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Volumn 31, Issue 3, 2011, Pages 807-818

Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: Systematic review and meta-analysis

Author keywords

blood glucose; cerebrovascular disease; focal cerebral ischaemia; hyperglycaemia; insulin; stroke

Indexed keywords

GLUCOSE; INSULIN; STREPTOZOCIN;

EID: 79952190509     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.210     Document Type: Review
Times cited : (84)

References (76)
  • 1
    • 34247844511 scopus 로고    scopus 로고
    • Guidelines for the early management of adults with ischemic stroke: A guideline from the American heart association/American stroke association stroke council, clinical cardiology council, cardiovascular radiology and intervention council, and the atherosclerotic peripheral vascular disease and quality of care outcomes in research interdisciplinary working groups
    • DOI 10.1161/STROKEAHA.107.181486, PII 0000767020070500000051
    • Adams Jr HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EF (2007) Guidelines for the Early Management of Adults with Ischemic Stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 38:1655-711 (Pubitemid 46691097)
    • (2007) Stroke , vol.38 , Issue.5 , pp. 1655-1711
    • Adams Jr., H.P.1    Del Zoppo, G.2    Alberts, M.J.3    Bhatt, D.L.4    Brass, L.5    Furlan, A.6    Grubb, R.L.7    Higashida, R.T.8    Jauch, E.C.9    Kidwell, C.10    Lyden, P.D.11    Morgenstern, L.B.12    Qureshi, A.I.13    Rosenwasser, R.H.14    Scott, P.A.15    Wijdicks, E.F.M.16
  • 3
    • 0041917474 scopus 로고    scopus 로고
    • Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome
    • DOI 10.1161/01.STR.0000085087.41330.FF
    • Baird TA, Parsons MW, Phanh T, Butcher KS, Desmond PM, Tress BM, Colman PG, Chambers BR, Davis SM (2003) Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke 34:2208-14 (Pubitemid 37099838)
    • (2003) Stroke , vol.34 , Issue.9 , pp. 2208-2214
    • Baird, T.A.1    Parsons, M.W.2    Phanh, T.3    Butcher, K.S.4    Desmond, P.M.5    Tress, B.M.6    Colman, P.G.7    Chambers, B.R.8    Davis, S.M.9
  • 4
    • 67649117904 scopus 로고    scopus 로고
    • Systematic review and stratified meta-analysis of the efficacy of interleu-kin-1 receptor antagonist in animal models of stroke
    • Banwell V, Sena ES, Macleod MR (2009) Systematic review and stratified meta-analysis of the efficacy of interleu-kin-1 receptor antagonist in animal models of stroke. J Stroke Cerebrovasc Dis 18:269-76
    • (2009) J Stroke Cerebrovasc Dis , vol.18 , pp. 269-76
    • Banwell, V.1    Sena, E.S.2    MacLeod, M.R.3
  • 5
    • 0024581875 scopus 로고
    • Nimodipine prevents hyperglycemia-induced cerebral acidosis in middle cerebral artery occluded rats
    • Berger L, Hakim AM (1989) Nimodipine prevents hyper-glycemia-induced cerebral acidosis in middle cerebral artery occluded rats. J Cereb Blood Flow Metab 9:58-64 (Pubitemid 19053435)
    • (1989) Journal of Cerebral Blood Flow and Metabolism , vol.9 , Issue.1 , pp. 58-64
    • Berger, L.1    Hakim, A.M.2
  • 7
    • 0029056093 scopus 로고
    • Neuroprotection after focal cerebral ischaemia in hyperglycaemic and diabetic rats
    • Bomont L, MacKenzie ET (1995) Neuroprotection after focal cerebral ischaemia in hyperglycaemic and diabetic rats. Neurosci Lett 197:53-6
    • (1995) Neurosci Lett , vol.197 , pp. 53-6
    • Bomont, L.1    MacKenzie, E.T.2
