Process development and optimization for production of a potassium ion channel blocker, ICA-17043

Organic Process Research and Development

Volumn 16, Issue 8, 2012, Pages 1385-1392

  Mobele, Bingidimi I ^a,c   Venkatraman, Sripathy ^a   McNaughton Smith, Grant ^b   Gibb, Cameron ^a   Ulysse, Luckner G ^a   Lindmark, Carl A ^a   Shaw, Stephen ^a   Marron, Brian ^b   Spear, Kerry ^b   Suto, Mark J ^b  

^a ALBANY MOLECULAR RESEARCH INC   (United States)

^b Icagen Inc   (United States)

^c OKAPI Chemtech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC HYDROLYSIS; ACTIVE PHARMACEUTICAL INGREDIENTS; ALCOHOL DERIVATIVES; CYANATION; CYANATION REACTION; GRIGNARD; GRIGNARD REACTION; KEY FEATURE; PILOT SCALE; POTASSIUM ION CHANNELS; PROCESS DEVELOPMENT;

CYANIDES; HYDROLYSIS; MANUFACTURE; REACTION INTERMEDIATES;

OPTIMIZATION;

EID: 84865263126     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op3000916     Document Type: Article

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