A new efficient synthetic route for the synthesis of the antiallergic drug, olopatadine hydrochloride, via stereospecific palladium-catalyzed reaction

Organic Process Research and Development

Volumn 16, Issue 2, 2012, Pages 225-231

  Nishimura, Koichiro ^a   Kinugawa, Masahiko ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-ALLERGIC DRUG; HIGH YIELD; PALLADIUM CATALYST; PALLADIUM-CATALYZED REACTIONS; SEVEN-MEMBERED RINGS; STEREOSPECIFIC; STEREOSPECIFIC REACTION; SYNTHETIC ROUTES;

ACETYLENE; REACTION INTERMEDIATES;

CYCLIZATION;

EID: 84857604730     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op200312m     Document Type: Article

References (11)

1. Ohshima, E.; Otaki, S.; Sato, H.; Kumazawa, T.; Obase, H.; Ishii, A.; Ishii, H.; Ohmori, K.; Hirayama, N. J. Med. Chem. 1992, 35, 2074
2. Sano, T; Sugaya, T.; Kasai, M. Org. Process. Res. Dev. 1998, 2, 169
3. Katsura, T.; Hayashi, T.; Komatsu, K.; Tanaka, M. PCT Int. Appl. WO/2009/044838 A1, 2009.
4. Bosch, C. J.; Bachs, R. J.; Gomez, G. A.; Alonso, M. Y.; Bessa, S. M. PCT Int. Appl. WO/2006/010459 A1, 2006.
5. Burns, B.; Grigg, R.; Sridharan, V.; Worakun, T. Tetrahedron Lett. 1988, 29, 4325
6. Finch, H.; Pegg, N. A.; Evans, B. Tetrahedron Lett. 1993, 34, 8353
7. Kita, Y.; Egi, M.; Takeda, T.; Tohma, H. Synthesis 1999, 5, 885
8. Warker, W. H.; Rokita, S. E. J. Org. Chem. Soc. 2003, 68, 1563
9. Sy, W. Tetrahedron Lett. 1993, 34, 6223
10. Arcadi, A; Bernocch, E.; Burini, S.; Cacch, F.; Marinelli, F.; Pirtroni, B. Tetrahedron 1988, 44, 481
11. Nishimura, K.; Kinugawa, M. PCT Int. Appl. WO/2006/129781 A1, 2006.