  • 8
    • 0041419591 scopus 로고    scopus 로고
    • The effects of middle cerebral artery occlusion on central nervous system apoptotic events in normal and diabetic rats
    • DOI 10.1080/15438600303727
    • Britton M, Rafols J, Alousi S, Dunbar JC (2003) The effects of middle cerebral artery occlusion on central nervous system apoptotic events in normal and diabetic rats. Int J Exp Diabesity Res 4:13-20 (Pubitemid 37038669)
    • (2003) Experimental Diabesity Research , vol.4 , Issue.1 , pp. 13-20
    • Britton, M.1    Rafols, J.2    Alousi, S.3    Dunbar, J.C.4
  • 12
    • 0034800666 scopus 로고    scopus 로고
    • Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: A systematic overview
    • Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC (2001) Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32:2426-32 (Pubitemid 32954818)
    • (2001) Stroke , vol.32 , Issue.10 , pp. 2426-2432
    • Capes, S.E.1    Hunt, D.2    Malmberg, K.3    Pathak, P.4    Gerstein, H.C.5
  • 13
    • 0025741093 scopus 로고
    • Hyperglycemia augments ischemic brain injury: In vivo MR imaging/spectroscopic study with nicardi-pine in cats with occluded middle cerebral arteries
    • Chew W, Kucharczyk J, Moseley M, Derugin N, Norman D (1991) Hyperglycemia augments ischemic brain injury: in vivo MR imaging/spectroscopic study with nicardi-pine in cats with occluded middle cerebral arteries. AJNR Am J Neuroradiol 12:603-9
    • (1991) AJNR Am J Neuroradiol , vol.12 , pp. 603-9
    • Chew, W.1    Kucharczyk, J.2    Moseley, M.3    Derugin, N.4    Norman, D.5
  • 14
    • 0025690874 scopus 로고
    • Focal cerebral infarction in cats in the presence of hyperglycemia and increased insulin
    • Combs DJ, Dempsey RJ, Kumar S, Donaldson D (1990) Focal cerebral infarction in cats in the presence of hyperglycemia and increased insulin. Metab Brain Dis 5:169-78
    • (1990) Metab Brain Dis , vol.5 , pp. 169-78
    • Combs, D.J.1    Dempsey, R.J.2    Kumar, S.3    Donaldson, D.4
  • 15
    • 0023889707 scopus 로고
    • Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats
    • De Courten-Myers G, Myers RE, Schoolfield L (1988) Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats. Stroke 19:623-30
    • (1988) Stroke , vol.19 , pp. 623-30
    • De Courten-Myers, G.1    Myers, R.E.2    Schoolfield, L.3
  • 18
    • 0032930284 scopus 로고    scopus 로고
    • Serum glucose level and diabetes predict tissue plasminogen activator- related intracerebral hemorrhage in acute ischemic stroke
    • Demchuk AM, Morgenstern LB, Krieger DW, Linda Chi T, Hu W, Wein TH, Hardy RJ, Grotta JC, Buchan AM (1999) Serum glucose level and diabetes predict tissue plasmi-nogen activator-related intracerebral hemorrhage in acute ischemic stroke. Stroke 30:34-9 (Pubitemid 29029438)
    • (1999) Stroke , vol.30 , Issue.1 , pp. 34-39
    • Demchuk, A.M.1    Morgenstern, L.B.2    Krieger, D.W.3    Chi, T.L.4    Hu, W.5    Wein, T.H.6    Hardy, R.J.7    Grotta, J.C.8    Buchan, A.M.9
  • 19
    • 0442309557 scopus 로고    scopus 로고
    • A nonparametric 'trim and fill' method of accounting for publication bias in meta-analysis
    • Duval S, Tweedie R (2000) A nonparametric 'trim and fill' method of accounting for publication bias in meta-analysis. J Am Stat Assoc 95:89-98
    • (2000) J Am Stat Assoc , vol.95 , pp. 89-98
    • Duval, S.1    Tweedie, R.2
  • 20
    • 0023801585 scopus 로고
