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Volumn 46, Issue , 2015, Pages 21-33

Molecular pathophysiology of hepatic glucose production

Author keywords

glucagon; gluconeogenesis; glucose; insulin; liver

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; FRUCTOSE 1,6 BISPHOSPHATE; FRUCTOSE 6 PHOSPHATE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOCORTICOID; GLUCOSE; GLUCOSE 6 PHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE; PYRUVIC ACID; SULFONYLUREA; GLUCOSE BLOOD LEVEL;

EID: 84948129361     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2015.09.003     Document Type: Review
Times cited : (220)

References (114)
  • 1
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • D. Accili, and K.C. Arden FoxOs at the crossroads of cellular metabolism, differentiation, and transformation Cell 117 4 2004 421 426
    • (2004) Cell , vol.117 , Issue.4 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 2
    • 0017113111 scopus 로고
    • Influence of lactate infusion on glucose and FFA metabolism in man
    • G. Ahlborg, L. Hagenfeldt, and J. Wahren Influence of lactate infusion on glucose and FFA metabolism in man Scand. J. Clin. Lab. Invest 36 2 1976 193 201
    • (1976) Scand. J. Clin. Lab. Invest , vol.36 , Issue.2 , pp. 193-201
    • Ahlborg, G.1    Hagenfeldt, L.2    Wahren, J.3
  • 3
    • 79951962147 scopus 로고    scopus 로고
    • CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals
    • J.Y. Altarejos, and M. Montminy CREB and the CRTC co-activators: sensors for hormonal and metabolic signals Nat. Rev. Mol. Cell Biol 12 3 2011 141 151
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , Issue.3 , pp. 141-151
    • Altarejos, J.Y.1    Montminy, M.2
  • 4
    • 0024917106 scopus 로고
    • Electrophysiology of the pancreatic beta-cell
    • F.M. Ashcroft, and P. Rorsman Electrophysiology of the pancreatic beta-cell Prog. Biophys. Mol. Biol 54 2 1989 87 143
    • (1989) Prog. Biophys. Mol. Biol , vol.54 , Issue.2 , pp. 87-143
    • Ashcroft, F.M.1    Rorsman, P.2
  • 5
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • A.D. Baron, G. Brechtel, P. Wallace, and S.V. Edelman Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans Am. J. Physiol 255 6 Pt 1 1988 E769 E774
    • (1988) Am. J. Physiol , vol.255 , Issue.6 , pp. E769-E774
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 6
    • 1442352339 scopus 로고    scopus 로고
    • Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach
    • H. Bays, L. Mandarino, and R.A. DeFronzo Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach J. Clin. Endocrinol. Metab 89 2 2004 463 478
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , Issue.2 , pp. 463-478
    • Bays, H.1    Mandarino, L.2    DeFronzo, R.A.3
  • 7
    • 0031038124 scopus 로고    scopus 로고
    • Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats
    • M.A. Borg, R.S. Sherwin, W.P. Borg, W.V. Tamborlane, and G.I. Shulman Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats J. Clin. Invest 99 2 1997 361 365
    • (1997) J. Clin. Invest , vol.99 , Issue.2 , pp. 361-365
    • Borg, M.A.1    Sherwin, R.S.2    Borg, W.P.3    Tamborlane, W.V.4    Shulman, G.I.5
  • 8
    • 0028296222 scopus 로고
    • Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia
    • W.P. Borg, M.J. During, R.S. Sherwin, M.A. Borg, M.L. Brines, and G.I. Shulman Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia J. Clin. Invest 93 4 1994 1677 1682
    • (1994) J. Clin. Invest , vol.93 , Issue.4 , pp. 1677-1682
    • Borg, W.P.1    During, M.J.2    Sherwin, R.S.3    Borg, M.A.4    Brines, M.L.5    Shulman, G.I.6
  • 9
    • 0028931891 scopus 로고
    • Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release
    • W.P. Borg, R.S. Sherwin, M.J. During, M.A. Borg, and G.I. Shulman Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release Diabetes 44 2 1995 180 184
    • (1995) Diabetes , vol.44 , Issue.2 , pp. 180-184
    • Borg, W.P.1    Sherwin, R.S.2    During, M.J.3    Borg, M.A.4    Shulman, G.I.5
  • 10
    • 78149373656 scopus 로고    scopus 로고
    • Projection of the year 2050 burden of diabetes in the US adult population: Dynamic modeling of incidence, mortality, and prediabetes prevalence
    • J.P. Boyle, T.J. Thompson, E.W. Gregg, L.E. Barker, and D.F. Williamson Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence Popul. Health Metr 8 2010 29
    • (2010) Popul. Health Metr , vol.8 , pp. 29
    • Boyle, J.P.1    Thompson, T.J.2    Gregg, E.W.3    Barker, L.E.4    Williamson, D.F.5
  • 11
    • 0026447087 scopus 로고
    • Mammalian facilitative glucose transporters: Evidence for similar substrate recognition sites in functionally monomeric proteins
    • C.F. Burant, and G.I. Bell Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins Biochemistry 31 42 1992 10414 10420
    • (1992) Biochemistry , vol.31 , Issue.42 , pp. 10414-10420
    • Burant, C.F.1    Bell, G.I.2
  • 12
