A trial of imaging selection and endovascular treatment for ischemic stroke

New England Journal of Medicine

Volumn 368, Issue 10, 2013, Pages 914-923

  Kidwell, Chelsea S ^a   Jahan, Reza ^b   Gornbein, Jeffrey ^b   Alger, Jeffry R ^b,c   Nenov, Val ^b   Ajani, Zahra ^d   Feng, Lei ^d   Meyer, Brett C ^e,g   Olson, Scott ^f,h   Schwamm, Lee H ⁱ   Yoo, Albert J ⁱ   Marshall, Randolph S ^j   Meyers, Philip M ^j   Yavagal, Dileep R ^k   Wintermark, Max ^l   Guzy, Judy ^b   Starkman, Sidney ^b   Saver, Jeffrey L ^b,c  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KAISER PERMANENTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h SCRIPPS CLINIC   (United States)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^j Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^k JACKSON MEMORIAL HOSPITAL   (United States)

^l UNIVERSITY OF VIRGINIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR DERIVATIVE;

ADULT; AGE; AGED; ARTICLE; BRAIN CIRCULATION; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CEREBRAL REVASCULARIZATION; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ENDOVASCULAR SURGERY; FEMALE; HEALTH CARE QUALITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MECHANICAL THROMBECTOMY; MORTALITY; MULTICENTER STUDY; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; OUTCOME ASSESSMENT; PENUMBRAL PATTERN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANKIN SCALE; REPERFUSION; SAFETY;

EID: 84874751053     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1212793     Document Type: Article

References (22)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-7.
2. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-29.
3. Fisher M. Characterizing the target of acute stroke therapy. Stroke 1997;28:866-72.
4. Barber PA, Darby DG, Desmond PM, et al. Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI. Neurology 1998;51:418-26.
5. Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432-8.
6. Smith WS, Sung G, Saver J, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 2008;39:1205-12.
7. Nogueira RG, Lutsep HL, Gupta R, et al. Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet 2012;380:1231-40. [Erratum, Lancet 2012;380:1230.]
8. Saver JL, Jahan R, Levy EI, et al. Solitaire flow restoration device versus the Merci retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet 2012;380:1241-9.
9. Costalat V, Machi P, Lobotesis K, et al. Rescue, combined, and stand-alone thrombectomy in the management of large vessel occlusion stroke using the Solitaire device: a prospective 50-patient single-center study: timing, safety, and efficacy. Stroke 2011;42:1929-35.
10. The Penumbra Pivotal Stroke Trial Investigators. The Penumbra Pivotal Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 2009;40:2761-8.
11. Albers GW, Thijs VN, Wechsler L, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) study. Ann Neurol 2006;60:508-17.
12. Lansberg MG, Kemp S, Straka M, et al. Results of DEFUSE 2: clinical endpoints. Stroke 2012;43:A73. abstract.
13. Davis SM, Donnan GA, Parsons MW, et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008;7:299-309.
14. Parsons M, Spratt N, Bivard A, et al. A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med 2012;366:1099-107.
15. Kidwell CS, Jahan R, Alger JR, et al. Design and rationale of the Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) Trial. Int J Stroke 2012 September 13 (Epub ahead of print).
16. Kidwell CS, Wintermark M, De Silva DA, et al. Multiparametric MRI and CT models of infarct core and favorable penumbral imaging patterns in acute ischemic stroke. Stroke 2013;44:73-9.
17. Bateman BT, Meyers PM, Schumacher HC, Mangla S, Pile-Spellman J. Conducting stroke research with an exception from the requirement for informed consent. Stroke 2003;34:1317-23.
18. Tomsick T, Broderick J, Carrozella J, et al. Revascularization results in the Interventional Management of Stroke II trial. AJNR Am J Neuroradiol 2008;29:582-7.
19. Lansberg MG, Straka M, Kemp S, et al. MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012;11:860-7.
20. Kidwell CS. MRI biomarkers in acute ischemic stroke: a conceptual framework and historical analysis. Stroke 2012 November 6 (Epub ahead of print).
21. Shuaib A, Butcher K, Mohammad AA, Saqqur M, Liebeskind DS. Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target. Lancet Neurol 2011;10:909-21.
22. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke - the PROACT II study: a randomized controlled trial. JAMA 1999;282:2003-11.