메뉴 건너뛰기




Volumn 6, Issue 1, 2009, Pages 4-13

Multifunctional Receptor-Directed Drugs for Disorders of the Central Nervous System

Author keywords

Alzheimer's disease; attention deficit disorder; cognition; delayed responses tasks; Drug discovery; neuroprotection; working memory

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; 5 (4 CYANOPHENYL) 2 [2 (2 METHYL 1 IMIDAZOLIDINYL)ETHYL]BENZOFURAN; ACETYLSALICYLIC ACID; AMANTADINE; ATYPICAL ANTIPSYCHOTIC AGENT; CARBIDOPA; CENTRAL NERVOUS SYSTEM AGENTS; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; CLONIDINE; DONEPEZIL; ENTACAPONE; GLYCOPYRRONIUM BROMIDE; HALOPERIDOL; HEXAMETHONIUM; JWS USC 75 IX; JWS USC 75IX; LADOSTIGIL; LEVODOPA; LISURIDE; MECAMYLAMINE; METHYLATROPINE; MHP 133; MPH 133; NICOTINE; PHYSOSTIGMINE; PRAMIPEXOLE; RASAGILINE; RIVASTIGMINE; RS 17017; RS 56812; RS 66331; THIOPERAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 57749105459     PISSN: 19337213     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nurt.2008.10.031     Document Type: Article
Times cited : (26)

References (42)
  • 2
    • 0036253409 scopus 로고    scopus 로고
    • Nussbaum M. Emerging therapies in the pharmacological treatment of Parkinson's disease
    • Korczyn A.D. Nussbaum M. Emerging therapies in the pharmacological treatment of Parkinson's disease. Drugs 62 (2002) 775-786
    • (2002) Drugs , vol.62 , pp. 775-786
    • Korczyn, A.D.1
  • 3
    • 33746628593 scopus 로고    scopus 로고
    • Jürgen Drews Case histories, magic bullets and the state of drug discovery
    • Jürgen Drews Case histories, magic bullets and the state of drug discovery. Nature Rev Drug Discovery 5 (2006) 635-640
    • (2006) Nature Rev Drug Discovery , vol.5 , pp. 635-640
  • 4
    • 50349086333 scopus 로고    scopus 로고
    • Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis
    • Kuroki T., Nagao N., and Nakahara T. Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis. Prog Brain Res 172 (2008) 199-212
    • (2008) Prog Brain Res , vol.172 , pp. 199-212
    • Kuroki, T.1    Nagao, N.2    Nakahara, T.3
  • 5
    • 34147108307 scopus 로고    scopus 로고
    • Pathway analysis for design of promiscuous drugs and selective drug mixtures
    • Sivachenko A., Kalinin A., and Yuryev A. Pathway analysis for design of promiscuous drugs and selective drug mixtures. Curr Drug Discov Technologies 3 (2006) 269-277
    • (2006) Curr Drug Discov Technologies , vol.3 , pp. 269-277
    • Sivachenko, A.1    Kalinin, A.2    Yuryev, A.3
  • 6
    • 0029777507 scopus 로고    scopus 로고
    • The effect of ranitidine on NSAID related dyspeptic symptoms with and without peptic ulcer disease of patients with rheumatoid arthritis and osteoarthritis
    • Van Groenendael J.H., Markusse H.M., Dijkmans B.A., and Breedveld F.C. The effect of ranitidine on NSAID related dyspeptic symptoms with and without peptic ulcer disease of patients with rheumatoid arthritis and osteoarthritis. Clin Rheumatol 15 (1996) 450-456
    • (1996) Clin Rheumatol , vol.15 , pp. 450-456
    • Van Groenendael, J.H.1    Markusse, H.M.2    Dijkmans, B.A.3    Breedveld, F.C.4
  • 7
    • 0032510315 scopus 로고    scopus 로고
    • A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group
    • Yeomans N.D., Tulassay Z., Juhász L., Rácz I., Howard J.M., van Rensburg C.J., Swannell A.J., and Hawkey C.J. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med 338 (1998) 719-726
    • (1998) N Engl J Med , vol.338 , pp. 719-726
    • Yeomans, N.D.1    Tulassay, Z.2    Juhász, L.3    Rácz, I.4    Howard, J.M.5    van Rensburg, C.J.6    Swannell, A.J.7    Hawkey, C.J.8
  • 8
    • 33846174632 scopus 로고    scopus 로고
    • The emerging role of cannabinoid neuromodulators in symptom management
    • Davis M., Maida V., Daeninck P., and Pergolizzi J. The emerging role of cannabinoid neuromodulators in symptom management. Supp Care Cancer 15 (2007) 63-71
    • (2007) Supp Care Cancer , vol.15 , pp. 63-71
    • Davis, M.1    Maida, V.2    Daeninck, P.3    Pergolizzi, J.4
  • 9
    • 0037198060 scopus 로고    scopus 로고
    • Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline
