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Volumn 19, Issue 11, 2015, Pages 1605-1633

Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications

Author keywords

[No Author keywords available]

Indexed keywords

OPTIMIZATION;

EID: 84947785951     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op500169m     Document Type: Article
Times cited : (397)

References (106)
  • 2
    • 2942611506 scopus 로고    scopus 로고
    • Design of Experiments in Pharmaceutical Process Research and Development
    • Abdel-Magid, A. F. Ragan, J. A. ACS Symposium Series 870; American Chemical Society: Washington, DC, Chapter 6
    • Mills, J. E. Design of Experiments in Pharmaceutical Process Research and Development. In Chemical Process Research; Abdel-Magid, A. F.; Ragan, J. A., Eds.; ACS Symposium Series 870; American Chemical Society: Washington, DC, 2003; Chapter 6, pp 87-109.
    • (2003) Chemical Process Research , pp. 87-109
    • Mills, J.E.1
  • 3
    • 85050580646 scopus 로고    scopus 로고
    • Design of Experiments Makes A Comeback
    • APRIL 1
    • Mullin, R. Design of Experiments Makes A Comeback. Chem. Eng. News 2013, April 1, pp 25-28.
    • (2013) Chem. Eng. News , pp. 25-28
    • Mullin, R.1
  • 4
    • 0037175723 scopus 로고    scopus 로고
    • In 2002, it was stated that delaying the introduction of a product by six months could reduce the lifetime profit by 50%: Ritter, S. K. Chem. Eng. News 2002, 80 (47) 19
    • (2002) Chem. Eng. News , vol.80 , Issue.47 , pp. 19
    • Ritter, S.K.1
  • 5
    • 84947729494 scopus 로고    scopus 로고
    • For example, the FDA now provides the breakthrough NDA filing designation to sponsors for fast track or accelerated approvals and priority review. For more information, see http://www.fda.gov/Drugs/DevelopmentApprovalProcess.
  • 12
    • 33746928924 scopus 로고    scopus 로고
    • Using Factorial Experiments in the Development of Process Chemistry
    • Gadamasetti, K. G. Dekker: New York
    • Pilipauskas, D. R. Using Factorial Experiments in the Development of Process Chemistry. In Process Chemistry in the Pharmaceutical Industry; Gadamasetti, K. G., Ed.; Dekker: New York, 1999.
    • (1999) Process Chemistry in the Pharmaceutical Industry
    • Pilipauskas, D.R.1
  • 15
    • 3042593299 scopus 로고    scopus 로고
    • For instance, Pfizer researchers determined through DoE the optimal catalyst and solvents to minimize hydrogenolysis byproducts from the reductive amination used to manufacture sertraline: Taber, G. P.; Pfisterer, D. M.; Colberg, J. C. Org. Process Res. Dev. 2004, 8, 385
    • (2004) Org. Process Res. Dev. , vol.8 , pp. 385
    • Taber, G.P.1    Pfisterer, D.M.2    Colberg, J.C.3
  • 18
    • 84885652372 scopus 로고    scopus 로고
    • Analytical Quality by Design (AQbD) in Pharmaceutical Development
    • Aug. 27, 2013. (accessed June 25, 2014)
    • An overview of the application of DoE to optimization of an HPLC method can be found here: Reid, G. L.; Morgado, J.; Barnett, K.; Harrington, B.; Wang, J.; Harwood, J.; Fortin, D. Analytical Quality by Design (AQbD) in Pharmaceutical Development. Am. Pharm. Rev. published online: Aug. 27, 2013. http://www.americanpharmaceuticalreview.com/Featured-Articles/144191-Analytical-Quality-by-Design-AQbD-in-Pharmaceutical-Development/ (accessed June 25, 2014).
    • Am. Pharm. Rev.
    • Reid, G.L.1    Morgado, J.2    Barnett, K.3    Harrington, B.4    Wang, J.5    Harwood, J.6    Fortin, D.7
  • 38
    • 43949162718 scopus 로고
    • In glass-lined vessels, the reaction of Deoxo-Fluor with the glass, as evidenced by the observance of pitting, is surmised to produce a fluorosilicate, which is known to be beneficial to this type of reactions (see;)
    • In glass-lined vessels, the reaction of Deoxo-Fluor with the glass, as evidenced by the observance of pitting, is surmised to produce a fluorosilicate, which is known to be beneficial to this type of reactions (see Radhamani, K. N.; Padma, D. K. J. Fluorine Chem. 1993, 95)
    • (1993) J. Fluorine Chem. , pp. 95
    • Radhamani, K.N.1    Padma, D.K.2
  • 88
    • 84947804262 scopus 로고    scopus 로고
    • (accessed 11 April)
    • http://thalesnano.com/products/h-cube (accessed 11 April 2014).
    • (2014)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.