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Volumn 46, Issue 7, 1997, Pages 1111-1119

Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; FATTY ACID; GLUCAGON; GLUCOSE; HEPARIN; INSULIN; INTRALIPID; TOLBUTAMIDE; TRIACYLGLYCEROL;

EID: 0030975131     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.7.1111     Document Type: Article
Times cited : (120)

References (44)
  • 1
    • 0025297310 scopus 로고
    • Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
    • Ader M, Bergman RN: Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 258:E1020-E1032, 1990
    • (1990) Am J Physiol , vol.258
    • Ader, M.1    Bergman, R.N.2
  • 2
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca A, Fisher SJ, Shi ZQ, Gupta R, Lickley HL, Vranic M: Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90:1769-1777, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1769-1777
    • Giacca, A.1    Fisher, S.J.2    Shi, Z.Q.3    Gupta, R.4    Lickley, H.L.5    Vranic, M.6
  • 3
    • 0029969117 scopus 로고    scopus 로고
    • A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
    • Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD: A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45:1594-1604, 1996
    • (1996) Diabetes , vol.45 , pp. 1594-1604
    • Sindelar, D.K.1    Balcom, J.H.2    Chu, C.A.3    Neal, D.W.4    Cherrington, A.D.5
  • 4
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin K, Steil GM, Getty L, Bergman RN: Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44:1038-1045, 1995
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 5
    • 0029861999 scopus 로고    scopus 로고
    • Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
    • Rebrin K, Steil GM, Mittelman SD, Bergman RM: Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98:741-749, 1996
    • (1996) J Clin Invest , vol.98 , pp. 741-749
    • Rebrin, K.1    Steil, G.M.2    Mittelman, S.D.3    Bergman, R.M.4
  • 6
    • 0023546855 scopus 로고
    • Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects
    • Prager R, Wallace P, Olefsky JM: Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36:607-611, 1987
    • (1987) Diabetes , vol.36 , pp. 607-611
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3
  • 7
    • 0029936779 scopus 로고    scopus 로고
    • Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans
    • Lewis GF, Zinman B, Groenewoud Y, Vranic M, Giacca A: Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes 45:454-462, 1996
    • (1996) Diabetes , vol.45 , pp. 454-462
    • Lewis, G.F.1    Zinman, B.2    Groenewoud, Y.3    Vranic, M.4    Giacca, A.5
  • 8
    • 0027370114 scopus 로고
    • Effects of insulin on fatty acid reesterification in healthy subjects
    • Boden G, Chen X, Desantis RA, Kendrick Z: Effects of insulin on fatty acid reesterification in healthy subjects. Diabetes 42:1588-1593, 1993
    • (1993) Diabetes , vol.42 , pp. 1588-1593
    • Boden, G.1    Chen, X.2    Desantis, R.A.3    Kendrick, Z.4
  • 9
    • 0025007289 scopus 로고
    • Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans
    • Bonadonna RC, Groop LC, Zych K, Shank M, DeFronzo RA: Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol 259:E736-E750, 1990
    • (1990) Am J Physiol , vol.259
    • Bonadonna, R.C.1    Groop, L.C.2    Zych, K.3    Shank, M.4    DeFronzo, R.A.5
  • 10
    • 50549202600 scopus 로고
    • The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785-789, 1963
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 11
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus: Evidence for multiple sites of insulin resistance
    • Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E, DeFronzo RA: Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus: evidence for multiple sites of insulin resistance. J Clin Invest 84:205-213, 1989
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    DelPrato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6    DeFronzo, R.A.7
  • 12
    • 0025775034 scopus 로고
    • Effects of lipid on basal carbohydrate metabolism in nor- Mal men
    • Boden G, Jadali F: Effects of lipid on basal carbohydrate metabolism in nor- mal men. Diabetes 40:686-692, 1991
    • (1991) Diabetes , vol.40 , pp. 686-692