    • Youdim M.B., and Weinstock M. Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline. Mechanisms Ageing Develop 123 (2002) 1081-1086
    • (2002) Mechanisms Ageing Develop , vol.123 , pp. 1081-1086
    • Youdim, M.B.1    Weinstock, M.2
  • 10
    • 0038155162 scopus 로고    scopus 로고
    • Attenuation of MPTP-induced dopaminergic neurotoxicity by ladostigil, a cholinesterase-monoamine oxidase inhibitor
    • Sagi Y., Weinstock M., and Youdim M.B. Attenuation of MPTP-induced dopaminergic neurotoxicity by ladostigil, a cholinesterase-monoamine oxidase inhibitor. J Neurochem 86 (2003) 290-297
    • (2003) J Neurochem , vol.86 , pp. 290-297
    • Sagi, Y.1    Weinstock, M.2    Youdim, M.B.3
  • 11
    • 0036121418 scopus 로고    scopus 로고
    • Effect of ladostigil, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression
    • Weinstock M., Poltyrev T., Bejar C., and Youdim M.B. Effect of ladostigil, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression. Psychopharmacology 160 (2002) 318-324
    • (2002) Psychopharmacology , vol.160 , pp. 318-324
    • Weinstock, M.1    Poltyrev, T.2    Bejar, C.3    Youdim, M.B.4
  • 12
    • 0037507200 scopus 로고    scopus 로고
    • Potential cognitive actions of ladostigil, a novel neuroprotective agent, as assessed in old rhesus monkeys in their performance of versions of a delayed matching task
    • Buccafusco J.J., Terry Jr. A.V., Goren T., and Blaugrun E. Potential cognitive actions of ladostigil, a novel neuroprotective agent, as assessed in old rhesus monkeys in their performance of versions of a delayed matching task. Neuroscience 119 (2003) 669-678
    • (2003) Neuroscience , vol.119 , pp. 669-678
    • Buccafusco, J.J.1    Terry Jr., A.V.2    Goren, T.3    Blaugrun, E.4
  • 13
    • 33746840955 scopus 로고    scopus 로고
    • Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases
    • Van der Schyf C.J., Gal S., Geldenhuys W.J., and Youdim M.B. Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases. Expert Opin Investig Drugs 15 (2006) 873-886
    • (2006) Expert Opin Investig Drugs , vol.15 , pp. 873-886
    • Van der Schyf, C.J.1    Gal, S.2    Geldenhuys, W.J.3    Youdim, M.B.4
  • 14
    • 33845669856 scopus 로고    scopus 로고
    • The multifunctional neuroprotective anti-Alzheimer/ anti-Parkinson drug ladostigil (TV3326) regulates holo-APP translation and processing
    • Yogev-Falach M., Bar-Am O., Amit T., and Youdim M.B. The multifunctional neuroprotective anti-Alzheimer/ anti-Parkinson drug ladostigil (TV3326) regulates holo-APP translation and processing. FASEB J 20 (2006) 2177-2179
    • (2006) FASEB J , vol.20 , pp. 2177-2179
    • Yogev-Falach, M.1    Bar-Am, O.2    Amit, T.3    Youdim, M.B.4
  • 15
    • 33947546504 scopus 로고    scopus 로고
    • Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil
    • Youdim M.B., Amit T., Bar-Am O., and Yogev-Falach M. Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil. Neurotox Res 10 (2006) 1-11
    • (2006) Neurotox Res , vol.10 , pp. 1-11
    • Youdim, M.B.1    Amit, T.2    Bar-Am, O.3    Yogev-Falach, M.4
  • 17
    • 16544394141 scopus 로고    scopus 로고
    • Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys
    • Buccafusco J.J., and Terry Jr. A.V. Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys. J. Mol Neurosci 24 (2004) 85-91
    • (2004) J. Mol Neurosci , vol.24 , pp. 85-91
    • Buccafusco, J.J.1    Terry Jr., A.V.2
  • 18
    • 0023683671 scopus 로고
    • Nicotine enhances delayed matching-to-sample performance by primates
    • Elrod K., Buccafusco J.J., and Jackson W.J. Nicotine enhances delayed matching-to-sample performance by primates. Life Sci 43 (1988) 277-287
    • (1988) Life Sci , vol.43 , pp. 277-287
    • Elrod, K.1    Buccafusco, J.J.2    Jackson, W.J.3
  • 19
    • 0025780198 scopus 로고
    • Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys
    • Buccafusco J.J., and Jackson W.J. Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys. Neurobiol Aging 12 (1991) 233-238
    • (1991) Neurobiol Aging , vol.12 , pp. 233-238
    • Buccafusco, J.J.1    Jackson, W.J.2
  • 21
    • 0030444590 scopus 로고    scopus 로고
    • Nicotine/mecamylamine combination treatment for smoking cessation