    • 0023832956 scopus 로고
    • Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus
    • P.J. Campbell, L.J. Mandarino, and J.E. Gerich Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus Metabolism 37 1 1988 15 21
    • (1988) Metabolism , vol.37 , Issue.1 , pp. 15-21
    • Campbell, P.J.1    Mandarino, L.J.2    Gerich, J.E.3
  • 13
    • 84858702540 scopus 로고    scopus 로고
    • The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives
    • Chen L., D.J. Magliano, and P.Z. Zimmet The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives Nat. Rev. Endocrinol 8 4 2012 228 236
    • (2012) Nat. Rev. Endocrinol , vol.8 , Issue.4 , pp. 228-236
    • Chen, L.1    Magliano, D.J.2    Zimmet, P.Z.3
  • 14
    • 0033126490 scopus 로고    scopus 로고
    • Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo
    • A.D. Cherrington Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo Diabetes 48 5 1999 1198 1214
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 1198-1214
    • Cherrington, A.D.1
  • 15
    • 0016251982 scopus 로고
    • The fructose 1,6-diphosphatase-phosphofructokinase substrate cycle. A site of regulation of hepatic gluconeogenesis by glucagon
    • M.G. Clark, N.M. Kneer, A.L. Bosch, and H.A. Lardy The fructose 1,6-diphosphatase-phosphofructokinase substrate cycle. A site of regulation of hepatic gluconeogenesis by glucagon J. Biol. Chem 249 18 1974 5695 5703
    • (1974) J. Biol. Chem , vol.249 , Issue.18 , pp. 5695-5703
    • Clark, M.G.1    Kneer, N.M.2    Bosch, A.L.3    Lardy, H.A.4
  • 17
    • 0024511329 scopus 로고
    • Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
    • A. Consoli, N. Nurjhan, F. Capani, and J. Gerich Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM Diabetes 38 5 1989 550 557
    • (1989) Diabetes , vol.38 , Issue.5 , pp. 550-557
    • Consoli, A.1    Nurjhan, N.2    Capani, F.3    Gerich, J.4
  • 18
    • 3042750643 scopus 로고    scopus 로고
    • Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
    • H. Daitoku, M. Hatta, H. Matsuzaki, S. Aratani, T. Ohshima, M. Miyagishi, and et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proc. Natl. Acad. Sci. U.S.A. 101 27 2004 10042 10047
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , Issue.27 , pp. 10042-10047
    • Daitoku, H.1    Hatta, M.2    Matsuzaki, H.3    Aratani, S.4    Ohshima, T.5    Miyagishi, M.6
  • 19
    • 78649686908 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review
    • C.F. Deacon Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review Diabetes Obes. Metab 13 1 2011 7 18
    • (2011) Diabetes Obes. Metab , vol.13 , Issue.1 , pp. 7-18
    • Deacon, C.F.1
  • 20
    • 4143151942 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes mellitus
    • ix
    • R.A. DeFronzo Pathogenesis of type 2 diabetes mellitus Med. Clin. North Am 88 4 2004 787 835 ix
    • (2004) Med. Clin. North Am , vol.88 , Issue.4 , pp. 787-835
    • DeFronzo, R.A.1
  • 21
    • 0019995650 scopus 로고
    • Hepatic and peripheral insulin resistance: A common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus
    • R.A. DeFronzo, D. Simonson, and E. Ferrannini Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus Diabetologia 23 4 1982 313 319
    • (1982) Diabetologia , vol.23 , Issue.4 , pp. 313-319
    • DeFronzo, R.A.1    Simonson, D.2    Ferrannini, E.3
  • 22
    • 0021994683 scopus 로고
    • Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
    • R.A. DeFronzo, R. Gunnarsson, O. Bjorkman, M. Olsson, and J. Wahren Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus J. Clin. Invest 76 1 1985 149 155
    • (1985) J. Clin. Invest , vol.76 , Issue.1 , pp. 149-155
    • DeFronzo, R.A.1    Gunnarsson, R.2    Bjorkman, O.3    Olsson, M.4    Wahren, J.5
  • 23
    • 0023832957 scopus 로고
    • Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog
    • M.P. Diamond, R.C. Rollings, K.E. Steiner, P.E. Williams, W.W. Lacy, and A.D. Cherrington Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog Metabolism 37 1 1988 28 33
    • (1988) Metabolism , vol.37 , Issue.1 , pp. 28-33
    • Diamond, M.P.1    Rollings, R.C.2    Steiner, K.E.3    Williams, P.E.4    Lacy, W.W.5    Cherrington, A.D.6
  • 24
    • 84871676013 scopus 로고    scopus 로고
    • The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis
    • J.E. Dominy Jr., Y. Lee, M.P. Jedrychowski, H. Chim, M.J. Jurczak, J.P. Camporez, and et al. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis Mol. Cell 48 6 2012 900 913
    • (2012) Mol. Cell , vol.48 , Issue.6 , pp. 900-913
    • Dominy, J.E.1    Lee, Y.2    Jedrychowski, M.P.3    Chim, H.4    Jurczak, M.J.5    Camporez, J.P.6
  • 25
    • 0031936954 scopus 로고    scopus 로고
    • Glucagon-like peptides
    • D.J. Drucker Glucagon-like peptides Diabetes 47 2 1998 159 169
    • (1998) Diabetes , vol.47 , Issue.2 , pp. 159-169
    • Drucker, D.J.1
  • 26
