Thrombectomy within 8 hours after symptom onset in ischemic stroke

New England Journal of Medicine

Volumn 372, Issue 24, 2015, Pages 2296-2306

  Jovin, T G ^a   Chamorro, A ^b   Cobo, E ^d   De Miquel, M A ^c   Molina, C A ^c   Rovira, A ^c   San Roman L ^c   Serena, J ^c,e   Abilleira, S ^c   Ribo M ^c   Millan M ^c   Urra, X ^b   Cardona, P ^c   Lopez Cancio E ^c   Tomasello, A ^c   Castano C ^c   Blasco, J ^c   Aja, L ^c   Dorado, L ^c   Quesada, H ^c   Rubiera, M ^c   Hernandez Perez M ^c   Goyal, M ^c   Demchuk, A M ^f   Von Kummer, R ^g   Gallofre M ^f   Davalos A ^c   more..

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b Stroke Unit   (United States)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^e Hospital Josep Trueta   (Spain)

^f UNIVERSITY OF CALGARY   (Canada)

^g DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BRAIN EDEMA; BRAIN HEMATOMA; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBRAL REVASCULARIZATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISABILITY SEVERITY; DISEASE REGISTRY; ENDOVASCULAR THERAPY; FEMALE; HUMAN; INDEPENDENCE; MAJOR CLINICAL STUDY; MALE; MINIMALLY INVASIVE PROCEDURE; MORTALITY; MULTICENTER STUDY; NEUROLOGIC DISEASE; OPEN STUDY; OUTCOME ASSESSMENT; PATIENT SAFETY; PHASE 3 CLINICAL TRIAL; POPULATION RESEARCH; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RANKIN SCALE; REPERFUSION; SAMPLE SIZE; SPAIN; STENT RETRIEVER; SUBARACHNOID HEMORRHAGE; SYMPTOM; THROMBECTOMY; TIME TO TREATMENT; TREATMENT CONTRAINDICATION; ACUTE DISEASE; ADVERSE EFFECTS; CONTRAINDICATIONS; DEVICES; ENDOVASCULAR SURGERY; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PROCEDURES; STENT; STROKE;

ACUTE DISEASE; ADMINISTRATION, INTRAVENOUS; AGED; BRAIN ISCHEMIA; COMBINED MODALITY THERAPY; ENDOVASCULAR PROCEDURES; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; STENTS; STROKE; THROMBECTOMY; TIME-TO-TREATMENT; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84929454086     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1503780     Document Type: Article

References (15)

1. Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 2015;372:2285-95.
2. Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 2015;372:1019-30.
3. Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 2015;372:1009-18.
4. Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015;372:11-20. [Erratum, N Engl J Med 2015;372:394.]
5. Goyal M, Almekhlafi M, Menon B, et al. Challenges of acute endovascular stroke trials. Stroke 2014;45:3116-22.
6. Abilleira S, Cardona P, Rib?M, et al. Outcomes of a contemporary cohort of 536 consecutive patients with acute ischemic stroke treated with endovascular therapy. Stroke 2014;45:1046-52.
7. Molina CA, Chamorro A, Rovira A, et al. REVASCAT: a randomized trial of evascularization with SOLITAIRE FR device vs. best medical therapy in the treatment of acute stroke due to anterior circulation large vessel occlusion presenting within eight-hours of symptom onset. Int J Stroke 2013 November 10 (Epub ahead of print).
8. Saver JL. Novel end point analytic techniques and interpreting shifts across the entire range of outcome scales in acute stroke trials. Stroke 2007;38:3055-62.
9. Kelly AG, Hoskins KD, Holloway RG. Early stroke mortality, patient preferences, and the withdrawal of care bias. Neurology 2012;79:941-4.
10. Wilson JT, Hareendran A, Grant M, et al. Improving the assessment of outcomes in stroke: use of a structured interview to assign grades on the modified Rankin Scale. Stroke 2002;33:2243-6.
11. Wahlgren N, Ahmed N, D?alos A, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007;369:275-82. [Erratum, Lancet 2007;369:826.]
12. Hacke W, Kaste M, Fieschi C, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998;352:1245-51.
13. Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med 2013;368:893-903. [Erratum, N Engl J Med 2013;368:1265.]
14. McTaggart RA, Jovin TG, Lansberg MG, et al. Alberta Stroke Program Early Computed Tomographic Scoring performance in a series of patients undergoing computed tomography and MRI: reader agreement, modality agreement, and outcome prediction. Stroke 2015;46:407-12.
15. Khatri P. The state of acute endovascular therapy: a report from the 12th TTST Conference. Stroke (in press).