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Volumn 14, Issue 4, 2010, Pages 832-839

Correction to: Development of a control strategy for a defluorinated analogue in the manufacturing process of casopitant mesylate (Organic Process Research and Development (2010) 14 (832-839) DOI: 10.1021/op1000836);Development of a control strategy for a defluorinated analogue in the manufacturing process of casopitant mesylate

Author keywords

[No Author keywords available]

Indexed keywords

CONTROLLED DRUG DELIVERY; PLANNING; QUALITY ASSURANCE; RISK ANALYSIS; RISK ASSESSMENT;

EID: 77955345182     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/acs.oprd.7b00226     Document Type: Erratum
Times cited : (3)

References (22)
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    • We have recently published an application of the QbD principles to the control of genotoxin impurities
    • We have recently published an application of the QbD principles to the control of genotoxin impurities
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    • Activation of the strong C-F bond is a topic of growing interest, and different metals have been reported to perform this transformation. From a bibliographic search, it would seem more likely that Rh is the responsible due to a higher number of hits, although both Rh and Pd-based catalyst have been reported to conduct the defluorination reaction. Indeed, there is a relatively higher number of examples of defluorination of fluorobenzenes in the presence of Rh, in particular employing homogeneous Rh complexes; see for instance
    • Activation of the strong C-F bond is a topic of growing interest, and different metals have been reported to perform this transformation. From a bibliographic search, it would seem more likely that Rh is the responsible due to a higher number of hits, although both Rh and Pd-based catalyst have been reported to conduct the defluorination reaction. Indeed, there is a relatively higher number of examples of defluorination of fluorobenzenes in the presence of Rh, in particular employing homogeneous Rh complexes; see for instance
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    • 2). In less extent, Pd-based catalyst have also been successfully employed.; J. Mol. Catal. A: Chem. 1997, 125, 135-142 (heterogeneous Pd/C)
    • 2). In less extent, Pd-based catalyst have also been successfully employed. Ukisu, Y.; Miyadera, T. J. Mol. Catal. A: Chem. 1997, 125, 135-142 (heterogeneous Pd/C)
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    • In contrast with the literature precedents, the information collected by catalyst suppliers suggests the use of Pd/C for defluorination, see: Handbook of Pharmaceutical Catalysis; Johnson Matthey Catalysts: Royston, U.K., 2009, p 37.
    • Aramendia, M. A.; Borau, V.; Garcia, I. M.; Jimenez, C.; Marinas, A.; Marinas, J. M.; Urbano, F. J. C. R. Acad. Sci. Paris, Ser. IIC, Chim. 2000, 3, 465-470 In contrast with the literature precedents, the information collected by catalyst suppliers suggests the use of Pd/C for defluorination, see: Handbook of Pharmaceutical Catalysis; Johnson Matthey Catalysts: Royston, U.K., 2009, p 37.
    • (2000) C. R. Acad. Sci. Paris, Ser. IIC, Chim. , vol.3 , pp. 465-470
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    • The y-axis of the graph is defined as cumulative probability, a measure of the % of individuals expected to fall below a given level. The x-axis is defined as a measure of the magnitude of the effect.
    • The y-axis of the graph is defined as cumulative probability, a measure of the % of individuals expected to fall below a given level. The x-axis is defined as a measure of the magnitude of the effect.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.