)
3. M.D. Fox, and M.E. Raichle Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging Nat Rev Neurosci 8 2007 700 711 (Pubitemid 47283145)
4. D.P. Auer Spontaneous low-frequency blood oxygenation level-dependent fluctuations and functional connectivity analysis of the 'resting' brain Magn Reson Imaging 26 2008 1055 1064
5. G.B. Fox, C.L. Chin, F. Luo, M. Day, and B.F. Cox Translational neuroimaging of the CNS: novel pathways to drug development Mol Interv 9 2009 302 313
6. Y.X. Wang, and S.X. Yan Biomedical imaging in the safety evaluation of new drugs Lab Anim 42 2008 433 441
7. C.L. Chin, G.B. Fox, V.P. Hradil, M.A. Osinski, S.P. McGaraughty, and P.D. Skoubis Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: relevance as a potential biomarker for detecting drug-induced emesis Neuroimage 33 2006 1152 1160 (Pubitemid 44708788)
8. L.F. Andersen, L. Meinert, C. Rygaard, J. Junge, P. Prento, and B.S. Ottesen Thermal balloon endometrial ablation: safety aspects evaluated by serosal temperature, light microscopy and electron microscopy Eur J Obstet Gynecol Reprod Biol 79 1998 63 68 (Pubitemid 28234427)
9. P.A. Bandettini, E.C. Wong, R.S. Hinks, R.S. Tikofsky, and J.S. Hyde Time course EPI of human brain function during task activation Magn Reson Med 25 1992 390 397
10. J. Frahm, H. Bruhn, K.D. Merboldt, and W. Hanicke Dynamic MR imaging of human brain oxygenation during rest and photic stimulation J Magn Reson Imaging 2 1992 501 505
11. K.K. Kwong, J.W. Belliveau, D.A. Chesler, I.E. Goldberg, R.M. Weisskoff, and B.P. Poncelet Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation Proc Natl Acad Sci USA 89 1992 5675 5679
12. S. Ogawa, D.W. Tank, R. Menon, J.M. Ellermann, S.G. Kim, and H. Merkle Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging Proc Natl Acad Sci USA 89 1992 5951 5955
13. A.G. Garrity, G.D. Pearlson, K. McKiernan, D. Lloyd, K.A. Kiehl, and V.D. Calhoun Aberrant "default mode" functional connectivity in schizophrenia Am J Psychiatry 164 2007 450 457 (Pubitemid 46513159)
14. M.D. Greicius, and V. Menon Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation J Cogn Neurosci 16 2004 1484 1492 (Pubitemid 39614250)
15. M.D. Greicius, G. Srivastava, A.L. Reiss, and V. Menon Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI Proc Natl Acad Sci USA 101 2004 4637 4642 (Pubitemid 38437463)
16. M.D. Greicius, B. Krasnow, A.L. Reiss, and V. Menon Functional connectivity in the resting brain: a network analysis of the default mode hypothesis Proc Natl Acad Sci USA 100 2003 253 258 (Pubitemid 36078061)
17. M.E. Raichle, A.M. MacLeod, A.Z. Snyder, W.J. Powers, D.A. Gusnard, and G.L. Shulman A default mode of brain function Proc Natl Acad Sci USA 98 2001 676 682 (Pubitemid 32105102)
18. M.J. Jafri, and V.D. Calhoun Functional classification of schizophrenia using feed forward neural networks Conf Proc IEEE Eng Med Biol Soc Suppl. 2006 6631 6634 (Pubitemid 46521446)
19. V.D. Calhoun, P.K. Maciejewski, G.D. Pearlson, and K.A. Kiehl Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder Hum Brain Mapp 29 2008 1265 1275
20. M.P. van den Heuvel, and H.E. Hulshoff Pol Exploring the brain network: a review on resting-state fMRI functional connectivity Eur Neuropsychopharmacol 20 2010 519 534
21. M.E. Raichle, and M.A. Mintun Brain work and brain imaging Annu Rev Neurosci 29 2006 449 476 (Pubitemid 44476853)
22. L. Sokoloff, R. Mangold, R.L. Wechsler, C. Kenney, and S.S. Kety The effect of mental arithmetic on cerebral circulation and metabolism J Clin Invest 34 1955 1101 1108
23. G.L. Shulman, J.A. Fiez, M. Corbetta, R.L. Buckner, F.M. Miezin, and M.E. Raichle Common blood flow changes across visual tasks: II. Decreases in cerebral cortex J Cogn Neurosci 9 1997 648 663 (Pubitemid 27455556)