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • M.Y. El-Mir, V. Nogueira, E. Fontaine, N. Averet, M. Rigoulet, and X. Leverve Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I J. Biol. Chem 275 1 2000 223 228
    • (2000) J. Biol. Chem , vol.275 , Issue.1 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 27
    • 0017831784 scopus 로고
    • The regulation of liver pyruvate kinase by phosphorylation-dephosphorylation
    • L. Engstrom The regulation of liver pyruvate kinase by phosphorylation-dephosphorylation Curr. Top. Cell. Regul 13 1978 28 51
    • (1978) Curr. Top. Cell. Regul , vol.13 , pp. 28-51
    • Engstrom, L.1
  • 28
    • 0014198445 scopus 로고
    • Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats
    • J.H. Exton, and C.R. Park Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats J. Biol. Chem 242 11 1967 2622 2636
    • (1967) J. Biol. Chem , vol.242 , Issue.11 , pp. 2622-2636
    • Exton, J.H.1    Park, C.R.2
  • 29
    • 2442733778 scopus 로고
    • Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes
    • J.E. Feliu, L. Hue, and H.G. Hers Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes Proc. Natl. Acad. Sci. U.S.A. 73 8 1976 2762 2766
    • (1976) Proc. Natl. Acad. Sci. U.S.A. , vol.73 , Issue.8 , pp. 2762-2766
    • Feliu, J.E.1    Hue, L.2    Hers, H.G.3
  • 30
    • 0022467301 scopus 로고
    • Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues
    • R.G. Firth, P.M. Bell, H.M. Marsh, I. Hansen, and R.A. Rizza Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues J. Clin. Invest 77 5 1986 1525 1532
    • (1986) J. Clin. Invest , vol.77 , Issue.5 , pp. 1525-1532
    • Firth, R.G.1    Bell, P.M.2    Marsh, H.M.3    Hansen, I.4    Rizza, R.A.5
  • 31
    • 0016175306 scopus 로고
    • Kinetic properties of rat liver pyruvate kinase at cellular concentrations of enzyme, substrates and modifiers
    • W. Flory, B.D. Peczon, R.E. Koeppe, and H.O. Spivey Kinetic properties of rat liver pyruvate kinase at cellular concentrations of enzyme, substrates and modifiers Biochem. J. 141 1 1974 127 131
    • (1974) Biochem. J. , vol.141 , Issue.1 , pp. 127-131
    • Flory, W.1    Peczon, B.D.2    Koeppe, R.E.3    Spivey, H.O.4
  • 32
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • M. Foretz, S. Hébrard, J. Leclerc, E. Zarrinpashneh, M. Soty, G. Mithieux, and et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state J. Clin. Invest 120 7 2010 2355 2369
    • (2010) J. Clin. Invest , vol.120 , Issue.7 , pp. 2355-2369
    • Foretz, M.1    Hébrard, S.2    Leclerc, J.3    Zarrinpashneh, E.4    Soty, M.5    Mithieux, G.6
  • 33
    • 0020335927 scopus 로고
    • Glucagon and the Ca2+-linked hormones angiotensin II, norepinephrine, and vasopressin stimulate the phosphorylation of distinct substrates in intact hepatocytes
    • J.C. Garrison, and J.D. Wagner Glucagon and the Ca2+-linked hormones angiotensin II, norepinephrine, and vasopressin stimulate the phosphorylation of distinct substrates in intact hepatocytes J. Biol. Chem 257 21 1982 13135 13143
    • (1982) J. Biol. Chem , vol.257 , Issue.21 , pp. 13135-13143
    • Garrison, J.C.1    Wagner, J.D.2
  • 34
    • 0035430524 scopus 로고    scopus 로고
    • Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients
    • A. Gastaldelli, E. Toschi, M. Pettiti, S. Frascerra, A. Quiñones-Galvan, A.M. Sironi, and et al. Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients Diabetes 50 8 2001 1807 1812
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1807-1812
    • Gastaldelli, A.1    Toschi, E.2    Pettiti, M.3    Frascerra, S.4    Quiñones-Galvan, A.5    Sironi, A.M.6
  • 35
    • 33645071314 scopus 로고    scopus 로고
    • Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes
    • R.W. Gelling, G.J. Morton, C.D. Morrison, K.D. Niswender, M.G. Myers Jr., C.J. Rhodes, and et al. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes Cell Metab 3 1 2006 67 73
    • (2006) Cell Metab , vol.3 , Issue.1 , pp. 67-73
    • Gelling, R.W.1    Morton, G.J.2    Morrison, C.D.3    Niswender, K.D.4    Myers, M.G.5    Rhodes, C.J.6
  • 36
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications
    • J.E. Gerich Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications Diabet. Med 27 2 2010 136 142
    • (2010) Diabet. Med , vol.27 , Issue.2 , pp. 136-142
    • Gerich, J.E.1
  • 37
    • 0025068821 scopus 로고
    • Contribution of impaired muscle glucose clearance to reduced postabsorptive systemic glucose clearance in NIDDM
    • J.E. Gerich, A. Mitrakou, D. Kelley, L. Mandarino, N. Nurjhan, J. Reilly, and et al. Contribution of impaired muscle glucose clearance to reduced postabsorptive systemic glucose clearance in NIDDM Diabetes 39 2 1990 211 216
    • (1990) Diabetes , vol.39 , Issue.2 , pp. 211-216
    • Gerich, J.E.1    Mitrakou, A.2    Kelley, D.3    Mandarino, L.4    Nurjhan, N.5    Reilly, J.6
  • 38
    • 0031677781 scopus 로고    scopus 로고
    • Tissue specificity of sulfonylureas: Studies on cloned cardiac and beta-cell K(ATP) channels