    • Boden, G.1    Jadali, F.2
  • 13
    • 0025911738 scopus 로고
    • Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men
    • Clore JN, Glickman PS, Helm ST, Nestler JE, Blackard WG: Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men. Diabetes 40:1033-1040, 1991
    • (1991) Diabetes , vol.40 , pp. 1033-1040
    • Clore, J.N.1    Glickman, P.S.2    Helm, S.T.3    Nestler, J.E.4    Blackard, W.G.5
  • 14
    • 0027530994 scopus 로고
    • Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs
    • Shi ZQ, Giacca A, Yamatani K, Fisher SJ, Lickley HL, Vranic M: Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs. Am J Physiol 264:E334-E341, 1993
    • (1993) Am J Physiol , vol.264
    • Shi, Z.Q.1    Giacca, A.2    Yamatani, K.3    Fisher, S.J.4    Lickley, H.L.5    Vranic, M.6
  • 16
    • 0027493805 scopus 로고
    • Metabolic consequences of sustained suppression of free fatty acids by acipimox in patients with NIDDM
    • Saloranta C, Taskinen MR, Widen E, Harkonen M, Melander A, Groop L: Metabolic consequences of sustained suppression of free fatty acids by acipimox in patients with NIDDM. Diabetes 42:1559-1566, 1993
    • (1993) Diabetes , vol.42 , pp. 1559-1566
    • Saloranta, C.1    Taskinen, M.R.2    Widen, E.3    Harkonen, M.4    Melander, A.5    Groop, L.6
  • 18
    • 0030969441 scopus 로고    scopus 로고
    • The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
    • Sindelar DK, Chu C, Rohlie M, Neal DW, Swift LL, Cherrington AD: The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes 46:187-196, 1997
    • (1997) Diabetes , vol.46 , pp. 187-196
    • Sindelar, D.K.1    Chu, C.2    Rohlie, M.3    Neal, D.W.4    Swift, L.L.5    Cherrington, A.D.6
  • 19
    • 84995865300 scopus 로고
    • A new method for comparing portal and peripheral venous insulin delivery in humans: Tolbutamide versus insulin infusion
    • Lewis GF, Steiner G, Polonsky KS, Weller B, Zinman B: A new method for comparing portal and peripheral venous insulin delivery in humans: tolbutamide versus insulin infusion. J Clin Endocrinol Metab 79:66-70, 1994
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 66-70
    • Lewis, G.F.1    Steiner, G.2    Polonsky, K.S.3    Weller, B.4    Zinman, B.5
  • 20
    • 0028033936 scopus 로고
    • VLDL production is decreased to a similar extent by acute portal vs. peripheral venous insulin
    • Lewis GF, Zinman B, Uffelman KD, Szeto L, Weller B, Steiner G: VLDL production is decreased to a similar extent by acute portal vs. peripheral venous insulin. Am J Physiol 267:E566-E572, 1994
    • (1994) Am J Physiol , vol.267
    • Lewis, G.F.1    Zinman, B.2    Uffelman, K.D.3    Szeto, L.4    Weller, B.5    Steiner, G.6
  • 22
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood DT, Bergman RN, Vranic M: Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36:914-924, 1987
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 23
    • 0024265025 scopus 로고
    • Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps
    • Finegood DT, Bergman RN, Vranic M: Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37:1025-1034, 1988
    • (1988) Diabetes , vol.37 , pp. 1025-1034
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 24
    • 0026504160 scopus 로고
    • Estimation of insulin secretion rates from C-peptide levels: Comparison of individual and standard kinetic parameters for C-peptide clearance
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS: Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41:368-377, 1992
    • (1992) Diabetes , vol.41 , pp. 368-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 25
    • 0020757484 scopus 로고
    • Optimal segments: A method for smoothing tracer data to calculate metabolic fluxes
    • Finegood DT, Bergman RN: Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol 244:E472-E479, 1983
    • (1983) Am J Physiol , vol.244
    • Finegood, D.T.1    Bergman, R.N.2
  • 26
    • 0027223164 scopus 로고
    • Quantitation of measurement error with optimal segments: Basis for adaptive time course smoothing
    • Bradley DC, Steil GM, Bergman RN: Quantitation of measurement error with optimal segments: basis for adaptive time course smoothing. Am J Physiol 264:E902-E911, 1993
