Synthetic process development and scale-up of the oxidative cleavage of a double bond catalyzed by ruthenium trichloride

Organic Process Research and Development

Volumn 8, Issue 6, 2004, Pages 1036-1041

  Quittmann, Wilhelm ^a   Roberge, Dominique M ^a   Bessard, Yves ^a  

^a LONZA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

RUTHENIUM DERIVATIVE; RUTHENIUM TRICHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL BOND; CHEMICAL REACTION; FEASIBILITY STUDY; OXIDATIVE STRESS; STATISTICAL ANALYSIS; SYNTHESIS;

EID: 10044244975     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op040014f     Document Type: Article

References (11)

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11. For the ∼20% missing yield, less than 5% can be attributed to loss of material. At least 15% represent the 10-12 different side products formed during the oxidation reaction. Most of these side products disappear during the workup. As mentioned, only three of them cause problems while, when formed, they remain in the final product. The goal of our work was to ascertain experimental conditions where their formation was minimized, allowing to get a conform material.