    • F.M. Gribble, S.J. Tucker, S. Seino, and F.M. Ashcroft Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels Diabetes 47 9 1998 1412 1418
    • (1998) Diabetes , vol.47 , Issue.9 , pp. 1412-1418
    • Gribble, F.M.1    Tucker, S.J.2    Seino, S.3    Ashcroft, F.M.4
  • 39
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
    • L.C. Groop, R.C. Bonadonna, S. DelPrato, K. Ratheiser, K. Zyck, E. Ferrannini, and et al. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance J. Clin. Invest 84 1 1989 205 213
    • (1989) J. Clin. Invest , vol.84 , Issue.1 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    DelPrato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6
  • 40
    • 78149272381 scopus 로고    scopus 로고
    • FoxOs function synergistically to promote glucose production
    • R.A. Haeusler, K.H. Kaestner, and D. Accili FoxOs function synergistically to promote glucose production J. Biol. Chem 285 46 2010 35245 35248
    • (2010) J. Biol. Chem , vol.285 , Issue.46 , pp. 35245-35248
    • Haeusler, R.A.1    Kaestner, K.H.2    Accili, D.3
  • 42
    • 84922844480 scopus 로고    scopus 로고
    • Metformin action: Concentrations matter
    • He L., and F.E. Wondisford Metformin action: concentrations matter Cell Metab 21 2 2015 159 162
    • (2015) Cell Metab , vol.21 , Issue.2 , pp. 159-162
    • He, L.1    Wondisford, F.E.2
  • 43
    • 0035855905 scopus 로고    scopus 로고
    • CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    • S. Herzig, Long F., U.S. Jhala, S. Hedrick, R. Quinn, A. Bauer, and et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 Nature 413 6852 2001 179 183
    • (2001) Nature , vol.413 , Issue.6852 , pp. 179-183
    • Herzig, S.1    Long, F.2    Jhala, U.S.3    Hedrick, S.4    Quinn, R.5    Bauer, A.6
  • 44
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • J.J. Holst The physiology of glucagon-like peptide 1 Physiol. Rev 87 4 2007 1409 1439
    • (2007) Physiol. Rev , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 46
    • 84864285795 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • S.E. Inzucchi, R.M. Bergenstal, J.B. Buse, M. Diamant, E. Ferrannini, M. Nauck, and et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetologia 55 6 2012 1577 1596
    • (2012) Diabetologia , vol.55 , Issue.6 , pp. 1577-1596
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6
  • 47
    • 58149525327 scopus 로고    scopus 로고
    • Molecular physiology of mammalian glucokinase
    • P.B. Iynedjian Molecular physiology of mammalian glucokinase Cell. Mol. Life Sci 66 1 2009 27 42
    • (2009) Cell. Mol. Life Sci , vol.66 , Issue.1 , pp. 27-42
    • Iynedjian, P.B.1
  • 48
    • 0025214987 scopus 로고
    • The relationship between gluconeogenic substrate supply and glucose production in humans
    • F. Jahoor, E.J. Peters, and R.R. Wolfe The relationship between gluconeogenic substrate supply and glucose production in humans Am. J. Physiol 258 2 Pt 1 1990 E288 E296
    • (1990) Am. J. Physiol , vol.258 , Issue.2 , pp. E288-E296
    • Jahoor, F.1    Peters, E.J.2    Wolfe, R.R.3
  • 49
    • 0025079179 scopus 로고
    • Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration
    • T. Jenssen, N. Nurjhan, A. Consoli, and J.E. Gerich Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration J. Clin. Invest 86 2 1990 489 497
    • (1990) J. Clin. Invest , vol.86 , Issue.2 , pp. 489-497
    • Jenssen, T.1    Nurjhan, N.2    Consoli, A.3    Gerich, J.E.4
  • 50
    • 84874045511 scopus 로고    scopus 로고
    • The origins and drivers of insulin resistance
    • A.M. Johnson, and J.M. Olefsky The origins and drivers of insulin resistance Cell 152 4 2013 673 684
    • (2013) Cell , vol.152 , Issue.4 , pp. 673-684
    • Johnson, A.M.1    Olefsky, J.M.2
  • 51
    • 0034116143 scopus 로고    scopus 로고
    • A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen
    • D. Knutti, A. Kaul, and A. Kralli A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen Mol. Cell. Biol 20 7 2000 2411 2422
    • (2000) Mol. Cell. Biol , vol.20 , Issue.7 , pp. 2411-2422
    • Knutti, D.1    Kaul, A.2    Kralli, A.3
  • 52
    • 27144506185 scopus 로고    scopus 로고
    • The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    • S.H. Koo, L. Flechner, Qi L., Zhang X., R.A. Screaton, S. Jeffries, and et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism Nature 437 7062 2005 1109 1111
    • (2005) Nature , vol.437 , Issue.7062 , pp. 1109-1111
    • Koo, S.H.1    Flechner, L.2    Qi, L.3    Zhang, X.4    Screaton, R.A.5    Jeffries, S.6
  • 53
    • 0025261239 scopus 로고
    • Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice
    • L. Koranyi, D. James, M. Mueckler, and M.A. Permutt Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice J. Clin. Invest 85 3 1990 962 967
    • (1990) J. Clin. Invest , vol.85 , Issue.3 , pp. 962-967
    • Koranyi, L.1    James, D.2    Mueckler, M.3    Permutt, M.A.4