24. J.R. Binder, J.A. Frost, T.A. Hammeke, P.S. Bellgowan, S.M. Rao, and R.W. Cox Conceptual processing during the conscious resting state. A functional MRI study J Cogn Neurosci 11 1999 80 95
25. B. Mazoyer, L. Zago, E. Mellet, S. Bricogne, O. Etard, and O. Houde Cortical networks for working memory and executive functions sustain the conscious resting state in man Brain Res Bull 54 2001 287 298 (Pubitemid 32273621)
26. R.L. Buckner, J.R. Andrews-Hanna, and D.L. Schacter The brain's default network: anatomy, function, and relevance to disease Ann N Y Acad Sci 1124 2008 1 38 (Pubitemid 351506788)
27. P. Hagmann, L. Cammoun, X. Gigandet, R. Meuli, C.J. Honey, and V.J. Wedeen Mapping the structural core of human cerebral cortex PLoS Biol 6 2008 e159
28. B. Biswal, F.Z. Yetkin, V.M. Haughton, and J.S. Hyde Functional connectivity in the motor cortex of resting human brain using echo-planar MRI Magn Reson Med 34 1995 537 541
29. S.M. Smith, P.T. Fox, K.L. Miller, D.C. Glahn, P.M. Fox, and C.E. Mackay Correspondence of the brain's functional architecture during activation and rest Proc Natl Acad Sci USA 106 2009 13040 13045
30. J.S. Damoiseaux, S.A. Rombouts, F. Barkhof, P. Scheltens, C.J. Stam, and S.M. Smith Consistent resting-state networks across healthy subjects Proc Natl Acad Sci USA 103 2006 13848 13853 (Pubitemid 44413996)
31. F. Esposito, A. Bertolino, T. Scarabino, V. Latorre, G. Blasi, and T. Popolizio Independent component model of the default-mode brain function: assessing the impact of active thinking Brain Res Bull 70 2006 263 269 (Pubitemid 44508789)
32. J.L. Vincent, G.H. Patel, M.D. Fox, A.Z. Snyder, J.T. Baker, and D.C. Van Essen Intrinsic functional architecture in the anaesthetized monkey brain Nature 447 2007 83 86 (Pubitemid 46685840)
33. H. Lu, Y. Zuo, H. Gu, J.A. Waltz, W. Zhan, and C.A. Scholl Synchronized delta oscillations correlate with the resting-state functional MRI signal Proc Natl Acad Sci USA 104 2007 18265 18269 (Pubitemid 350210855)
34. B.B. Biswal, M. Mennes, X.N. Zuo, S. Gohel, C. Kelly, and S.M. Smith Toward discovery science of human brain function Proc Natl Acad Sci USA 107 2010 4734 4739
35. G. Pelled, and G. Goelman Different physiological MRI noise between cortical layers Magn Reson Med 52 2004 913 916 (Pubitemid 39314997)
36. P.M. Matthews, G.D. Honey, and E.T. Bullmore Applications of fMRI in translational medicine and clinical practice Nat Rev Neurosci 7 2006 732 744 (Pubitemid 44267497)
37. C.L. Chin, J.R. Pauly, B.W. Surber, P.D. Skoubis, S. McGaraughty, and V.P. Hradil Pharmacological MRI in awake rats predicts selective binding of alpha4beta2 nicotinic receptors Synapse 62 2008 159 168 (Pubitemid 351186396)
38. L. Luan, F. Ding, Y. Ai, A. Andersen, P. Hardy, and E. Forman Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys Cell Transplant 17 2008 417 425 (Pubitemid 351717344)
39. D. Borsook, L. Becerra, and R. Hargreaves A role for fMRI in optimizing CNS drug development Nat Rev Drug Discov 5 2006 411 424
40. E.R. Kandel, J.H. Schwarz, and T.M. Jessell Principles of Neural Science 2000 McGraw-Hill
41. W.C. Drevets, J.L. Price, J.R. Simpson Jr., R.D. Todd, T. Reich, and M. Vannier Subgenual prefrontal cortex abnormalities in mood disorders Nature 386 1997 824 827 (Pubitemid 27181254)
42. A.R. Damasio, and Neuropsychology Towards a neuropathology of emotion and mood Nature 386 1997 769 770 (Pubitemid 27181238)
43. M.D. Greicius, B.H. Flores, V. Menon, G.H. Glover, H.B. Solvason, and H. Kenna Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus Biol Psychiatry 62 2007 429 437 (Pubitemid 47284017)