    • The quantification of cerebral infarction following focal ischemia in the rat: Influence of strain, arterial pressure, blood glucose concentration, and age
    • Duverger D, MacKenzie ET (1988) The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age. J Cereb Blood Flow Metab 8:449-61
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 449-61
    • Duverger, D.1    MacKenzie, E.T.2
  • 21
    • 34548131648 scopus 로고    scopus 로고
    • Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening
    • DOI 10.1038/sj.jcbfm.9600454, PII 9600454
    • Ennis SR, Keep RF (2007) Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening. J Cereb Blood Flow Metab 27:1573-82 (Pubitemid 47301440)
    • (2007) Journal of Cerebral Blood Flow and Metabolism , vol.27 , Issue.9 , pp. 1573-1582
    • Ennis, S.R.1    Keep, R.F.2
  • 22
    • 63849229179 scopus 로고    scopus 로고
    • The NICE-SUGAR (Normogly-caemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) study: Statistical analysis plan
    • Finfer S, Heritier S (2009) The NICE-SUGAR (Normogly-caemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) study: statistical analysis plan. Crit Care Resusc 11:46-57
    • (2009) Crit Care Resusc , vol.11 , pp. 46-57
    • Finfer, S.1    Heritier, S.2
  • 23
    • 0026601272 scopus 로고
    • Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats
    • Folbergrova J, Memezawa H, Smith ML, Siesjo BK (1992) Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats. J Cereb Blood Flow Metab 12:25-33
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 25-33
    • Folbergrova, J.1    Memezawa, H.2    Smith, M.L.3    Siesjo, B.K.4
  • 25
    • 0023235238 scopus 로고
    • Hyperglycemia reduces the extent of cerebral infarction in rats
    • Ginsberg MD, Prado R, Dietrich WD, Busto R, Watson BD (1987) Hyperglycemia reduces the extent of cerebral infarction in rats. Stroke 18:570-4 (Pubitemid 17080569)
    • (1987) Stroke , vol.18 , Issue.3 , pp. 570-574
    • Ginsbery, M.D.1    Prado, R.2    Dietrich, W.D.3
  • 28
    • 1642432937 scopus 로고    scopus 로고
    • Prevalence and prediction of unrecognised diabetes mellitus and impaired glucose tolerance following acute stroke
    • DOI 10.1093/ageing/afh026
    • Gray CS, Scott JF, French JM, Alberti KG, O'Connell JE (2004) Prevalence and prediction of unrecognised diabetes mellitus and impaired glucose tolerance following acute stroke. Age Ageing 33:71-7 (Pubitemid 38111452)
    • (2004) Age and Ageing , vol.33 , Issue.1 , pp. 71-77
    • Gray, C.S.1    Scott, J.F.2    French, J.M.3    Alberti, K.G.M.M.4    O'Connell, J.E.5
  • 30
    • 0028797405 scopus 로고
    • Insulin reduction of cerebral infarction due to transient focal ischemia
    • Hamilton MG, Tranmer BI, Auer RN (1995) Insulin reduction of cerebral infarction due to transient focal ischemia. J Neurosurg 82:262-8
    • (1995) J Neurosurg , vol.82 , pp. 262-8
    • Hamilton, M.G.1    Tranmer, B.I.2    Auer, R.N.3
  • 31
    • 0029877221 scopus 로고    scopus 로고
    • A comparison of the early development of ischemic brain damage in normoglycemic and hyperglycemic rats using magnetic resonance imaging
    • Huang NC, Wei J, Quast MJ (1996) A comparison of the early development of ischemic brain damage in normo-glycemic and hyperglycemic rats using magnetic resonance imaging. Exp Brain Res 109:33-42 (Pubitemid 26119963)
    • (1996) Experimental Brain Research , vol.109 , Issue.1 , pp. 33-42
