DOE (design of experiments) in development chemistry: Potential obstacles

Organic Process Research and Development

Volumn 5, Issue 3, 2001, Pages 324-327

  Lendrem, Dennis ^a,b   Owen, Martin ^a   Godbert, Sonya ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b New Moor House   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035533036     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op000025i     Document Type: Article

References (7)

1. Box, G. E. P.; Hunter, W. G.; Hunter, J. S. Statistics for Experimenters; Wiley: New York, 1978; Carlson, R. Design and Optimisation in Organic Synthesis; Elsevier: Amsterdam, 1992. Godbert, S. Design and Analysis in Chemical Research; Tranter, R. L., Ed.; Sheffield Academic Press: Sheffield, 2000; Chapter 6, pp 188-236.
2. Box, G. E. P.; Hunter, W. G.; Hunter, J. S. Statistics for Experimenters; Wiley: New York, 1978; Carlson, R. Design and Optimisation in Organic Synthesis; Elsevier: Amsterdam, 1992. Godbert, S. Design and Analysis in Chemical Research; Tranter, R. L., Ed.; Sheffield Academic Press: Sheffield, 2000; Chapter 6, pp 188-236.
3. Box, G. E. P.; Hunter, W. G.; Hunter, J. S. Statistics for Experimenters; Wiley: New York, 1978; Carlson, R. Design and Optimisation in Organic Synthesis; Elsevier: Amsterdam, 1992. Godbert, S. Design and Analysis in Chemical Research; Tranter, R. L., Ed.; Sheffield Academic Press: Sheffield, 2000; Chapter 6, pp 188-236.
4. Owen, M. R.; Dewitt, S. H. Laboratory Automation in Chemical Development. In Process Chemistry in the Pharmaceutical Industry; Gadamasetti, K., Ed.; Marcel Dekker Inc.: New York, 1998.
5. Emiabata-Smith, D. F.; Crookes, D.; Owen, M. R. Org. Process Res. Dev. 1999, 3, 281-288.
6. Owen, M. R.; Smith, L. C. Presented at the 3rd Laboratory Automation in Process R&D symposium; Boston, 2000.
7. Bayne, C. K.; Rubin, I. B. Practical Experimental Designs and Optimisation Methods for Chemists; VCH Publishers: Deerfield Beach, FL, 1986.