  • 54
    • 23244458439 scopus 로고    scopus 로고
    • Regulation of blood glucose by hypothalamic pyruvate metabolism
    • T.K. Lam, R. Gutierrez-Juarez, A. Pocai, and L. Rossetti Regulation of blood glucose by hypothalamic pyruvate metabolism Science 309 5736 2005 943 947
    • (2005) Science , vol.309 , Issue.5736 , pp. 943-947
    • Lam, T.K.1    Gutierrez-Juarez, R.2    Pocai, A.3    Rossetti, L.4
  • 55
    • 0030866606 scopus 로고    scopus 로고
    • Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets
    • C. Lambillotte, P. Gilon, and J.C. Henquin Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets J. Clin. Invest 99 3 1997 414 423
    • (1997) J. Clin. Invest , vol.99 , Issue.3 , pp. 414-423
    • Lambillotte, C.1    Gilon, P.2    Henquin, J.C.3
  • 57
    • 84903521363 scopus 로고    scopus 로고
    • Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression
    • Y. Lee, J.E. Dominy, Y.J. Choi, M. Jurczak, N. Tolliday, J.P. Camporez, and et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression Nature 510 7506 2014 547 551
    • (2014) Nature , vol.510 , Issue.7506 , pp. 547-551
    • Lee, Y.1    Dominy, J.E.2    Choi, Y.J.3    Jurczak, M.4    Tolliday, N.5    Camporez, J.P.6
  • 58
    • 33744534726 scopus 로고    scopus 로고
    • GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha
    • C. Lerin, J.T. Rodgers, D.E. Kalume, S.H. Kim, A. Pandey, and P. Puigserver GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha Cell Metab 3 6 2006 429 438
    • (2006) Cell Metab , vol.3 , Issue.6 , pp. 429-438
    • Lerin, C.1    Rodgers, J.T.2    Kalume, D.E.3    Kim, S.H.4    Pandey, A.5    Puigserver, P.6
  • 59
    • 0030975131 scopus 로고    scopus 로고
    • Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    • G.F. Lewis, M. Vranic, P. Harley, and A. Giacca Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans Diabetes 46 7 1997 1111 1119
    • (1997) Diabetes , vol.46 , Issue.7 , pp. 1111-1119
    • Lewis, G.F.1    Vranic, M.2    Harley, P.3    Giacca, A.4
  • 60
    • 0842288445 scopus 로고    scopus 로고
    • Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice
    • Liang Y., M.C. Osborne, B.P. Monia, S. Bhanot, W.A. Gaarde, C. Reed, and et al. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice Diabetes 53 2 2004 410 417
    • (2004) Diabetes , vol.53 , Issue.2 , pp. 410-417
    • Liang, Y.1    Osborne, M.C.2    Monia, B.P.3    Bhanot, S.4    Gaarde, W.A.5    Reed, C.6
  • 61
    • 79959962745 scopus 로고    scopus 로고
    • Hormonal regulation of hepatic glucose production in health and disease
    • Lin H.V., and D. Accili Hormonal regulation of hepatic glucose production in health and disease Cell Metab 14 1 2011 9 19
    • (2011) Cell Metab , vol.14 , Issue.1 , pp. 9-19
    • Lin, H.V.1    Accili, D.2
  • 62
    • 84857934301 scopus 로고    scopus 로고
    • Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
    • Lu M., Wan M., K.F. Leavens, Chu Q., B.R. Monks, S. Fernandez, and et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 Nat. Med 18 3 2012 388 395
    • (2012) Nat. Med , vol.18 , Issue.3 , pp. 388-395
    • Lu, M.1    Wan, M.2    Leavens, K.F.3    Chu, Q.4    Monks, B.R.5    Fernandez, S.6
  • 63
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • C.N. Lumeng, and A.R. Saltiel Inflammatory links between obesity and metabolic disease J. Clin. Invest 121 6 2011 2111 2117
    • (2011) J. Clin. Invest , vol.121 , Issue.6 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 64
    • 79959635928 scopus 로고    scopus 로고
    • Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase
    • Y. Lustig, J.L. Ruas, J.L. Estall, J.C. Lo, S. Devarakonda, D. Laznik, and et al. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase Genes Dev 25 12 2011 1232 1244
    • (2011) Genes Dev , vol.25 , Issue.12 , pp. 1232-1244
    • Lustig, Y.1    Ruas, J.L.2    Estall, J.L.3    Lo, J.C.4    Devarakonda, S.5    Laznik, D.6
  • 65
    • 84903524608 scopus 로고    scopus 로고
    • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
    • A.K. Madiraju, D.M. Erion, Y. Rahimi, Zhang X.M., D.T. Braddock, R.A. Albright, and et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Nature 510 7506 2014 542 546
    • (2014) Nature , vol.510 , Issue.7506 , pp. 542-546
    • Madiraju, A.K.1    Erion, D.M.2    Rahimi, Y.3    Zhang, X.M.4    Braddock, D.T.5    Albright, R.A.6
  • 66
    • 0026488079 scopus 로고
    • Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study
    • I. Magnusson, D.L. Rothman, L.D. Katz, R.G. Shulman, and G.I. Shulman Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study J. Clin. Invest 90 4 1992 1323 1327
    • (1992) J. Clin. Invest , vol.90 , Issue.4 , pp. 1323-1327
    • Magnusson, I.1    Rothman, D.L.2    Katz, L.D.3    Shulman, R.G.4    Shulman, G.I.5
  • 67
    • 84864056422 scopus 로고    scopus 로고
    • Metformin: A diabetes drug for cancer, or a cancer drug for diabetics?