    • (1993) Am J Physiol , vol.264
    • Bradley, D.C.1    Steil, G.M.2    Bergman, R.N.3
  • 28
    • 0002529921 scopus 로고
    • The hepatic circulation
    • Arias IM, Popper H, Schachter D, Shafritz DA, Eds. New York, Raven Press
    • Campra JL, Reynolds TB: The hepatic circulation. In The Liver: Biology and Pathobiology. Arias IM, Popper H, Schachter D, Shafritz DA, Eds. New York, Raven Press, 1982, p. 627-645
    • (1982) The Liver: Biology and Pathobiology , pp. 627-645
    • Campra, J.L.1    Reynolds, T.B.2
  • 30
    • 0031046709 scopus 로고    scopus 로고
    • Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: Role of glucagon
    • Giacca A, Fisher SJ, McCall RH, Shi ZQ, Vranic M: Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: role of glucagon. Endocrinology 138:999-1007, 1997
    • (1997) Endocrinology , vol.138 , pp. 999-1007
    • Giacca, A.1    Fisher, S.J.2    McCall, R.H.3    Shi, Z.Q.4    Vranic, M.5
  • 31
    • 0030932918 scopus 로고    scopus 로고
    • Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans
    • Lewis GF, Vranic M, Giacca A: Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans. Am J Physiol 272:E371-E378, 1997
    • (1997) Am J Physiol , vol.272
    • Lewis, G.F.1    Vranic, M.2    Giacca, A.3
  • 32
    • 0026080645 scopus 로고
    • Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man
    • Groop LC, Bonadonna RC, Shank M, Petrides AS, DeFronzo RA: Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man. J Clin Invest 87:83-89, 1991
    • (1991) J Clin Invest , vol.87 , pp. 83-89
    • Groop, L.C.1    Bonadonna, R.C.2    Shank, M.3    Petrides, A.S.4    DeFronzo, R.A.5
  • 33
    • 0025872319 scopus 로고
    • Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources
    • Yki-Jarvinen H, Puhakainen I, Saloranta C, Groop L, Taskinen MR: Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources. Am J Physiol 260:E680-E689, 1991
    • (1991) Am J Physiol , vol.260
    • Yki-Jarvinen, H.1    Puhakainen, I.2    Saloranta, C.3    Groop, L.4    Taskinen, M.R.5
  • 36
    • 0025764186 scopus 로고
    • Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus
    • Saloranta C, Franssila-Kallunki A, Ekstrand A, Taskinen MR, Groop L: Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:409-415, 1991
    • (1991) Diabetologia , vol.34 , pp. 409-415
    • Saloranta, C.1    Franssila-Kallunki, A.2    Ekstrand, A.3    Taskinen, M.R.4    Groop, L.5
  • 37
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV, Rossetti L: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 38
    • 0020972416 scopus 로고
    • Gluconeogenesis and related aspects of glycolysis
    • Hers HG, Hue L: Gluconeogenesis and related aspects of glycolysis (Review). Ann Rev Biochem 52:617-653, 1983
    • (1983) Ann Rev Biochem , vol.52 , pp. 617-653
    • Hers, H.G.1    Hue, L.2
  • 39
    • 0025214987 scopus 로고
    • The relationship between gluconeogenic substrate supply and glucose production in humans
    • Jahoor F, Peters EJ, Wolfe RR: The relationship between gluconeogenic substrate supply and glucose production in humans. Am J Physiol 258:E288-E296, 1990
    • (1990) Am J Physiol , vol.258
    • Jahoor, F.1    Peters, E.J.2    Wolfe, R.R.3
  • 40
    • 0028276676 scopus 로고
    • Insulin regulation of renal glucose metabolism in conscious dogs
    • Cersosimo E, Judd RL, Miles JM: Insulin regulation of renal glucose metabolism in conscious dogs. J Clin Invest 93:2584-2589, 1994
    • (1994) J Clin Invest , vol.93 , pp. 2584-2589
    • Cersosimo, E.1    Judd, R.L.2    Miles, J.M.3
  • 41
    • 0029046673 scopus 로고
    • Effects of a 48-h fat infusion on insulin secretion and glucose utilization
    • Boden G, Chen X, Rosner J, Barton M: Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 44:1239-1242, 1995
    • (1995) Diabetes , vol.44 , pp. 1239-1242
    • Boden, G.1    Chen, X.2    Rosner, J.3    Barton, M.4
  • 43
    • 0024995157 scopus 로고
    • A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y, Grill VE: A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589, 1990
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.E.2
  • 44
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2


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