    • Rose J.E., Westman E.C., and Behm F.M. Nicotine/mecamylamine combination treatment for smoking cessation. Drug Develop Res 38 (1996) 243-256
    • (1996) Drug Develop Res , vol.38 , pp. 243-256
    • Rose, J.E.1    Westman, E.C.2    Behm, F.M.3
  • 22
    • 0026473764 scopus 로고
    • Neuropharmacologic and behavioral actions of clonidine: interactions with central neurotransmitters
    • Buccafusco J.J. Neuropharmacologic and behavioral actions of clonidine: interactions with central neurotransmitters. International Rev Neurobiol 33 (1992) 55-107
    • (1992) International Rev Neurobiol , vol.33 , pp. 55-107
    • Buccafusco, J.J.1
  • 23
    • 0021715671 scopus 로고
    • Inhibition of regional brain acetylcholine biosynthesis by clonidine in spontaneously hypertensive rats
    • Buccafusco J.J. Inhibition of regional brain acetylcholine biosynthesis by clonidine in spontaneously hypertensive rats. Drug Devel Res 4 (1984) 627-633
    • (1984) Drug Devel Res , vol.4 , pp. 627-633
    • Buccafusco, J.J.1
  • 24
    • 46649086754 scopus 로고    scopus 로고
    • The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant conditioning memory tasks for screening drug candidates
    • Buccafusco J.J., Terry Jr. A.V., Webster S.J., Martin D.M., Hohnadel E.J., Bouchard K.A., and Warner S.E. The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant conditioning memory tasks for screening drug candidates. Psychopharmacology 199 (2008) 481-494
    • (2008) Psychopharmacology , vol.199 , pp. 481-494
    • Buccafusco, J.J.1    Terry Jr., A.V.2    Webster, S.J.3    Martin, D.M.4    Hohnadel, E.J.5    Bouchard, K.A.6    Warner, S.E.7
  • 25
    • 0025783827 scopus 로고
    • Clonidine enhances delayed matching-to-sample performance by young and aged monkeys
    • Jackson W.J., and Buccafusco J.J. Clonidine enhances delayed matching-to-sample performance by young and aged monkeys. Pharmacol Biochem Behav 39 (1991) 79-84
    • (1991) Pharmacol Biochem Behav , vol.39 , pp. 79-84
    • Jackson, W.J.1    Buccafusco, J.J.2
  • 26
    • 33847137816 scopus 로고    scopus 로고
    • Effect of ispronicline, a neuronal acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)
    • Dunbar G.C., Inglis R., Kuchibhatla R., Sharma T., Tomlinson M., and Wamsley J. Effect of ispronicline, a neuronal acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI). J Psychopharmacol 21 (2007) 171-178
    • (2007) J Psychopharmacol , vol.21 , pp. 171-178
    • Dunbar, G.C.1    Inglis, R.2    Kuchibhatla, R.3    Sharma, T.4    Tomlinson, M.5    Wamsley, J.6
  • 27
    • 0031003185 scopus 로고    scopus 로고
    • Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21. In vitro and in vivo
    • Briggs C.A., Anderson D.J., Brioni J.D., et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21. In vitro and in vivo. Pharmacol Biochem Behav 57 (1997) 231-241
    • (1997) Pharmacol Biochem Behav , vol.57 , pp. 231-241
    • Briggs, C.A.1    Anderson, D.J.2    Brioni, J.D.3
  • 28
    • 20544460348 scopus 로고    scopus 로고
    • Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance
    • Buccafusco J.J., Letchworth S.R., Bencherif M., and Lippillo P.M. Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance. Trends Pharmacological Sci 26 (2005) 352-360
    • (2005) Trends Pharmacological Sci , vol.26 , pp. 352-360
    • Buccafusco, J.J.1    Letchworth, S.R.2    Bencherif, M.3    Lippillo, P.M.4
  • 29
    • 57749090740 scopus 로고    scopus 로고
    • Protracted cognitive effects produced by clonidine in Macaca Nemestrina performing a delayed matching task
    • [Epub ahead of print] Sep 11
    • Buccafusco J.J., Webster S.J., Terry Jr. A.V., Kille N., and Blessing D. Protracted cognitive effects produced by clonidine in Macaca Nemestrina performing a delayed matching task. [Epub ahead of print]. Psychopharmacology (Berl) (2008) Sep 11
    • (2008) Psychopharmacology (Berl)
    • Buccafusco, J.J.1    Webster, S.J.2    Terry Jr., A.V.3    Kille, N.4    Blessing, D.5
  • 30
    • 57749107028 scopus 로고    scopus 로고
    • Georgia Tech Research Corporation, Atlanta, GA
    • inventors assignee US patent 5 714 615. February 3