    • M. Martin, and R. Marais Metformin: a diabetes drug for cancer, or a cancer drug for diabetics? J. Clin. Oncol 30 21 2012 2698 2700
    • (2012) J. Clin. Oncol , vol.30 , Issue.21 , pp. 2698-2700
    • Martin, M.1    Marais, R.2
  • 68
    • 0030067124 scopus 로고    scopus 로고
    • Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • F.M. Matschinsky Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm Diabetes 45 2 1996 223 241
    • (1996) Diabetes , vol.45 , Issue.2 , pp. 223-241
    • Matschinsky, F.M.1
  • 69
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    • M. Matsumoto, A. Pocai, L. Rossetti, R.A. Depinho, and D. Accili Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver Cell Metab 6 3 2007 208 216
    • (2007) Cell Metab , vol.6 , Issue.3 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    Depinho, R.A.4    Accili, D.5
  • 71
    • 0021261122 scopus 로고
    • Effects of phosphorylation on the kinetic properties of rat liver fructose-1,6-bisphosphatase
    • D.W. Meek, and H.G. Nimmo Effects of phosphorylation on the kinetic properties of rat liver fructose-1,6-bisphosphatase Biochem. J. 222 1 1984 125 130
    • (1984) Biochem. J. , vol.222 , Issue.1 , pp. 125-130
    • Meek, D.W.1    Nimmo, H.G.2
  • 72
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • M.D. Michael, R.N. Kulkarni, C. Postic, S.F. Previs, G.I. Shulman, M.A. Magnuson, and et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Mol. Cell 6 1 2000 87 97
    • (2000) Mol. Cell , vol.6 , Issue.1 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6
  • 73
    • 84873707522 scopus 로고    scopus 로고
    • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    • R.A. Miller, Chu Q., Xie J., M. Foretz, B. Viollet, and M.J. Birnbaum Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Nature 494 7436 2013 256 260
    • (2013) Nature , vol.494 , Issue.7436 , pp. 256-260
    • Miller, R.A.1    Chu, Q.2    Xie, J.3    Foretz, M.4    Viollet, B.5    Birnbaum, M.J.6
  • 74
    • 0026019648 scopus 로고
    • Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction
    • A. Mitrakou, C. Ryan, T. Veneman, M. Mokan, T. Jenssen, I. Kiss, and et al. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction Am. J. Physiol 260 1 Pt 1 1991 E67 E74
    • (1991) Am. J. Physiol , vol.260 , Issue.1 , pp. E67-E74
    • Mitrakou, A.1    Ryan, C.2    Veneman, T.3    Mokan, M.4    Jenssen, T.5    Kiss, I.6
  • 76
    • 82255185902 scopus 로고    scopus 로고
    • Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: Induction of renal and intestinal gluconeogenesis by glucagon
    • E. Mutel, A. Gautier-Stein, A. Abdul-Wahed, M. Amigo-Correig, C. Zitoun, A. Stefanutti, and et al. Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon Diabetes 60 12 2011 3121 3131
    • (2011) Diabetes , vol.60 , Issue.12 , pp. 3121-3131
    • Mutel, E.1    Gautier-Stein, A.2    Abdul-Wahed, A.3    Amigo-Correig, M.4    Zitoun, C.5    Stefanutti, A.6
  • 78
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • S. Obici, Zhang B.B., G. Karkanias, and L. Rossetti Hypothalamic insulin signaling is required for inhibition of glucose production Nat. Med 8 12 2002 1376 1382
    • (2002) Nat. Med , vol.8 , Issue.12 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 79
    • 77951146612 scopus 로고    scopus 로고
    • C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
    • A.E. Obstfeld, E. Sugaru, M. Thearle, A.M. Francisco, C. Gayet, H.N. Ginsberg, and et al. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis Diabetes 59 4 2010 916 925
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 916-925
    • Obstfeld, A.E.1    Sugaru, E.2    Thearle, M.3    Francisco, A.M.4    Gayet, C.5    Ginsberg, H.N.6
  • 80
    • 2542495763 scopus 로고    scopus 로고
    • Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus
    • C. Opherk, F. Tronche, C. Kellendonk, D. Kohlmuller, A. Schulze, W. Schmid, and et al. Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus Mol. Endocrinol 18 6 2004 1346 1353
    • (2004) Mol. Endocrinol , vol.18 , Issue.6 , pp. 1346-1353
    • Opherk, C.1    Tronche, F.2    Kellendonk, C.3    Kohlmuller, D.4    Schulze, A.5    Schmid, W.6
  • 81
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • M.R. Owen, E. Doran, and A.P. Halestrap Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem. J. 348 Pt 3 2000 607 614
    • (2000) Biochem. J. , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 82
    • 80054986457 scopus 로고    scopus 로고
    • The effects of glucocorticoids on adipose tissue lipid metabolism
    • A.J. Peckett, D.C. Wright, and M.C. Riddell The effects of glucocorticoids on adipose tissue lipid metabolism Metabolism 60 11 2011 1500 1510
    • (2011) Metabolism , vol.60 , Issue.11 , pp. 1500-1510
    • Peckett, A.J.1    Wright, D.C.2    Riddell, M.C.3