44. X.H. Zhao, P.J. Wang, C.B. Li, Z.H. Hu, Q. Xi, and W.Y. Wu Altered default mode network activity in patient with anxiety disorders: an fMRI study Eur J Radiol 63 2007 373 378 (Pubitemid 47321037)
45. A.W. MacDonald, and S.C. Schulz What we know: findings that every theory of schizophrenia should explain Schizophr Bull 35 2009 493 508
46. P.F. Liddle The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy Br J Psychiatry 151 1987 145 151 (Pubitemid 17102086)
47. L. Palacios-Araus, A. Herran, M. Sandoya, E. Gonzalez de la Huebra, J.L. Vazquez-Barquero, and J.F. Diez-Manrique Analysis of positive and negative symptoms in schizophrenia. A study from a population of long-term outpatients Acta Psychiatr Scand 92 1995 178 182
48. G. Kuperberg, and S. Heckers Schizophrenia and cognitive function Curr Opin Neurobiol 10 2000 205 210 (Pubitemid 30201113)
49. D.L. Braff, and M.A. Geyer Sensorimotor gating and schizophrenia. Human and animal model studies Arch Gen Psychiatry 47 1990 181 188 (Pubitemid 20058094)
50. K.J. Friston, and C.D. Frith Schizophrenia: a disconnection syndrome? Clin Neurosci 3 1995 89 97
51. V.D. Calhoun, T. Adali, G.D. Pearlson, and J.J. Pekar A method for making group inferences from functional MRI data using independent component analysis Hum Brain Mapp 14 2001 140 151 (Pubitemid 33032347)
52. D.N. McIntosh, L.J. Miller, V. Shyu, and R.J. Hagerman Sensory-modulation disruption, electrodermal responses, and functional behaviors Dev Med Child Neurol 41 1999 608 615 (Pubitemid 29425587)
53. J.E. Jensen, Y.M. Al-Semaan, P.C. Williamson, R.W. Neufeld, R.S. Menon, and B. Schaeffer Region-specific changes in phospholipid metabolism in chronic, medicated schizophrenia: (31)P-MRS study at 4.0 Tesla Br J Psychiatry 180 2002 39 44 (Pubitemid 34093624)
54. V. Menon, R.T. Anagnoson, G.H. Glover, and A. Pfefferbaum Functional magnetic resonance imaging evidence for disrupted basal ganglia function in schizophrenia Am J Psychiatry 158 2001 646 649 (Pubitemid 32289833)
55. G.D. Honey, E. Pomarol-Clotet, P.R. Corlett, R.A. Honey, P.J. McKenna, and E.T. Bullmore Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function Brain 128 2005 2597 2611 (Pubitemid 41552945)
56. G. Ende, D.F. Braus, S. Walter, W. Weber-Fahr, B. Soher, and A.A. Maudsley Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia Schizophr Res 41 2000 389 395 (Pubitemid 30109595)
57. Y. Zhou, M. Liang, L. Tian, K. Wang, Y. Hao, and H. Liu Functional disintegration in paranoid schizophrenia using resting-state fMRI Schizophr Res 97 2007 194 205 (Pubitemid 350088382)
58. M.J. Jafri, G.D. Pearlson, M. Stevens, and V.D. Calhoun A method for functional network connectivity among spatially independent resting-state components in schizophrenia Neuroimage 39 2008 1666 1681
59. M. Liang, Y. Zhou, T. Jiang, Z. Liu, L. Tian, and H. Liu Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging Neuroreport 17 2006 209 213 (Pubitemid 43100329)
60. R.L. Bluhm, J. Miller, R.A. Lanius, E.A. Osuch, K. Boksman, and R.W. Neufeld Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network Schizophr Bull 33 2007 1004 1012 (Pubitemid 47216653)
61. D. Ongur, M. Lundy, I. Greenhouse, A.K. Shinn, V. Menon, and B.M. Cohen Default mode network abnormalities in bipolar disorder and schizophrenia Psychiatry Res 183 2010 59 68
62. U. Sakoglu, A. Michael, and V.D. Calhoun Classification of schizophrenia patients vs. healthy controls with dynamic functional network connectivity The 15th annual meeting of the organization for human brain mapping 2009 Organization for Human Brain Mapping San Francisco, CA