    • Huang, N.C.1    Wei, J.2    Quast, M.J.3
  • 32
    • 0026767381 scopus 로고
    • Insulin protects brain tissue against focal ischemia in rats
    • Izumi Y, Pinard E, Roussel S, Seylaz J (1992) Insulin protects brain tissue against focal ischemia in rats. Neurosci Lett 144:121-3
    • (1992) Neurosci Lett , vol.144 , pp. 121-3
    • Izumi, Y.1    Pinard, E.2    Roussel, S.3    Seylaz, J.4
  • 33
    • 33947525763 scopus 로고    scopus 로고
    • Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: Relation to blood-brain barrier dysfunction
    • DOI 10.1161/01.STR.0000258041.75739.cb, PII 0000767020070300000044
    • Kamada H, Yu F, Nito C, Chan PH (2007) Influence of hyperglycemia on oxidative stress and matrix metallo-proteinase-9 activation after focal cerebral ischemia/ reperfusion in rats: relation to blood-brain barrier dysfunction. Stroke 38:1044-9 (Pubitemid 46568472)
    • (2007) Stroke , vol.38 , Issue.3 , pp. 1044-1049
    • Kamada, H.1    Yu, F.2    Nito, C.3    Chan, P.H.4
  • 34
    • 0031308215 scopus 로고    scopus 로고
    • Effects of hyperglycemia on cerebral blood flow and edema formation after carotid artery occlusion in Fischer 344 rats
    • Kawai N, Keep RF, Betz AL (1997) Effects of hyperglycemia on cerebral blood flow and edema formation after carotid artery occlusion in Fischer 344 rats. Acta Neurochir Suppl 70:34-6 (Pubitemid 127502043)
    • (1997) Acta Neurochirurgica, Supplement , vol.1997 , Issue.70 , pp. 34-36
    • Kawai, N.1    Keep, R.F.2    Betz, A.L.3
  • 36
    • 0025270224 scopus 로고
    • Effect of hyperglycemia on neuronal changes in a rabbit model of focal cerebral ischemia
    • Kraft SA, Larson Jr CP, Shuer LM, Steinberg GK, Benson GV, Pearl RG (1990) Effect of hyperglycemia on neuronal changes in a rabbit model of focal cerebral ischemia. Stroke 21:447-50 (Pubitemid 20089793)
    • (1990) Stroke , vol.21 , Issue.3 , pp. 447-450
    • Kraft, S.A.1    Larson Jr., C.P.2    Shuer, L.M.3    Steinberg, G.K.4    Benson, G.V.5    Pearl, R.G.6
  • 37
    • 0031709093 scopus 로고    scopus 로고
    • Effects of streptozotocin-induced hyperglycemia on brain damage following transient ischemia
    • DOI 10.1006/nbdi.1998.0189
    • Li C, Li PA, He QP, Ouyang YB, Siesjo BK (1998a) Effects of streptozotocin-induced hyperglycemia on brain damage following transient ischemia. Neurobiol Dis 5:117-28 (Pubitemid 28430722)
    • (1998) Neurobiology of Disease , vol.5 , Issue.2 , pp. 117-128
    • Li, C.1    Li, P.-A.2    He, Q.-P.3    Ouyang, Y.-B.4    Siesjo, B.K.5
  • 38
    • 0032585007 scopus 로고    scopus 로고
    • Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction
    • DOI 10.1016/S0006-8993(98)00651-9, PII S0006899398006519
    • Li PA, Gisselsson L, Keuker J, Vogel J, Smith ML, Kuschinsky W, Siesjo BK (1998b) Hyperglycemia-exaggerated ischemic brain damage following 30 minutes of middle cerebral artery occlusion is not due to capillary obstruction. Brain Res 804:36-44 (Pubitemid 28410476)
    • (1998) Brain Research , vol.804 , Issue.1 , pp. 36-44
    • Li, P.-A.1    Gisselsson, L.2    Keuker, J.3    Vogel, J.4    Smith, M.-L.5    Kuschinsky, W.6    Siesjo, B.K.7
  • 39
    • 0032567722 scopus 로고    scopus 로고
    • Preischemic hyperglycemia leads to rapidly developing brain damage with no change in capillary patency
    • DOI 10.1016/S0006-8993(97)01150-5, PII S0006899397011505
