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1
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85030350880
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Pharmaceutical cGMPs for the 21st century- A risk based approach (initiative launched in 2002).
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Pharmaceutical cGMPs for the 21st century- A risk based approach (initiative launched in 2002).
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2
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85030351125
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We have recently published an application of the QbD principles to the control of genotoxin impurities
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We have recently published an application of the QbD principles to the control of genotoxin impurities
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3
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77955378252
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[Online early access]. DOI: 10.1021/op900242x. Published Online: Nov 6, 2009.
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Cimarosti, Z.; Bravo, F.; Stonestreet, P.; Tinazzi, F.; Vecchi, O.; Camurri, G. Org. Proc. Res. Dev. [Online early access]. DOI: 10.1021/op900242x. Published Online: Nov 6, 2009.
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Org. Proc. Res. Dev.
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Cimarosti, Z.1
Bravo, F.2
Stonestreet, P.3
Tinazzi, F.4
Vecchi, O.5
Camurri, G.6
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4
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85030351106
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ICH Q8 Pharmaceutical Development.
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ICH Q8 Pharmaceutical Development.
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5
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85030350939
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ICH Q9 Quality Risk Management.
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ICH Q9 Quality Risk Management.
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6
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85030350892
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ICH Q10 Pharmaceutical Quality System.
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ICH Q10 Pharmaceutical Quality System.
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7
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85030351128
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Manuscript in preparation.
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Dams, R.; Bernab, E.; Nicoletti, A.; Loda, C.; Martini, L.; Papini, D.. Quantitation of Defluorinated Analogue of Casopitant Mesylate by Normal Phase Liquid Chromatography-Mass Spectrometry. Manuscript in preparation.
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Quantitation of Defluorinated Analogue of Casopitant Mesylate by Normal Phase Liquid Chromatography-Mass Spectrometry
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Dams, R.1
Bernab, E.2
Nicoletti, A.3
Loda, C.4
Martini, L.5
Papini, D.6
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8
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85030350896
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ICH Q6a Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances.
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ICH Q6a Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances.
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9
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85030351060
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Activation of the strong C-F bond is a topic of growing interest, and different metals have been reported to perform this transformation. From a bibliographic search, it would seem more likely that Rh is the responsible due to a higher number of hits, although both Rh and Pd-based catalyst have been reported to conduct the defluorination reaction. Indeed, there is a relatively higher number of examples of defluorination of fluorobenzenes in the presence of Rh, in particular employing homogeneous Rh complexes; see for instance
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Activation of the strong C-F bond is a topic of growing interest, and different metals have been reported to perform this transformation. From a bibliographic search, it would seem more likely that Rh is the responsible due to a higher number of hits, although both Rh and Pd-based catalyst have been reported to conduct the defluorination reaction. Indeed, there is a relatively higher number of examples of defluorination of fluorobenzenes in the presence of Rh, in particular employing homogeneous Rh complexes; see for instance
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12
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34548068316
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Braun, T.; Noveski, D.; Ahijado, M.; Wehmeier, F. Dalton Trans. 2007, 3820-3825
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(2007)
Dalton Trans.
, pp. 3820-3825
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Braun, T.1
Noveski, D.2
Ahijado, M.3
Wehmeier, F.4
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13
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11144346740
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Noveski, D.; Braun, T.; Stammler, A.; Stammler, H.-G. Dalton Trans. 2004, 4106-4119
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(2004)
Dalton Trans.
, pp. 4106-4119
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Noveski, D.1
Braun, T.2
Stammler, A.3
Stammler, H.-G.4
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15
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0346270715
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2). In less extent, Pd-based catalyst have also been successfully employed.; J. Mol. Catal. A: Chem. 1997, 125, 135-142 (heterogeneous Pd/C)
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2). In less extent, Pd-based catalyst have also been successfully employed. Ukisu, Y.; Miyadera, T. J. Mol. Catal. A: Chem. 1997, 125, 135-142 (heterogeneous Pd/C)
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(2004)
J. Mol. Catal. A: Chem.
, vol.207
, pp. 59-68
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Stanger, K.J.1
Angelici, R.J.2
Ukisu, Y.3
Miyadera, T.4
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16
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0034311263
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In contrast with the literature precedents, the information collected by catalyst suppliers suggests the use of Pd/C for defluorination, see: Handbook of Pharmaceutical Catalysis; Johnson Matthey Catalysts: Royston, U.K., 2009, p 37.
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Aramendia, M. A.; Borau, V.; Garcia, I. M.; Jimenez, C.; Marinas, A.; Marinas, J. M.; Urbano, F. J. C. R. Acad. Sci. Paris, Ser. IIC, Chim. 2000, 3, 465-470 In contrast with the literature precedents, the information collected by catalyst suppliers suggests the use of Pd/C for defluorination, see: Handbook of Pharmaceutical Catalysis; Johnson Matthey Catalysts: Royston, U.K., 2009, p 37.
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(2000)
C. R. Acad. Sci. Paris, Ser. IIC, Chim.
, vol.3
, pp. 465-470
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Aramendia, M.A.1
Borau, V.2
Garcia, I.M.3
Jimenez, C.4
Marinas, A.5
Marinas, J.M.6
Urbano, F.J.7
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17
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85030350997
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The y-axis of the graph is defined as cumulative probability, a measure of the % of individuals expected to fall below a given level. The x-axis is defined as a measure of the magnitude of the effect.
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The y-axis of the graph is defined as cumulative probability, a measure of the % of individuals expected to fall below a given level. The x-axis is defined as a measure of the magnitude of the effect.
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18
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85030350897
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PCT Int. Appl. WO 2002/032867
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Alvaro, G.; Di Fabio, R.; Maragni, P.; Tampieri, M.; Tranquillini, M. E. PCT Int. Appl. WO 2002/032867, 2002
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(2002)
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Alvaro, G.1
Di Fabio, R.2
Maragni, P.3
Tampieri, M.4
Tranquillini, M.E.5
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19
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77955352691
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Chem. Abstr. 2002, 136, 325568.
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(2002)
Chem. Abstr.
, vol.136
, pp. 325568
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20
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85030351049
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PCT Int. Appl. WO 2007/048642
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Bientinesi, I.; Cimarosti, Z.; Guercio, G.; Leroi, C.; Perboni, A. PCT Int. Appl. WO 2007/048642, 2007
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(2007)
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Bientinesi, I.1
Cimarosti, Z.2
Guercio, G.3
Leroi, C.4
Perboni, A.5
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21
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77955343787
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Chem. Abstr. 2007, 146, 461973.
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(2007)
Chem. Abstr.
, vol.146
, pp. 461973
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22
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72449121823
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Guercio, G.; Bacchi, S.; Perboni, A.; Leroi, C.; Tinazzi, F.; Bientinesi, I.; Hourdin, M.; Goodyear, M.; Curti, S.; Provera, S.; Cimarosti, Z. Org. Process Res. Dev. 2009, 13, 1100-1110
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(2009)
Org. Process Res. Dev.
, vol.13
, pp. 1100-1110
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Guercio, G.1
Bacchi, S.2
Perboni, A.3
Leroi, C.4
Tinazzi, F.5
Bientinesi, I.6
Hourdin, M.7
Goodyear, M.8
Curti, S.9
Provera, S.10
Cimarosti, Z.11
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