    • Powers J.C., Buccafusco J.J., and Starks K. Georgia Tech Research Corporation, Atlanta, GA. inventors assignee. Pyridinium Compounds (1998) US patent 5 714 615. February 3
    • (1998) Pyridinium Compounds
    • Powers, J.C.1    Buccafusco, J.J.2    Starks, K.3
  • 31
    • 57749107028 scopus 로고    scopus 로고
    • Georgia Tech Research Corporation, Atlanta, GA
    • inventors assignee US patent 5 726 314. March 10
    • Powers J.C., Buccafusco J.J., and Starks K. Georgia Tech Research Corporation, Atlanta, GA. inventors assignee. Pyridinium Compounds (1998) US patent 5 726 314. March 10
    • (1998) Pyridinium Compounds
    • Powers, J.C.1    Buccafusco, J.J.2    Starks, K.3
  • 33
    • 0344758441 scopus 로고    scopus 로고
    • Ranitidine analog, JWS-USC-75IX, enhances memory-related task performance in rats
    • Terry Jr. A.V., Gattu M., Buccafusco J.J., Sowell J.W., and Kosh J.W. Ranitidine analog, JWS-USC-75IX, enhances memory-related task performance in rats. Drug Dev Res 47 (1999) 97-106
    • (1999) Drug Dev Res , vol.47 , pp. 97-106
    • Terry Jr., A.V.1    Gattu, M.2    Buccafusco, J.J.3    Sowell, J.W.4    Kosh, J.W.5
  • 34
    • 0031770363 scopus 로고    scopus 로고
    • Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humans. Neurotoxicol
    • Paule M.G., Bushnel P.J., Maurissen J.P.J., et al. Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humans. Neurotoxicol. Teratol 20 (1998) 493-502
    • (1998) Teratol , vol.20 , pp. 493-502
    • Paule, M.G.1    Bushnel, P.J.2    Maurissen, J.P.J.3
  • 35
    • 33645287272 scopus 로고    scopus 로고
    • Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders
    • Esbenshade T.A., Fox G.B., and Cowart M.D. Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders. Mol Interventions 6 (2006) 77-88
    • (2006) Mol Interventions , vol.6 , pp. 77-88
    • Esbenshade, T.A.1    Fox, G.B.2    Cowart, M.D.3
  • 36
    • 34248562939 scopus 로고    scopus 로고
    • GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models
    • Medhurst A.D., Atkins A.R., Beresford I.J., et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther 321 (2007) 1032-1045
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1032-1045
    • Medhurst, A.D.1    Atkins, A.R.2    Beresford, I.J.3
  • 37
    • 33947119591 scopus 로고    scopus 로고
    • Histamine H3 receptor antagonists: from target identification to drug leads
    • Bonaventure P., Letavic M., Dugovic C., et al. Histamine H3 receptor antagonists: from target identification to drug leads. Biochem Pharmacol 73 (2007) 1084-1096
    • (2007) Biochem Pharmacol , vol.73 , pp. 1084-1096
    • Bonaventure, P.1    Letavic, M.2    Dugovic, C.3
  • 38
    • 20144386364 scopus 로고    scopus 로고
    • Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist
    • Fox G.B., Esbenshade T.A., Pan J.B., et al. Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther 313 (2005) 176-190
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 176-190
    • Fox, G.B.1    Esbenshade, T.A.2    Pan, J.B.3
  • 39
    • 33745828716 scopus 로고    scopus 로고
    • Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice
    • Akhtar M., Uma Devi P., Ali A., Pillai K.K., and Vohora D. Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice. Fund Clin Pharmacol 20 (2006) 373-378
    • (2006) Fund Clin Pharmacol , vol.20 , pp. 373-378
    • Akhtar, M.1    Uma Devi, P.2    Ali, A.3    Pillai, K.K.4    Vohora, D.5
  • 40
    • 0029080364 scopus 로고
    • Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications
    • Cassel J.C., and Jeltsch H. Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience 69 (1995) 1-41
    • (1995) Neuroscience , vol.69 , pp. 1-41
    • Cassel, J.C.1    Jeltsch, H.2
  • 41
    • 53149107135 scopus 로고    scopus 로고
    • Cognitive dysfunction in neuropsychiatric disorders: selected serotonin receptor subtypes as therapeutic targets
    • Terry Jr. A.V., Buccafusco J.J., and Wilson C. Cognitive dysfunction in neuropsychiatric disorders: selected serotonin receptor subtypes as therapeutic targets. Behav Brain Res 16 (2008) 30-38
    • (2008) Behav Brain Res , vol.16 , pp. 30-38
    • Terry Jr., A.V.1    Buccafusco, J.J.2    Wilson, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.