    • Li PA, Vogel J, He QP, Smith ML, Kuschinsky W, Siesjo BK (1998c) Preischemic hyperglycemia leads to rapidly developing brain damage with no change in capillary patency. Brain Res 782:175-83 (Pubitemid 28122992)
    • (1998) Brain Research , vol.782 , Issue.1-2 , pp. 175-183
    • Li, P.-A.1    Vogel, J.2    He, Q.-P.3    Smith, M.-L.4    Kuschinsky, W.5    Siesjo, B.K.6
  • 40
    • 7544238410 scopus 로고    scopus 로고
    • Diabetes enhances apoptosis induced by cerebral ischemia
    • DOI 10.1016/j.lfs.2004.03.039, PII S0024320504006538
    • Li ZG, Britton M, Sima AA, Dunbar JC (2004) Diabetes enhances apoptosis induced by cerebral ischemia. Life Sci 76:249-62 (Pubitemid 39452909)
    • (2004) Life Sciences , vol.76 , Issue.3 , pp. 249-262
    • Li, Z.-G.1    Britton, M.2    Sima, A.A.F.3    Dunbar, J.C.4
  • 41
    • 0017179001 scopus 로고
    • Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
    • Like AA, Rossini AA (1976) Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193:415-7
    • (1976) Science , vol.193 , pp. 415-7
    • Like, A.A.1    Rossini, A.A.2
  • 42
    • 34250199392 scopus 로고    scopus 로고
    • Comparison of two rat models of cerebral ischemia under hyperglycemic conditions
    • DOI 10.1002/micr.20351
    • Liu L, Wang Z, Wang X, Song L, Chen H, Bemeur C, Ste-Marie L, Montgomery J (2007) Comparison of two rat models of cerebral ischemia under hyperglycemic conditions. Microsurgery 27:258-62 (Pubitemid 46897026)
    • (2007) Microsurgery , vol.27 , Issue.4 , pp. 258-262
    • Liu, L.1    Wang, Z.2    Wang, X.3    Song, L.4    Chen, H.5    Bemeur, C.6    Ste-Marie, L.7    Montgomery, J.8
  • 43
    • 2142768247 scopus 로고    scopus 로고
    • Pooling of animal experimental data reveals influence of study design and publication bias
    • DOI 10.1161/01.STR.0000125719.25853.20
    • Macleod MR, O'Collins T, Howells DW, Donnan GA (2004) Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 35:1203-8 (Pubitemid 38543544)
    • (2004) Stroke , vol.35 , Issue.5 , pp. 1203-1208
    • Macleod, M.R.1    O'Collins, T.2    Howells, D.W.3    Donnan, G.A.4
  • 44
    • 0023010755 scopus 로고
    • Effect of hyperglycemia on brain pH levels in areas of focal incomplete cerebral ischemia in monkeys
    • Marsh WR, Anderson RE, Sundt Jr TM (1986) Effect of hyperglycemia on brain pH levels in areas of focal incomplete cerebral ischemia in monkeys. J Neurosurg 65:693-6 (Pubitemid 17177521)
    • (1986) Journal of Neurosurgery , vol.65 , Issue.5 , pp. 693-696
    • Marsh, W.R.1    Anderson, R.E.2    Sundt Jr., T.M.3
  • 45
    • 33646688199 scopus 로고    scopus 로고
    • Why does acute hyperglycemia worsen the outcome of transient focal cerebral ischemia? Role of corticosteroids, inflammation, and protein O-glycosylation
    • DOI 10.1161/01.STR.0000217389.55009.f8, PII 0000767020060500000039
    • Martin A, Rojas S, Chamorro A, Falcon C, Bargallo N, Planas AM (2006) Why does acute hyperglycemia worsen the outcome of transient focal cerebral ischemia? Role of corticosteroids, inflammation, and protein O-glycosylation. Stroke 37:1288-95 (Pubitemid 43731878)
    • (2006) Stroke , vol.37 , Issue.5 , pp. 1288-1295
    • Martin, A.1    Rojas, S.2    Chamorro, A.3    Falcon, C.4    Bargallo, N.5    Planas, A.M.6
  • 48
    • 79952188256 scopus 로고    scopus 로고
    • Prevalence of impaired glucose metabolism and metabolic syndrome in non-diabetic patients with acute post stroke hyperglycaemia
