A single dynamic metabolic model can describe mAb producing CHO cell batch and fed-batch cultures on different culture media

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Robitaille, Julien ^a   Chen, Jingkui ^a   Jolicoeur, Mario ^a  

^a ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUTAMINE; MONOCLONAL ANTIBODY; AMINO ACID; CULTURE MEDIUM;

ACCURACY; AMINO ACID METABOLISM; ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CALCULATION; CELL CULTURE; CELL FUNCTION; CELL GROWTH; CELL VIABILITY; CHO CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DYNAMIC METABOLIC MODEL; ENERGY METABOLISM; FED BATCH CULTURE; GLUCOSE INTAKE; GLYCOLYSIS; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NONHUMAN; SIMULATION; ANIMAL; BATCH CELL CULTURE; BIOLOGICAL MODEL; BIOTECHNOLOGY; CRICETULUS; CYTOLOGY; METABOLISM; PROCEDURES;

AMINO ACIDS; ANIMALS; ANTIBODIES, MONOCLONAL; BATCH CELL CULTURE TECHNIQUES; BIOTECHNOLOGY; CHO CELLS; CRICETULUS; CULTURE MEDIA; ENERGY METABOLISM; GLYCOLYSIS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL;

EID: 84947460115     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136815     Document Type: Article

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