63. U. Sakoglu, G.D. Pearlson, K.A. Kiehl, Y.M. Wang, A.M. Michael, and V.D. Calhoun A method for evaluating dynamic functional network connectivity and task-modulation: application to schizophrenia MAGMA 23 2010 351 366
64. U. Sakoglu, and V.D. Calhoun Temporal dynamics of functional network connectivity at rest: a comparison of schizophrenia patients and healthy controls The 15th annual meeting of the organization for human brain mapping 2009 Organization for Human Brain Mapping San Francisco, CA
65. G.S. Dawe, E.H. Hwang, and C.H. Tan Pathophysiology and animal models of schizophrenia 38 2009 Annals of the Academy of Medicine Singapore pp. 425-6
66. A. Bellon New genes associated with schizophrenia in neurite formation: a review of cell culture experiments Mol Psychiatry 12 2007 620 629 (Pubitemid 46998253)
67. M.A. Geyer, and B. Ellenbroek Animal behavior models of the mechanisms underlying antipsychotic atypicality Prog Neuropsychopharmacol Biol Psychiatry 27 2003 1071 1079 (Pubitemid 37464953)
68. C.D. Kilts The changing roles and targets for animal models of schizophrenia Biol Psychiatry 50 2001 845 855 (Pubitemid 34020698)
69. P. Flagstad, A. Mork, B.Y. Glenthoj, J. van Beek, A.T. Michael-Titus, and M. Didriksen Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens Neuropsychopharmacology 29 2004 2052 2064 (Pubitemid 39486557)
70. H. Moore, J.D. Jentsch, M. Ghajarnia, M.A. Geyer, and A.A. Grace A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia Biol Psychiatry 60 2006 253 264 (Pubitemid 44093447)
71. D.J. Lodge, and A.A. Grace Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia J Neurosci 27 2007 11424 11430 (Pubitemid 47621327)
72. M. Kubicki, R. McCarley, C.F. Westin, H.J. Park, S. Maier, and R. Kikinis A review of diffusion tensor imaging studies in schizophrenia J Psychiatr Res 41 2007 15 30 (Pubitemid 44780754)
73. M.E. Shenton, C.C. Dickey, M. Frumin, and R.W. McCarley A review of MRI findings in schizophrenia Schizophr Res 49 2001 1 52 (Pubitemid 32451739)
74. R.A. Kanaan, J.S. Kim, W.E. Kaufmann, G.D. Pearlson, G.J. Barker, and P.K. McGuire Diffusion tensor imaging in schizophrenia Biol Psychiatry 58 2005 921 929 (Pubitemid 41790701)
75. P. Sachdev, H. Brodaty, N. Rose, and S. Cathcart Schizophrenia with onset after age 50 years. 2: Neurological, neuropsychological and MRI investigation Br J Psychiatry 175 1999 416 421
76. D. Tkachev, M.L. Mimmack, M.M. Ryan, M. Wayland, T. Freeman, and P.B. Jones Oligodendrocyte dysfunction in schizophrenia and bipolar disorder Lancet 362 2003 798 805 (Pubitemid 37093922)
77. G. Douaud, S. Smith, M. Jenkinson, T. Behrens, H. Johansen-Berg, and J. Vickers Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia Brain 130 2007 2375 2386 (Pubitemid 47327642)
78. T.J. Whitford, S.M. Grieve, T.F. Farrow, L. Gomes, J. Brennan, and A.W. Harris Volumetric white matter abnormalities in first-episode schizophrenia: a longitudinal, tensor-based morphometry study Am J Psychiatry 164 2007 1082 1089 (Pubitemid 47121397)
79. E.R. Marcotte, D.M. Pearson, and L.K. Srivastava Animal models of schizophrenia: a critical review J Psychiatry Neurosci 26 2001 395 410 (Pubitemid 34082728)
80. S. Kumar, J.C. Biancotti, M. Yamaguchi, and J. de Vellis Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model Neurochem Res 32 2007 783 797 (Pubitemid 46481308)
81. L.A. Pasquini, C.A. Calatayud, A.L. Bertone Una, V. Millet, J.M. Pasquini, and E.F. Soto The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia Neurochem Res 32 2007 279 292 (Pubitemid 46238874)
82. L. Xiao, H. Xu, Y. Zhang, Z. Wei, J. He, and W. Jiang Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes Mol Psychiatry 13 2008 697 708 (Pubitemid 351861531)