    • 62 Abstract
    • McCormick M, Muir KW (2006) Prevalence of impaired glucose metabolism and metabolic syndrome in non-diabetic patients with acute post stroke hyperglycaemia. Cerebrovasc Dis 21(Suppl 4):62 Abstract
    • (2006) Cerebrovasc Dis , vol.21 , Issue.SUPPL. 4
    • McCormick, M.1    Muir, K.W.2
  • 49
    • 0023944657 scopus 로고
    • Triple-tracer autoradiography demonstrates effects of hyperglycemia on cerebral blood flow, pH, and glucose utilization in cerebral ischemia of rats
    • Nakai H, Yamamoto YL, Diksic M, Worsley KJ, Takara E (1988) Triple-tracer autoradiography demonstrates effects of hyperglycemia on cerebral blood flow, pH, and glucose utilization in cerebral ischemia of rats. Stroke 19:764-72
    • (1988) Stroke , vol.19 , pp. 764-72
    • Nakai, H.1    Yamamoto, Y.L.2    Diksic, M.3    Worsley, K.J.4    Takara, E.5
  • 50
    • 0023204401 scopus 로고
    • Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction
    • DOI 10.1016/0006-8993(87)90360-X
    • Nedergaard M (1987) Transient focal ischemia in hypergly-cemic rats is associated with increased cerebral infarction. Brain Res 408:79-85 (Pubitemid 17068418)
    • (1987) Brain Research , vol.408 , Issue.1-2 , pp. 79-85
    • Nedergaard, M.1
  • 51
    • 0023182295 scopus 로고
    • Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration
    • DOI 10.1007/BF00693778
    • Nedergaard M, Diemer NH (1987) Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration. Acta Neuropathol 73:131-7 (Pubitemid 17060008)
    • (1987) Acta Neuropathologica , vol.73 , Issue.2 , pp. 131-137
    • Nedergaard, M.1    Diemer, N.H.2
  • 52
    • 0022874759 scopus 로고
    • Focal ischemia of the rat brain: Autoradiographic determination of cerebral glucose utilization, glucose content, and blood flow
    • Nedergaard M, Gjedde A, Diemer NH (1986) Focal ischemia of the rat brain: autoradiographic determination of cerebral glucose utilization, glucose content, and blood flow. J Cereb Blood Flow Metab 6:414-24 (Pubitemid 16010624)
    • (1986) Journal of Cerebral Blood Flow and Metabolism , vol.6 , Issue.4 , pp. 414-424
    • Nedergaard, M.1    Gjedde, A.2    Diemer, N.H.3
  • 53
    • 0023572206 scopus 로고
    • Hyperglycaemia protects against neuronal injury around experimental brain infarcts
    • Nedergaard M, Gjedde A, Diemer NH (1987) Hyperglycae-mia protects against neuronal injury around experimental brain infarcts. Neurol Res 9:241-4 (Pubitemid 18066102)
    • (1987) Neurological Research , vol.9 , Issue.4 , pp. 241-244
    • Nedergaard, M.1    Gjedde, A.2    Diemer, N.H.3
  • 56
    • 0028939857 scopus 로고
    • Nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats
    • Quast MJ, Wei J, Huang NC (1995) Nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats. Brain Res 677:204-12
    • (1995) Brain Res , vol.677 , pp. 204-12
    • Quast, M.J.1    Wei, J.2    Huang, N.C.3
  • 58
    • 0034790645 scopus 로고    scopus 로고
    • The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia
    • DOI 10.1016/S0924-977X(01)00107-9, PII S0924977X01001079
    • Rejdak K, Rejdak R, Sieklucka-Dziuba M, Stelmasiak Z, Grieb P (2001) The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia. Eur Neuropsychopharmacol 11:333-41 (Pubitemid 32946883)
    • (2001) European Neuropsychopharmacology , vol.11 , Issue.5 , pp. 333-341
    • Rejdak, K.1    Rejdak, R.2    Sieklucka-Dziuba, M.3    Stelmasiak, Z.4    Grieb, P.5