  • 83
    • 0026520193 scopus 로고
    • Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis
    • S.J. Pilkis, and D.K. Granner Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis Annu. Rev. Physiol 54 1992 885 909
    • (1992) Annu. Rev. Physiol , vol.54 , pp. 885-909
    • Pilkis, S.J.1    Granner, D.K.2
  • 85
    • 0029043852 scopus 로고
    • 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: A metabolic signaling enzyme
    • S.J. Pilkis, T.H. Claus, I.J. Kurland, and A.J. Lange 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme Annu. Rev. Biochem 64 1995 799 835
    • (1995) Annu. Rev. Biochem , vol.64 , pp. 799-835
    • Pilkis, S.J.1    Claus, T.H.2    Kurland, I.J.3    Lange, A.J.4
  • 87
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • P. Puigserver, Wu Z., C.W. Park, R. Graves, M. Wright, and B.M. Spiegelman A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 92 6 1998 829 839
    • (1998) Cell , vol.92 , Issue.6 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 88
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • P. Puigserver, J. Rhee, J. Donovan, C.J. Walkey, J.C. Yoon, F. Oriente, and et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction Nature 423 6939 2003 550 555
    • (2003) Nature , vol.423 , Issue.6939 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3    Walkey, C.J.4    Yoon, J.C.5    Oriente, F.6
  • 89
    • 55049124487 scopus 로고    scopus 로고
    • Physiology of the pancreatic α-cell and glucagon secretion: Role in glucose homeostasis and diabetes
    • I. Quesada, E. Tudurí, C. Ripoll, and Á. Nadal Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes J. Endocrinol 199 1 2008 5 19
    • (2008) J. Endocrinol , vol.199 , Issue.1 , pp. 5-19
    • Quesada, I.1    Tudurí, E.2    Ripoll, C.3    Nadal, Á.4
  • 90
    • 0025370378 scopus 로고
    • Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element
    • P.G. Quinn, and D.K. Granner Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element Mol. Cell. Biol 10 7 1990 3357 3364
    • (1990) Mol. Cell. Biol , vol.10 , Issue.7 , pp. 3357-3364
    • Quinn, P.G.1    Granner, D.K.2
  • 91
    • 23044517378 scopus 로고    scopus 로고
    • Maintenance of the postabsorptive plasma glucose concentration: Insulin or insulin plus glucagon?
    • B. Raju, and P.E. Cryer Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon? Am. J. Physiol. Endocrinol. Metab 289 2 2005 E181 E186
    • (2005) Am. J. Physiol. Endocrinol. Metab , vol.289 , Issue.2 , pp. E181-E186
    • Raju, B.1    Cryer, P.E.2
  • 92
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • K. Rebrin, G.M. Steil, L. Getty, and R.N. Bergman Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin Diabetes 44 9 1995 1038 1045
    • (1995) Diabetes , vol.44 , Issue.9 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 93
    • 0242349197 scopus 로고    scopus 로고
    • Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): Requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    • J. Rhee, Y. Inoue, J.C. Yoon, P. Puigserver, Fan M., F.J. Gonzalez, and et al. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis Proc. Natl. Acad. Sci. U.S.A. 100 7 2003 4012 4017
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , Issue.7 , pp. 4012-4017
    • Rhee, J.1    Inoue, Y.2    Yoon, J.C.3    Puigserver, P.4    Fan, M.5    Gonzalez, F.J.6
  • 94
    • 78049259220 scopus 로고    scopus 로고
    • Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: Implications for therapy
    • R.A. Rizza Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy Diabetes 59 11 2010 2697 2707
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2697-2707
    • Rizza, R.A.1
  • 95
    • 0019275583 scopus 로고
    • Adrenergic mechanisms of catecholamine action on glucose homeostasis in man
    • R.A. Rizza, P.E. Cryer, M.W. Haymond, and J.E. Gerich Adrenergic mechanisms of catecholamine action on glucose homeostasis in man Metabolism 29 11 Suppl. 1 1980 1155 1163
    • (1980) Metabolism , vol.29 , Issue.11 , pp. 1155-1163
    • Rizza, R.A.1    Cryer, P.E.2    Haymond, M.W.3    Gerich, J.E.4
  • 96
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman, and P. Puigserver Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 7029 2005 113 118
    • (2005) Nature , vol.434 , Issue.7029 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 97
    • 72649098153 scopus 로고    scopus 로고
    • Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis
    • J.T. Rodgers, W. Haas, S.P. Gygi, and P. Puigserver Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis Cell Metab 11 1 2010 23 34
    • (2010) Cell Metab , vol.11 , Issue.1 , pp. 23-34
    • Rodgers, J.T.1    Haas, W.2    Gygi, S.P.3    Puigserver, P.4
  • 98
    • 4644253021 scopus 로고    scopus 로고
    • Neuronal glucosensing what do we know after 50 years?
