The lactol route to fesoterodine: An amine-promoted Friedel-Crafts alkylation on commercial scale

Organic Process Research and Development

Volumn 15, Issue 5, 2011, Pages 1010-1017

  Dirat, Olivier ^a   Bibb, Andrew J ^a   Burns, Colin M ^a   Checksfield, Graham D ^a   Dillon, Barry R ^a   Field, Stuart E ^a   Fussell, Steven J ^a   Green, Stuart P ^a   Mason, Clive ^a   Mathew, Jinu ^a   Mathew, Suju ^a   Moses, Ian B ^a   Nikiforov, Petar I ^a   Pettman, Alan J ^a   Susanne, Flavien ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CINNAMALDEHYDE; FRIEDEL-CRAFTS ALKYLATION;

ALDEHYDES; ALKYLATION; METHANOL; PHENOLS;

ORGANIC COMPOUNDS;

EID: 80053003159     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op200107g     Document Type: Article

References (11)

1. McKeage, K.; Keating, G. M. Drugs 2009, 69 (6) 731
2. Malhotra, B.; Gandelman, K.; Sachse, R.; Wood, N.; Michel, M. C. Curr. Med. Chem. 2009, 16, 4481
3. Browne, R.; Kilkelly, M. Patent WO 2007/137799 A1, 2007.
4. Meese, C. Patent WO 2007/144097 A1, 2007.
5. Paras, N. A.; MacMillan, D. W. C. J. Am. Chem. Soc. 2001, 123, 4370
6. Bartoli, G.; Melchiorre, P. Synlett 2008, 1759
7. Paras, N. A.; Simmons, B.; MacMillan, D. W. C. Tetrahedron 2009, 65, 3232
8. List, B. Angew. Chem., Int. Ed. 2010, 49, 1730
9. Mills, I. W.; Scholfield, D. P. Patent WO 2010/018484 A1, 2010.
10. Ahman, J. B.; Dillon, B. R.; Pettman, A. J. Patent WO 2007/138440 A1, 2007.
11. For an example of a Langmuir-Hinshelwood kinetic model applied to heterogeneous hydrogenation, see: Vincent, M. J.; Gonzalez, R. D. Appl. Catal., A 2001, 217, 143