  • 59
    • 33745252164 scopus 로고    scopus 로고
    • Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: Effects of insulin and C-peptide
    • DOI 10.1016/j.brainres.2006.04.060, PII S0006899306011036
    • Rizk NN, Rafols JA, Dunbar JC (2006) Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain Res 1096: 204-12 (Pubitemid 43928921)
    • (2006) Brain Research , vol.1096 , Issue.1 , pp. 204-212
    • Rizk, N.N.1    Rafols, J.A.2    Dunbar, J.C.3
  • 60
    • 0032894044 scopus 로고    scopus 로고
    • Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: The glucose insulin in stroke trial (GIST)
    • Scott JF, Robinson GM, French JM, O'Connell JE, Alberti KG, Gray CS (1999) Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the Glucose Insulin in Stroke Trial (GIST). Stroke 30:793-9 (Pubitemid 29156370)
    • (1999) Stroke , vol.30 , Issue.4 , pp. 793-799
    • Scott, J.F.1    Robinson, G.M.2    French, J.M.3    O'Connell, J.E.4    Alberti, K.G.M.M.5    Gray, C.S.6
  • 61
    • 34548475597 scopus 로고    scopus 로고
    • How can we improve the pre-clinical development of drugs for stroke?
    • DOI 10.1016/j.tins.2007.06.009, PII S0166223607001804
    • Sena E, van der Worp HB, Howells D, Macleod M (2007) How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci 30:433-9 (Pubitemid 47374833)
    • (2007) Trends in Neurosciences , vol.30 , Issue.9 , pp. 433-439
    • Sena, E.1    Van Der Worp, H.B.2    Howells, D.3    Macleod, M.4
  • 62
    • 77950572352 scopus 로고    scopus 로고
    • Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    • Sena ES, van der Worp HB, Bath PM, Howells DW, Macleod MR (2010) Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol 8:e1000344
    • (2010) PLoS Biol , vol.8
    • Sena, E.S.1    Van Der Worp, H.B.2    Bath, P.M.3    Howells, D.W.4    MacLeod, M.R.5
  • 63
    • 0025988481 scopus 로고
    • Hypertension and hyperglycemia in experimental stroke
    • Slivka AP (1991) Hypertension and hyperglycemia in experimental stroke. Brain Res 562:66-70
    • (1991) Brain Res , vol.562 , pp. 66-70
    • Slivka, A.P.1
  • 64
    • 0034823867 scopus 로고    scopus 로고
    • Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis
    • DOI 10.1016/S0895-4356(01)00377-8, PII S0895435601003778
    • Sterne JA, Egger M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54:1046-55 (Pubitemid 32888370)
    • (2001) Journal of Clinical Epidemiology , vol.54 , Issue.10 , pp. 1046-1055
    • Sterne, J.A.C.1    Egger, M.2
  • 65
    • 0021827417 scopus 로고
    • The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat
    • Venables GS, Miller SA, Gibson G, Hardy JA, Strong AJ (1985) The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat. J Neurol Neurosurg Psychiatry 48:663-9 (Pubitemid 15026242)
    • (1985) Journal of Neurology Neurosurgery and Psychiatry , vol.48 , Issue.7 , pp. 663-669
    • Venables, G.S.1    Miller, S.A.2    Gibson, G.3
  • 67
    • 0038367530 scopus 로고    scopus 로고
    • Effects of 2-Deoxy-D-glucose on focal cerebral ischemia in hyperglycemic rats
    • Wei J, Cohen DM, Quast MJ (2003) Effects of 2-deoxy-d-glucose on focal cerebral ischemia in hyperglycemic rats. J Cereb Blood Flow Metab 23:556-64 (Pubitemid 36566132)
    • (2003) Journal of Cerebral Blood Flow and Metabolism , vol.23 , Issue.5 , pp. 556-564
    • Wei, J.1    Cohen, D.M.2    Quast, M.J.3
  • 68