83. H. Xu, H.J. Yang, Y. Zhang, R. Clough, R. Browning, and X.M. Li Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone Behav Neurosci 123 2009 418 429
84. H.J. Yang, H. Wang, Y. Zhang, L. Xiao, R.W. Clough, and R. Browning Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia Brain Res 1270 2009 121 130
85. Y. Zhang, H. Xu, W. Jiang, L. Xiao, B. Yan, and J. He Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse Schizophr Res 106 2008 182 191
86. P.N. Koutsoudaki, T. Skripuletz, V. Gudi, D. Moharregh-Khiabani, H. Hildebrandt, and C. Trebst Demyelination of the hippocampus is prominent in the cuprizone model Neurosci Lett 451 2009 83 88
87. T. Skripuletz, M. Lindner, A. Kotsiari, N. Garde, J. Fokuhl, and F. Linsmeier Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent Am J Pathol 172 2008 1053 1061 (Pubitemid 351520001)
88. S.W. Sun, H.F. Liang, K. Trinkaus, A.H. Cross, R.C. Armstrong, and S.K. Song Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum Magn Reson Med 55 2006 302 308 (Pubitemid 43238098)
89. Q.Z. Wu, Q. Yang, H.S. Cate, D. Kemper, M. Binder, and H.X. Wang MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model J Magn Reson Imaging 27 2008 446 453 (Pubitemid 351354726)
90. C.R. Jack Jr., M. Slomkowski, S. Gracon, T.M. Hoover, J.P. Felmlee, and K. Stewart MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD Neurology 60 2003 253 260 (Pubitemid 36152018)
91. J. Schroder, J. Pantel, P. Schonknecht, and M. Essig [Magnetic resonance imaging in clinical diagnosis of dementia] Radiologe 43 2003 513 520 (Pubitemid 36966289)
92. M. Savoiardo, and M. Grisoli Imaging dementias Eur Radiol 11 2001 484 492 (Pubitemid 32755480)
93. B.H. Ridha, J. Barnes, J.W. Bartlett, A. Godbolt, T. Pepple, and M.N. Rossor Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study Lancet Neurol 5 2006 828 834 (Pubitemid 44715810)
94. N.C. Fox, R.S. Black, S. Gilman, M.N. Rossor, S.G. Griffith, and L. Jenkins Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease Neurology 64 2005 1563 1572 (Pubitemid 40617692)
95. E.S. Korf, L.O. Wahlund, P.J. Visser, and P. Scheltens Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment Neurology 63 2004 94 100 (Pubitemid 38943785)
96. N.C. Fox, E.K. Warrington, P.A. Freeborough, P. Hartikainen, A.M. Kennedy, and J.M. Stevens Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study Brain 119 Pt 6 1996 2001 2007
97. C.R. Jack Jr., R.C. Petersen, Y. Xu, P.C. O'Brien, G.E. Smith, and R.J. Ivnik Rates of hippocampal atrophy correlate with change in clinical status in aging and AD Neurology 55 2000 484 489 (Pubitemid 30647242)
98. L.K. McEvoy, C. Fennema-Notestine, J.C. Roddey, D.J. Hagler Jr., D. Holland, and D.S. Karow Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment Radiology 251 2009 195 205
99. S.Y. Bookheimer, M.H. Strojwas, M.S. Cohen, A.M. Saunders, M.A. Pericak-Vance, and J.C. Mazziotta Patterns of brain activation in people at risk for Alzheimer's disease N Engl J Med 343 2000 450 456 (Pubitemid 30646483)
100. A. Golby, G. Silverberg, E. Race, S. Gabrieli, J. O'Shea, and K. Knierim Memory encoding in Alzheimer's disease: an fMRI study of explicit and implicit memory Brain 128 2005 773 787 (Pubitemid 40516915)
101. S.S. Bassett, D.M. Yousem, C. Cristinzio, I. Kusevic, M.A. Yassa, and B.S. Caffo Familial risk for Alzheimer's disease alters fMRI activation patterns Brain 129 2006 1229 1239
102. A.C. Burggren, G.W. Small, F.W. Sabb, and S.Y. Bookheimer Specificity of brain activation patterns in people at genetic risk for Alzheimer disease Am J Geriatr Psychiatry 10 2002 44 51 (Pubitemid 34052902)
