Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation

Diabetes

Volumn 52, Issue 7, 2003, Pages 1649-1654

  She, Pengxiang ^a   Burgess, Shawn C ^b   Shiota, Masakazu ^a   Flakoll, Paul ^a   Donahue, E Patrick ^c   Malloy, Craig R ^b   Sherry, A Dean ^b,d   Magnuson, Mark A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL; GLYCOGEN; LIVER ENZYME; PHOSPHOENOLPYRUVATE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE UTILIZATION; GLYCOGEN SYNTHESIS; HYPERGLYCEMIA; ISOTOPE LABELING; KNOCKOUT MOUSE; LIPID METABOLISM; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STARVATION;

EID: 0038353781     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.7.1649     Document Type: Article

References (23)

1. Granner D, Pilkis S: The genes of hepatic glucose metabolism. J Biol Chem 265:10173-10176, 1990
2. Hanson RW, Garber AJ: Phosphoenolpyruvate carboxykinase. I. Its role in ginconeogenesis. Am J Clin Nutr 25:1010-1021, 1972
3. Hanson RW, Reshef L: Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem 66:581-611, 1997
4. Kibler RF, Taylor WJ, Myers JD: The effect of glucagon on the net splanchnic balances of glucose, amino acid nitrogen, urea, ketones, and oxygen in man. J Clin Invest 43:904-910, 1964
5. Hendrick GK, Frizzell RT, Williams PE, Cherrington AD: Effect of hyper-glucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am J Physiol 258:E841-E849, 1990
6. She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA: Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol 20:6508-6517, 2000
7. Jones JG, Naidoo R, Sherry AD, Jeffrey FM, Cottam GL, Malloy CR: Measurement of gluconeogenesis and pyruvate recycling in the rat liver: a simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-(13)C3]propionate. FEBS Lett 412:131-137, 1997
8. Jones JG, Solomon MA, Cole SM, Sherry AD, Malloy CR: An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans. Am J Physiol 281:E848-E856, 2001
9. Shiota M, Tanaka T, Sugano T: Effect of norepinephrine on gluconeogenesis in perfused livers of cold-exposed rats. Am J Physiol 249:E281-E286, 1985
10. Niswender KD, Shiota M, Postic C, Cherrington AD, Magnuson MA: Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem 272:22570-22575, 1997
11. Flakoll PJ, Zheng M, Vaughan S, Borel MJ: Determination of stable isotopic enrichment and concentration of glycerol in plasma via gas chromatography-mass spectrometry for the estimation of lipolysis in vivo. J Chromatogr B Biomed Sci Appl 744:47-54, 2000
12. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC: Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 98:378-385, 1996
13. Jones JG, Carvalho RA, Franco B, Sherry AD, Malloy CR: Measurement of hepatic glucose output, Krebs cycle, and gluconeogenic fluxes by NMR analysis of a single plasma glucose sample. Anal Biochem 263:39-45, 1998
14. Kunst A, Draeger B, Ziegenhorn J: UV-methods with hexokinase and glucose-6-phosphatase. In Methods of Enzymatic Analysis. Vol. 6, 3rd ed., Weinheim, Germany, VCH Verlagesllschaft, 1985, p. 163-172
15. Barzilai N, Massillon D, Rossetti L: Effects of fasting on hepatic and peripheral glucose metabolism in conscious rats with near-total fat depletion. Biochem J 310:819-826, 1995
16. Giaccari A, Rossetti L: Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J Clin Invest 89:36-45, 1992
17. Owen OE, Felig P, Morgan AP, Wahren J, Cahill GF Jr: Liver and kidney metabolism during prolonged starvation. J Clin Invest 48:574-583, 1969
18. Croset M, Rajas F, Zitoun C, Hurot JM, Montano S, Mithieux G: Rat small intestine is an insulin-sensitive gluconeogenic organ. Diabetes 50:740-746, 2001
19. Cersosimo E, Garlick P, Ferretti J: Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans. Diabetes 49:1186-1193, 2000
20. Stumvoll M, Meyer C, Perriello G, Kreider M, Welle S, Gerich J: Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity. Am J Physiol 274:E817-E826, 1998
21. Fiermonte G, Palmieri L, Dolce V, Lasorsa FM, Palmieri F, Runswick MJ, Walker JE: The sequence, bacterial expression, and functional reconstitution of the rat niitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. J Biol Chem 273:24754-24759, 1998
22. Brosnan JT: Comments on metabolic needs for glucose and the role of gluconeogenesis. Eur J Clin Nutr 53 (Suppl. 1): S107-S111, 1999
23. Postic C, Shiota M, Magnuson MA: Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog Horm Res 56:195-217, 2001