    • V.H. Routh, Kang L., N.M. Sanders, and A.A. Dunn-Meynell Neuronal glucosensing what do we know after 50 years? Diabetes 53 10 2004 2521 2528
    • (2004) Diabetes , vol.53 , Issue.10 , pp. 2521-2528
    • Routh, V.H.1    Kang, L.2    Sanders, N.M.3    Dunn-Meynell, A.A.4
  • 99
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 6865 2001 799 806
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 100
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • V.T. Samuel, and G.I. Shulman Mechanisms for insulin resistance: common threads and missing links Cell 148 5 2012 852 871
    • (2012) Cell , vol.148 , Issue.5 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 101
    • 5344228270 scopus 로고    scopus 로고
    • The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector
    • R.A. Screaton, M.D. Conkright, Y. Katoh, J.L. Best, G. Canettieri, S. Jeffries, and et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector Cell 119 1 2004 61 74
    • (2004) Cell , vol.119 , Issue.1 , pp. 61-74
    • Screaton, R.A.1    Conkright, M.D.2    Katoh, Y.3    Best, J.L.4    Canettieri, G.5    Jeffries, S.6
  • 102
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • R.J. Shaw, K.A. Lamia, D. Vasquez, S.H. Koo, N. Bardeesy, R.A. Depinho, and et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 5754 2005 1642 1646
    • (2005) Science , vol.310 , Issue.5754 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6
  • 103
    • 0033847132 scopus 로고    scopus 로고
    • Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
    • She P., M. Shiota, K.D. Shelton, R. Chalkley, C. Postic, and M.A. Magnuson Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism Mol. Cell. Biol 20 17 2000 6508 6517
    • (2000) Mol. Cell. Biol , vol.20 , Issue.17 , pp. 6508-6517
    • She, P.1    Shiota, M.2    Shelton, K.D.3    Chalkley, R.4    Postic, C.5    Magnuson, M.A.6
  • 104
    • 0038353781 scopus 로고    scopus 로고
    • Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation
    • She P., S.C. Burgess, M. Shiota, P. Flakoll, E.P. Donahue, C.R. Malloy, and et al. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation Diabetes 52 7 2003 1649 1654
    • (2003) Diabetes , vol.52 , Issue.7 , pp. 1649-1654
    • She, P.1    Burgess, S.C.2    Shiota, M.3    Flakoll, P.4    Donahue, E.P.5    Malloy, C.R.6
  • 105
    • 0030969441 scopus 로고    scopus 로고
    • The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
    • D.K. Sindelar, Chu C.A., M. Rohlie, D.W. Neal, L.L. Swift, and A.D. Cherrington The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog Diabetes 46 2 1997 187 196
    • (1997) Diabetes , vol.46 , Issue.2 , pp. 187-196
    • Sindelar, D.K.1    Chu, C.A.2    Rohlie, M.3    Neal, D.W.4    Swift, L.L.5    Cherrington, A.D.6
  • 106
    • 0014776021 scopus 로고
    • Studies of pancreatic alpha cell function in normal and diabetic subjects
    • R.H. Unger, E. Aguilar-Parada, W.A. Muller, and A.M. Eisentraut Studies of pancreatic alpha cell function in normal and diabetic subjects J. Clin. Invest 49 4 1970 837 848
    • (1970) J. Clin. Invest , vol.49 , Issue.4 , pp. 837-848
    • Unger, R.H.1    Aguilar-Parada, E.2    Muller, W.A.3    Eisentraut, A.M.4
  • 107
    • 79955590704 scopus 로고    scopus 로고
    • Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes
    • P.D. van Poelje, S.C. Potter, and M.D. Erion Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes Handb. Exp. Pharmacol 203 2011 279 301
    • (2011) Handb. Exp. Pharmacol , vol.203 , pp. 279-301
    • Van Poelje, P.D.1    Potter, S.C.2    Erion, M.D.3
  • 109
    • 0019133757 scopus 로고
    • Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase
    • E. Van Schaftingen, L. Hue, and H.G. Hers Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase Biochem. J. 192 3 1980 887 895
    • (1980) Biochem. J. , vol.192 , Issue.3 , pp. 887-895
    • Van Schaftingen, E.1    Hue, L.2    Hers, H.G.3
  • 110
    • 0019130510 scopus 로고
    • Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase
    • E. Van Schaftingen, L. Hue, and H.G. Hers Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase Biochem. J. 192 3 1980 897 901
    • (1980) Biochem. J. , vol.192 , Issue.3 , pp. 897-901
    • Van Schaftingen, E.1    Hue, L.2    Hers, H.G.3
  • 111
    • 20044384728 scopus 로고    scopus 로고
    • Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism
    • L.M. Watts, V.P. Manchem, T.A. Leedom, A.L. Rivard, R.A. McKay, Bao D., and et al. Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism Diabetes 54 6 2005 1846 1853
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1846-1853
    • Watts, L.M.1    Manchem, V.P.2    Leedom, T.A.3    Rivard, A.L.4    McKay, R.A.5    Bao, D.6
  • 112
    • 0022998516 scopus 로고
    • Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers
    • A. Wynshaw-Boris, J.M. Short, D.S. Loose, and R.W. Hanson Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers J. Biol. Chem 261 21 1986 9714 9720
    • (1986) J. Biol. Chem , vol.261 , Issue.21 , pp. 9714-9720
    • Wynshaw-Boris, A.1    Short, J.M.2    Loose, D.S.3    Hanson, R.W.4
  • 113
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • J.C. Yoon, P. Puigserver, Chen G., J. Donovan, Wu Z., J. Rhee, and et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 Nature 413 6852 2001 131 138
    • (2001) Nature , vol.413 , Issue.6852 , pp. 131-138
    • Yoon, J.C.1    Puigserver, P.2    Chen, G.3    Donovan, J.4    Wu, Z.5    Rhee, J.6
  • 114
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G., R. Myers, Li Y., Chen Y., Shen X., J. Fenyk-Melody, and et al. Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Invest 108 8 2001 1167 1174
    • (2001) J. Clin. Invest , vol.108 , Issue.8 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3    Chen, Y.4    Shen, X.5    Fenyk-Melody, J.6


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