103. R.A. Sperling, J.F. Bates, E.F. Chua, A.J. Cocchiarella, D.M. Rentz, and B.R. Rosen fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease J Neurol Neurosurg Psychiatry 74 2003 44 50 (Pubitemid 36069035)
104. B. Hou, and L. Xu Values of default mode network to Alzheimer's disease call for consilience of multimodal neuroimaging and genetics J Neurosci 30 2010 3553 3554
105. S.J. Li, Z. Li, G. Wu, M.J. Zhang, M. Franczak, and P.G. Antuono Alzheimer disease: evaluation of a functional MR imaging index as a marker Radiology 225 2002 253 259
106. S.A. Rombouts, F. Barkhof, R. Goekoop, C.J. Stam, and P. Scheltens Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study Hum Brain Mapp 26 2005 231 239 (Pubitemid 41759880)
107. K. Supekar, V. Menon, D. Rubin, M. Musen, and M.D. Greicius Network analysis of intrinsic functional brain connectivity in Alzheimer's disease PLoS Comput Biol 4 2008 e1000100
108. C.J. Stam, W. de Haan, A. Daffertshofer, B.F. Jones, I. Manshanden, and A.M. van Cappellen van Walsum Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease Brain 132 2009 213 224
109. Y.I. Sheline, M.E. Raichle, A.Z. Snyder, J.C. Morris, D. Head, and S. Wang Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly Biol Psychiatry 67 2010 584 587
110. T. Hedden, K.R. Van Dijk, J.A. Becker, A. Mehta, R.A. Sperling, and K.A. Johnson Disruption of functional connectivity in clinically normal older adults harboring amyloid burden J Neurosci 29 2009 12686 12694
111. M. Day, J.L. Rutkowski, and G.Z. Feuerstein Translational medicine: a paradigm shift in modern drug discovery and development: the role of biomarkers Adv Exp Med Biol 655 2009 1 12
112. J.R. Cirrito, K.A. Yamada, M.B. Finn, R.S. Sloviter, K.R. Bales, and P.C. May Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo Neuron 48 2005 913 922 (Pubitemid 41814696)
113. R.A. Sperling, P.S. Laviolette, K. O'Keefe, J. O'Brien, D.M. Rentz, and M. Pihlajamaki Amyloid deposition is associated with impaired default network function in older persons without dementia Neuron 63 2009 178 188
114. T.L. Spires, and B.T. Hyman Transgenic models of Alzheimer's disease: learning from animals NeuroRx 2 2005 423 437 (Pubitemid 41444876)
115. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, and S. Younkin Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102 (Pubitemid 26332733)
116. G. Vanhoutte, I. Dewachter, P. Borghgraef, F. Van Leuven, and A. Van der Linden Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease Magn Reson Med 53 2005 607 613 (Pubitemid 40332281)
117. O. Wirths, and T.A. Bayer Neuron loss in transgenic mouse models of Alzheimer's disease Int J Alzheimers Dis 2010
118. M. Pfeifer, S. Boncristiano, L. Bondolfi, A. Stalder, T. Deller, and M. Staufenbiel Cerebral hemorrhage after passive anti-Abeta immunotherapy Science 298 2002 1379 (Pubitemid 35346131)
119. D.M. Wilcock, P.T. Jantzen, Q. Li, D. Morgan, and M.N. Gordon Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid Neuroscience 144 2007 950 960 (Pubitemid 46019842)
120. M.M. Racke, L.I. Boone, D.L. Hepburn, M. Parsadainian, M.T. Bryan, and D.K. Ness Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta J Neurosci 25 2005 629 636
121. F. Luo, N.R. Rustay, T. Seifert, B. Roesner, V. Hradil, and H. Hillen MRI detection and time course of cerebral microhemorrhages during passive immunotherapy in living APP transgenic mice J Pharmacol Exp Ther 2010
122. S. Barghorn, V. Nimmrich, A. Striebinger, C. Krantz, P. Keller, and B. Janson Globular amyloid beta-peptide oligomer: a homogenous and stable neuropathological protein in Alzheimer's disease J Neurochem 95 2005 834 847 (Pubitemid 41567174)
123. A. Viswanathan, and H. Chabriat Cerebral microhemorrhage Stroke 37 2006 550 555 (Pubitemid 43732025)
