Animal modelling of traumatic brain injury in preclinical drug development: Where do we go from here?

British Journal of Pharmacology

Volumn 164, Issue 4, 2011, Pages 1207-1229

  Marklund, Niklas ^a   Hillered, Lars ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

animal modelling; contusion; cyclosporin; glutamate; inflammation; magnesium; neuroprotection; plasticity; reactive oxygen species; review; Traumatic brain injury

Indexed keywords

CYCLOSPORIN A; ERYTHROPOIETIN; MAGNESIUM; PLACEBO; PROGESTERONE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TOPIRAMATE;

AGE; BLAST INJURY; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN CONTUSION; BRAIN DAMAGE; BRAIN EDEMA; COGNITIVE DEFECT; CONTINUOUS INFUSION; DIFFUSE AXONAL INJURY; DISEASE MODEL; DRUG DOSE ESCALATION; ECLAMPSIA; EPIGENETICS; EXCITOTOXICITY; GLASGOW COMA SCALE; HEAD INJURY; HUMAN; INJURY SEVERITY; INTRACRANIAL HYPERTENSION; NERVE REGENERATION; NEUROPROTECTION; NEUROREHABILITATION; NONHUMAN; PATHOPHYSIOLOGY; PERSISTENT VEGETATIVE STATE; PRIORITY JOURNAL; REHABILITATION; REVIEW; SEX DIFFERENCE; SKULL FRACTURE; SPECIES DIFFERENCE; STRAIN DIFFERENCE; SUBARACHNOID HEMORRHAGE; SUBDURAL HEMATOMA; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; MALE; MICE; NEUROPROTECTIVE AGENTS; RATS; TRANSLATIONAL MEDICAL RESEARCH; TREATMENT OUTCOME;

EID: 80053317403     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01163.x     Document Type: Review

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