Development and optimisation of an unsymmetrical Hantzsch reaction for plant-scale manufacture

Organic Process Research and Development

Volumn 10, Issue 4, 2006, Pages 808-813

  Hopes, Phillip A ^a   Parker, Alexandra J ^a   Patel, Ian ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33746878527     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op060057r     Document Type: Article

References (11)

1. Hantzsch, A. Justus Liebigs Ann. Chem. 1882, 215, 1-82.
2. Natale, N. R. Chem. Innov. 2000, 30, 22-28.
3. Li, J.-J.; Corey, E. J. Name Reactions in Hetercyclic Chemistry; Wiley: New Jersey, 2005, and references therein.
4. See, for example: Sausios, A.; Duburs, G. Heterocycles 1988, 27, 269-289.
5. See, for example: Wong, W. C.; Chiu, G.; Wetzel, J. M.; Marzabadi, M. R.; Nagarathnam, D.; Wang, D.; Fang, J.; Miao, S. W.; Hong, X.; Forray, C.; Vaysse, P. J.-J.; Branchek, T. A.; Gluchowski, C. J. Med. Chem. 1998, 41, 2643-2650.
6. Triggle, D. J. Curr. Pharm. Des. 2006, 12, 443-457.
7. See, for example: Furlan, B.; Copar, A.; Jeriha, A. EP599220, 1996;
8. Campbell, S. F.; Cross, P. E.; Stubbs, J. K. EP89167, 1996.
9. Ashworth, I.; Hopes, P.; Levin, D.; Patel, I.; Salloo, R. Tetrahedron Lett. 2002, 43, 4931-4933.
10. Ogawa, T.; Matsummoto, K.; Yoshimura, M.; Hatayama, K.; Kitamura, K.; Kita, Y. Tetrahedron Lett. 1993, 12, 1967-1970.
11. Moseley, J. D. Tetrahedron Lett. 2005, 46, 3179-3181.