124. J. Rosand, A. Muzikansky, A. Kumar, J.J. Wisco, E.E. Smith, and R.A. Betensky Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy Ann Neurol 58 2005 459 462 (Pubitemid 41266633)
125. T. Mueggler, D. Baumann, M. Rausch, M. Staufenbiel, and M. Rudin Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease J Neurosci 23 2003 8231 8236 (Pubitemid 37129639)
126. F. Luo, T.R. Seifert, R. Edalji, R.W. Loebbert, V.P. Hradil, and J. Harlan Non-invasive characterization of beta-amyloid(1-40) vasoactivity by functional magnetic resonance imaging in mice Neuroscience 155 2008 263 269
127. F. Luo, N.R. Rustay, U. Ebert, V.P. Hradil, T.B. Cole, and D.A. Llano Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease Neurobiol Aging 2010
128. G. Richter-Levin, and I. Akirav Amygdala-hippocampus dynamic interaction in relation to memory Mol Neurobiol 22 2000 11 20
129. A. May Chronic pain may change the structure of the brain Pain 137 2008 7 15
130. M. Zhuo Cortical excitation and chronic pain Trends Neurosci 31 2008 199 207
131. R.C. Coghill, C.N. Sang, J.M. Maisog, and M.J. Iadarola Pain intensity processing within the human brain: a bilateral, distributed mechanism J Neurophysiol 82 1999 1934 1943 (Pubitemid 29471282)
132. J. Upadhyay, G. Pendse, J. Anderson, A.J. Schwarz, R. Baumgartner, and A. Coimbra Improved characterization of BOLD responses for evoked sensory stimuli Neuroimage 49 2010 2275 2286
133. M.N. Baliki, P.Y. Geha, A.V. Apkarian, and D.R. Chialvo Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics J Neurosci 28 2008 1398 1403 (Pubitemid 351231512)
134. M.N. Baliki, P.Y. Geha, H.L. Fields, and A.V. Apkarian Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain Neuron 66 2010 149 160
135. V. Napadow, L. LaCount, K. Park, S. As-Sanie, D.J. Clauw, and R.E. Harris Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity Arthritis Rheum 62 2010 2545 2555
136. F. Cauda, K. Sacco, F. D'Agata, S. Duca, D. Cocito, and G. Geminiani Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain BMC Neurosci 10 2009 138
137. A. Hess, M. Sergejeva, L. Budinsky, H.U. Zeilhofer, and K. Brune Imaging of hyperalgesia in rats by functional MRI Eur J Pain 11 2007 109 119 (Pubitemid 44636282)
138. Shih Y-YI, C. Chang, J.-C. Chen, and F.-S. Jaw BOLD fMRI mapping of brain responses to nociceptive stimuli in rats under ketamine anesthesia Med Eng Phys 30 2008 953 958
139. K.L. Malisza, P.W. Stroman, A. Turner, L. Gregorash, T. Foniok, and A. Wright Functional MRI of the rat lumbar spinal cord involving painful stimulation and the effect of peripheral joint mobilization J Magn Reson Imaging 18 2003 152 159 (Pubitemid 36935945)
140. P. Chandran, M. Pai, E.A. Blomme, G.C. Hsieh, M.W. Decker, and P. Honore Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis Eur J Pharmacol 613 2009 39 45
141. K. Kobayashi, R. Imaizumi, H. Sumichika, H. Tanaka, M. Goda, and A. Fukunari Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats J Vet Med Sci 65 2003 1195 1199 (Pubitemid 41380043)
142. F. Blankenberg, D. Cheng, J. Tait, and S. Biswal Imaging chronic pain with annexin V-128 in a rodent model of spared nerve injury J Nucl Med Meeting Abstracts 49 2008 211P-b-
143. C. Fu-yong Advances in brain imaging of neuropathic pain Chin Med J 121 2008 653 657
144. S. Hume Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography Synapse 12 1992 47 54
145. J.R. Lever PET and spect imaging of the opoid system: receptors, radioligands and avenues for drug discovery and development Curr Pharmaceut Des 2007 33 49 (Pubitemid 46090490)
146. V. Neugebauer, V. Galhardo, S. Maione, and S.C. Mackey Forebrain pain mechanisms Brain Res Rev 60 2009 226 242