The synthesis of GV143253A: A case study for the use of analytical and statistical tools to elucidate the reaction mechanism and to Optimize the process

Organic Process Research and Development

Volumn 14, Issue 4, 2010, Pages 840-848

  Guercio, Giuseppe ^a   Perboni, Alcide ^a   Tinazzi, Francesco ^a   Rovatti, Luca ^a   Provera, Stefano ^a  

^a GSK   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL TECHNIQUES; NMR SPECTROSCOPY; PROCESS UNDERSTANDING; REACTION MECHANISM; STATISTICAL TOOLS;

DESIGN OF EXPERIMENTS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTIMIZATION; STATISTICAL MECHANICS;

SYNTHESIS (CHEMICAL);

EID: 77955387626     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100097c     Document Type: Article

References (10)

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6. The software used for the statistical analysis was Design Expert DX 5. A central composite design (10 experiments with two central points) was performed considering FmOCOCOCl and DIPEA equivalents. The parallel equipment used was SK233-Anachem.
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10. The software used for the statistical analysis was Design Expert DX 5. A central composite design (20 experiments with 6 central points) was performed considering phosphine equivalents, concentration, and temperature. As output, the ratio between the HPLC areas of the phosphorane and of naphthalene was considered as the internal standard. The parallel equipment used was SK233-Anachem.