    • 0030851862 scopus 로고    scopus 로고
    • Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion
    • DOI 10.1016/S0891-5849(97)00127-5, PII S0891584997001275
    • Wei J, Huang NC, Quast MJ (1997) Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion. Free Radic Biol Med 23:986-95 (Pubitemid 27451285)
    • (1997) Free Radical Biology and Medicine , vol.23 , Issue.7 , pp. 986-995
    • Wei, J.1    Huang, N.C.2    Quast, M.J.3
  • 69
    • 0032571790 scopus 로고    scopus 로고
    • Effect of nitric oxide synthase inhibitor on a hyperglycemic rat model of reversible focal ischemia: Detection of excitatory amino acids release and hydroxyl radical formation
    • DOI 10.1016/S0006-8993(98)00089-4, PII S0006899398000894
    • Wei J, Quast MJ (1998) Effect of nitric oxide synthase inhibitor on a hyperglycemic rat model of reversible focal ischemia: detection of excitatory amino acids release and hydroxyl radical formation. Brain Res 791:146-56 (Pubitemid 28238320)
    • (1998) Brain Research , vol.791 , Issue.1-2 , pp. 146-156
    • Wei, J.1    Quast, M.J.2
  • 70
    • 0030966075 scopus 로고    scopus 로고
    • Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study
    • Weir CJ, Murray GD, Dyker AG, Lees KR (1997) Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study. BMJ 314:1303-6 (Pubitemid 27183316)
    • (1997) British Medical Journal , vol.314 , Issue.7090 , pp. 1303-1306
    • Weir, C.J.1    Murray, G.D.2    Dyker, A.G.3    Lees, K.R.4
  • 71
    • 39549087868 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke
    • DOI 10.1159/000111493
    • Wheble PC, Sena ES, Macleod MR (2008) A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke. Cerebrovasc Dis 25:5-11 (Pubitemid 351280369)
    • (2008) Cerebrovascular Diseases , vol.25 , Issue.1-2 , pp. 5-11
    • Wheble, P.C.R.1    Sena, E.S.2    Macleod, M.R.3
  • 72
    • 54049111024 scopus 로고    scopus 로고
    • Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial
    • Yong M, Kaste M (2008) Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial. Stroke 39:2749-55
    • (2008) Stroke , vol.39 , pp. 2749-55
    • Yong, M.1    Kaste, M.2
  • 73
    • 0024511626 scopus 로고
    • Hyperglycemia decreases acute neuronal ischemic changes after middle cerebral artery occlusion in cats
    • Zasslow MA, Pearl RG, Shuer LM, Steinberg GK, Lieberson RE, Larson Jr CP (1989) Hyperglycemia decreases acute neuronal ischemic changes after middle cerebral artery occlusion in cats. Stroke 20:519-23 (Pubitemid 19117381)
    • (1989) Stroke , vol.20 , Issue.4 , pp. 519-523
    • Zasslow, M.A.1    Pearl, R.G.2    Shuer, L.M.3    Steinberg, G.K.4    Lieberson, R.E.5    Larson Jr., C.P.6
  • 74
    • 0842277730 scopus 로고    scopus 로고
    • Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats
    • Zhang RL, Lu CZ, Ren HM, Xiao BG (2003) Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats. Exp Neurol 184:746-52
    • (2003) Exp Neurol , vol.184 , pp. 746-52
    • Zhang, R.L.1    Lu, C.Z.2    Ren, H.M.3    Xiao, B.G.4
  • 76
    • 7944227011 scopus 로고    scopus 로고
    • Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia
    • Zhu CZ, Auer RN (2004) Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia. J Neurosurg 101:664-8 (Pubitemid 43186427)
    • (2004) Journal of Neurosurgery , vol.101 , Issue.4 , pp. 664-668
    • Zhu, C.Z.1    Auer, R.N.2


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