A scalable oxidation for the final stage of synthesis of cathepsin K inhibitor SB-462795

Organic Process Research and Development

Volumn 15, Issue 1, 2011, Pages 123-130

  Goodman, Steven N ^a   Dai, Qunying ^a   Wang, Jun ^a   Clark, William M ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL STAGES; OXIDATION REACTIONS; SAFETY CONCERNS; SECONDARY ALCOHOLS;

ENVIRONMENTAL IMPACT; FREE RADICALS; MANUFACTURE; TRANSITION METALS;

OXIDATION;

EID: 79251471096     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100266s     Document Type: Article

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29. -1 water for 1 h prior to performing the EtOAc extraction.